臨床血液
Online ISSN : 1882-0824
Print ISSN : 0485-1439
ISSN-L : 0485-1439
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17 巻, 6 号
選択された号の論文の9件中1～9を表示しています
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第17回総会
会長講演
特別講演
綜説
臨床研究
  • 慢性骨髄性白血病症例の細胞遺伝学的研究
    —分染法によるPh1染色体転座部位の検討—
    松永 マサ子, 貞森 直樹, 朝長 優, 田川 真須子, 市丸 道人
    1976 年 17 巻 6 号 p. 618-625
    発行日: 1976年
    公開日: 2009/01/19
    DOIhttps://doi.org/10.11406/rinketsu.17.618
    ジャーナル 認証あり
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    Cytogenetic study on bone marrow cells of 15 patients with chronic myelogenous leukemia, using banding technique was performed.
    Fourteen patients showed Ph1 positive and one did Ph1 negative. All patients with positive Ph1 revealed translocation between chromosome No. 22 and No. 9, except for one who showed between chromosome No. 22 and No. 17 which was unusual. The latter patient, a 17-year-old male, was diagnosed C. M. L. at 12 years of age and took a typical clinical course of adult type of C. M. L.
    Among 4 patients developed acute crisis, two showed clonal evolution. Their karyotypes were 47, XY, +8, t(9 q+; 22 q-) and 50, XYY, +8, +19, +22q-, t (9q+; 22q-), respectively. One patient, a 47-year-old male, showed abnormal clone in 70% of the metaphases two years before occurrence of acute crisis and died a month later. The other patient, a 27-year-old male, showed at the time of occurrence of acute crisis and died two months later. Double Ph1 and double Y chromosomes were formed in 100% of his marrow cells. Double Ph1 chromosomes appeared to be same in morphology and only one pair of chromosome No. 9 presented an existence of dull extra segment. Peripheral lymphocytes and skin fibroblasts at the patient's terminal stage showed normal karyogram.
    Both cases had chromosome No. 8 trisomy. These findings indicated that the occurrence of aneuploidy was due to non-disjunction and might be related with a condition of acute crisis of. C. M. L.
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  • 再生不良性貧血の免疫学的研究
    依田 安弘, 阿部 帥, 小宮 正文
    1976 年 17 巻 6 号 p. 626-631
    発行日: 1976年
    公開日: 2009/01/19
    DOIhttps://doi.org/10.11406/rinketsu.17.626
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    Autoantibody spectrum, immunoglobulin and complement levels were studied in 30 cases of aplastic anemia diagnosed in our department. Four patients were found to have thyroglobulin or gastric parietal cell antibody. But other autoantibodies; rheumatoid factor, ANF, etc., were all negative, indicating the rare occurrence of autoantibodies in aplastic anemia. Immunoglobulin and complement levels appeared to be within normal range in most of the cases. It was considered that hyperglobulinemia or decrcase of complement level would be quite unusual in this disorder unless any complications such as infections occurred.
    However, five of thirty patients were found to have a sort of IgG which specifically reacted with fibrous structure in the spleen and lymph node of mice. This immunoglobulin was considered as a tissue autoantibody, although the pathophysiological significance is still under investigation. There were no particular differences in clinical or hematological findings between the antibody carriers and other cases of aplastic anemia. But, it was noted that four of five carriers successfully responded to anabolic steroid therapy.
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  • ヒト尿中血小板様小体の走査型ならびに透過型電子顕微鏡所見
    河野 南雄, 藤原 達司
    1976 年 17 巻 6 号 p. 632-635
    発行日: 1976年
    公開日: 2009/01/19
    DOIhttps://doi.org/10.11406/rinketsu.17.632
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    In urine of the normal and diseased persons were found always small bodies resembling platelets. The platelet-like particles from a normal and a patient with suspected tumor of the left kidney were studied by scanning and transmission electron microscopy.
    It was considered that the cells in urine should be platelets or platelet-ghosts.
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