巻号一覧
11 巻 (1970)
- 6 号 p. 669-
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11 巻, 6 号
選択された号の論文の6件中1～6を表示しています
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綜説
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藤木 典生1970 年 11 巻 6 号 p. 669-680
発行日: 1970年
公開日: 2008/10/31
ジャーナル 認証ありPDF形式でダウンロード (1228K)
症例
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山口 黎子, 川口 尚志, 足立 山夫, 古沢 新平, 野村 武夫1970 年 11 巻 6 号 p. 681-686
発行日: 1970年
公開日: 2008/10/31
ジャーナル 認証ありTwo cases of acute leukemia, who developed massive pulmonary thromboembolism probably caused by mucarmyces in their terminal phase, were reported.
At autopsy it was revealed that thrombi were consisted of mucormyces. Since their platelet count remained below 10,000/cmm throughont their hospital course, pathogenesis of thromboembolism was analysed and discussed in relation to mucormycosis.抄録全体を表示PDF形式でダウンロード (761K) -
中山 志郎, 堺 幹太, 疋田 善平, 服部 譲, 三宅 儀, 古田 睦広, 井谷 舜郎, 星野 孝1970 年 11 巻 6 号 p. 687-696
発行日: 1970年
公開日: 2008/10/31
ジャーナル 認証ありThis report deals with our recent observations on 3 cases of atypical acute leukemia difficult to differentiate from aplastic anemia. They were all males, over 60 years old and had lack of definite signs of acute leukemia in their clinical pictures. Onset was insidious, clinical course was mild and prolonged, and physical examinations were unremarkable except for pallor.
Examinations of the blood showed marked pancytopenia with few or no immature cells. Aspirated bone marrow specimens were markedly hypocellular with an infiltration of a small number of blast cells which were characterized by bizzare shape, negative peroxidase reaction and prominent nucleoli and were barely identifiable as myeloblast by the phase contrast microscopical findings.
Chromosomal analysis of cultured peripheral leukocytes disclosed many aneuploid cells including few of 21-Trisomy in 2 cases.
Anemia remained refractory to various therapies, but blood transfusions and administration of prednisolone made the patients' general condition improved.
One case died of unknown cause suddenly after blood transfusion. The principal anatomical findings of this case were bone marrow hypoplasia and mild infiltrations of immature cells in the bone marrow, lymphnodes, spleen and liver.
It is widely known that the clinical picture and course of malignant tumors in aged persons are somewhat different from those in younger people. On this aspect, characteristics of acute leukemia in advanced age group are discussed mainly in association with changes in the immunobiologic capabilities and in the functions of endocrine organs.抄録全体を表示PDF形式でダウンロード (1279K) -
青木 紀生, 河合 忠, 土屋 俊夫, 山岸 安子, 大島 寿美子, 柴沼 達夫1970 年 11 巻 6 号 p. 697-705
発行日: 1970年
公開日: 2008/10/31
ジャーナル 認証ありA fifty-eight year old male was admitted with the chief complaint of lumbago. Bone marrow examination revealed 11.0% pleomorphic plasma cells, but no abnormal cell was found in the peripheral blood.
X-ray survey of the skeletal system showed various osteolytic changes in the left femur, left fibula, left humerus and skull.
The patient's serum showed marked hyperproteinemia (12 g/dl) with hypergammaglobulinemia up to 39%. Cellulose acetate electrophoretic pattern of the serum showed a characteristic discrete band at slow-gamma area.
The pathologic immunoglobulin was identified as IgG-L type, immunochemically. No Bence Jones protein was identified in both urine and serum.
Upon heating the serum to 56°C for 30 minutes, whitish coagulum was formed, its pyrocrit reading to be 45%. On agar gel electrophoresis of the original serum, two Mspots could be recognized distinctly at the gamma and slow-gamma areas, corresponded to biphasic M-bow formation of IgG precipitation line on immunoelectrophoresis.
By using various analytical methods, the M-spot at the gamma area was identified as pyroglobulin, while the M-spot at the slow-gamma area as non-heat-coagulable M-protein. From the findings obtained with the gel filtration and ultracentrifugal techniques, the pyroglobulin was found to be of larger molecular size, probably due to molecular aggregation of the pathological immunoglobulin.
Because of these laboratory data, a diagnosis of multiple myeloma with pyroglobulinemia was made. He was treated with steroid hormones and vitamins. But he died of generalized weakness, after one and a half year's clinical course. No autopsy was done.抄録全体を表示PDF形式でダウンロード (1135K) -
黒田 迪子, 近江 忠尚, 富田 重照, 吉田 豊, 木村 正方1970 年 11 巻 6 号 p. 706-711
発行日: 1970年
公開日: 2008/10/31
ジャーナル 認証ありA 48-year-old man was transferred to our department on July 4, 1969. For high fever and anemia, steroid, antibiotics and Vit. B12 had been given without benefit for previous 45 days. 7 years ago, the patient was found to be anemic.
Blood examination on admission showed a hemoglobin of 6.8 Gm. and a white cell count of 8900 with 2% myelocytes and 2% metamyelocytes. Only one normoblast was seen per 200 leukocytes.
The patient's condition improved with prednisolone and blood transfusion. But, after 3 months anemia became more severe and erythroblasts increased and meglaoblastoid cells appeared. PAS staining was positive in those megaloblastoid cells. A diagnosis of erythremia was established. A Schilling test showed only 4.8% urinary excretion of radioactive Vit. B12. But, with intrinsic factor, the excretion increased to 12.8%.
Gradually the blood picture changed to erythroleukemia, then to acute myelocytic leukemia, and the patient died on Feb. 6, 1970.
It was speculated that the patient might have had pernicious anemia for at least 7 years before erythremia occurred.抄録全体を表示PDF形式でダウンロード (657K) -
斎藤 達雄, 桧森 巽, 菅原 一布, 氏家 重紀, 菅原 伸夫1970 年 11 巻 6 号 p. 712-721
発行日: 1970年
公開日: 2008/10/31
ジャーナル 認証ありA 39-year-old male was referred to our hospital because of mediastinal tumor suspected. During preoperative examinations fever, hepatomegaly and leukocytosis appeared, and was diagnosed as acute lymphoblastic leukemia on hematological examination.
Complete remission was induced with 6-MP and prednisolone. During complete remission remarked specific cutaneous and subcutaneous lesions of leukemia with meningeal leukemia and mediastinal tumor were noticed 4 times at sculp, face, conjunctiva palpebrae, neck, chest, back, and upper extremities.
Administrations of L-Asparaginase (400IU/kg/day) were very effective each 3 times but 4 th administration of L-Asparaginase could not improve the symptoms like above any more. He died of cerebral bleeding.
Statistical observations on specific cutaneous and subcutaneous lesions of autopsied leukemia recorded in the “Annual of the Autopsy Cases in Japan” during the years 1958 through 1967 were performed and the following results were obtained.
1) Total number of autopsied leukemias in Japan for 10 years was 4661 cases and type distribution was as follows; AML 2399 cases (51.6%), CML 607 cases (13.0%), ALL 251 cases (5.4%), MoL 215 cases (4.6%), CLL 79 cases (1.7%) and so on.
2) Specific leukemic skin involvements were obserbed in 106 cases (2.3% of total autopsied leukemias) including AML 44 cases (41.5%), CML 17 cases (16.0%), ALL 8 cases (7.6%) and MoL 8 cases (7.6%), respectively.
Incidence of specific cutaneous lesions in each type of leukemia was, however, as follows; MoL 3.7%, ALL 3.2%, CML 2.8%, AML 1.8%, and so on.
3) Leukemic infiltrations in the subcutaneous tissues were noticed in 27 cases (0.6% of total autopsied leukemias) which included AML 17 case (63.0%), chloroleukemia 4 cases (14.8%) and so on.
4) Leukemia cutis was more common in adults than in children in Japan.抄録全体を表示PDF形式でダウンロード (1365K)
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