巻号一覧
18 巻, 9 号
選択された号の論文の13件中1～13を表示しています
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綜説
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松田 道生1977 年 18 巻 9 号 p. 1065-1081
発行日: 1977年
公開日: 2009/01/19
ジャーナル 認証ありPDF形式でダウンロード (1632K)
臨床研究
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—発症におよぼす因子の検討—藤本 孟男, 宮崎 澄雄, 武 弘道, 岸田 邦雄, 合屋 長英, 長谷川 恵子1977 年 18 巻 9 号 p. 1082-1089
発行日: 1977年
公開日: 2009/01/19
ジャーナル 認証ありThe incidence of central nervous system leukemia (CNS-leukemia) and the factors influencing this complication have been studied in a group of 100 cases with acute childhood leukemia (peroxidase negative) during 1960 to 1973, at Pediatric clinic of Kyushu University Hospital.
The overall incidence of CNS-leukemia was 30%. However, cumulative incidence of CNS-leukemia calculated by modified Life-Table Method using IBM computer showed 56.8% in children who survived over 48 months after diagnosis of leukemia. It was considered that the chief cause for the increased incidence of CNS-leukemia was prolongation of survival.
The CNS-leukemia was significantly greater in patients with under 10 year of age (p<0.05), high initial leukemic cell counts (p<0.025), high appearance rate of leukemic cells in peripheral blood (over 50%) (p<0.005), and hepatosplenomegaly, especially lymph node enlargement (p<0.05). It was suggested that blood-borne metastasis was probably the chief route of leukemic infiltration to the CNS.
These data suggested that prophylaxis for CNS-leukemia should be instituted as early as possible after achievement of bone marrow remission. In the cases having high risk for CNS-leukemia, more intensive CNS-prophylactic treatment should be necessary.抄録全体を表示PDF形式でダウンロード (563K) -
河野 南雄, 須沢 祝子, 溝上 隆1977 年 18 巻 9 号 p. 1090-1096
発行日: 1977年
公開日: 2009/01/19
ジャーナル 認証ありThe normal human platelets suspended in normal human urine were examined by Giemsa or Wright stain, phase contrast microscopy, scanning electron microscopy and transmission electron microscopy in time course.
The appearances and the ultrastructures of the platelets were almost similar to that of the peripheral blood for one hour after suspension. The platelet granules were grouped in a mass or arranged along platelet membranes and some of platelets began to swell after 2 or 3 hours. After 30 or 31 hours, the staining of the platelets became worse, and most of the platelets became swollen. However, these platelets were not destroyed and the swollen platelets were recognized even on the 103rd day.
Therefore, the human platelets suspended in the human urine could not be destroyed easily.抄録全体を表示PDF形式でダウンロード (1123K) -
松尾 理, 美原 恒1977 年 18 巻 9 号 p. 1097-1101
発行日: 1977年
公開日: 2009/01/19
ジャーナル 認証ありIn thrombolytic therapy by UK, standards for the mode and amount of UK administration have not yet been established in Japan. In particular, the efficacy of small dose administration, which is a popular method of administering UK, has been questioned. In the present studies, the metabolism of UK was investigated with regard to the plasma fibrinolytic activity, which is essential for effective thrombolysis. The results indicated the operation of threshold phenomena and a latent time for the appearance of fibrinolytic activity in the plasma, and the inactivation rate constant of UK changed on the appearance of fibrinolytic activity. These results were explained with a two-compartment model for UK metabolism. Based on this model, concomitant use was made of one-shot and infusion administrations of UK, and this program was successful in inducing fibrinolytic activity from the outset of UK administration. The amount of UK given by such concomitant administration was thus of the large dose category. Clearly, concomitant use of one-shot and infusion administrations of UK may well be useful clinically for inducing effective thrombolysis.抄録全体を表示PDF形式でダウンロード (382K) -
—T-cell形質例の臨床・血液学的病態像について—木下 研一郎, 上平 憲, 池田 柊一, 山田 恭暉, 北村 勉, 古賀 庸之, 牟田 隆也, 市丸 道人1977 年 18 巻 9 号 p. 1102-1110
発行日: 1977年
公開日: 2009/01/19
ジャーナル 認証ありSurface markers of neoplastic cells in peripheral blood were studied in 36 cases of malignant lymphoma with leukemic manifestation. The results are as follows:
1) Fifteen cases were of T-cell nature in origin, only one case was B cell proliferation.
2) T-cell lymphomas were frequently accompanied by cutaneous infiltration as initial symptom or in their course. In contrast to small superficial lymphadenopathies and mild symptom, marked leukocytosis with high percent of neoplastic cells was observed on initial examination in T-cell lymphoma.
3) Neoplastic cells with T-cell nature in peripheral blood were like mature lymphocytes or “prolymphocytes”, but they had characteristic lobulation of the nucleus. So, these cases seemed to be just like leukemia on hematological picture and they were considered to be the same reported as “adult T-cell leukemia” (Takatsuki et al. 1975).
4) Neoplastic cells which resembled Sézary cells were seen in some cases of T-cell lymphomas with skin rashes. Therefore, they were very difficult to be distinguished from Sezary syndrome in clinical and hematological pictures. So, Sézary syndrome may be classifiable into T-cell lymphoma with leukemic manifestation.
5) Most cases of T-cell lymphoma with leukemic manifestation had typical histopathological features characteristic of malignant lymphoma. But, there were observed very few cases that showed histopathological features resembling “malignant histiocytosis” or “malignant reticulosis”. Finally, some discussions were done about classification of these border line cases.抄録全体を表示PDF形式でダウンロード (1229K) -
—病理所見を中心として—根本 啓一, 大西 義久1977 年 18 巻 9 号 p. 1111-1120
発行日: 1977年
公開日: 2009/01/19
ジャーナル 認証ありPathological findings of 7 cases of chronic lymphocytic leukemia (CLL) were presented. Electronmicroscopic and immunological features were also examined.
The cases were classified into two types; the one is the severe type showing short clinical course and another is the mild one, showing long clinical course. In the former type, there were striking splenomegaly, hemorrhagic tendency and a few immature lymphocytes but in the latter type such findings were only slight. The cause of death in the former type was mainly brain hemorrhage due to early bone marrow failure but in the latter type death was mainly caused by various infections.
Histologically, in the former type, leukemic cells were slightly large and immature which seemed to invade in nodular form, to the contrary, in the latter type, the cells were smaller and mature and infiltrated diffusely.
In 2/4 cases, immunological abnormality was found. In one of the cases, we found M-component of IgG Kappa by the immunoelectrophoresis, moreover IgG Kappa were also identified on the surface of peripheral lymphocytes.
Finally, we presumed that one of the factors of pathogenesis of CLL was immunological deficiency caused by aging.抄録全体を表示PDF形式でダウンロード (1469K) -
三沢 信一, 沢井 公和, 井出 透, 薗田 精昭, 竹村 周平, 滝野 辰郎, 森田 益次, 阿部 達生, 神崎 光也1977 年 18 巻 9 号 p. 1121-1127
発行日: 1977年
公開日: 2009/01/19
ジャーナル 認証ありA combination chemotherapy “DCMP” which is one of the most intensive chemotherapeutic regimen for acute non-lymphatic leukemia, was applied for chronic myelocytic leukemia (CML) during the chronic phase. The incidence of the Philadelphia (Ph1) chromosome was examined before and after five courses of DCMP-therapy in three patients with Ph1 positive CML. Two of three patients had no previous treatment for their CML. After DCMP-therapy, hepatosplenomegaly was diminished in size and white blood cell count and nucleated cell count of bone marrow were decreased, but the Ph1 chromosome was found in almost all metaphases obtained from bone marrow cells. In one patient previously treated with busulfan for one year and three months, WBC fell to 2,700 per cmm and NCC 35×103 per cmm after DCMP-therapy, but Ph1 positive cells were found in 18 out of 19 metaphases of bone marrow cells.
Intensive chemotherapy with DCMP in three patients with Ph1 positive CML during its chronic phase, accomplished no conversion of the dividing bone marrow cells to Ph1-negative. And the other implication of the DCMP-therapy to postpone the blastic transformation of CML is not evaluable yet.抄録全体を表示PDF形式でダウンロード (467K) -
川島 康平, 上田 竜三, 竹山 英夫, 小林 政英, 森島 泰雄, 加藤 幸男, 鈴木 久三, 若山 喜久子, 山田 一正1977 年 18 巻 9 号 p. 1128-1136
発行日: 1977年
公開日: 2009/01/19
ジャーナル 認証ありAt autopsy, we have observed 36 cases (25%) of secondary fungal infections among 144 leukemic patients during 15 and half years, from January 1961 to June 1976. The incidence represented 24.3% in 1961 to 1967, 31% in 1968 to 1970 and 21.6% in 1971 to 1976, respectively. All cell types of leukemia may be associated with secondary fungal infection. However, there are no definitive relationships between the cell types of leukemia.
Seventy-two per cent of patients with fungal infection was judged as severe fungal infection. Most of these fungal infections in leukemic patients were caused by aspergillus, candida and cryptococcus.
The fungal infection mostly was not diagnosed antemortem. Chest X rays seemed frequently normal in patients with fungal infection of the lung. At autopsy, the type of pulmonary involvement represented mainly bronchopneumonia, hemorrhagic infarction and focal necrosis. Antibiotics and antileukemic agents including corticosteroids were demonstrated to all patients with fungal infection. In association with neutropenia in the peripheral blood, severe lymphopenia predisposed greatly to fungal infection in patients with acute leukemia.
Candidiasis most frequently involved the G-I tract. The isolation of candida sp. from sputum or throat always did not indicate the presence of candidiasis. Aspergillus was most common and always involved the lung. Cryptococcus seemed to have affinity to lung, kidney and lymph node.抄録全体を表示PDF形式でダウンロード (629K)
症例
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—特に血小板膜の生化学的検討—高橋 隆一, 塚田 理康, 安藤 泰彦1977 年 18 巻 9 号 p. 1137-1142
発行日: 1977年
公開日: 2009/01/19
ジャーナル 認証ありThrombasthenia is a rare hemorrhagic disorder associated with abnormal platelet function and is transmitted as an autosomal recessive gene. However, in Japan only two familial cases have been reported. We report identical twin sisters with thrombasthenia.
Recently biochemical studies of platelets from thrombasthenic patients have been reported. Nurden and Caen found an abnormal glycoprotein pattern in thrombasthenic platelet membranes by sodium dodecyl sulfate (SDS) acrylamide gel electrophoresis. According to their method we found the same result. Löhr et al reported disturbance of glycolysis in thrombasthenic platelets, but we found a decrease in pyruvate kinase activity only. This is the first report of biochemical studies in thrombasthenic platelets in this country.抄録全体を表示PDF形式でダウンロード (686K) -
佐藤 功, 遠藤 一靖, 三上 雅嗣, 新井川 勝久, 佐々木 毅, 石田 秀一, 鈴木 隆城, 田島 剛一, 掘野 豊, 佐伯 重昭, 小 ...1977 年 18 巻 9 号 p. 1143-1149
発行日: 1977年
公開日: 2009/01/19
ジャーナル 認証ありA 51 year old health nurse had helped X ray photography for 22 years without any protector. Her routine medical check up in September, 1973, showed WBC 14400/cumm, appearance of immature granulocytes, basophilia in peripheral blood and predominant granulocytes series in bone marrow. But she did not have splenomegaly, low neutrophil alkaline phosphatase score, confirmed Ph1 chromosome and marked neutrophilia.
We thought she was in early stage of CML and kept observing her clinical course, but she was admitted with chief complaints of general malaise, slight fever and pain of lower legs in April, 1974. Findings in physical and laboratory examinations on admission were as follows: slight splenomegaly, accelerated blood sedimentation rate, 12.5% myeloblasts in peripheral blood, 37.6% myeloblasts in bone marrow and positive Ph1 chromosome.
At this stage, she was regarded to be in blast crisis of CML. The administration of 6MP and prednisolone brought the blast crisis back to chronic phase of CML, but two months later, blast crisis developed again.
She died of sepsis and pulmonary hemorrhage in December, 1974.
Some aspects of the atypical course were discussed.抄録全体を表示PDF形式でダウンロード (549K) -
三好 勇夫, 藤原 淳, 中山 孝, 岸本 博文, 中村 一夫, 宇野 順三郎, 田仲 俊雄, 栄 勝美1977 年 18 巻 9 号 p. 1150-1153
発行日: 1977年
公開日: 2009/01/19
ジャーナル 認証ありA case of immunoblastic lymphadenopathy (IL) in a 60-year-old man is described. The patient presented with fever, malaise, skin rash, generalized lymphadenopathy and hepatosplenomegaly. Laboratory examination revealed polyclonal hypergammaglobulinemia. Although there was no convincing evidence of malignancy, a combination chemotherapy (vincristine, cyclophosphimide, 6-MP and prednisolone) was administered because of progressive lymphadenopathy. This was followed by what appeared to be vincristine neuropathy and the patient died of bilateral bronchopneumonia 3.5 months after the onset of the disease. Although a possibility of Hodgkin's disease was once entertained, retrospective review of both biopsy and autopsy slides favored the diagnosis of IL. On the basis of recent findings on IL, an account is given of the possible pathogenesis of IL.抄録全体を表示PDF形式でダウンロード (450K) -
小林 政英, 大野 竜三, 山田 一正, 平林 紀男1977 年 18 巻 9 号 p. 1154-1159
発行日: 1977年
公開日: 2009/01/19
ジャーナル 認証ありA case of acute myelogenous leukemia is reported, which started with the tumor of the obaries followed by progressive and diffuse infiltration into the serosa of the abdominal and thoracic cavities. But the involvement of the bone marrow, liver and spleen was minimal. This case could be classified as granulocytic sarcoma, a variant type of AML, according to Rappaport's proposal.
The patient was a 16-year old girl, who had lower abdominal pain in July, 1974. A large mass was felt in her left lower abdomen. A laparotomy was done in September and a left ovarian tumor was found. Since the tumor had infiltrated diffusely into the pelvic cavity, only the partial resection was performed. Histological diagnosis was reticulum cell sarcoma and COP therapy was started.
In October the number of peroxidase-positive myeloblasts was increased in the peripheral blood (18%) as well as in the bone marrow (13.2%). Tumor cells of the ovarian tumor were also positive for peroxidase. Therefore the diagnosis was revised as granulocytic sarcoma. Although DCNP therapy induced a hematological remission, the tumor showed progressive growth. She died of ileus in March, 1975.
Autopsy revealed the infiltration of leukemic cells in the peritoneum, pleura, diaphragm, pericardium and thymus, but not in the bone-marrow, liver and spleen.抄録全体を表示PDF形式でダウンロード (803K)
例会
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1977 年 18 巻 9 号 p. 1160-1184
発行日: 1977年
公開日: 2009/01/19
ジャーナル 認証ありPDF形式でダウンロード (2365K)
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