巻号一覧
14 巻, 5 号
選択された号の論文の11件中1～11を表示しています
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第14回総会
教育講演
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—白血病の疫学—小林 博1973 年 14 巻 5 号 p. 565-569
発行日: 1973年
公開日: 2008/10/31
ジャーナル 認証ありPDF形式でダウンロード (375K) -
大北 威1973 年 14 巻 5 号 p. 570-579
発行日: 1973年
公開日: 2008/10/31
ジャーナル 認証ありPDF形式でダウンロード (774K)
綜説
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—本邦報告例の検討—中村 公一, 行木 康夫, 土橋 招一, 高口 二郎1973 年 14 巻 5 号 p. 580-589
発行日: 1973年
公開日: 2008/10/31
ジャーナル 認証ありPDF形式でダウンロード (709K)
臨床研究
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—第2報 血尿—豊坂 比沙子, 長尾 大1973 年 14 巻 5 号 p. 590-595
発行日: 1973年
公開日: 2008/10/31
ジャーナル 認証ありSpontaneous hematuria is a rather rare hemorrhagic symptom in hemophilia. The etiology of it is unknown and standardization of treatment has not been fully established.
We are reporting five cases of spontaneous hematuria who were treated successfully with high dose replacement therapy and oral prednisolone.
Our treatment schedule was as follows:
1) Initially AHF was given 10-15 u/kg intravenously every 12 hours until hematuria disappeared.
After hematu riadisappeared, the same dosis was given twice daily every 12 hours. Subsequently half the dose was given once a day for two days, then stopped.
Prednisolone was administered together with AHF. Initially 1 mg/kg/day was given orally in 2 divided dosis for two days and then half the dose for three subsequent days.
With this treatment schedule, hematuria disappeared in all cases within 72 hours, without any complication.抄録全体を表示PDF形式でダウンロード (425K) -
月本 一郎, 三問屋 純一, 豊坂 比沙子, 長尾 大, 塙 嘉之1973 年 14 巻 5 号 p. 596-603
発行日: 1973年
公開日: 2008/10/31
ジャーナル 認証ありFourteen children with acute leukemia were treated with cytosine arabinoside and daunomycin in combination. All the cases had been already treated with two or more of the conventional chemotherapeutic agents. Cytosine arabinoside was administered intravenously with a does of 50 to 150 mg/m2 daily for 2 days, and on the 3rd day 1 mg/kg of daunomycin was injected intravenously. In cases 7 out of 14, prednisolone were also administered in parallel with chemotherapy.
In the total cases, 50% of the overall remission rate was obtained. For the maintenance chemotherapy, employed were either oral cyclophosphamide, intravenous methotrexate or the combination of cytosine arabinoside and daunomycin. The duration of remission was ranged from 2 weeks to 3 months.
Unfavorable effects were as follows: leukopenia (14 cases), thrombocytopenia (7 cases), anorexia (7 cases), fever (8 cases), buccal ulcer (4 cases), sinus tachycardia (2 cases) and abnormal liver function tests (GOT, 3 cases).抄録全体を表示PDF形式でダウンロード (612K) -
伊藤 尹敦, 伊勢 泰, 沢部 孝昭, 中山 昇, 大倉 久直, 藤田 浩, 木村 禧代二, 竹下 隆裕1973 年 14 巻 5 号 p. 604-610
発行日: 1973年
公開日: 2008/10/31
ジャーナル 認証ありThe most peculiar form of toxicity observed in patients on L-asparaginase therapy would be hypersensitivity reactions.
A precipitating antibody could be demonstrated in two patients, who developed allergic reactions during treatment with this enzyme preparations.
It has been shown that the antibody is directed against the enzyme specifically and not against any of the impurities by Kohn's method.
Antibody was detected on 13th L-asparaginase therapeutic day in one patient, 22th in another patient and on the day 14 after the immunization in the rabbits, which developed allergic reactions by i.v. administration of L-asparaginase on the day 28.
We could demonstrate reagins, i.e. IgE antibodies in one patient.
The relationship between antibody formation and allergic manifestations, and the possible new method of using this enzyme were discussed.抄録全体を表示PDF形式でダウンロード (613K)
症例
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小野 一男, 加藤 達夫, 森 和夫, 鈴木 是光1973 年 14 巻 5 号 p. 611-618
発行日: 1973年
公開日: 2008/10/31
ジャーナル 認証ありA pedigree of congenital afibrinogenemia was described. In our cases, bleeding episodes were started with umbilical bleeding, but no hematuria and melena, nor spontaneous hemoarthrosis were seen.
Fibrinogen in the blood was not demonstrated by coagulative, physicochemical and immunological methods. In our cases and their families remarkably decreased fibrinolytic activities were demonstrated, and the rate of disappearance of fibrinogen from the blood stream after transfusion of Cohn,'s Fraction I has been studied.
In the genealogy, the grandparents and parents were in cousinship, and many members were found to have hypofibrinogenemia.抄録全体を表示PDF形式でダウンロード (771K) -
柴田 寿彦, 池田 靖, 磯部 敬, 太田 宏, 新美 守彦, 小野 三郎1973 年 14 巻 5 号 p. 619-625
発行日: 1973年
公開日: 2008/10/31
ジャーナル 認証ありA male patient, born on January 2, 1916, was referred to the Nagoya University Hospital in June, 1966, because of a painful tumor on the sternum. He was diagnosed as having plasmacytoma by sternal biopsy which revealed plasma cell proliferation. Later, he developed multiple bone lesions at sacrum, scapula, ribs and skull.
Serum analysis demonstrated M-component of IgG class and κ-type with some residual normal immunoglobulin. No Bence Jones protein in urine was found throughout his whole course. Repeated bone marrow aspirations performed at various sites with some intervals showed no plasma cell proliferation indicating that tumor cells did not infiltrate diffusely and that multiple bone lesions remained localized.
The patient responded to the high dose of melphalan in a total of 2,800 mg (10 mg daily for 10 to 14 days as one course) and survived for 65 months from the diagnosis.
Varied patterns of tumor cell infiltration were demonstrated at autopsy, for example, infiltration of plasma cells into surrounding tissues at one site and fibrotic change of bone lesions at the other sites.
Factors influencing good response to melphalan were discussed.抄録全体を表示PDF形式でダウンロード (1121K) -
津田 紘輔, 木村 道夫, 安達 浩行, 酒井 孝夫, 鶴岡 延熹, 寺田 秀夫, 与儀 洋, 桑門 皓, 金光 恒好, 風間 和男, 田代 ...1973 年 14 巻 5 号 p. 626-633
発行日: 1973年
公開日: 2008/10/31
ジャーナル 認証ありThe patient was 63-year-old man who was admitted because of remarkable anemia and mild fever.
On the admission, the laboratory examination revealed that the number of RBC was 1,200,000 and Hb was 3.7g/dl and the remarkable increase in the number of thrombocytes and megakaryocytes in the bone marrow. The test of platelet function indicated that the decrease of aggregation, adhesiveness and activity of platelet factor 3.
The most interesting finding was very strange and atypical morphology of megakaryocytes and their productivity of platelet was reached to 98%.
The combined therapy of myleran and prednisolone was effective for the blood finding of this case. However he died, after 2 months of his admission, due to the pneumonia of aspergillosis.抄録全体を表示PDF形式でダウンロード (1031K) -
三浦 守司, 緒方 完治, 横幕 省三, 武市 政之, 神崎 正紀, 神谷 忠, 平野 正美, 山田 一正1973 年 14 巻 5 号 p. 634-640
発行日: 1973年
公開日: 2008/10/31
ジャーナル 認証ありThree cases of leukemia with acute cardiac tamponade were presented. Two of them were of acute phase of chronic myelogenous leukemia. Another one was of acute lymphoblastic leukemia. The two died of acute cardiac tamponade less than 24 hours after the appearance of the symptoms without any response to the therapy of cardiac tamponade and anti-leukemic chemotherapy. Another one with acute lymphoblastic leukemia responded well to anti-leukemic chemotherapy (a combination of steroid hormon and daunomycin), resulting in a dramatic improvement by removing pericardial effusion, in addition to achieve a remission of acute leukemia.
The laboratory examination and histological findings on autopsy revealed the following results: Case 1 was considered to be of bacterial pericarditis and acute cardiac tamponade. Case 2 and 3 suffered from a leukemic pericarditis and acute cardiac tamponade.
There seems to be a modification and/or a change of the leukemic mainfestation in the course of anti-leukemic chemotherapy and supportive therapy. The cardiac tamponade in the leukemic patients presented here might be one result of the modifications and/or changes of the leukemic manifestation.抄録全体を表示PDF形式でダウンロード (820K) -
矢野 陽三, 山縣 香, 野田 明孝, 浅川 瑞穂, 滝川 清治1973 年 14 巻 5 号 p. 641-647
発行日: 1973年
公開日: 2008/10/31
ジャーナル 認証ありA case of chronic erythroleukemia was reported. A 57-year-old woman was admitted to our clinic because of a marked macrocytic anemia with slight leukopenia and normal platelet count. Examination of the blood smear revealed mild normoblastosis and monocytosis. A bone marrow aspirate showed an erythroid hyperplasia with megaloblastoid cells and hyperactive monocytopoiesis. The hematological abnormality remained unchanged despite of treatment with vitamin B12 and folic acid. Therefore, the patient was followed only with occasional blood transfusions. Repeated blood transfusions improved anemia, with simultaneous decrease in erythroid hyperplasia, erythropoietin activity in patient's serum and monocytopoiesis until development of acute monoblastic crisis after about 2 years' course of illness.
Simultaneous occurrence of erythroid hyperplasia with megaloblastoid cells and hyperactive monocytopoiesis and its clinical significance were discussed.抄録全体を表示PDF形式でダウンロード (598K)
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