巻号一覧
16 巻, 3 号
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第16回総会
特別講演
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—疫学的考察を中心として—日比野 進1975 年 16 巻 3 号 p. 299-304
発行日: 1975年
公開日: 2008/10/31
ジャーナル 認証ありPDF形式でダウンロード (502K)
臨床研究
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吉川 治哉, 今井 邦之, 大野 竜三, 神谷 忠, 西脇 洋, 石黒 順造, 上田 龍三, 竹山 英夫, 若山 喜久子, 横幕 省三, 緒 ...1975 年 16 巻 3 号 p. 305-312
発行日: 1975年
公開日: 2008/10/31
ジャーナル 認証ありA new quadruple combination chemotherapy (Neo-DCMP) was designed, applying a phenomenon of partial synchronization of leukemic blasts into S-phase maneuvered by cytosine arabinoside (Ara-C). Twenty one patients with acute nonlymphocytic leukemia were treated by Neo-DCMP, of whom 12 achieved complete remission. The duration till remission by Neo-DCMP was 54 days. It was longer as compared to that of 31 days by previous DCMP. The courses of Neo-DCMP till remission took 1 to 3 courses with a mean of 2 courses. The median remission length of the patients treated with Neo-DCMP was 4 months +, and the median survival of the 21 patients was 8 ½ months +. The comparative study of hematological changes during and after Neo-DCMP and DCMP indicated that the recovery of leukocytes and platelets was delayed in Neo-DCMP. Consequently the interval of Neo-DCMP courses had to be delayed to 23 days as compared to that of 13 days by DCMP. The partial synchronization of leukemic blasts and normal myeloid precursors with Ara-C in term of the effect of Neo-DCMP and DCMP was discussed. And, the interval of treatment courses of combination chemotherapy was discussed based on the results of sequential changes in the labeling index of leukemic blasts in Neo-DCMP.抄録全体を表示PDF形式でダウンロード (549K) -
—化学療法における腫瘍縮小効果判定への超音波法の応用—小林 利次, 坂井 保信, 近田 千尋, 下山 正徳, 坂野 輝夫, 北原 武志, 湊 啓輔, 井深 田鶴子, 井上 雄弘, 佐々木 常雄, ...1975 年 16 巻 3 号 p. 313-324
発行日: 1975年
公開日: 2008/10/31
ジャーナル 認証ありUltrasonic evaluation by contact compound B-mode scanning is a valuable diagnostic procedure for the detection and definition of malignant or benign abdominal tumors. In the past two years, 53 cases with malignant lymphomas such as Hodgkin's disese (15), lymphosarcoma (13) and reticulum cell sarcoma (25) were echographically examined. Echographic features as diagnostic information were found as follows: irregular boundary echoes, non-uniform sized, mottled pattern for internal echoes such as mantle-like continuous plaque of enlarged lymph node at para-vertebral or para-aortic regions, scattered multiple separated echoes, organ compression toward abnormal sites (kidney and spleen) and echo-pattern of obliterating or narrowing of aortic and vena cava contours. Basing upon these echographic features, 25 cases with stage III and IV were followed up by serial ultrasonic examinations for assessment of changes in tumor size or echo pattern during antineoplastic treatment, especially chemotherapy. Concomitant clinical observations were used for correlation with the ultrasonic findings. Typical echograms were demonstrated and the echographic features for malignant lymphoma were proposed. It is concluded that ultrasonic echography proved to be a very useful and convenient way to evaluate the tumor regression effect of abdominal tumor in malignant lymphoma as non-invasive method.抄録全体を表示PDF形式でダウンロード (1589K)
症例
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—本疾病の本態に関する考察及び本邦剖検例の検討—八田 喜弘, 楢本 千珠子, 堀江 昭夫, 奥村 幸哉, 本村 正治1975 年 16 巻 3 号 p. 325-331
発行日: 1975年
公開日: 2008/10/31
ジャーナル 認証ありA 66-year-old male was admitted on January, 1971 because of malaise, palpitation and precordial discomforts. About six months prior to admission, he was found to be anemic, but treatment with iron and vitamin B12 was ineffective and occasional blood transfusions were necessary. Hematologic studies on admission revealed hemoglobin to be 4.2 g/dl, red blood cells 149×104, reticulocytes 0.6%, packed cell volume 12%, white blood cells 3100/cmm, platelets 10.7×104. Bone marrow aspiration showed hypercellular specimen with maturation arrest of granuloid series and erythroblastic hyperplasia with many ringed sideroblasts. Chromosome studies of marrow cells by the direct method revealed pseudodiploid karyotype (46, XY, -17, +17 qi). The diagnosis of primary acquired sideroblastic anemia in preleukemic stage was made on the basis of these hematologic and cytogenetic findings. He was treated with pyridoxine, folic acid, vitamine B12 and anabolic steroids. However, his condition did not improve and he died of gastrointestinal bleeding 18 months after admission. The postmortem examination showed hyperplasia of bone marrow cells and myeloid metaplasia of liver, spleen, lung and other organs, but there was no evidence of leukemia. The authors summarized six autopsy cases with primary acquired sideroblastic anemia reported in Japan by the end of 1971 and discussed a possible nature of this disease.抄録全体を表示PDF形式でダウンロード (981K) -
高橋 章子, 沖田 肇, 岡田 浩佑, 鎌田 七男, 内野 治人, 山本 正美, 原 弘1975 年 16 巻 3 号 p. 332-339
発行日: 1975年
公開日: 2008/10/31
ジャーナル 認証ありA 60-year-old male, who initially showed some characteristics of hypoplastic leukemia with fibrosis of the bone marrow and terminally developed into acute granulocytic leukemia was presented.
He was admitted to our hospital because of exertional dyspnea. No hepato-splenomegaly nor lymphnode swelling were seen. His peripheral blood showed anemia, thrombocytopenia and leukopenia with relative monocytosis and a small percentage of myeloblasts. Because of the failure of bone marrow aspiration after several trials, bone marrow biopsy was performed. The specimen revealed hypoplasia of the bone marrow elements with mild fibrosis. 13.2% of myeloblasts were seen in the bone marrow smears which were taken at the time of the biopsy. He was diagnosed hypoplastic leukemia and was treated with steroid hormones, blood transfusions and 6 MP; 6 MP was given only for one week at the beginning. Five months after admission, the condition aggravated, showing leukocytosis with high percentage of myeloblasts, thrombocytosis and hepato-splenomegaly. Chromosome analysis by means of one day culture of peripheral blood without phytohaemagglutinin showed abnormal karyotype of 45, XY, -C in 95% of cells examined. Diagnosis at the time of autopsy was acute granulocytic leukemia and myelofibrosis with myeloid metaplasia.
Relations between hypoplastic conditions and fibrosis in the bone marrow at the beginning of the disease and acute granulocytic leukemia in the terminal stage were discussed, from the view-point of myeloproliferative disorders.抄録全体を表示PDF形式でダウンロード (1345K) -
—特にその剖検所見の特異性について—沖田 肇, 中津井 俊之, 井内 浩子, 藤村 欣吾, 鎌田 七男, 蔵本 淳, 内野 治人1975 年 16 巻 3 号 p. 340-346
発行日: 1975年
公開日: 2008/10/31
ジャーナル 認証ありThe characteristics of the autopsy findings were reported on three cases of leukemic patients who had history of Atomic Bomb exposure and the hematological disorders, such as anemia and leukopenia for a long period (so-called preleukemic stage) preceding the terminal development of acute leukemia.
We have already reported that the chromosomal and the cytological abnormalities had been observed in three cases before their leukemia became overt clinically.
Case 1 (54 years old female), and Case 2 (61 years old female), both patients died of erythroleukemia after the prolonged leukopenia continued for 11 and 13 years.
Autopsy revealed hypo and/or normocellular marrow with mild leukemic cell proliferation, preserving the basic structure and the very few leukemic cell infiltrations in all the other organs, in spite of receiving no treatment with antileukemic agents.
Case 3 (38 years old female) developed monocytic leukemia after hypoplastic anemia for 13 years. In contrast against case 1 and case 2, the autopsy in case 3. revealed the fully developed leukemic involvement. Such discrepancies and the differences between the three cases were discussed in terms of the characteristics from various view points and the emphasis was put on the necessity of studying the enviroment where leukemic cells would proliferate.抄録全体を表示PDF形式でダウンロード (1342K) -
山本 正美, 山根 敏子, 原 弘, 武富 嘉亮, 蔵本 淳1975 年 16 巻 3 号 p. 347-353
発行日: 1975年
公開日: 2008/10/31
ジャーナル 認証ありAn autopsy case of pulmonary alveolar proteinosis associated with chronic granulocytic leukemia treated with busulphan is reported. After receiving 350 mg of this drug over a period of two years the patient became dyspneic and developed chest pain and roentgenologic changes suggesting pulmonary fibrosis. At autopsy the lungs weighed 965g. on the right and 870g. on the left. The lungs were voluminous and grayish white in colour and elastic hard in consistency. Histologically the alveoli were filled with a granular and floccular, eosinophilic proteinaceous material containing lipid. In addition the lungs showed also diffuse interstitial fibrosis. Electron microscopic examination revealed that the proteinaceous material in the alveoli was consisted of osmiophilic bodies of various sizes, myelin figures and concentric lamellar structures. The pathogenesis of pulmonary alveolar proteinosis was discussed briefly.抄録全体を表示PDF形式でダウンロード (1013K) -
堀越 昶, 馬場 真澄, 伊藤 由紀子, 雨宮 洋一, 大島 年照, 堀内 篤, 陸川 容亮, 森 弘一, 橋本 慶紀, 根岸 七雄, 竹中 ...1975 年 16 巻 3 号 p. 354-360
発行日: 1975年
公開日: 2008/10/31
ジャーナル 認証ありA thirty-nine-year-old male, who complained of tarry stool and anemia, was admitted to the Department of Surgery of Nihon University Hospital in June, 1973. His spleen was enlarged and he showed hematemesis after admission.
A spleen of 1,250 g was resected on June 14 under the diagnosis of Banti's syndrome without examination of platelet count. Then hematemesis did not recur but gingival bleeding appeared two weeks after the removal of spleen. Five days after the splenectomy, the platelet count was 720,000 per mm3 and was raised to 2,750,000 per mm3 in August.
As no tendency of decrease in the platelet count, the patient was referred to the First Department of Internal Medicine for further examination in September, 1973. On the peripheral blood smear many large and small platelets with abundant granules and frequent platelet aggregates were seen. A marrow puncture showed numerous megakaryocytes. On the coagulation studies abnormal platelet aggregation in response to ADP and epinephrin was observed.
Diagnosed as essential thrombocythemia, 274 mg of busulfan was administered in the total dose. Nine months after splenectomy, he was in good condition with platelet count of about 500,000 per mm3 under no therapy.抄録全体を表示PDF形式でダウンロード (760K)
例会
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1975 年 16 巻 3 号 p. 361-377
発行日: 1975年
公開日: 2008/10/31
ジャーナル 認証ありPDF形式でダウンロード (1620K)
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