臨床血液
Online ISSN : 1882-0824
Print ISSN : 0485-1439
ISSN-L : 0485-1439
10 巻, 5 号
選択された号の論文の10件中1~10を表示しています
綜説
臨床研究
  • 安永 幸二郎
    1969 年 10 巻 5 号 p. 605-609
    発行日: 1969年
    公開日: 2008/10/20
    ジャーナル 認証あり
    No satisfactory treatments have appeared for the patients with hemorrhagic diathesis so for and difficulty is always encountered in hemostatic countermeasures. In such cases, even, if the effects by a single agent were not enough, combined use of several hemostatic agents with different mechanism of action might produce better hemostatic effect.
    In the therapeutic result with pyridinolcarbamate (Anginin), positive effect was obtained in 8 of 12 cases of vascular purpura, but effect was not definite in 4 cases. In 6 cases of thrombocytopenic purpura, no effect was seen in 3 and effect was not clear in 3.
    This preparation, a unique hemostatic agent with mechanism of action entirly different from that of hesperidine, Rutin, adrenochrome, etc, might be used in trial.
  • 橋本 健
    1969 年 10 巻 5 号 p. 610-619
    発行日: 1969年
    公開日: 2008/10/20
    ジャーナル 認証あり
    The studies on fibrinolytic activity of the circulating blood during surgical procedure were performed after evaluation of the measuring method, and the following conclusions were obtained.
    1) Blood or plasma fibrinolytic activity decreased markedly at room temperature, but the euglobulin fraction separated from the plasma immediately after venous puncture revealed no decrease after 24 hours' storage.
    2) Fibrinolytic activity during operative procedure was elevated most markedly in the cases of stomach, liver and biliary system operations.
    3) Significance of fibrinolytic activity of euglobulin fraction was discussed, and its activator activity was considered to be caused by the summation of the fibrinolytic factors in the blood.
症例
  • 佐藤 琢司, 森 彪, 常松 喜久子
    1969 年 10 巻 5 号 p. 620-629
    発行日: 1969年
    公開日: 2008/10/20
    ジャーナル 認証あり
    An 11-year-old female case of systemic lupus erythematosus with bleeding tendency caused by coagulation abnormalities was reported. Her first symptom was a fracture of the clavicula and its subsequent hematoma formation. Other bleeding episodes such as epistaxis, ecchymoses and petechiae were also observed.
    The results of coagulation tests revealed deficiencies of prothrombin, factor VII and platelet factor 3, and thrombopenia.
    In addition, increase of circulating anticoagulants including antithromboplastin, antithrombin II and heparin-like substance was disclosed, and some of them were inferred to inhibit the formation of thromboplastin.
    Previously reported cases of SLE in the literature were also reviewed from the view point of bleeding tendency caused by coagulation abnormalities, especially by circulating anticoagulant.
  • 半沢 敦正, 久山 栄一, 波柴 忠利, 林 久智, 藤井 千秋, 品川 晃二, 松森 宏
    1969 年 10 巻 5 号 p. 630-636
    発行日: 1969年
    公開日: 2008/10/20
    ジャーナル 認証あり
    A report was made on a case 41-year old male, of pure red cell anemia complicated with hypo-gamma globulinemia. It is a case believed to have started with contact epidermal inflammation in 1954. Steroid hormone treatment in the early stage of the disease improved anemia and bone marrow pictures of the patient for a certain period but at the present stage ACTH, steroid hormones, estradiol, Vitamin B12, and Cobalt green pole proved to be of no avail, and anemia is now solely being treated by blood transfusion. However, hypo-gamma globulinemia of this case still persists, and due to the decrease in various immuno-globulins the systemic resistance against infection has fallen so much so that the patient had once fallen into the state of septicemia. Recently, the patient has developed the complication of cryptococcus meningitis due to bacterioalterance phenomenon and he has been treated with Amphotericine B which brought fever under control and has improved this condition. Nonetheless, the treatments with steroids, estradiol and ACTH still prove to be ineffective.
    A discussion is made on the etiology, clinical findings and treatments of this anemic case along with available date by various investigators.
  • 間森 坦, 笹脇 敏郎, 安見 敏彦
    1969 年 10 巻 5 号 p. 637-642
    発行日: 1969年
    公開日: 2008/10/20
    ジャーナル 認証あり
    A 81-year-old man was admitted to our hospital with complaints of dyspnea and pruritis on July 3, 1966. Chest x-ray film showed right pleural effusion.
    The most outstanding findings on physical examination were generalized superficial lymphadenopathy and exfoliative dermatitis. Laboratory data revealed elevated leukocyte count (16700 per cu. mm) with 65 per cent of mature lymphocytes and 25 per cent of atypical lymphoid cells.
    The clinical diagnosis was chronic lymphocytic leukemia. Lymphnode biopsy, however, revealed Hodgkin's disease (paragranuloma) which was confirmed by autopsy.
    The literatures of 9 similar cases were reviewed.
  • 中山 志郎, 赤沢 好温, 服部 譲, 佐竹 喜三雄, 星野 孝
    1969 年 10 巻 5 号 p. 643-649
    発行日: 1969年
    公開日: 2008/10/20
    ジャーナル 認証あり
    A 32-year-old housewife was transferred to our hospital on July 14, 1966, with a chief complaint of severe genital hemorrhage after premature delivery due to abruptio placentae in the 8th month of gestation. Physical examination revealed anemia, large suggillation on lower extremities without lymphadenopathy and hepatosplenomegaly. Her peripheral white blood cell count was 14,000 with 67.0% of promyelocytes.
    Myelogram showed 66.8% of promyelocytes. Marked hypofibrinogenemia and reduction of factor V were observed. Under a diagnosis of promyelocytic leukemia she was treated with blood-transfusions, 6MP, corticosteroids, fibrinogen and antiplasmic drugs, but did not respond to any of the treatments and died of cerebral hemorrhage one month later. Autopsy findings revealed proliferation of leukemic cells in the bone marrow. The liver (2100 g), spleen (165 g) and other organs were infiltrated by dominating leukemic cells. Marked bleeding was observed in several organs. The child died of respiratory distres s 10 hours after birth. The autopsy of the child showed infiltration and increased mitosis of atypical cells in the liver. Some bibliographical considerations were made concerning this case.
  • 杉田 浩, 外山 圭助, 秋山 実, 五島 雄一郎, 三方 淳男
    1969 年 10 巻 5 号 p. 650-655
    発行日: 1969年
    公開日: 2008/10/20
    ジャーナル 認証あり
    A 73-year-old male with acute promyelocytic leukemia, gastric cancer and congenital atrophy of spleen was reported.
    On admission to Keio University Hospital on Aug. 28, 1967, physical examination revealed marked anemia but no lymphadenopathy nor hepatosplenomegaly.
    Laboratory examination showed low ESR, anemia, thrombocytopenia, fibrinogenopenia, factor V deficiency and hyperfibrinolysis. Leucocytes collected from peripheral blood lysed the fibrin plate markedly.
    Atypical promyelocytes were 54 per cent of peripheral WBC and 85 per cent of bone marrow cells.
    Post-mortem examination revealed infiltration of atypical promyelocytes in the bone marrow, liver, spleen and kidneys, hyaline thrombi in the pulmonary vessels and glomeruli of the kidneys, adenocarcinoma of the stomach, and congenital atrophy of the spleen.
    Possible etiology of hypofibrinogenemia in this case was discussed.
例会
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