All issues
Volume 18, Issue 12
Displaying 1-5 of 5 articles from this issue
- |<
- <
- 1
- >
- >|
-
—With Special Reference to the Method of Its Administration—Noritoyo FUJIYAMA, Kenji NAKAZAWA1977 Volume 18 Issue 12 Pages 1393-1400
Published: 1977
Released on J-STAGE: January 19, 2009
JOURNAL RESTRICTED ACCESSTransfusion hemosiderosis developed in aplastic anemia patients was treated with Desferrioxamine. Clinical studies were designed to evaluate the different ways of administration to obtain the maximal excretion of iron into urine.
Three patients had received 23,000, 10,000 and 30,000 ml of blood transfusion, respectively, before Desferrioxamine was initiated. All patients showed high serum iron levels with low unsaturated iron binding capacity. After the administration of Desferrioxamine, there was a significant increase of urinary iron excretion in all patients. In each individual, Desferrioxamine was given in various ways on different occasions and the following results were obtained;
1) Total iron excretion was higher with divided administration than with a single dosage.
2) There was no significant difference in iron excretion per day between daily and every other day administration. This suggests that daily administration could expedite excretion of iron to a greater extent than does a dose given every other day.
3) No significant iron excretion was observed in initial 24 hours after the administration of the drug, when it was given every other day.
4) There was no significant difference in urinary iron excretion between intramuscular and intravenous administrations.
5) No side effects were noted even after long-term treatment with this iron-chelating agent.View full abstractDownload PDF (481K) -
—Screen Filtration Rate Method—Hideo SHIO, Kenji TAKASU, Masakuni KAMEYAMA1977 Volume 18 Issue 12 Pages 1401-1407
Published: 1977
Released on J-STAGE: January 19, 2009
JOURNAL RESTRICTED ACCESSA new method for platelet aggregometry of whole blood has been developed. The method—screen filtration rate (SFR)—was based on a simple phenomenon that platelet aggregates in blood samples reduced the flow of specimen through a sheet of microsieve (20 micron square opening). In contrast to Swank's screen filtration pressure method, we determined the natural flow rate of the blood sample which had been fixed with formaldehyde (0.5%) and diluted to hematocrit value 10%, thus making time study capable and reducing the influence of viscosity on the flow.
Using this method, ADP-induced platelet aggregation in citrated whole blood was studied. Immediately after collecting blood in Na citrate, the sensitivity of platelets to ADP was extremely low. The aggregability then increased by one hour and decreased thereafter. This finding indicates importance of the conditions of sampling and storage of blood specimen as seen in Born's turbidometry.
Chlorpromazine, a membrane stabilizer, exerted a unique effect on platelet aggregation in whole blood. It inhibited the platelet clumping in whole blood at low concentrations which were not sufficient to inhibit platelet aggregation in platelet-rich plasma. This phenomenon suggested interaction between platelets and red blood cells during platelet aggregation.
Thus platelet aggregaometry in whole blood might provide a new view to the study on mechanism of thrombus formation.View full abstractDownload PDF (537K) -
Michiko SAKAI1977 Volume 18 Issue 12 Pages 1408-1413
Published: 1977
Released on J-STAGE: January 19, 2009
JOURNAL RESTRICTED ACCESSThe measurement of mean red cell life span with 32P-diisopropylfluorophosphate and ferrokinetics were performed in 12 patients with aplastic anemia. The patients showed no abnormal blood loss or tissue hemorrhage. Hemolytic anemia, malignancies, inflammation, and congenital aplastic anemia were excluded.
Mean red cell life span was shortened in all cases (Mean±SD: 60±13 days, Range: 34-80 days).
The amount of radioiron retention in the erythroid bone marrow as observed by quantitative whole body linear scanning 10 days after intravenous radioiron injection was inversely correlated to red cell life span.
The ratio of ineffective erythropoiesis was 42%; 38% in 5 cases without the history of blood transfusion, and 45% in 7 cases having the history of blood transfusion.
The results indicate the existence of intramedullary and peripheral hemolysis in aplastic anemia.View full abstractDownload PDF (429K)
-
Keiichi NEMOTO, Yoshihisa OHNISHI1977 Volume 18 Issue 12 Pages 1414-1421
Published: 1977
Released on J-STAGE: January 19, 2009
JOURNAL RESTRICTED ACCESSFour autopsy cases of atypical leukemia were reported all in the higher age bracket and resembled chronic myelogenous leukemia (CML) but differed from common leukemoid reaction.
These cases were different from CML in the following points:
1) All cases were found in the higher age bracket (over 70 years old), and the clinical course was relatively short but blastic crisis was not seen.
2) Hematologically, blastic cells increased comparatively and the platelet count decreased from the early stages.
3) Ph1 was negative in a examined case.
4) Pathologically, severe granulocytic hyperplasia was found in all examined bone marrows with erythroblastic and megakaryocytic depletion but no hepatosplenomegaly was found.
We surmised that these cases were in the process of myeloproliferative state and was one of the atypical types of leukemia.View full abstractDownload PDF (1102K)
-
1977 Volume 18 Issue 12 Pages 1422-1440
Published: 1977
Released on J-STAGE: January 19, 2009
JOURNAL RESTRICTED ACCESSDownload PDF (1798K)
- |<
- <
- 1
- >
- >|