A 73-year-old male with acute promyelocytic leukemia, gastric cancer and congenital atrophy of spleen was reported.
On admission to Keio University Hospital on Aug. 28, 1967, physical examination revealed marked anemia but no lymphadenopathy nor hepatosplenomegaly.
Laboratory examination showed low ESR, anemia, thrombocytopenia, fibrinogenopenia, factor V deficiency and hyperfibrinolysis. Leucocytes collected from peripheral blood lysed the fibrin plate markedly.
Atypical promyelocytes were 54 per cent of peripheral WBC and 85 per cent of bone marrow cells.
Post-mortem examination revealed infiltration of atypical promyelocytes in the bone marrow, liver, spleen and kidneys, hyaline thrombi in the pulmonary vessels and glomeruli of the kidneys, adenocarcinoma of the stomach, and congenital atrophy of the spleen.
Possible etiology of hypofibrinogenemia in this case was discussed.
抄録全体を表示