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Volume 16, Issue 12
Displaying 1-8 of 8 articles from this issue
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Kazuo MORI, Iwao HIRATSUKA, Hideaki SAKAI, Katsuhide HIWATASHI, Toyosh ...1975 Volume 16 Issue 12 Pages 1099-1108
Published: 1975
Released on J-STAGE: October 31, 2008
JOURNAL RESTRICTED ACCESSCorrelations between blood coagulation tests and histological findings in 65 cases of various liver diseases were evaluated and following conclusions were obtained.
1) Decreased coagulation factor activities and prolonged STT (enhanced fibrinolytic activity) were observed in all patients with liver diseases. These abnormalities of clotting and fibrinolytic functions were in parallel with the severity of histological changes in the liver.
2) In the cases with parenchymatous changes of the liver, activities of coagulation factor VII, IX and X were sensitively decreased, while factor II activity remained normal. When parenchymatous changes were accompanied by fibrosis, these changes were more prominent. Moreover, factor V activity showed the same tendency, which was statistically insignificant. However, fibrinogen content decreased only in the extremely severe cases.
Factor VIII activity was normal or increased and the behavior was different from the other clotting factors.
Among the numbers of screening tests for blood coagulability, TT activity revealed a significant decrease, reflecting the changes of clotting factors II, VII, IX and X (vitamin K dependent clotting factors), while 1 stage PT decreased significantly only in the cases with fibrosis of the liver: however, K-PTT did not show any abnomalities in these cases.
3) Even though there were fairly good correlations between coagulation studies and histological findings, there was some discrepancy between the results of blood coagulation tests of various liver diseases histologically diagnosed and those of the cases with some paticular histological pattern regardless the diagnosis. There was a reason why the histological diagnosis was dependent on the combination of individual histological findings.View full abstractDownload PDF (734K) -
I. Results of Intrathecal Single or Multiple Drug Combination TherapyTakeo FUJIMOTO, Keiko HASEGAWA, Hiroyuki SHIN, Kunio KISHIDA, Hiromich ...1975 Volume 16 Issue 12 Pages 1109-1116
Published: 1975
Released on J-STAGE: October 31, 2008
JOURNAL RESTRICTED ACCESSA total of 40 episodes of CNS leukemia in children were treated with intrathecal Methotrexate alone, or combination regimens with Methotrexate 15 mg/M2, Hydrocortisone 15 mg/M2, and/or Cytosine arabinoside 30 mg/M2.
Complete remission was obtained in 72.5% of 40 episodes of CNS diseases. Median lengths of CNS remission were: “no therapy” maintenance 2.2 months; two and three drug maintenance regimens 11.4 plus months and 17.2 plus months, respectively. Differences were of ststistically significance between “no therapy” maintenance and multiple drug maintenance regimens (P<0.01), and between two and three drug regimens (p=0.05).
Toxicity of the intrathecal chemotherapy for CNS leukemia induction was not prohibitive. However, during the intrathecal maintenance period, headache, fever, and/or vomiting occurred in 15.7% of the children, one or two hours after receiving intrathecal medication. One patient developed leukoencephalopathy due to intrathecal and intravenous Methotrexate, which was morphologically found diffuse reactive astrocytosis and multiple, noninflammatory necrotic foci in telencephalic white matter.View full abstractDownload PDF (584K) -
Concentrations in Patients with Malignant Lymphoma with special reference to Hodgkin's diseaseIkuro KIMURA, Taisuke ONOSHI, Yoshiro TANIZAKI, Nobuo UEDA1975 Volume 16 Issue 12 Pages 1117-1123
Published: 1975
Released on J-STAGE: October 31, 2008
JOURNAL RESTRICTED ACCESSMarkedly elevated serum IgE concentrations have been noticed in nonallergic patients with abnormalities of cellular immunity and disorders of T cell functions.
The purpose of the present study was to determine the serum IgE concentrations in patients with malignant lymphoma (mainly Hodgkin's disease) before and after treatment with chemotherapy.
In these investigations we utilized a radioimmunosorbent test technique (R.I.S.T.) to determine the serum IgE concentrations in group of patients with different types of malignant lymphoma including 19 patients with Hodgkin's disease, 13 with reticulum cell sarcoma, 2 with lymphosarcoma and 4 with other unclassified malignant lymphoma.
The results were as follows:
1) The geometric mean of IgE concentrations of 50 normal adults were 224±133 u/ml. In general, serum IgE concentrations in patients with reticulum cell sarcoma and lymphosarcoma were reduced below the geometric mean of normal controls. In contrast, elevated IgE concentrations were demonstrated in patients with Hodgkin's disease. Twelve of 19 patients with Hodgkin's disease showed over 500 u/ml serum IgE concentrations—9 patients over 1000 u/ml and 3 over 4000 u/ml—but after chemotherapy, serum IgE concentrations were reduced in all cases with Hodgkin's disease.
2) Almost all of patients of Hodgkin's disease showed high IgE concentrations in stage III.
3) Patients of Hodgkin's disease with mixed cellularity showed higher IgE concentrations than other histological types of the disease.
4) Most cases of Hodgkin's disease showed negative skin reactions to PPD and lower blastogenic activity of lymphocytes to PHA, but IgG, IgA and IgM showed no characteristic changes. Then the immunological abnormalities in Hodgkin's disease were characterized by cellular immunity disorders of T cell functions and by elevated serum IgE concentrqtion. These findings suggested that the reduction in T cell regulatory function might be the cause of the high IgE concentrations seen in patients with Hodgkin's disease.View full abstractDownload PDF (576K)
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Toshihiko TSUDA, Noboru IIDA, Yoshihisa WAKABAYASHI, Yuichi SHIOKAWA1975 Volume 16 Issue 12 Pages 1124-1130
Published: 1975
Released on J-STAGE: October 31, 2008
JOURNAL RESTRICTED ACCESSIn this investigation, we present a case of 24-year-old man with disseminated eosinophilic collagen disease. (Hereinafter we call it DECD.)
In January, 1971, he noticed frequent onsets of diarrhea, containing mucus and blood. In December, 1972, complaining of fever and pain of bilateral knee joints with swelling, he was admitted to our hospital for medical evaluation.
On physical examination, hepatosplenomegaly and lymphadenopathy were noted. The WBC count was 15,900 mm3 with 65.5% mature eosinophils. Bone marrow aspiration showed 64.3% eosinophils, but no increase of immature cell or blast cell were recognized. The ESR was 112mm/h. He had hypoproteinemia, liverdisfunction, and immunological abnormalities. Stool tests for ova and parasites were negative. Skin tests for allergens were also negative except for cotton. Eosinophils with mature cell were infiltrated on biopsy of cervical lymph-node. The structure of lymph-node was normal and there was no malignancy. His barium enema remarkably suggested a complication of ulcerative colitis.
The patient brilliantly responded to corticosteroid. The consultation and medical examination to him have been regularly followed up for two years by our clinic.
DECD is so closely akin to eosinophilic leukemia and some allergic or autoimmune diseases with eosinophilia that it is extremely difficult to make difference between them.
On the above matter, we had thoroughly discussed and issued him in DECD.View full abstractDownload PDF (874K) -
Katsuji NAKAMURA, Teizo TOMISAWA1975 Volume 16 Issue 12 Pages 1131-1140
Published: 1975
Released on J-STAGE: October 31, 2008
JOURNAL RESTRICTED ACCESSA Family study of cyclic neutropenia was performed on a pedigree including 2 generations and 6 members with a propositus of 7-year-old girl.
The propositus had been well until February 1972, when she suffered from otitis externa dextra and the peripheral blood showed neutropenia and monocytosis. Follow-up study revealed that neutropenia accompanied by fever up to 38°C and gingivitis, all compatible with cyclic neutropenia (CN), periodically occurred every three weeks.
Family study revealed CN with 21, 21, 14 day periodicity in her younger sister (III-3) with acute myelocytic leukemia in complete remission, her cousin (III-7), and her maternal aunt (II-6), respectively. Moreover, agranulocytosis in her maternal cousin (III-8) and chronic neutropenia in her mother (II-3) were suspected, but both had no clinical manifestations.
Based on the extensive review of literature of CN reported thus far and data obtained from this study, possible pathogenesis of CN was discussed and the induction by a primary impairment of the bone marrow functions under the strong genetic control was suggested.
Our family study may imply that CN is a subtype of familial chronic neutropenia with an autosomal dominant transmission of high Penetrance and variable expressivity.View full abstractDownload PDF (774K) -
Takao SUZUKI, Tetsugoro TANAKA, Norio ENDO, Shin MATSUDA, Tsuyoshi AKI ...1975 Volume 16 Issue 12 Pages 1141-1146
Published: 1975
Released on J-STAGE: October 31, 2008
JOURNAL RESTRICTED ACCESSA 39 aged male who had subcutaneous petechiae and epistaxis was admitted with AML in November, 1972. A complete remission was obtained by CMP treatment in MAY, 1973. In January, 1974, leukemic cells of peripheral blood were increased in number and he was readmitted.
Reinduction therapy was repeated five times, but he had not remission. In August, 1974, he had remittent fever, and in September, in rentogenographic study of the chest, an abnormal shadow of right upper lobe which had a round shape in a size of a hens' egg was recognized.
In November, the shadow was spread with right lower lobe and left upper lobe of the lung, and he was died.
At autopsy, mucormycotic pneumonia in the all lobes of the both lungs, especially in the upper lobe of the left, and white thrombus throughout the pulmonary trunk and arteries (microscopically mucormycetes found) were there.View full abstractDownload PDF (741K) -
—Report of a cace with decreased in vitro colony formationToshio SUDA, Takaharu MATSUYAMA, Takeshi NAGAO, Tatsutoshi NAKAHATA, H ...1975 Volume 16 Issue 12 Pages 1147-1152
Published: 1975
Released on J-STAGE: October 31, 2008
JOURNAL RESTRICTED ACCESSA sixteen month old boy with Shwachman syndrome was evaluated. He had frequent and bulky bowel movements, and short stature. His duodenal juice contained markedly reduced amount of lipase and no trypsin or amylase activity. His bone change was not specific. Blood examination revealed mild anemia, severe neutropenia and normal platelet counts. Bone marrow aspirates showed myeloid hypoplasia as well as mild erythroid hypoplasia.
Autoradiographic studies of the bone marrow, using 3H-thymidine, revealed essentialy normal labelling indexes of both erythroid and myeloid precursors (erythroid: 80.2%, myeloid: 28.5%). Soft agar culture method was applied to the bone marrow aspirates after Metcalf. Number of in vitro colony forming cells (CFC) of his bone marrow was significantly lower than normal, as well as colony stimulating activity of his serum or white blood cells.
These findings suggest that abnormalities of granulopoiesis in this case might be resulted from either decrease of CFC, poor stimulation or inhibitor to CFC level.View full abstractDownload PDF (566K) -
Seitoku FUJIOKA, Haruki KONDO, Hiroshi OAMI1975 Volume 16 Issue 12 Pages 1153-1159
Published: 1975
Released on J-STAGE: October 31, 2008
JOURNAL RESTRICTED ACCESSA 20-year-old female case of acute basophilic leukemia with complication of histamine excess symptoms was reported. She first noticed malaise, fever, skin rash and bleeding of gum. On physical examination, anemic pallor, enlargement of cervical lymph nodes, bone tenderness, petechiae and ecchymoses were recognized. Hematological investigation revealed severe anemia, thrombocytopenia and leukocytosis of 53,800 WBC with 89% atypical myeloblasts and 7% basophils. Bone marrow examination disclosed 39% atypical myeloblasts and 51% basophils including 35.6% basophilic promyelocytes, which meant hiatus basophils. Thereafter basophils increased to 66% and maximal basophil counts reached 43,500. These cells agreed with basophils on several histochemical stainings as well as electron microscopic examination. Chromosome analysis of bone marrow-cells showed translocation of 10 q- and 10 q+. No symptom of disseminated intravascular coagulation was presented. Following the quadraple combination of antileukemic chemotherapy (cyclocytidine, adriamycin, 6MP, prednisolone), atypical myeloblasts and basophils were extremely decreased in number in both circulating and bone marrow blood, and finally they were not found by ordinary examination. At this time, urticaria, flushing, nausea, vomiting, hypersecretion of gastric juice and tachycardia appeared. Plasma histamine level investigated was 41.4 μg/dl, which was tremendously higher consentration than normal level. She died due to pseudomonas pneumonia and diagnosis was confirmed by autopsy. This case reported here may be the first case of acute basophilic leukemia with histamine excess symptoms.View full abstractDownload PDF (830K)
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