巻号一覧
19 巻, 10 号
選択された号の論文の26件中1～26を表示しています
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臨床研究
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林 久智, 新谷 憲治, 古谷 裕道, 野崎 宏幸, 喜多嶋 康一, 木村 郁郎1978 年 19 巻 10 号 p. 1303-1313
発行日: 1978年
公開日: 2009/01/19
ジャーナル 認証ありTwo cases of Glanzmann's thrombasthenia (TA) and essential athrombia (EA), respectively have been investigated. TA and EA could be differentiated by clot retraction and platelet adhesiveness with fibrin fibers after the addition of CaCl2 to PRP.
ADP and ATP in platelets and ADP released from platelets during platelet aggregation were estimated by the firefly luciferin-luciferase assay. Both ADP and ATP in platelets of TA or EA were within normal ranges. Neither epinephrine nor ADP released from platelets. On the other hand, collagen released normal amount of ADP from platelets, however, it did not cause platelet aggregation. Ristocetin released very small amount of ADP from platelets, but aggregated platelets well.
Membrane fractions of TA and EA platelets were studied by SDS-polyacrylamide gel disc electrophresis. Three major glycoprotein bands stained by Zacharius' periodate-shiff reaction were observed, which molecular weights were 157,000 (Gp-I), 134,000 (Gp-II) and 107,000 (Gp-III) respectively. Both TA and EA showed different patterns of glycoprotein, namely very predominant Gp-I, faint Gp-II and normal Gp-III bands. On the other hand, 15 different polypeptides stained with amide-black 10 B were almost normal in distribution.抄録全体を表示PDF形式でダウンロード (1133K) -
竹中 武昭, 下山 正徳, 北原 武志, 坂野 輝夫, 湊 啓輔, 近田 千尋, 井上 雄弘, 木村 禧代二1978 年 19 巻 10 号 p. 1314-1321
発行日: 1978年
公開日: 2009/01/19
ジャーナル 認証ありSingle adriamycin (ADM) therapy was given to 29 courses of 27 patients with advanced (stage III and IV) non-Hodgkin's lymphoma refractory to prior combination chemotherapy with vincristine and/or bleomycin.
Fifteen patients received ADM in a dose of 30∼40mg intravenously for 2∼3 consecutive days every 3 or 4 weeks (schedule A).
Five complete and four partial remission were obtained with mean remission duration of 32 days.
Nine patients received ADM in a dose of 10∼20mg intravenously for 4∼8 consecutive days every 3 or 4 weeks (schedule B). One complete and four partial remission were obtained with mean remission duration of 41 days.
Five patients received ADM in a dose of 20∼40mg intravenously once a week for 3∼4 weeks (schedule C). Only 3 patients went into partial remission with mean remission duration of 10 days.
Major side effects included alopecia, stomatitis, and myelosuppression. Alopecia and stomatitis were observed in 59.6% and 48.1%, respectively. Thrombocytopenia (<50,000/cmm) and severe leukopenia (<1,000/cmm) were observed in 49% and 29%, respectively.
The changes in ECG were seen in 20% of patients with cumulative dose less than 100mg.
Thus, our study suggests that ADM is an effective agent in the treatment of advanced non-Hodgkin's lymphoma, and schedule A appeared to be more effective than schedule B and C.抄録全体を表示PDF形式でダウンロード (580K) -
新谷 憲治, 古谷 裕道, 林 久智, 野崎 宏幸, 喜多島 康一1978 年 19 巻 10 号 p. 1322-1331
発行日: 1978年
公開日: 2009/01/19
ジャーナル 認証ありThe authors studied on the role of factor VIII and platelet membrane glycoproteins implicated in ristocetin-induced platelet aggregation.
The residual levels of factor VIII procoagulant activity, factor VIII-like antigen and von Willebrand factor in plasma after aggregation of platelet-rich plasma by ristocetin (final concentration; 1.5mg/ml) were assayed. The level of factor VIII-like antigen was found to be significantly decreased and that of von Willebrand factor was slightly decreased, whereas there was no changes in factor VIII procoagulant activity.
The level of factor VIII-like antigen in plasma of patients with DIC was found to be markedly increased.
Analysis by SDS polyacrylamide gel electrophoresis of platelets treated with ristocetin revealed no remarkable changes in the distribution of membrane glycoproteins except that glycoprotein II was slightly reduced. Normal human washed platelets treated with low concentration of trypsin had reduced membrane glycoprotein I and did not respond in ristocetin-and bovine fibrinogen-induced platelet aggregation.
These data suggest that a small amount of factor VIII in plasma is utilized during ristocetin-induced platelet aggregation and that human factor VIII and platelet membrane glycoprotein I may play a functional role in ristocetin-induced platelet aggregation.抄録全体を表示PDF形式でダウンロード (863K) -
吉川 治哉1978 年 19 巻 10 号 p. 1332-1340
発行日: 1978年
公開日: 2009/01/19
ジャーナル 認証ありA new quadruple combination chemotherapy with ACNU 50mg/day IV (drip over 4 hrs)×4, Adriamycin 30mg/day IV (push)×4, Methotrexate 25mg IV (push) on day 1 and 4, and Prednisolone 60mg/day IV (push)×4 was designed and codenamed AAAP.
Fourteen courses of AAAP were administered in 13 occasions of relapses of 11 acute leukemia cases: all adult patients received intensive maintenance chemotherapy, from 15 to 64 (median 49) year-old at diagnosis; AML, 6 cases, AMoL, 2 cases and ALL, 3 cases. Of 13 relapsed cases, 7 (AML 3, AMoL 1, ALL 3) obtained complete remission (CR), 3 partial remission and 3 failure. In a case of AML (46 year-old), AAAP was indicated for the 3rd relapse resistant to PADOC, then CR was obtained and maintained over 9 mos, which exceeded the initial remission length of 8 mos. In the other case of ALL (62 year-old), AAAP was performed at the 1st relapse, and CR was achieved and maintained for 202 days, which also exceeded the initial remission length of 147 days. Furthermore, in 2 cases (AML, 49 year-old; ALL, 46 year-old), the survival from AAAP exceeded that prior to AAAP.
CR was obtained after only 1 course of AAAP and the median duration to reach CR was 22 days from the beginning of the treatment (20∼33 days). On the other hand, as to hematological changes in CR cases, the median time spent to recover was 32 days in WBC over 3,000/cmm and 27 days in Plt. over 100,000/cmm, from day 1 of AAAP respectively. Thus, myelosuppression was delayed compared to leukemocydal effect in AAAP.抄録全体を表示PDF形式でダウンロード (603K) -
中嶋 幹治1978 年 19 巻 10 号 p. 1341-1350
発行日: 1978年
公開日: 2009/01/19
ジャーナル 認証ありThe responsiveness of the bone marrow cells to erythropoietin in vitro was investigated according to Krantz's method in order to clarify the abnormal mechanism of erythropoiesis in various blood diseases. The bone marrow cells of seven normal persons and twenty eight cases of the patients from hematological diseases were examined.
1) The heme synthesis rate of seven normal persons to erythropoietin was 331±77.8% of controls lacking erythropoietin.
2) Twelve cases of aplastic anemia showed the heme synthesis rate of 117±27.4% of controls. It was deduced, therefore, that the erythropoietin responsive cells (ERC) pool in aplastic anemia was decreased in comparison to normal controls.
3) The heme synthesis rate of four cases from pure red cell aplasia was 132±67.4% of controls. It was presumed that the quantitative decrease of the ERC pool or the qualitative defect of the ERC was present in the bone marrow cells from pure red cell aplasia.
4) The bone marrow cells of three cases from atypical leukemia showed the heme synthesis rate of 151±25.1%, which was less responsiveness to erythropoietin than normal controls but much more than aplastic anemia.
5) The heme synthesis rate of four cases from polycythemia vera was 339±109.8% of controls lacking erythropoietin. It was proved that some ERC which was responsive to EPO and could differentiate, existed in the bone marrow cells of the polycythemia vera.抄録全体を表示PDF形式でダウンロード (710K) -
吉川 治哉1978 年 19 巻 10 号 p. 1351-1356
発行日: 1978年
公開日: 2009/01/19
ジャーナル 認証ありIn adults treated with the five drug combination, “PADOC” protocol, the incidence of complete remission in 20 therapy-resistent patients with acute non-lymphocytic leukemia (ANLL) for conventional combination chemotherapy was 60% and the median survival of all patients was 10 months.
Now, twelve patients with ANLL older than 60 years were treated with the same protocol or less intensive use of the same regimen. Seventeen courses of PADOC were performed for initial remission induction of 11 cases and remission reinduction of 1 case. Of 12 patients 7 (58.3%) obtanied a complete remission and 5 (41.7%) failure. The median survival time of patients attaining a complete remission was 12 months, as compared with 2/3 month for patients not attaining remission.
This study indicates that aged patients may have the opportunity for nealy the same response rate and survival as younger patients with ANLL.抄録全体を表示PDF形式でダウンロード (427K) -
佐々木 道子, 恒松 由記子, 小出 亮1978 年 19 巻 10 号 p. 1357-1364
発行日: 1978年
公開日: 2009/01/19
ジャーナル 認証ありPeriodic acid-Schiff (PAS) staining was carried out on leukemic cells from 83 patients of acute childhood leukemia and the results of PAS reactions by percentage positivities were classified into 4 patterns: coarse granular-bandlike type, drop- (or spot-) like type, fine granular type and negative type.
The correlations between PAS-Patterns and each one of cytomorphologic types of leukemic cells, initial features (white blood cell count, age and mediastinal mass) and prognoses were also studied.
1) Three of five patients with ALL showed coarse granular-bandlike type and their mean percentage positivity was 59.7%.
2) All seven patients with peroxidase positive AML showed fine granular type and their mean percentage positivity was 75.8%.
3) For AUL and peroxidase negative AML, there were all types of PAS-Patterns and no remarkable difference for their mean percentage positivities.
4) Patients were classified into three groups by initial features (white blood cell count, age and mediastinal mass), two of them had all types of PAS-Patterns and they showed no significant difference, but in the last group with mediastinal mass, two of four patients showed negative type.
5) In ten of nineteen patients to whom more than twice PAS stainings were carried out, the results of PAS reaction were changed during their course of acute leukemia.
6) 50% survival of coarse granular-bandlike type was 41.5 months, while droplike type showed 21.6 months, fine granular type 19.5 months and negative type 16.5 months. 50% first complete remission duration diminished in the order of coarse granular-bandlike type (16.5 months), droplike type (12.3 months), fine granular type (5.6 months) and negative type (4.6 months).
From these data, we may conclude that PAS reaction is available to estimate prognosis of acute leukemia of childhood.抄録全体を表示PDF形式でダウンロード (823K)
症例
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田村 滋, 黒川 和泉, 森山 美昭, 斎藤 秀晁1978 年 19 巻 10 号 p. 1365-1371
発行日: 1978年
公開日: 2009/01/19
ジャーナル 認証ありA case of plasma cell dyscrasia, which was difficult to diagnosis, with polyneuropathy and endocrine disorders has been reported: on admission, a 47-year-old male had various clinical signs, such as pigmentation, hard hairs, edema and paresthesia on his extremities, gynecomastia, choked disk, and pseudopolycythemia, suggesting polyneuropathy and endocrine disorders. He has also chronic constrictive pericarditis and gastric ulcer. Acetate cellulose membrane electrophoresis revealed IgG (λ) M protein in both serum and spinal fluid. However, no Bence-Jones protein in urine nor plasmacytosis in bone marrow smears was detected. At that time a diagnosis was not made. After years plasmacytoma was demonstrated by the biopsy of right ishium. Therefore, Melphalan was given that was effective for his clinical symptoms and his M protein disappeared further.抄録全体を表示PDF形式でダウンロード (729K) -
出浦 喜丈, 石井 善一郎, 下山 正徳, 湊 啓輔, 松田 幹夫1978 年 19 巻 10 号 p. 1372-1378
発行日: 1978年
公開日: 2009/01/19
ジャーナル 認証ありA case that could be classified as “monocytic sarcoma of the peritoneal type” was described, which presented ascites, and diffuse peritoneal and retroperitoneal infiltration, with minimal involvement of the bone marrow and peripheral blood throughout the course.
The patient was 27 years old, male, who visited our hospital on May, 1976 with chief complaints of abdominal distension and the tumor of right sided spermatic cord.
The cytological examination revealed that the neoplastic cells in ascites had the characteristics of monocyte as evidenced by peroxidase (+), India-ink phagocytosis (+), acid-phosphatase (+), α-naphthyl acetate esterase (+)-(-), PAS (+). In addition, immunological examination disclosed that the cells had Fc recepter, C3 recepter and immunophagocytosis, which were also characteristics of monocyte. However, there was no leukemic manifestation until 6 months from the time of initial diagnosis, when there was subleukemic manifestation of about 10% tumor cells in the peripheral blood and bone marrow. In the peripheral blood, leukemic cells increased to 50%∼80% in terminal stage associated with leukopenia (3,000/cmm>). Finally he died of ileus, 12 months after initial diagnosis.
Autopsy revealed the infiltration of the neoplastic cells in the peritoneum, omentum, retroperitoneum, diaphragma, but not in the bone marrow, liver, spleen. Therefore, this case could be classified as “monocytic sarcoma of the peritoneal type”. Literature is reviewed with emphasis on report of granulocytic sarcoma or chloroma occurring in the absence of leukemia. Then, for differential diagnosis, importance of employing immunological surface marker as well as cyto-chemical and ultrastructural method is pointed out.抄録全体を表示PDF形式でダウンロード (917K) -
林 英夫, 武元 香里, 貝塚 逸郎, 小関 忠尚, 春山 春枝1978 年 19 巻 10 号 p. 1379-1386
発行日: 1978年
公開日: 2009/01/19
ジャーナル 認証ありA 44-year-old male visited the outpatient clinic of the Kyoto Second Red Cross Hospital on November 7, 1975, with chief complaints of fever and pain in the left knee joint. A diagnosis of agranulocytosis was made and he was admitted on December 1. He was on oral prednisolone, but no effect was noted on the agranulocytosis, although the temperature became normal. Intravenous drip infusion of glutathione, 1,000mgm/day was begun on February 1, 1976, with Rinderon. After 5 days peripheral granulocytes began to increase and on February 12 granulocyte count was 13,000/cu. mm., without pathological cells. Bone marrow aspirate revealed an increase in mature granulocytes for the first time.
Thereafter fever began to run high and serum LDH level became higher and a bone marrow aspirate on February 12 showed 12% leukemic cells. Glutathione administration was stopped.
After that the peripheral blood showed pancytopenia with scattered leukemic cells. A bone marrow aspirate on March 1 revealed nucleated cells 20,000/cu. mm. with more than 80% leukemic cells.
He succumbed to the cerebral bleeding on March 2, 1976.抄録全体を表示PDF形式でダウンロード (837K) -
田嶌 政郎, 澤田 博義, 山岸 司久, 中村 徹, 大熊 稔, 稲本 康彦, 内野 治人1978 年 19 巻 10 号 p. 1387-1392
発行日: 1978年
公開日: 2009/01/19
ジャーナル 認証ありA 38-year old female with chronic myeloid leukemia was treated by splenectomy followed by remarkable thrombocytosis. She was diagnosed as CML because of anemia, leucocytosis and existence of Ph1 chromosome in bone marrow cells in 1973, and was successfully treated with Busulfan.
Her spleen began to enlarge progressively at the begining of 1976, and she complained occasionally of left-hypochondralgia due probably to infarction of the spleen from January, 1977. Hematological finding at this time showed increase of immature myeloid cells in her peripheral blood. Splenectomy was performed on 25 May, 1977 in order to prevent blastic crisis and infarction of the spleen. After splenectomy, the left-hypochondralgia subsided and immature myeloid cells decreased. However, platelet count in the peripheral blood and megakaryocytes in the bone marrow have been increasing prominently. The significance of splenectomy and the cause of remarkable thrombocytosis in this case were discussed.抄録全体を表示PDF形式でダウンロード (671K) -
竹山 英夫, 川島 康平, 森島 泰雄, 渡辺 英二, 平林 憲之, 堀田 知光, 山田 一正, 山田 博豊, 倉科 正徳, 平林 紀男1978 年 19 巻 10 号 p. 1393-1401
発行日: 1978年
公開日: 2009/01/19
ジャーナル 認証ありThis report describes a 32-year-old female with acute lymphoblastic leukemia (ALL) successfully grafted with bone marrow from a male HLA identical sibling.
In August 1975, she was diagnosed as having ALL cytologically and achieved complete remission with multi-combination chemotherapy. This remission was terminated by the advent of CNS leukemia after 8 months' maintenance treatment. Also she was in bone marrow relapse. Fortunately she entered the 2nd remission with an intensive chemotherapy including courses of intrathecal methotrexate.
However, she relapsed again in January 1977 and became refractory to the conventional chemotherapy.
In April 1977, she was transferred to the Nagoya University Hospital for bone marrow transplantation (BMT).
Prior to BMT, she was conditioned for grafts with cyclophosphamide, 60mg/kg/day for two days, followed by 1,000 rads total body irradiation (TBI). Bone marrow cells (1.2×1010) from her HLA matched sibling were infused intravenously 24 hours after TBI.
Bone marrow examination on 32nd day after BMT showed a hypocellular marrow with normal hematopoietic elements. Karyotypically, successful engraftment has been demonstrated by full replacement of bone marrow and peripheral blood cells with donor (male) origin.
She received intermittent methotrexate therapy after BMT to prevent graft vs host disease (GVHD). However, mild GVHD developed 3 weeks after BMT which was well controlled with methotrexate and prednisolone. She began to complain of dyspnea on 90th day after BMT and was diagnosed interstitial pneumonia on the chest X-ray film. She died with acute respiratory failure on day 98 after BMT.
An autopsy finding revealed interstitial pneumonia of unknown etiology. GVHD lesions were slightly noted in the skin and liver. Lymphoid tissue was severely atrophied, however, there was no infiltration of leukemia cells in any tissue.抄録全体を表示PDF形式でダウンロード (1007K) -
生野 茅子, 岡村 純, 田坂 英子, 琴尾 泰典1978 年 19 巻 10 号 p. 1402-1408
発行日: 1978年
公開日: 2009/01/19
ジャーナル 認証ありA 14-year-old girl was diagnosed to have lymphosarcoma (Stage I) after needle biopsy of the huge mediastinal mass. By radiation therapy to the mediastinum (5,400 rads) and combination chemotherapy (according to St. Jude protocol by Aur), complete remission was obtained. During the maintenance therapy, she started to complain of weakness and decreased sensation on her lower extremities 8 months after the diagnosis. CNS relapse was diagnosed one week later, which was successfully treated with intrathecally administered methotrexate (MTX) and hydrocortisone (HDC) and then, she received cranial radiation (2,000 rads). However, neurological symptoms progressed gradually and she developed loss of pain sensation, absence of deep tendon reflex of the lower extremities, and neulogenic bladder symptoms, which were finally diagnosed as radiation-induced myelopathy. She also developed asymptomatic radiation pericarditis 18 months after diagnosis. She experienced 3 more episodes of CNS relapse which were successfully treated with MTX and HDC.
At 26 months after diagnosis, she developed headache, loss of taste and bilateral facial palsy. She had generalized convulsion one hour after intrathecal medication with MTX, HDC and cytosine arabinoside, then became comatous and died 3 days later. Autopsy revealed performation of duodenal ulcers and demyelinisation of the pons, medulla and thoracic spine (leukoencephaloprthy). No tumor cell was seen at any place examined.
The possible relations between complications, cause of death and treatment were discussed.抄録全体を表示PDF形式でダウンロード (910K)
例会
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三比 和美, 服部 理男1978 年 19 巻 10 号 p. 1411-1416
発行日: 1978年
公開日: 2009/01/19
ジャーナル 認証ありPDF形式でダウンロード (437K) -
藤原 義久, 古川 鋼一, 田中 正夫, 田中 岑也, 中出 泰充, 広田 豊1978 年 19 巻 10 号 p. 1417-1421
発行日: 1978年
公開日: 2009/01/19
ジャーナル 認証ありPDF形式でダウンロード (335K) -
雨宮 洋一, 久松 順一, 伊藤 武善, 馬場 真澄, 天木 一太1978 年 19 巻 10 号 p. 1422-1428
発行日: 1978年
公開日: 2009/01/19
ジャーナル 認証ありPDF形式でダウンロード (446K) -
柴田 洋一, 十字 猛夫1978 年 19 巻 10 号 p. 1429-1431
発行日: 1978年
公開日: 2009/01/19
ジャーナル 認証ありPDF形式でダウンロード (225K) -
神田 裕三, 桜井 雅温1978 年 19 巻 10 号 p. 1432-1435
発行日: 1978年
公開日: 2009/01/19
ジャーナル 認証ありPDF形式でダウンロード (311K) -
連続血液成分採血装置Haemonetics Model 30を用いたhyperviscosity syndromeの血漿交換雨宮 洋一, 馬場 真澄, 久松 順一, 伊藤 武善, 天木 一太, 臼井 亮平, 神田 靖男1978 年 19 巻 10 号 p. 1436-1438
発行日: 1978年
公開日: 2009/01/19
ジャーナル 認証ありPDF形式でダウンロード (231K) -
長谷川 廣文, 西田 雅喜, 岩永 隆行, 堀内 篤1978 年 19 巻 10 号 p. 1439-1442
発行日: 1978年
公開日: 2009/01/19
ジャーナル 認証ありPDF形式でダウンロード (280K) -
植田 高彰, 柴田 弘俊, 正岡 徹, 田窪 孝行, 中村 博行, 吉武 淳介1978 年 19 巻 10 号 p. 1443-1446
発行日: 1978年
公開日: 2009/01/19
ジャーナル 認証ありPDF形式でダウンロード (245K) -
岩永 隆行, 長谷川 廣文, 堀内 篤1978 年 19 巻 10 号 p. 1447-1452
発行日: 1978年
公開日: 2009/01/19
ジャーナル 認証ありPDF形式でダウンロード (544K) -
下山 正徳, 湊 啓輔, 井上 雄弘, 木村 禧代二1978 年 19 巻 10 号 p. 1453-1456
発行日: 1978年
公開日: 2009/01/19
ジャーナル 認証ありPDF形式でダウンロード (321K) -
—Haemonetics Model 30による—小原 寛治, 神谷 修, 名倉 英一, 鬼塚 俊夫, 木下 淳, 星野 章, 山崎 健之1978 年 19 巻 10 号 p. 1457-1460
発行日: 1978年
公開日: 2009/01/19
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清水 勝1978 年 19 巻 10 号 p. 1461-1466
発行日: 1978年
公開日: 2009/01/19
ジャーナル 認証ありPDF形式でダウンロード (444K) -
Charles A. Schiffer1978 年 19 巻 10 号 p. 1467-1473
発行日: 1978年
公開日: 2009/01/19
ジャーナル 認証ありPDF形式でダウンロード (612K)
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