Rinsho Ketsueki
Online ISSN : 1882-0824
Print ISSN : 0485-1439
ISSN-L : 0485-1439
Search
Advanced search
OR
Browse
Search
Volume 20, Issue 6
Displaying 1-13 of 13 articles from this issue
Show all abstracts
    • |<
    • <
    • 1
    • >
    • >|
  • The Effect of Penicillin and Its Derivatives on Platelet Function
    Masao KIKUCHI, Shigeyoshi MATSUDA, Hiroyuki MURAKI, Yasuo IKEDA, Keisu ...
    1979 Volume 20 Issue 6 Pages 601-607
    Published: 1979
    Released on J-STAGE: January 19, 2009
    DOIhttps://doi.org/10.11406/rinketsu.20.601
    JOURNAL RESTRICTED ACCESS
    Show abstractHide abstract
    The effect of penicillin and its derivatives on platelet function was studied. Prolongation of bleeding time and abnormalities in platelet aggregation following administration of daily dose of 32g of carbenicillin, 8g of cefazolin and 120mg of gentamicin for treatment of sepsis were observed. After drugs were discontinued, these abnormalities disappeared. The inhibitory effect of penicillins on platelet aggregation, serotonin release and platelet adhesiveness to everted rabbit aorta was observed. However, the minimal concentration of drugs to show its inhibitory effects in vitro far exceeded the blood level of the antibiotics reached during treatment of severe gram negative bacterial infection. To clarify this discrepancy of in vivo and in vitro results, the effect of sulbenicillin (SB-PC) and its major metabolite, α-sulphobenzyl penicilloic acid (SB-PA), on platelet function in vitro was studied. SB-PA was found to cause much stronger inhibition of platelet function. This might help us understand the reason for this discrepancy.
    View full abstract
    Download PDF (442K)
  • Prophylactic CNS-leukemia Therapy with Cyclic Intrathecal Methotrexate and Hydrocortisone Injection
    Nobuyuki TAGUCHI, Ryo KOIDE, Yukiko TSUNEMATSU, Michiko SASAKI, Naoko ...
    1979 Volume 20 Issue 6 Pages 608-615
    Published: 1979
    Released on J-STAGE: January 19, 2009
    DOIhttps://doi.org/10.11406/rinketsu.20.608
    JOURNAL RESTRICTED ACCESS
    Show abstractHide abstract
    A total of 117 previously untreated children with acute leukemia (peroxidase negative) have been treated with cyclic intensive chemotherapy with or without intrathecal methotrexate (MTX) and hydrocortisone (HCS) injection between January 1969 and March 1978.
    These protocols consist of 3 phases; Remission induction with vincristin and prednisolone, Intensive chemotherapy with “VAMP” regimen with or without prophylactic CNS-leukemia therapy with intrathecal MTX and HCS for 3 years and Maintenance with 6-mercaptopurine.
    Of sixty-six patients who received prophylactic CNS-leukemia therapy with MTX 10-15mg/M2 only or plus HCS 15mg/M2 intrathecaly every 12 weeks, 22 patients (33.3%) had CNS-leukemia relapses 2.5-67 months after the start of CNS-leukemia therapy. Of fifty-one patients who received no prophylactic CNS-leukemia therapy, 28 patients (54.9%) had CNS-leukemia relapses.
    In prophylactic CNS-leukemia therapy group, complete and hematological remission durations and survival were significantly prolonged than those in without prophylactic CNS-leukemia therapy group.
    Toxicity of intrathecal MTX and HCS was observed in some patients who complained fever, nausea, vomiting and headache.
    View full abstract
    Download PDF (544K)
  • Immunological Assay for Plasma Prothrombin
    —Application to Coagulation test and Liver function test—
    Kazuhiko KITAJIMA, Makoto OKUMURA
    1979 Volume 20 Issue 6 Pages 616-622
    Published: 1979
    Released on J-STAGE: January 19, 2009
    DOIhttps://doi.org/10.11406/rinketsu.20.616
    JOURNAL RESTRICTED ACCESS
    Show abstractHide abstract
    Anti-human prothrombin was obtained from rabbits immunized with purified human prothrombin which was prepared from citrated human plasma by DeVilee's method. There was statistically significant correlation between the immunologicaly assayed-plasma prothrombin level and result of conventional coagulation tests representing the factor II concentration. Immunologicaly measurement for plasma prothrombin level will, therefore, be useful as one of the coagulation tests.
    Plasma prothrombin content of patients with various liver diseases were measured by the immunological methods. Abnormal plasma prothrombin level was detected clearly in the majority of them, and it was especially marked in patients with cirrhosis of the liver. Plasma prothrombin levels by the immunological assay were 12.5±2.4mg/dl (mean+SD) in healthy people, 6.5±2.5mg/dl in acute hepatitis (active stage), 10.6±3.7mg/dl in acute hepatitis (covalescent stage), 9.06±2.2mg/dl in chronic inactive hepatitis, 8.4±2.4mg/dl in chronic active hepatitis and 6.0±2.1mg/dl in liver cirrhosis. In acute hepatitis, particularly in fulminant hepatitis the plasma prothrombin levels mirrored clinical course more sensitively and precisely than did the serum albumin levels. The plasma prothrombin immunologically assayed will be a useful index for the impaired liver functions in hepatobiliary diseases.
    View full abstract
    Download PDF (507K)
  • Bone Marrow Aspiration by Spicule Smear Technique
    Hiromichi SUZUKI, Keiichi HARADA
    1979 Volume 20 Issue 6 Pages 623-627
    Published: 1979
    Released on J-STAGE: January 19, 2009
    DOIhttps://doi.org/10.11406/rinketsu.20.623
    JOURNAL RESTRICTED ACCESS
    Show abstractHide abstract
    In Japan, most of the bone marrow aspiration smears have been made without any attention to the spicules. In this report, we introduced so-called spicule smear method, which has been commonly used in U.S.A. and Europe.
    This fundamental difference is very important, because it can lead to a serious misdiagnosis.
    Advantages of spicule smear technique are as follows:
    1. Ease to obtain good specimen. 2. Ability to differentiate hypocellular marrow from false one due to poor aspiration technique. 3. Determination of bone marrow hemosiderin by Persian blue stain. 4. Estimation of the number of megakaryocytes.
    We hope that this new aspiration technique will be widely accepted in our country soon.
    View full abstract
    Download PDF (576K)
  • Tuberculosis in Hematological Diseases
    Katsuyo YAMAUCHI, Noboru MATSUMOTO, Hiroshi FUJITA, Susumu ODA, Shiro ...
    1979 Volume 20 Issue 6 Pages 628-639
    Published: 1979
    Released on J-STAGE: January 19, 2009
    DOIhttps://doi.org/10.11406/rinketsu.20.628
    JOURNAL RESTRICTED ACCESS
    Show abstractHide abstract
    Among 130 autopsied cases with hematological disease, active tuberculosis was demonstrated in eight cases. (6.2 per cent) Seven cases had generalized miliary tuberculosis. The underlying diseases were acute myelocytic leukemia (AML), malignant lymphoma, aplastic anemia, myelofibrosis and May-Hegglin anomaly. In 2 cases with AML no leukemic cell infiltration was found on autopsy and hematological abnormality might be due to leukemoid reaction to tuberculosis.
    Because tuberculosis could cause various hematological changes, it is difficult to diagnose tuberculosis in hematological diseases. No case was diagnosed as tuberculosis from chest X-ray film, Mantoux test or the culture of various specimens. It is important to find tuberculous bacilli or granuloma by bone marrow aspiration and/or biopsy.
    Five cases received prednisolone totalling from 350 to 3,000 mg. On corticosteroid administration, it must be considered the possibility that it might cause the dissemination of tuberculosis.
    View full abstract
    Download PDF (1056K)
  • A Case of Acute Lymphocytic Leukemia with Persistent High Levels of Hemoglobin F
    Takeo TAKEDA, Bunsaku NAGAI, Tatsuhito TONO-OKA, Shigeo SATO
    1979 Volume 20 Issue 6 Pages 640-645
    Published: 1979
    Released on J-STAGE: January 19, 2009
    DOIhttps://doi.org/10.11406/rinketsu.20.640
    JOURNAL RESTRICTED ACCESS
    Show abstractHide abstract
    This is a study on the red blood cells of a 4-year-old Japanese boy with acute lymphocytic leukemia. During the complete remission he continued to show very high levels of hemoglobin F (over 5%) in the peripheral red blood cells.
    When the patient developed meningeal leukemia, the level of hemoglobin F showed no change, and was rather decreased in hematological relapse.
    The studies of I antigen, carbonic anhydrase level and NH4HCO3 hemolysis test on his peripheral red blood cells suggested no embryonal hematopoiesis.
    View full abstract
    Download PDF (446K)
  • A Case of Acute Myelogenous Leukemia with Massive Breast Involvement During Hematological Remission
    Tadako NAKATSUJI, Noboru MATSUMOTO, Kohei KAKU, Toru IKESONO, Masako M ...
    1979 Volume 20 Issue 6 Pages 646-650
    Published: 1979
    Released on J-STAGE: January 19, 2009
    DOIhttps://doi.org/10.11406/rinketsu.20.646
    JOURNAL RESTRICTED ACCESS
    Show abstractHide abstract
    A case of acute myelogenous leukemia who developed myeloblastoma of the breast was described.
    A 16-year-old girl had the diagnosis of acute myelogenous leukemia in December, 1974. A complete remission was achieved after one course of treatment with a combination of daunomycin, ara-C and prednisolone, followed by COAP (cyclophosphamide, oncovin, cytosine arabinoside, prednisolone). Since then, bone marrow relapse was noted twice and reinduction with COAP was again effective.
    Three years and nine months after the onset of her illness she developed rapidgrowing tumors in the breast during hematological remission. Histology of the breast tumor was compatible with myeloblastoma. Bone marrow aspirate performed one month later revealed 12% myeloblasts, consistent with an early relapse.
    Eleven cases of acute myelogenous leukemia with the breast tumor formation have so far been reported since 1963. Clinical and hematological features of these cases were briefly summarized and the possible causative effect of estrogen in the development of myeloblastoma was discussed.
    View full abstract
    Download PDF (508K)
  • A Case of Acute Myeloblastic Leukemia After Immunosuppresive Therapy for Nephrosis
    Yuzo SHINOZAKI, Munamoto ITO
    1979 Volume 20 Issue 6 Pages 651-657
    Published: 1979
    Released on J-STAGE: January 19, 2009
    DOIhttps://doi.org/10.11406/rinketsu.20.651
    JOURNAL RESTRICTED ACCESS
    Show abstractHide abstract
    One case of a 27 years old housewife with typical acute myeloblastic leukemia after immunosuppresive treatment on nephrosis with prednisole for about three years and then with cyclophosphamide for one year and half was reported. DCMP treatment was also given but she died after one year and four months from the beginning of leukemia.
    Some refergntial consideration and discussion were made on carcinogenesis after immunosuppresive therapy, especially on leukemia as well as secondary carcinogenesis after general anticarcinogenic treatment, including substantial denaturation or malformation of DNA, cell constitution and defending mechanism against carcinoma.
    View full abstract
    Download PDF (517K)
  • A Case of IgG λ Myeloma Associated with Hyperviscosity Syndrome
    A Speculative Mechanism of Hyperviscosity Syndrome with Relative Low Serum Viscosity
    Akito KATSUKI, Chihiro SHIMAZAKI, Kichiro OSAMURA, Shinobu NAKANISHI, ...
    1979 Volume 20 Issue 6 Pages 658-666
    Published: 1979
    Released on J-STAGE: January 19, 2009
    DOIhttps://doi.org/10.11406/rinketsu.20.658
    JOURNAL RESTRICTED ACCESS
    Show abstractHide abstract
    A case of IgG λ myeloma died of acute cardiac failure due to hyperviscosity syndrome was reported.
    Although the incidence of hyperviscosity syndrome in IgG myeloma is said to be very low (4.2%) and hyperviscosity syndrome is not associated if the relative serum viscosity is less than 5, the relative serum viscosity of the present case was rather low. In this case, plasmapheresis was very effective and possibility of amyloidosis as a cause of cardiac insufficiency was negated by ECG and UCG findings, and by histological observations of rectal mucosa. Therefore, the occurrence of hyperviscosity syndrome was suspected basing upon an idea that RBC of this patient tends to aggregate themselves to elevate whole blood viscosity, since formation of peripheral blood rouleaux was found to be so remarkable.
    To test this possibility, viscosity of whole blood model prepared by incubating normal erythrocytes with the serum of this patient was compared with viscosities of similar models prepared by incubating normal erythrocytes of the same type with sera of various myeloma patients. As a result, it was found that the viscosity of the whole blood model of this patient is higher than the viscosities of others.
    Hyperviscosity syndrome associated with myeloma may not be so rare because in recent years the opportunities of discovery of myeloma is increased in one hand by the advancement in immunological techniques, and the incidence of myeloma is actually increasing on the other hand, due to the expansion of aged population. It seems therefore important to measure not only serum viscosity but also whole blood viscosity whenever hyperviscosity syndrome-like symptoms are associated with advanced myeloma patients.
    View full abstract
    Download PDF (788K)
    • |<
    • <
    • 1
    • >
    • >|
feedback
 Top