RADIOISOTOPES
Online ISSN : 1884-4111
Print ISSN : 0033-8303
ISSN-L : 0033-8303
Volume 68 , Issue 2
Showing 1-5 articles out of 5 articles from the selected issue
Review Articles
Applications of Stable Isotopes
  • Yasuhiro Kajiwara, Masahiro Kajiwara
    2019 Volume 68 Issue 2 Pages 37-48
    Published: February 15, 2019
    Released: February 15, 2019
    JOURNALS OPEN ACCESS

    There are so many papers relevant to stable isotope researches, and yet increase all the more. In this article, we describe separation and concentration techniques of stable isotope, application of 13C-labeled compounds in the biosynthesis of vitamin B12 researches from the 1970s to the present, and the development of 13C-urea breath test as 13C-medical application.

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  • Hiroshi Kunugi, Toshiya Teraishi, Masahiro Kajiwara
    2019 Volume 68 Issue 2 Pages 49-58
    Published: February 15, 2019
    Released: February 15, 2019
    JOURNALS OPEN ACCESS

    We introduced our studies on the possible clinical use of 13C-phynylalanine breath test and 13C-tryptophan breath test in psychiatric disorders. By the phenylalanine test, we detected decreased metabolism of phenylalanine in patients with schizophrenia. In the tryptophan test, on the other hand, we obtained evidence supporting the enhanced metabolism of the tryptophan-kynurenine pathway in patients with major depressive disorder. Collectively, these 13C-labelled breath tests may be useful in the diagnosis and subtyping psychiatric disorders such as schizophrenia and depressive disorder.

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  • Tomokazu Matsuura, Hirotaka Ezaki, Mariko Nakamura, Yoshihiro Mezaki, ...
    2019 Volume 68 Issue 2 Pages 59-64
    Published: February 15, 2019
    Released: February 15, 2019
    JOURNALS OPEN ACCESS

    Fasting 13C-glucose breath test (FGBT) was newly developed as a fast diagnostic method for liver insulin resistance. It is a test to evaluate liver insulin resistance from glucose metabolism in liver, especially balance of gluconeogenesis and glycolysis system. In general, liver insulin resistance often evaluates the condition after hyperinsulinemia. FGBT can evaluate liver insulin resistance before becoming hyperinsulinemia and can contribute to the prevention of diabetes through its early diagnosis.

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  • Yukimoto Ishii, Satoshi Asai
    2019 Volume 68 Issue 2 Pages 65-71
    Published: February 15, 2019
    Released: February 15, 2019
    JOURNALS OPEN ACCESS

    Nihon University School of Medicine has incorporated a 13C breath test into its pharmacological training since 2016. In the training, (i) 13C-urease, (ii) 13C-phenylalanine (L-[1-13C] phenylalanine), and (iii) 13C-leucine (L-[1-13C] leucine) breath tests are conducted. Introducing a 13C breath test into student training can collateralize the activity of the basic educational principle and the association with the clinical medicine. Unlike radioactive isotopes, the stable isotope 13CO2 requires no special facility and can be simply handled with measuring equipment. Introducing a 13C breath test into student training poses problems, such as the initial cost of measuring equipment and the use of expensive reagents, but should enhance the association between basic and clinical medical education.

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