巻号一覧
11 巻 (1970)
- 6 号 p. 669-
- 5 号 p. 571-
- 4 号 p. 457-
- 3 号 p. 277-
- 2 号 p. 81-
- 1 号 p. 1-
11 巻, 5 号
選択された号の論文の12件中1～12を表示しています
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例会
招待講演
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小林 忠義, 渡辺 裕1970 年 11 巻 5 号 p. 571-577
発行日: 1970年
公開日: 2008/10/31
ジャーナル 認証ありPDF形式でダウンロード (682K)
臨床研究
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—Basophilogramを中心に—木村 郁郎, 守谷 欣明, 谷崎 勝朗1970 年 11 巻 5 号 p. 578-584
発行日: 1970年
公開日: 2008/10/31
ジャーナル 認証ありBasophilic leucocytes in peripheral blood and bone marrow of 13 cases of CML were calculated by our improved method. The results of these calculations were used to form basophilograms. The basophilogram in healthy controls showed a left type and that in CML generally a right type. It shifted to the left approaching to the normal type in remission by chemotherapy. In an aggravation of CML, the basophilogram clearly shifted to the right. The basophilogram in 2 cases of pre-stage of blastic crisis of CML indicated a definite right type. S type, sharply defined granules, and diffuse N type in III and IV type of basophilogram were classified, and it was shown that an increase of S type occurred in the aggravation stage. Consequently, appearance of S type as well as a right type in basophilogram would be a useful guide in the follow-up of CML. A basophil of S type was considered to be immature. The bone marrow basophilogram was shown to be more shifted to the right than that of peripheral blood, and this tendency became more remarkable in relapse. The fact that there are a right type in basophilogram and appearance of S type is significant for the observation of the clinical course in CML, especially in the judgment of acute exacerbation.抄録全体を表示PDF形式でダウンロード (646K) -
神谷 忠, 鯉江 捷夫, 斎藤 英彦, 佐光 冨士男, 塩屋 雅夫, 勝見 乙平1970 年 11 巻 5 号 p. 585-591
発行日: 1970年
公開日: 2008/10/31
ジャーナル 認証ありLeupeptin is a new substance isolated from various species of actinomyces by Umezawa in 1968.
It is reported that this substance possesses a potent anticoagulant as well as antifibrinolytic activity.
Our report describes in vitro effects of this substance on the blood clotting and fibrinolytic systems. It was found that Leupeptin exerted a strong inhibitory effect on the action of thrombin and on the thromboplastin generation. The substance also was markedly inhibitory on the function of already activated contact factor, although it did not affect the process of its activation whatsoever.
Upon the adhesiveness of platelets, Leupeptin showed a significant and a complete suppression at the concentration of 10 γ/ml and 1000 γ/ml, respectively.
The substance was also found to be antiplasmic as measured by fibrinolysis (plasmin, urokinase, streptokinase), caseinolysis and plasmin-induced activation of the contact factor (ID50=10∼28 γ/ml in each method).
Its effect on esterolysis was only minimal.抄録全体を表示PDF形式でダウンロード (478K) -
雨宮 禎子, 斎藤 伊希子, 滝川 道子, 上田 俊男, 三神 美和1970 年 11 巻 5 号 p. 592-598
発行日: 1970年
公開日: 2008/10/31
ジャーナル 認証ありChromosomal analysis was made on a sixty five year old female patient suffering from pernicious anemia. The disease started with glossitis, numbness of extremities and severe fatigue. Blood examination in admittion reveales RBC of 0.79 million/cmm, Hb of 3.2 g/dl, WBC of 1800 /cmm, platelets of 11800/cmm and reticulocytes of 0.5%. Magaloblasts were found in 13.4% of bone marrow cells. Schilling test was 2.7% and rose up to 12.5% with administration of IF. Serum iron was 26 μg/ml, serum LDH was 695 mmμ/ml.
Chromosome analysis was made on bone marrow aspirates with direct method. Chromosome counts made on 23 cells in relapse and 3 cells in remission showed the model number of 46 with normal diploidy. Only in three cells out of 23 cells in relapse, chromosome counts were 43, 44 and 45, which should be regarded as an artefact because these chromosomal losses were not in order. In relapse centromere spreadings were seen in C group in one cell. Other chromosomal aberration was not found. Literatures were reviewed.抄録全体を表示PDF形式でダウンロード (598K) -
河村 節子1970 年 11 巻 5 号 p. 599-607
発行日: 1970年
公開日: 2008/10/31
ジャーナル 認証ありElucidation of the changes in the process of heme synthesis is considered to be most important for the understanding of the mechanism of anemia in various diseases. From this point, the activity of δ-ALA synthetase and dehydrase has been studied by several investigators.
In this present study, the change in activity of the heme synthetase, iron-protoporphyrin chelating enzyme, in the bone marrow cells was investigated in various diseases.
The paste of nuclei-mitochondria obtained from hemolysate of bone marrow cells after Goldberg was used as the enzyme solution. The solution together with incubation medium was then incubated at 37°C for two hours according to Labbe. Hemin was extracted and the radioactivity was counted by well-type scintillation counter. The activity was expressed as mμ moles per mg protein.
The following results were obtained. A considerable increase in the enzyme activity was seen in iron deficiency anemia and in cancer without cachexia. No significant difference from the controls was seen in the hepatic and renal diseases. A decreased activity was seen in some of panmyelopathy, cancer with cachexia and hyperthyroidism. Based on these findings, the factors regulating the enzyme activity and their relationship to the development of anemia were discussed.抄録全体を表示PDF形式でダウンロード (711K) -
野村 武夫, 古沢 新平, 金津 赫生, 足立 山夫, 川田 健一1970 年 11 巻 5 号 p. 608-612
発行日: 1970年
公開日: 2008/10/31
ジャーナル 認証ありObservations were made on erythropoiesis before, during and after blood transfusion in three cases with erythroleukemia. A marked decrease was seen in marrow erythroblasts, peripheral reticulocytes and plasma iron turnover in association with the rise in hemoglobin level. Plasma erythropoietin concentration, which had shown a conspicuous elevation in two of the three cases before initiation of transfusion, was reduced to hardly, if any, detectable level after the transfusion therapy.
These results indicate that erythropoiesis in erythroleukemia is regulated by erythropoietin elaborated in response to hypoxia as in physiological conditions.抄録全体を表示PDF形式でダウンロード (401K) -
高林 嬉子, 清水 勝, 塚田 理康, 三輪 史朗, 浅井 一太郎1970 年 11 巻 5 号 p. 613-621
発行日: 1970年
公開日: 2008/10/31
ジャーナル 認証ありDuring the last 2 years, 93 platelet transfusions have been conducted in 13 cases of acute leukemia with marked bleeding tendency due to thrombocytopenia.
Soon after the infusion of Ringer solution into the donor being started, whole blood was collected by 500 to 600 gm at one time into a plastic blood-bag containing ACD solution as an anticoagulant. The whole blood was then centrifuged at 1,100 rpm for 15 minutes in order to separate the platelet-rich plasma (PRP) from the packed red cell. The PRP was transferred into another plastic bag. In the event that the platelet concentrate (PC) was preferred, the PRP was further centrifuged at 2,400 rpm for 30 minutes and the supernatant platelet-poor plasma (PPP) was removed. The PRP or PC thus obtained was immediately administered into the leukemic patients. The packed red cell and the PPP were transfused back into the donor before the second blood collection was started. Consequently, either PRP or PC separated from 1,000 to 1,500 gm (2 or 3 bags) of whole blood could be obtained within a few hours from a single donor quite safely and with relative ease. No serious side effects were observed on the donors except a slight transient decrease in serum protein. The mean content of the PRP or PC was about 60 per cent of the platelet count in the whole blood, and the total platelet suspension obtained from a single donor contained 1.95×1011 platelets. After the platelet transfusions, 2 out of the 12 cases (16.7 per cent) died of bleeding, whereas out of the other 60 cases of leukemia to whom the platelet transfusions were not conducted, 30 (50 per cent) died of bleeding.
In summary, it may be said that platelet transfusions are effective in the control of hemorrhage due to thrombocytopenia in leukemic patients.抄録全体を表示PDF形式でダウンロード (1040K)
症例
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山口 潜, 井上 修二, 千葉 一夫, 上田 英雄1970 年 11 巻 5 号 p. 622-625
発行日: 1970年
公開日: 2008/10/31
ジャーナル 認証ありS. K., 76-year-old farmer, was admitted to the Second Department of Internal Medicine, University of Tokyo, with chief complaints of a tumor of the hard palate, abnormal blood picture and hypertension.
Forty years ago, he noticed a non-tender tumor of the palate, which was excised and diagnosed as “endothelioma.” Eleven years ago, a tumor of the same nature was again excised. In September 1968, he noticed the same sort of tumor at the right hard palate. He was admitted to the Department of Oral Surgery, University of Tokyo. Because of changes in the peripheral blood and hypertension on pre-operative examination, he was referred to the Second Department of Internal Medicine on March 7, 1969.
On examination the patient was anemic and a non-tender tumor was present at the right hard palate. Liver and spleen were enlarged, both by one fingerbreadth. Examination of the peripheral blood revealed hemoglobin 9.0 gm/100 ml, WBC 251,000 with immature granulocytes and a few erythroblasts and platelets 362,000/cmm. Neutrophil alkaline phosphatase score was low. The findings of sternal marrow aspirate were consistent with chronic myelogenous leukemia, with positive Ph1 chromosome. Weight of the spleen calculated from a scintigram with MHP was 357 gm.
After admission, leukocyte count decreased by myleran therapy. The tumor of the palate was excised at the Department of Oral Surgery on April 4; it was elastic, the cut surface was reddish-brown and 2×2×3.5 cm in size. On histological examination it was the mixed tumor of the minor salivary glands.
Postoperative course was uneventful. After discharge on May 23, 1969, he has been followed at the outpatient clinic, on intermittent myleran therapy with no subjective complaints.抄録全体を表示PDF形式でダウンロード (562K) -
小島 峯雄, 安藤 喬, 旧井 公之, 松友 啓典, 野手 信哉, 高井 輝雄, 安藤 成人, 林 慶一1970 年 11 巻 5 号 p. 626-631
発行日: 1970年
公開日: 2008/10/31
ジャーナル 認証ありA female case of pure red cell aplasia without thymoma is described. The patient is sixty-eight years old. This case was of interest because of effective response to initial corticosteroid therapy, and the good hematological condition appeared to be continued. But after three years the beneficial effects decreased gradually. A remarkable feature was that some of lymphfollicles were demonstrated on smears obtained by sternal and iliac bone marrow biopsy.
The auto-immunity of pure red cell aplasia is discussed with reference to possible pathogenic mechanism.抄録全体を表示PDF形式でダウンロード (607K) -
栗田 宗次, 太田 和雄, 長与 健夫1970 年 11 巻 5 号 p. 632-635
発行日: 1970年
公開日: 2008/10/31
ジャーナル 認証ありA case of unusual presentation of Hodgkin's disease with terminal leukemic manifestation was reported.
A 43-year-old male was diagnosed as Hodgkin's disease by a cervical lymphnode biopsy on March 9, 1966. Then he was treated with 3 times of radiation therapy with good response. Three years and 3 months after diagnosis, he suffered from fever, ascites and anemia. Many large Hodgkin's cells and immature reticulum cells were found in the routine peripheral blood smears. He died on March 21, 1969 without any response to chemotherapy with prednisolone, cytoxan and vincristine. On autopsy, lymphadednopathies, hepatomegaly and splenomegaly with marked proliferation of Hodgkin's and Sternberg's cells were found. These cells were also found in the bone marrow, pancreas, kidney, suprarenal gland, etc.
The factors in the development of leukemic manifestation in Hodgkin's disease were discussed.抄録全体を表示PDF形式でダウンロード (687K) -
木村 あさの, 吉田 豊, 山本 実1970 年 11 巻 5 号 p. 636-640
発行日: 1970年
公開日: 2008/10/31
ジャーナル 認証ありA 69-year-old man was discovered to have anterior mediastinal tumor and was treated with Mitomycin C 6 mg/day orally for about two months. A severe anemia with erythroid aplasia followed. Administration of betamethasone resulted in normal erythroid response in bone marrow before the mediastinal tumor, thymoma, was removed. The tumor weighed 85 gm. and its histology showed spindle cell type thymoma.
He was in good health without treatment until 3 months after thymectomy, when pure red cell anemia relapsed. Betamethasone was again effective. Patient died from a severe diarrhea at a local hospital 16 months after a diagnosis of pure red cell anemia was first made.
It was concluded that PRCA was potentially present in this patient with thymoma and was induced by Mitomycin C administration. Review of the literature on the relationship between thymoma and PRCA was made.抄録全体を表示PDF形式でダウンロード (667K)
例会
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1970 年 11 巻 5 号 p. 641-660
発行日: 1970年
公開日: 2008/10/31
ジャーナル 認証ありPDF形式でダウンロード (1920K)
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