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Volume 23, Issue 3
Displaying 1-19 of 19 articles from this issue
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Shoki SAKURAMA, Masataka DENO, Yoshinori KOYANAGAWA, Hideki YAMAMOTO, ...1982 Volume 23 Issue 3 Pages 261-271
Published: 1982
Released on J-STAGE: January 26, 2009
JOURNAL RESTRICTED ACCESSA patient with B Cell Chronic Lymphocytic Leukemia (B-CLL) was found to have IgM paraproteins in serum showing a diphasic precipitin line in immunoelectrophoresis and a λ type Bence Jones Protein (BJP) in urine. These paraproteins as well as the BJP were isolated and were analysed immunochemically, and following results were obtained: First, the mechanism to form the diphasic IgM precipitin line in immunoelectrophoresis was due to the coexistence of two types (19S and 7S) of IgM-paraproteins in serum. Second, the light chain type of 19S IgM was easily determined to be λ type but that of 7S IgM could not be assessed by the simple immunological procedure. The latter was concluded to be also λ type by means of an interference effect of anti-λ type antisera on the precipitin line produced by anti-μ antisera. Third, the molecular weights of 19S IgM, 7S IgM and λ-BJP were calculated approximately to be 120x104, 24x104 and 6x104 daltons, respectively, based on the molecu lar forms of (μ2λ2)5 J for 19S, μ2λ2 for 7S and λ2 for BJP. Fourth, reduction and alkylation of the IgMs in serum was necessary to quantify the exact concentration of IgM in the case with the coexistence of 19S and 7S IgM. Otherwise, unduly high value of IgM concentration was obtained by the routine single radial immunodiffusion method (SRID). The exact concentration of IgM in serum of the patient was quantified to be 2.2g/dl. The concentration of a subfraction of 19S IgM was calculated as 1.9g/dl by a planimetrical analysis of the ultracentrifugal pattern. The concentration of 7S IgM subfraction was, therefore, assumed to be 0.3g/dl.
The clinical significance and the origin of the monoclonal 7S IgM were also referred to in literatures, and the relationship between these paraprotein producing cells and the cells of B-CLL still remains to be solved in the further studies involving in the point of the sharing of the idiotypic specificity.View full abstractDownload PDF (877K) -
—Characteristics and problems of non-Hodgkin's lymphoma in Japan—Teruo SAKANO, Hisao YAMASHITA, Koichi KANETA, Kazuo OHTA, Yasushi SHIG ...1982 Volume 23 Issue 3 Pages 272-285
Published: 1982
Released on J-STAGE: January 26, 2009
JOURNAL RESTRICTED ACCESSSince 1970, the 503 previously untreated cases of non-Hodgkin's lymphoma in adults which have beeen reported by 14 institutes throughout Japan registered with the Subcommitee on Malignant Lymphomas.
Histological diagnosis was conducted on the basis of the LSG classification. The Ann-Arbor clinical stage was employed for staging classfication.
1. As regards the primary site, the Waldeyer's ring accounted for the highest percentge of 38%.
2. A check of the histological classification indicates that follicular lymphoma accounted for an exceedingly low rate of 14.3% but the diffuse large cell type registered quite a high ratio of 49.5% in contrast to the Western countries. It has also been observed that the diffuse pleomorphic type, which characterized Japan, shared 3.4%.
3. In the staging classification, no significant difference was observed between stage III and IV and also between group A and B in the same group in termes of the survival time.
4. The complete remission rate stood at 44.1% for the group with chemotherapy, 84.4% for the group with radiation therapy and 61.2% for the group with chemotherapy and radiation therapy.
5. In a study on prognostic factors, the prognosis in favorable for the follicular medium-sized and diffuse small cell types, for stage I (Waldeyer's ring) in a combination of clinical staging and the primary site, for the complete remission in the effects of response and for cases of 40-49 years of age with the five-year survival rate standing at more than 60% and/or with the median survival time at more than 69 months.View full abstractDownload PDF (1060K) -
—Clinico-stastical Observation of 365 cases from 1935 through 1977—Koki GOTO1982 Volume 23 Issue 3 Pages 286-292
Published: 1982
Released on J-STAGE: January 26, 2009
JOURNAL RESTRICTED ACCESSThree hundred sixty-five patients with childhood acute leukemia treated at Nagoya University Hospital during 43 years from 1935 through 1977 have been reviewed and classified into 5 groups according to the chronological periods when different therapeutic procedures were employed and compared with each other from various aspects.
The rate of complete remission was 0, 3, 60, 71 and 93% for the groups I (1935-1950), II (1951-1956), III (1957-1967), IV (1968-1972) and V (1973-1977), respectively.
The median survival time was prolonged from 2.8 (group I) to 26 months or more (group V) during the 43 years, and there are now 17 five-year survivals.
Moreover, the interval between presumed onset of the disease and a difinite diagnosis was shortened from 1.3 to 0.6 months.
Thus, there has been a remarkable advance in the treatment result as well as the diagnostic technique of the disorder.
The clinical features were also remarkably changed. Hepatosplenomegaly was initially noticed in 71% of cases, in contrast to 34% in the IV and V groups.
Severe anemia was also found in 38% of the groups I and II, whereas it became less significant in groups IV and V.
These results indicate that the progress in the treatment of childhood acute leukemia has been brought about by the therapeutic improvement as well as the rapid diagnosis.View full abstractDownload PDF (508K) -
Kazuyoshi YAMADA, Naoe OKABE, Yoshiro UZUKA1982 Volume 23 Issue 3 Pages 293-304
Published: 1982
Released on J-STAGE: January 26, 2009
JOURNAL RESTRICTED ACCESSTwenty eight cases with adult acute leukemia were classified by the FAB classification. The ultrastructural morphology and the surface markers of the cells were examined on the basis of the FAB classification. The relationship between the maturation and surface morphology of the cells were also examined. The surface architectures of the cells obtained by scanning electron microscopy (SEM) were expressed according to the classification of Polliack.
1) The cells of villi type were dominated in L1 and L2. The population of the cells of ridge type increased in L2, as compared with L1. One case of L2 had predominantly ridgelike profiles. This case had peroxidase-negative blast cells which might be MO according to Mertelsmann's classification.
2) The cells of ridge type were dominated in M1, M2 and M3. There were more cells of smooth, villi or bleb type in M1 than M2. The cells of M3 had prominent ridge-like profiles compared with M1 and M2.
3) M4 cases showed mixed population of cells with ridge-like profiles and ruffled membranes. In all cases of M4, there were double-esterase positive cells which had both alphanaphthyl acetate esterase (ANE) and naphthol AS-D chloroacetate esterase (CAE) in the same cell. These cells possessed neither surface markers nor phagocytic activities. Surface architecture of these cells was mostly ridge type. By transmission electron microscopy, these cells had round nuclei, granules with various size and density, and rough endoplasmic reticulums with wide spread parallel distributions.
4) The cells of M5a which had Fc receptors or had no surface markers showed mostly ridge-like profiles. In proportion to the maturation of the cells, Fc or C3 receptors and phagocytic activities increased such as M5b, and the prominent ridges or ruffles of the cell also simultaneously increased.View full abstractDownload PDF (2114K) -
Shunichi SHIMIZU, Tadatoshi KURATSUJI, Tadashi OJIMA1982 Volume 23 Issue 3 Pages 305-308
Published: 1982
Released on J-STAGE: January 26, 2009
JOURNAL RESTRICTED ACCESSLithium carbonate was added to semisolid cultures of human bone marrow. Bone marrow cells were obtained from 10 children, aged 7 months to 5 years who were sufferring from various kinds of diseases. Bone marrow cells were prepared in two ways; non-separated cells (NS) and non-phagocytic cells (NP) which were freed from phagocytic cells using the iron ingestion methood. Human placental conditioned medium (HPCM) was prepared as a source of colony stimulating factor (CSF). The final concentration of lithium in the cultures was 1mEq/l.
Lithium enhanced the growth of colonies and clusters from NS cultures to 1.33±0.21 times of the control, while lithium had no influence on the number of colonies and clusters in NP cultures, 1.07±0.19 of the control.
We concluded that
1) lithium itself had no CSF activity,
2) lithium did not activate already formed CSF,
3) lithium enhanced the production of CSF by the phagocytic cells contained in NS culture plates.View full abstractDownload PDF (307K) -
Yasushi KOITABASHI, Takashi MARUYAMA, Masaaki IKOMA, Yoshikazu MIYAJI, ...1982 Volume 23 Issue 3 Pages 309-318
Published: 1982
Released on J-STAGE: January 26, 2009
JOURNAL RESTRICTED ACCESSSeven patients with nephritis resistant to the conventional treatment were treated with combined use of heparin and urokinase (UK). Ten thousands U/Kg/day of UK was administered to the patients for 3 days associated with 350-450 U/Kg/day of heparin which was continued for more than two weeks. Two out of 7 patients demonstrated improvement which has long been sustained, both in renal functions and various clinical manifestations such as urine protein, blood pressure, edema and others. The two cases which responded to the present therapy were an 11-year-old girl with rapidly progressive membranoproliferative glomerulonephritis (MPGN), and a 7-year-old boy with severe acute glomerulonephritis developing to the nephrosis. Five cases which were nonreactive to the therapy in present study were two cases of MPGN and, independent single cases of purpura nephritis, FGS, and so-called CGN,
By the administration of UK, the level of α2-PI mostly fell down to less than 60% of the normal. It was interesting that the level of α2-PI in the responded two cases had been lower at the time prior to the therapy. It might be indicated that the increased activity of native fibrinolysis in the patients will assist the effect of UK therapy.View full abstractDownload PDF (631K) -
Masakiyo MANNOJI1982 Volume 23 Issue 3 Pages 319-324
Published: 1982
Released on J-STAGE: January 26, 2009
JOURNAL RESTRICTED ACCESSDirector: Prof. Yoshihito Yawata
Acute hemolytic episodes were observed in patients during cardiovascular surgery employing extracorporeal circulation. Red cells showed a marked enhancement of Heinz body formation when incubated with acetylphenyl hydrazine in vitro. Hydroxyethyl starch (HES), a plasma expander that was used for the one of the priming solution, was proved to responsible for the increased Heinz body formation in these red cells. The increase of Heinz body formation in normal red cells incubated with HES was dependent on the concentration of HES. HES did not have direct effects on hemoglobin metabolism and the activities of pentose shunt pathway. The pathogenesis of the abnormalities could be due to the irreversible effect of HES on red cell membranes.View full abstractDownload PDF (473K) -
Yataro YOSHIDA, Tadashi OHKUBO, Takayuki KAMAMOTO, Eikun BOKU, Eiji KO ...1982 Volume 23 Issue 3 Pages 325-331
Published: 1982
Released on J-STAGE: January 26, 2009
JOURNAL RESTRICTED ACCESSIn order to assess the value of blood transfusions in the management of aplastic anemia patients, the amount and types of blood transfused were studied in 102 patients seen between 1958 and 1980. Transfusion requirement was inversely related to the blood hemoglobin level. The transfusion requirement also showed a close relationship to responsiveness to the androgen therapy. Thus, the median amount of blood transfused was 2,200ml in androgen-responding cases, and 8,800ml in androgen-nonresponding cases. A comparable amount of blood was transfused for the first 3 months in both groups. However, androgen responding groups required progressively lesser amount of blood with time after initiation of treatment, while the transfusion requirement showed a steady increase in androgen-nonresponding groups. Retrospective analysis of the blood transfusions in chronic aplastic anemia patients between 1958 and 1980 revealed that the average amount of blood transfused per patient per year decreased to nearly half during this period of time. Leukocyte-poor blood or washed red cells were the types of blood preferentially used in recent years. Platelet or granulocyte transfusions were employed only in acute cases and/or cases with severe complications. The significance of androgen therapy has been discussed in relation to the evaluation of transfusion requirement in aplastic anemia.View full abstractDownload PDF (502K)
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Michiko SASAKI, Ryo KOIDE, Yukiko TSUNEMATSU, Hirotaka TAKAHASHI, Yuki ...1982 Volume 23 Issue 3 Pages 332-339
Published: 1982
Released on J-STAGE: January 26, 2009
JOURNAL RESTRICTED ACCESSThis report concerns a case of one-year-9-month old boy with acute megakaryocytic leukemia.
On September 12, 1978, the patient admitted with hemorrhagic tendency, anemia, and hepatosplenomegaly.
On admission, peripheral blood smear showed 16% of blast-like cells, which were probably immature megakaryocytes. A bone marrow aspirate was hypercellular and occupied mostly by megakaryocytic series.
After chemotherapy with prednisolone, vincristine and DCVP-therapy, bone marrow showed a transient complete remission, then he was treated with VAMP-therapy as a first consolidation, but in January 9, 1979, he died suddenly due to pneumonia.
Autopsy findings showed leukemic infiltration of blast-like cells and megakaryocytes in the bone marrow, liver, spleen and lymph nodes.
Leukemic cells from bone marrow revealed abnormal karyotypes. Cytochemical findings showed strongly positive in acid phosphatase and β-glucuronidase, weakly positive in PAS and α-naphthyl acetate esterase reactions. Platelet-peroxidase reaction appeared in rough endoplasmic reticulum (contained nuclear envelope) of leukemic cells, but did not appear in granules and Golgi apparatus.
This was the first case in Japan that revealed platelet-peroxidase reaction by an ultrastructural method in a patient with megakaryocytic leukemia.View full abstractDownload PDF (888K) -
Yoji ASANO, Takehiro TAKENAKA, Naokazu NUNOUE, Nobuyoshi TSURUOKA, Mic ...1982 Volume 23 Issue 3 Pages 340-348
Published: 1982
Released on J-STAGE: January 26, 2009
JOURNAL RESTRICTED ACCESSThe Patient was a 78-year-old man. He was admitted to our hospital because of cough, sputum and slight fever. A pruritic erythroderma began about five years before. On physical examination, pigmented erythroderma, leonine face and lymphadenopathy were recognized. The peripheral leukocyte count was 26,100 per cmm with 75% abnormal lymphoid cells. Bone marrow was normal. Abnormal lymphoid cells were confirmed to have T cell properties with E rosette-forming method. In electron microscopic studies of peripheral blood and skin, the abnormal cells were 7-15μ in diameter. The nucleus was indented and serpentine. These cells had pseudodiploid chromosome numbers with B marker chromosome. A diagnosis of small cell variant Sézary's syndrome was made. The bronchograhy and bronchoscopy including biopsies revealed the complication of lung carcinoma. Six years ago, he had recieved radiation therapy for esophageal carcinoma. The combination chemotherapy with prednisolone, adriamycin and carboquone was not effective. He died of cachexia in 98 days after the admission.View full abstractDownload PDF (1034K) -
Jun FUJIKAWA, Ryuji HAYASHI, Haruo NISHIMURA, Katsuji KOHIGASHI, Yatar ...1982 Volume 23 Issue 3 Pages 349-355
Published: 1982
Released on J-STAGE: January 26, 2009
JOURNAL RESTRICTED ACCESSA 31-year-old woman was admitted to our hospital following 2 weeks of nausea, vomiting, polydipsia, and polyuria. She had been well until 3 months previously, when anemia was pointed out on an annual examination. Iron was prescribed to no effect.
On admission, she was pale but appeared well. There was no lymphadenopathy, hepatosplenomegaly, or petechiae. Daily urine output ranged from 3 to 5l. The urine was unremarkable except for low specific gravity. Initial hemoglobin level was 7.8g/dl. White blood cell (WBC) count was 2,300/mm3 with 8% myeloblasts, 4/100 WBC erythroblasts, 9/100 WBC megakaryocytes. Platelet count was 790×103/mm3. Bone marrow examination showed proliferation of myeloblasts and erythroblasts with PAS-positive megaloblastoid features. A diagnosis of erythroleukemia was made.
After 2 courses of DCMP (Daunomycin, Behenoyl Ara-C, 6MP, Prednisolone) therapy, urine output temporarily decreased to around 2l, but increased again 3 months later, ranging from 4 to 7l. Water deprivation test and Carter-Robbins test established the diagnosis of central diabetes insipidus. Neurological examination was unrevealing. DDAVP was given with unsatisfactory response. Although therapeutic irradiation of 4000 rad to the pituitary area showed no immediate effect, her diabetes insipidus was relatively mild several weeks later.
Despite chemotherapy including DCMP, aclacinomycin-A, and VP (Vindesine, Prednisolone), hematological remission was not attained. However, her general conditionremained well and as of end of July, 1981, she is being fairly controlled at the out-patient clinic, with small doses of corticosteroid and blood transfusion.View full abstractDownload PDF (451K) -
Hiroyuki SUGIYAMA, Hedeto SHIMADA, Shigeki SENZAKI, Takayuki TAKAHASHI ...1982 Volume 23 Issue 3 Pages 356-364
Published: 1982
Released on J-STAGE: January 26, 2009
JOURNAL RESTRICTED ACCESSA case of acute myelogenous leukemia occurring 8 years after 131I therapy for hyperthyroidism is described. The patient, a man, was diagnosed as Hashitoxicosis in 1971 when he was 62 years old, and was treated with 8 mCi of 131I followed by antithyroid drug, propylthiouracil, without significant effect. In May 1979, he returned with complaints of malaise and loss of weight. Hematological examinations revealed pancytopenia and bone marrow hypoplasia with marked increase in myeloblasts, which suggested he was in a state of hypoplastic leukemia. Two months later, however, he developed an overt type of acute myelogenous leukemia. Combination chemotherapy was given without success to induce complete remission, and the patient died of pneumonia in November, 1979.
Since 1956 when Pochin described the fist case, a total of 31 cases of leukemia following 131I therapy for hyperthyroidism were reported till 1968. Saenger et al statistically demonstrated, however, that there is no significant increase in the prevalence of leukemia in patients with hyperthyroidism who were treated with 131I, compared with that in surgically treated cases. He rather introduced a concept that hyperthyroidism itself might be a possible inducing factor to leukemia. Werner and later Nakayama suggested independently, that aleukemic forms of acute myelogenous type, as ours, were observed in leukemia following 131I therapy significantly in higher proportions than in adult leukemia in general public. The occurrence of leukemia following 131I therapy for hyperthyroidism is still to be analyzed to confirm its prevalence and to clarify its biological characteristics.View full abstractDownload PDF (1231K) -
—Report of two cases—Hiroyuki SUGIYAMA, Hideto SHIMADA, Masato YAGITA, Tetsuro HORIUCHI, Ta ...1982 Volume 23 Issue 3 Pages 365-370
Published: 1982
Released on J-STAGE: January 26, 2009
JOURNAL RESTRICTED ACCESSThe report deals with 2 cases of rare complication of deep vein thrombosis occurred during course of idiopathic thrombocytopenic purpura (ITP). Case 1, a 33-year-old man, entered our hospital because of bleeding tendency and anemia. Laboratory examinations disclosed RBC 2.33×106/cmm, PLT 28×103/cmm, positive direct Coombs'test, positive anti-platelet IgG antibody and both erythroid and megakaryocytic hyperplasia of the bone marrow. Under a diagnosis of Evans'syndrome he was treated with corticosteroid without significant. effect. Yet, a month later he developed a deep vein thrombosis in the left lower extremity, and further 2 months later he had an another episode of thrombosis in the right lower extremity. Case 2, a 63-year old man, has been continuously given corticosteroid since 5 years ago, when a diagnosis of ITP was made with positive anti-platelet antibody. He developed deep vein thrombosis in the left lower extremity following a mild contusion on the left leg when his platelet count was 13,000/cmm.
Possible pathogenesis of such deep vein thrombosis is discussed as follows:
1) preparatory aggregation of platelet due to presence of large amount of immunocomplexes in the circulation and on the platelet surface
2) hypercoagulability due to steroid therapy
3) an increase in the vascular platelet reserved pool
4) traumatic or other pathogenetic micro-hemorrhage in the vascular wall of large vein with subsequent thrombosis.View full abstractDownload PDF (499K) -
Masamichi HARA, Kozaburo UCHIDA, Keizo KUNICHIKA, Kazuko TAKAOKA, Seii ...1982 Volume 23 Issue 3 Pages 371-376
Published: 1982
Released on J-STAGE: January 26, 2009
JOURNAL RESTRICTED ACCESSA case of acute myelogenous leukemia (AML) with aure body and Ph1 like chromosome was reported. The patient, 72y/o, male, was admitted to our hospital with complaints of general weakness and nausea. On admission, he had no splenomegaly, and myeloblasts were 5% in the peripheral blood and 20.4% in the bone marrow, respectively. There was no basophilia. Blasts were positive to peroxidase staining and auer bodies were recognized. Neutrophil alkaline phosphatase score was 129. Chromosomal analysis showed Ph1 like additional chromosome and double Y chromosome in all bone marrow cells at mataphases. Karyotype was [48, XYY, +Ph1?). On the basis of hematological findings, he was diagnosed to be Ph1 positive AML, which has been considered to poorly response to chemotherapy. He could obtain the complete remission by the combination of daunorubicin and cytosine arabinoside. The remission duration was 75 days and the survival was one year after the diagnosis of AML.View full abstractDownload PDF (823K) -
Kazuma OHYASHIKI, Akira OHSUMI, Hisao ITO, Senji UMEHARA, Junko OHYASH ...1982 Volume 23 Issue 3 Pages 377-384
Published: 1982
Released on J-STAGE: January 26, 2009
JOURNAL RESTRICTED ACCESSAcute leukemia ocurred in siblings are reported. Elder sister, 10-year-old, was admitted to Narita Red Cross Hospital on October 19, 1974 because of fatigability. A peripheral blood examination revealed that white blood cells count was 7600/μl involving 6% monoblasts. She was diagnosed as having monocytic leukemia by bone marrow fims, and treated with prednisolone, 6-mercaptopurine and cytosine arabinoside, but she died on Novermber 15 with meningeal involvement. Her brother, 16-year-old, was admitted to Kasumigaura Hospital, Tokyo Medical College because of fever on Feburary 13, 1981. A peripheral blood examination on the admission revealed that Hb was 8.5g/dl, white blood cells count was 17800/μl involving 81% myeloblasts, and he was diagnosed as having acute myelogenous leukemia (Ml in FAB classification). Antileukemic agents (VCcMP and COAP therapy) were administrated to the patient, and a complete remission was achieved on April 17. Hematological and cytogenetic studies of their parents showed no abnormalities, and immunological examination revealed that the serum IgM of the father was only 50mg/dl, which was lower than the normal range (65-160mg/dl).View full abstractDownload PDF (839K) -
Takeshi MAEDA, Yoshimitsu ONODERA, Sumio SAKAMAKI, Yutaka KOHGO, Yoshi ...1982 Volume 23 Issue 3 Pages 385-391
Published: 1982
Released on J-STAGE: January 26, 2009
JOURNAL RESTRICTED ACCESSUp to the present, the pathogenesis of aplastic anemia has been discussed by many investigators, but it still remains in dispute. Lately in some cases of aplastic anemia the suppression to bone marrow stem cells through immunological mechanism was suspected for the ca use of this disease.
In the present report, we describe a young male patient of atypical aplastic anemia, whose peripheral lymphocytes suppressed a colony forming unit (CFU-C) of normal marrow cells.
Although the anabolic steroid was proved to be ineffective, complete remission was brought by the treatment with a high dose of betamethasone.
It was therefore assumed that in this patient the circulating lymphocyte was playing a pathognomonic role for aplastic anemia by their suppressive activity on the proliferation of bone marrow cells.View full abstractDownload PDF (534K) -
Masaru NAKANO, Shinji MORI, Hidetoshi SHIGEFUKU, Kohichi YUNOKAWA, Tak ...1982 Volume 23 Issue 3 Pages 392-399
Published: 1982
Released on J-STAGE: January 26, 2009
JOURNAL RESTRICTED ACCESSA case of adult T cell leukemia (ATL) with marked hypogammaglobulinemia is reported.
A 43-year-old woman, who had lived in Nagasaki prefecture for about 2 years soon after birth, was admitted on August 28, 1980, because of fever, dry cough and generalized lymphadenopathy.
The leukocyte count in the peripheral blood was 8900/mm3 with 45% atypical lymphocytes having so-called convoluted or lobulated nuclei. The 83% of the peripheral lymphocytes including convoluted lymphocytes formed E-rosette. Histological diagnosis of resected inguinal lymph node was non-Hodgkin's lymphoma of diffuse and pleomorphic type based on L.S.G. classification.
Therefore clinical diagnosis of adult T cell leukemia-lymphoma (ATL·L) was made and treated with both vindesine and prednisolone.
Immunological examination revealed hypogammaglobulinemia (IgG 425mg/dl, IgA<87mg/dl, IgM<32mg/dl) that remained throughout the whole clinical course from the admission. Negative skin test against PPD, decreased blastogenesis of lymphocyte by PHA, ConA and PWM, and negative TdT activity were also seen.
The results of analysis of leukemic T cell subsets by monoclonal antibodies (OKT series) were as follows: more than 95% of total T cells were reactive to OKT 3 antibody (peripheral T cell specific), 85% reactive to OKT 8 (suppressor/cytotoxic T cell specific), 10% reactive to OKT 4 (helper/inducer T cell specific). Then these leukemic T cells functionally suppressed in vitro differentiation of normal B cell into immunoglobulin producing cells by PWM.
In conclusion, this ATL was considered to be derived from proliferation of suppressor T cells.View full abstractDownload PDF (767K) -
Mitsuaki SUDA, Atsuo MIKATA, Hiroshi KAWABE, Takashi SASHO, Yasuhiro A ...1982 Volume 23 Issue 3 Pages 400-407
Published: 1982
Released on J-STAGE: January 26, 2009
JOURNAL RESTRICTED ACCESSPlasma muramidase levels were studied in 2 patients with Hodgkin's disease and found significantly increased. One untreated patient was studied at diagnosis and his plasma muramidase level was elevated. In this patient plasma muramidase rapidly decreased to normal level after a course of CHOP treatment. The other patient having been treated for Hodgkin's disease with CHOP therapy for seven years was studied at the time of relapse and had a high plasma muramidase level. The estimation of plasma muramidase may be valuable in the diagnosis, assessment of the activity and early detection of a relapse of Hodgkin's disease.View full abstractDownload PDF (776K) -
Hiroto ISHIKURA, Yoichiro IZUMI, Tadao USUI, Hiroshi KONISHI, Hiroyosh ...1982 Volume 23 Issue 3 Pages 408-414
Published: 1982
Released on J-STAGE: January 26, 2009
JOURNAL RESTRICTED ACCESSA case of acute non-lymphocytic leukemia with t (8q-; 21q+) which showed interesting cytochemical findings was reported.
The patient was a 18-year-old female. Her chief complaints were headache and general malaise and she was admitted to Kyoto City Hospital on November 25, 1980. Hematological examinations on admission revealed that WBC count of peripheral blood was 20,400/mm3 with 70% myeloblasts. Some of them showed folded nuclei or Auer rods. Bone marrow smears showed myeloid hyperplastic appearance with varying degree of maturation. According to the FAB criteria, she was diagnosed as M2 which was a characteristic feature of ANLL with t (8q-; 21q+).
Cytochemical analysis showed that these leukemic blast cells contained both specific and nonspecific esterase activities. This cytochemical finding suggested that leukemic blast cells of this case involved a differentiation into both granulocytic and monocytic series in a maturation process.
The relation between cytochemical findings and leukemic cell maturation was discussed.View full abstractDownload PDF (542K)
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