巻号一覧
15 巻, 4 号
選択された号の論文の10件中1～10を表示しています
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第15回総会
教育講演
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柴田 昭1974 年 15 巻 4 号 p. 329-342
発行日: 1974年
公開日: 2008/10/31
ジャーナル 認証ありPDF形式でダウンロード (1212K) -
塚田 理康, 浅井 一太郎1974 年 15 巻 4 号 p. 343-352
発行日: 1974年
公開日: 2008/10/31
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会長講演
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長谷川 弥人1974 年 15 巻 4 号 p. 353-358
発行日: 1974年
公開日: 2008/10/31
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シンポジウムI 白血病と感染症
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川戸 正文1974 年 15 巻 4 号 p. 359-366
発行日: 1974年
公開日: 2008/10/31
ジャーナル 認証ありThe author studied the infections in 61 adult patients with acute leukemia admitted to the 2nd Tokyo National Hospital from May 1967 to September 1973.
The results were as follow:
1. Fifty-six of 61 patients had 151 febrile episodes during the course of leukemia.
Infections were proved to be the cause of fever in 109 (72.2%) of febrile episodes.
2. The kinds of infections, in order of frequency, were pneumonia, sepsis, urinary tract infections and skin infections.
3. The identified organisms were gram-negative bacilli in most of the infections, and those avirulent organisms of ten caused fatal infections. Systemic fungus infections occurred in 4 of 61 patients.
4. Eighty-three percent of infectious episodes occurred during induction or consolidation therapy of leukemia.
5. The incidence of infectious episodes and fatality rate of infections increased with decreasing mature neutrophils.
6. In some cases, immunological abnormalities were thought to be one of the causes of infections in acute leukemia.抄録全体を表示PDF形式でダウンロード (611K) -
小川 哲平1974 年 15 巻 4 号 p. 367-374
発行日: 1974年
公開日: 2008/10/31
ジャーナル 認証ありThe clinical and microbiologic features of 67 episodes of septicemia occuring in patients with leukemia have been reviewed. Most were recieving induction therapy with antileukemic drugs, 74%, and/or antibiotics, 75%.
Fourteen episodes of multiple organ septisemia occured in 5 patients.
Septicemia due to pseudomonas spiecies had shown striking increse and klebsiellaenterobacter group had remained an important pathogen.
Nine patients with pseudomonas septicemia recovered by the treatment with combination of gentamicin and carbenicillin or sulbenicillin. Four patients with klebsiella septicemia treated with a combination of gentamicin and cephalosporin recovered.抄録全体を表示PDF形式でダウンロード (584K) -
石川 宗高, 堀内 篤1974 年 15 巻 4 号 p. 375-383
発行日: 1974年
公開日: 2008/10/31
ジャーナル 認証ありIn patients with acute leukemia, infections commonly are localized in the lung, paticularly, pneumonia is quite often (62.9%) in stage of remission induction. Roentgenographic findings in early stage of pneumonia, diffuse granular or reticulo-granular pattern shows such as interstitial pneumonitis. Histologically, infection is occasionally different to recognize in patients with acute leukemia since the inflammatory response is altered and is characterized by a paucity of neutrophils. Accordingly, it is possible that a lesion resembling and identified as recent intra-alveolar hemorrhage or edema actually may have been the early stage of pneumonia.
The fungal infections most frequently found in terminal stage were aspergillosis, candidiasis and mucormycosis. The incidence of these infections has been increasing in recent years.
Tuberculosis, although not statistically increased in patients with leukemia, should always be considered in any patient with pulmonary infiltration.抄録全体を表示PDF形式でダウンロード (1755K) -
植谷 忠昭, 大野 竜三, 山田 一正1974 年 15 巻 4 号 p. 384-392
発行日: 1974年
公開日: 2008/10/31
ジャーナル 認証ありFourteen patients with acute leukemia were treated in a bioclean isolator system devised by us. All patients had entire body cleaning with Chlorhexidine and i.v. antibiotics prior to the entry in the isolator and received nonabsorbable antibiotics and sterile food during the Study. Thirteen patients received combination chemotherapy for initial remission induction therapy. Eleven out of them achieved complete remission.
The incidence of infection among the patients in the isolator was significantly reduced as compared to that of the patients treated in the open ward. Days febrile in the confinement was also greatly reduced. With granulocytes less than 100/cmm, patients spent febrile 16.1% of their total days of the induction period in the isolator, whereas spent febrile 31.3% of their total days of the induction period in the open ward.
With granulocytes 100 to 500/cmm, patients spent febrile 8.2% in the isolator, whereas 15.2% in the open ward.
Documented infections were observed in 2 patients treated in the isolator. Both were pneumonia, one caused by klebsiella and the other by E-coli. Those were presumed to be endogenous infections, judging from the spectrum of the cultured organisms prior to the development of the infections.
Patients protection by isolation seems to offer important potential aids to intensive chemotherapy of acute leukemia.抄録全体を表示PDF形式でダウンロード (705K) -
—間質性肺臓炎を起し得る化学療法との関係を中心に—馬場 謙介, 下山 正徳1974 年 15 巻 4 号 p. 393-401
発行日: 1974年
公開日: 2008/10/31
ジャーナル 認証ありPDF形式でダウンロード (640K)
臨床研究
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渡辺 清明, 近藤 和興, 小川 哲平, 長谷川 弥人, 張ヶ谷 健一1974 年 15 巻 4 号 p. 405-414
発行日: 1974年
公開日: 2008/10/31
ジャーナル 認証ありPeripheral leukemic cells from a patient with acute promyelocytic leukemia (APL) were analysed for coagulant activity.
Suspensions of leukocytes were prepared by a modification of the method of Böyum. Washed preparations were disrupted by freezing and thawing six times and homogenized by a Potter-Elvenhjem apparatus 0.34 M sucrose solution.
Lysate of these leukemic cells significantly shortened the recalcification time and activated PTT in normal human plasma. Clot was formed in a time of 49 sec. when 0.1 ml of lysate (WBC: 150,000/mm3) was added into prothrombin time system, instead of tissue thromboplastin but not formed when it was added into thrombin time system instead of thrombin. These leukemic cells also shortened clotting time with factor VIII and factor IX deficient plasma, however not with factor II, factor V or factor VII complex deficient plasma. The activity was destroyed almost completely after heating for 120 min. at 56°C and 80°C.
The results suggest that this procoagulant activity has a characteristics of tissue thromboplastin. Approximately 1.5×107 leukemic cells has a thromboplastic activity of 0.2 mg of rabbit lung tissue thromboplastin (Lyoplastin). Small amount of sodium heparin could inhibit this activity in vitro.
No significant procoagulant activity was detectable in the leukemic cells from a patient witn AML or CML, or in normal leukocytes.
These data suggest that leukemic cells of APL has a significant quantity of thromboplastic activity and could be involved in the pathogenesis of disseminated intravascular coagulation of this disease.抄録全体を表示PDF形式でダウンロード (1007K)
例会
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1974 年 15 巻 4 号 p. 415-439
発行日: 1974年
公開日: 2008/10/31
ジャーナル 認証ありPDF形式でダウンロード (2437K)
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