All issues
Volume 26, Issue 4
Displaying 1-23 of 23 articles from this issue
- |<
- <
- 1
- >
- >|
-
Keiichi MARUOKA, Masayoshi YAMANAKA, Yoshihiro YAMASAKI, Masahiro MISA ...1985 Volume 26 Issue 4 Pages 475-481
Published: 1985
Released on J-STAGE: February 02, 2009
JOURNAL RESTRICTED ACCESSDiagnostic evaluation and elevation mechanism of serum RNases in CML and its related diseases were investigated. The study was done on 23 cases of CML, 24 other myeloproliferative diseases, 28 other hematological disorders, 38 miscellaneous malignancies, 20 leukocytosis secondary to infections and 50 healthy subjects. Acid RNases (Ac-RNase) activities and Acid RNase/Alkaline RNases ratio (Ac/Al ratio) were markedly increased in CML compared with those in any other groups examined (p<0.001). The Ac/Al ratio was far above 1.0 in all cases with CML, around 1.0 in its related disorders, while below 1.0 in other diseases and healthy subjects. The Ac-RNase activity and Ac/Al ratio in CML showed significant positive correlation with the number of peripheral leucocytes and neutrophils (p<0.001). The Ac/Al ratio of normal lymphocyte extracts was 1.8 while that of granulocyte 2.3.
The results suggested that the determination of serum Ac-RNase activity and Ac/Al ratio would be diagnostically useful for CML and serum Ac-RNase originated granulocytes of all stages of maturation.View full abstractDownload PDF (547K) -
Toshiyuki TAKAGI, Keiichi IWABUCHI, Kazumi SAMPI, Yasunobu KURAISHI, S ...1985 Volume 26 Issue 4 Pages 482-486
Published: 1985
Released on J-STAGE: February 02, 2009
JOURNAL RESTRICTED ACCESSOne hundred and three bone marrow biopsies and aspirations simultaneously obtained from the patients with malignant lymphomas were reviwed to evaluate their usefullness for detecting bone marrow involvement. Of fifteen cases whose biopsy was diagnosed as positive, 7 cases were positive in the aspiration smears, but 8 cases were negative or equivocal. On the other hand, all of 88 cases with negative biopsy were negative in aspiration and none of them became leukemic in their subsequent clinical courses. Bone marrow biopsy is therefore more useful than aspiration for detecting bone marrow involvement in malignant lymphomas.
Frequencies of bone marrow involvement were higer in follicular mediun cell (4 of 6 cases) and lymphoblastic (1 of 1) type, but lower in diffuse large (2 of 29), diffuse mixed (1 of 9) and follicular large (0 of 5) cell type.View full abstractDownload PDF (528K) -
Eiichi ISHII, Kunio KISHIDA, Sumio MIYAZAKI, Toshiro HARA, Eiichi NAKA ...1985 Volume 26 Issue 4 Pages 487-493
Published: 1985
Released on J-STAGE: February 02, 2009
JOURNAL RESTRICTED ACCESSEighteen children with acute lymphoblastic leukemia were treated with a modified LSA2-L2 multidrug protocol. Of the 18 cases, 17 attained to complete remission (CR) and CR rate was 94%. With life table analysis, the proportion of CR at the time of the 6th month and 12th month after the attainment of CR was 90% and 78%, respectively. Four patients who attained CR developed marrow relapse with a median duration of 10.5 months. As toxic effects of this protocol, allergic reaction due to N4-behenoyl-1-β-D-arabinofransylcytosine (BH-AC) in two cases, and acute pancreatitis and anaphylactic reaction due to L-asparaginase (L-ASP) in each one case were observed. For prophylaxis of involvement of the central nervous system, 17 patients were randomized to treatment with intrathecal radiocolloid plus methotrexate or to treatment with 1800 rad of cranial irradiation and high-dose intravenous methotrexate plus intrathecal methotrexate. Neither central nervous system relapse nor serious neurotoxicity was observed due to radiocolloid, irradiation and methotrexate. Modified LSA2-L2 therapy seems to be effective in children with acute lymphoblastic leukemia, especially for the protection against relapses in the central nervous system.View full abstractDownload PDF (527K) -
—Comparison of BH-AC•DMP Therapy and BH-AC•AMP Therapy—Fumio KAWANO, Hiroyuki TAJIMA, Yoshiko MATSUOKA, Norio ASOU, Kiyoshi T ...1985 Volume 26 Issue 4 Pages 494-498
Published: 1985
Released on J-STAGE: February 02, 2009
JOURNAL RESTRICTED ACCESSA comparative studies of gastrointestinal (GI) side effects of combination chemotherapies, BH-AC•AMP (behenoyl-ara-C, aclacinomycin A, 6-mercaptopurine, prednisolone) and BH-AC•DMP (behenoyl-ara-C, daunorubicin, 6-mercaptopurine, prednisolone) on cases with acute myelogenous leukemia was made.
Twenty-one (13 males and 8 females) were treated 59 courses with BH-AC•DMP therapy.
Thirty-one patients (21 males and 10 females) were treated 53 courses with BH-AC•AMP therapy.
GI toxicities were more frequent and severe in the BH-AC•AMP therapy than the BH-AC•DMP therapy. Diarrhea and abdominal pain were characteristic and the most frequent GI symptoms, and the most serious side effects were ileus and a sign of peritoneal irritation in the BH-AC•AMP therapy.
The severity of GI symptoms in the BH-AC•AMP therapy were correlated to administration of the total volume of a aclacinomycin A (ACM) per course, and the most severe side effects were appeared over ACM 4 mg/kg/course.
In the serial administration of the combination chemotherapy, only the BH-AC•AMP therapy group have a tendency to be complicated with severe GI symptoms. And the change of methods of the ACM administration was not related to the GI symptoms.View full abstractDownload PDF (375K) -
Yayeko ITAI, Shuichi KAMIZIKKOKU, Lee Sung YUL, Shinhachiro TOMINO, Ka ...1985 Volume 26 Issue 4 Pages 499-503
Published: 1985
Released on J-STAGE: February 02, 2009
JOURNAL RESTRICTED ACCESSFourteen patients with interstitial pneumonitis were investigated regarding the clinical and hematological features, various laboratory deta, complications, treatment regimens and prognosis. All were born in the Minamata and Ashikita area in Kumamoto Prefecture, where ATL and organic mercury poisoning are known to be endemic. Eleven out of 14 patients were positive for ATLA (ATL-associated antigen) antibody. This ratio (78.5%) is very high as compared with healthy individuals in some areas and the patients with bronchial asthma in Kumamoto City.
Some ATLA antibody positive patients with interstitial pneumonitis are compatible with smoldering ATL in clinical features.
This study indicates that the detection of ATLA antibody is necessary in patient with pulmonary complications in ATL endemic area.View full abstractDownload PDF (472K) -
Setsuko KAWAMURA, Takafumi MIKAMI, Ichiro ABE, Toshihiko YAMAYA, Yoshi ...1985 Volume 26 Issue 4 Pages 504-508
Published: 1985
Released on J-STAGE: February 02, 2009
JOURNAL RESTRICTED ACCESSIn adults with acute leukemia, the central nervous system (CNS) prophylaxis with intrathecal methotrexate (MTX) and prednisolone (PSL) reduced the incidence of the CNS leukemia.
The incidence of the CNS leukemia in patients with CNS prophylaxis which was done two to three times just after complete remission was 35% (7/20) compared to 24% (8/33) in patients without CNS prophylaxis. No difference was observed in these two groups (p<0.10). This result prompted us to try the intermittent CNS prophylaxis at 1. 3. 6. 10. 15 mo after the consolidation therapy and every 6 mo. thereafter when the intensification therapy was performed. Nineteen patients, who achieved complete remission and entered into this intermittent prophylactic treatment program between January 1980 and March 1983, were given 10 mg of MTX and 20 mg of PSL intrathecally as designed and observed for 19 to 58 mo. and none of them developed CNS leukemia in remission.
The intrathecal administration of MTX and PSL is easy to perform and there has been no adverse reaction in our series. We conclude that the intermittend CNS prophylaxis with MTX and PSL is of benefit in preventing CNS leukemia in adults with acute leukemia.View full abstractDownload PDF (353K)
-
Seiji TSUMOTO, Hiroshi OYABU, Takashi KAGEYAMA, Akira TAKANO, Katsuji ...1985 Volume 26 Issue 4 Pages 509-514
Published: 1985
Released on J-STAGE: February 02, 2009
JOURNAL RESTRICTED ACCESSThe patient was a 61-year-old housewife who began to have dyspnea and easy fatigability on exertion in September 1981. Shortly thereafter she was noticed of her having anemia and bleeding tendency by a neighbouring doctor, who referred her to us. Examination on admission led to a diagnosis of myeloma of Bence-Jones (λ) type and alkeran and steroid therapy was started. Hematologic examination done in February 1982 revealed: WBC 13000/mm3 with plasmacytosis (39%) and 70.5% plasma cells in bone marrow; diagnosis of plasma cell leukemia was thus made. There also was noted left-sided hydrothorax with tumor cells and M protein being demonstrable in the fluid. The patient died after receiving blood transfusion and chemotherapy without effect.
On autopsy numerous sporadic hemispherical masses consisting of plasma cells were noted on both the inner and outer surfaces of the thoracic wall. The bone marrow was demonstrated to contain an abundance of proliferating plasma cells. Moreover, the pericardial cavity, liver, spleen, lung, plevia, intercostal muscles, greater pectoral muscle, heart, kidneys and periesophageal lymph nodes were infiltrated by plasma cells.
A brief account was thus given of our personal case of plasma cell leukemia of Bence-Jones (λ) type with some comment on pertinent literature.View full abstractDownload PDF (825K) -
Masahiro KIZAKI, Tomoyoshi KAMIYA, Hideo OKAWA, Yasuyoshi KIRYU, Yukit ...1985 Volume 26 Issue 4 Pages 515-521
Published: 1985
Released on J-STAGE: February 02, 2009
JOURNAL RESTRICTED ACCESSA case of chronic lymphocytic leukemia associated with multiple myeloma (Bence Jones lambda type) was reported.
A 69 year old man was admitted to Nippon Kokan Hospital in June 1982, because of anorexia and weightloss.
Blood examination showed RBC 155×104/mm3, Hb 5.5 g/dl, WBC 25,700/mm3 with 72.8% lymphocyte, platelet 10.2×104/mm3, total protein 6.1 g/dl (gammaglobulin 18.5%, IgG 760 mg/dl, IgM 26 mg/dl, IgA 24 mg/dl), and severe renal dysfunction.
The number of mature small lymphocyte and atypical plasma cell were increased in bone marrow.
Immunoelectrophoresis showed Bence Jones lambda paraproteinemia. From these data, the diagnosis of chronic lymphocytic leukemia associated with multiple myeloma was made on him who was treated with predonisolone and cyclophosphamide, but died of sepsis in August 1982.
The analysis of enzyme labeled antibody method showed that immunoglobulin (lambda) was found in the margin of mature small lymphocyte and in the cytoplasma of atypical plasma cell.
It is conceived that chronic lymphocytic leukemia and multiple myeloma in this case was derived from the same clonal origin of B cells.View full abstractDownload PDF (1009K) -
Takayuki MORISAKI, Naomi HORIUCHI, Hiroshi MOHRI, Hideki KODO, Hisaich ...1985 Volume 26 Issue 4 Pages 522-526
Published: 1985
Released on J-STAGE: February 02, 2009
JOURNAL RESTRICTED ACCESSA case of primary macrogrobulinemia (Waldenström) with systemic, especially intramuscular dissemination of immunoglobulin-bearing cells is reported.
The patient was a 82-year-old female who had been admitted to the hospital in Oct. 1982 because of anemia and anorexia. Physical examinations revealed anemia and hoarseness, but no lymphadenopathy or hepatosplenomegaly. Peripheral blood smear showed increment of atypical lymphocytes and rouleaux formation of red cells. Serum IgM level was elevated (1.6 g/dl) and immunoelectrophoresis of serum indicated monoclonal increment of immunoglobulin (IgM, K). Despite of chemotherapy, serum IgM level increased and tumors appeared in the left elbow. In Dec. 1983, she died of respiratory failure.
At autopsy, she showed extranodular type of malignant lymphoma (diffuse, lymphoplasmacytoid type), involving the muscles in the elbows and anterior thorax, the larynx, pharynx, trachea, esophagus, lung, spleen, kidney and heart. Peroxidase-anti-peroxidase staining of the specimens of the muscles revealed monoclonal lymphoma cells bearing IgM, K type immunoglobulin.
It is very rare to see intramuscular lymphoma cells bearing immunoglobulin without lymphadenopathy and hepatosplenomegaly in primary macroglobulinemia.View full abstractDownload PDF (509K) -
Haruhiko ISOTANI, Keiichi SHINODA, Yoshitaka HISHITANI, Junta TAKAMATS ...1985 Volume 26 Issue 4 Pages 527-531
Published: 1985
Released on J-STAGE: February 02, 2009
JOURNAL RESTRICTED ACCESSA 66 year-old man was admitted because of generalized lymphadenopathy.
A diagnosis of immunoblastic lymphadenopathy was established from the characteristic histology of cervical lymph node with increased ESR and γ-globulin fraction.
Therapy with prednisolone and cyclophosphamide improved his physical state in some degree; however the patient died from severe respiratory tract infection three months after admission.
A high titer of anti-viral capsid antibody-IgG for EB virus was noted to persist throughout the clinical couse.
In addition, EB nuclear antigen antibody changed to positive while stay in hospital.
Electronmicroscopic examination of the lymph node revealed some particles with high electron density.
Although the particles are not clasified as the products of EB virus, they are suggestive that the cells in the lymph node were infected by EB virus.
From these findings, it was suggested that immunoblastic lymphadenopathy in our patient was caused by the infection of EB virus.View full abstractDownload PDF (886K) -
Satoru TANAKA, Masao NAGAO, Tadahiro ITO, Kiyoshi TAKIZAWA, Kenkichi K ...1985 Volume 26 Issue 4 Pages 532-536
Published: 1985
Released on J-STAGE: February 02, 2009
JOURNAL RESTRICTED ACCESSAn autopsy case of macroglobulinemia with gastric cancer is reported. A 75-year-old woman was admitted because of edema and short of breath. At that time she had not lymphadenopathy and hepatosplenomegaly, but marked increase in serum monoclonal IgM of Kappa and 19S globulin were observed.
The patient was treated with melphalan and cyclophosphamide, but after six months she died bronchopneumonia.
At postmortem examination, a small nodule was found at the cardia that proved to be an advanced papillary adenocarcinoma. In recent years the reports of macroglobulinemia with malignant tumor are increasing in number in Japan.View full abstractDownload PDF (624K) -
Mihiro OKABE, Masanobu KOBAYASHI, Ryoko MITANI, Nagahito SAITO, Manabu ...1985 Volume 26 Issue 4 Pages 537-543
Published: 1985
Released on J-STAGE: February 02, 2009
JOURNAL RESTRICTED ACCESSA79-year-old female of refractory anemia with ringed sideroblast is presented. Laboratory data showed macrocytic anemia with normal cellurality of bone marrow. Ringed sideroblasts were observed in about 25% of erythroblasts in bone marrow and the intramitochondrial iron deposition was ultrastructurally demonstrated.
Lymphocyte abnormalities have been described in myelodysplastic syndromes (MDS) including refractory anemia. The extent of the hematological abnormalities lead to the assumption that there may be a defect at the level of multipotential stem cell in MDS. However, it was not known whether or not there may be any relationship between lymphocyte abnormality and a defect of multipotential stem cell in MDS. We investigated various aspects of lymphocyte function in this patient. The number of T lymphocytes, T lymphocyte subsets and mitogen responses of peripheral blood mononuclear cells (PBMC) were almost normal, while NK cell activity and interleukin 2 (1L-2) production of PBMC from the patient were remarkably impaired. However, natural killer (NK) cell activity and 1L-2 production of this case were restored by depletion of plastic dish-adherent cells. Although the plastic dish-adherent cells were found to suppress NK activity and 1L-2 production of the patient's lymphocyte in the mixing experiments, these suppressions were restored only partially by the addition of indomethacin.
This results suggested the involvement of any mechanisms other than prostaglandin E in these suppressions. The roles of adherent suppressor cells in abnormalities of lymphocyte function in preleukemia also was discussed in the present paper.View full abstractDownload PDF (697K) -
Naoko ISHITOYA, Junichi AKATSUKA, Takuo HIROTSU, Yoritaka HOSHI, Haruo ...1985 Volume 26 Issue 4 Pages 544-548
Published: 1985
Released on J-STAGE: February 02, 2009
JOURNAL RESTRICTED ACCESSA 14-year-old boy was admitted because of common cold like symptom lasting for 2 weeks and palor. On admission the examination of his peripheral blood revealed Hb 5.5 g/dl, Ht 16.5%, RBC 180×104/μl which suggested normochromic, normocytic anemia, despite of having biochemically severe iron deficency. In the process of definite diagnosis of his anemia before treatment, the clinical course was further complicated by gradual appearance of neutropenia and hypoplastic erytriod bone marrow. Moreover, red cell survival study showed shortened life span as 9.8 days. Eventually, his anemia was ascertained apparent iron deficiency anemia by the fact that all abnormalities mentioned above were cleared away with iron therapy alone. Hematological abnormalitis due to iron deficiency were discussed.View full abstractDownload PDF (381K) -
—Associated with Pregnancy Report of a Case—Tetsuji KOYAMA, Mitsuhiro HIGUCHI, Tokuo NAKAJIMA, Eizo KAKISHITA, Kiy ...1985 Volume 26 Issue 4 Pages 549-554
Published: 1985
Released on J-STAGE: February 02, 2009
JOURNAL RESTRICTED ACCESSThis report presents a case of 28-year-old woman who suffered from thrombotic thrombocytopenic purpura (TTP) with typical findings including severe hemolytic anemia, thrombocytopenic purpura, moderate proteinuria and hemiparesis in the 14th week of her first pregnancy.
She progressively became comatose with convulsions in spite of treatment with methylprednisolone, aspirin and FOY, but completely recovered on plasma exchange and plasma infusion followed by artificial abortion.
However, she continued to suffer from relapses, manifested by thrombocytopenia, which were observed with the menstrual cycle in spite of oral administration of aspirin and dipyridamole. Relapses of TTP could be successfully controlled by plasma infusion, but not by immunoglobulin infusion.View full abstractDownload PDF (478K) -
—Allergic Reaction to Casteo Oil HCO-60-A Case Report—Shigeru OHTA, Satoshi IWANE, Tadahiko KATSURA, Morimi SHIMADA, Seiko H ...1985 Volume 26 Issue 4 Pages 555-559
Published: 1985
Released on J-STAGE: February 02, 2009
JOURNAL RESTRICTED ACCESSN4-behenoyl-1-β-D-arabinofuranosylcytosine (BH-AC) is one of the potential drugs in the treatment of acute leukemias. Various allergic reactions have been reported in several cases treated by this drug. These allergic reactions were the anaphylaxis, skin rash and/or other symptoms including hyperpyrexia. However, there is so far, no report of increased white cell count accompanied by the pyrexia, facial flushing and other symptoms resembling to systemic infection.
We reported a 13-year-old female with AML, who developed the hyperpyrexia, facial flushing, general fatigue and headache accompanied by marked leukocytosis. There was no evidence of systemic infection. The same event was noted twice after administration of BH-AC and doxorubicin. Drug challenge tests were performed in order to confirm the diagnosis of drug allergy. Doxorubicin evoked no change. However, BH-AC induced the hyperpyrexia, facial flushing and leukocytosis. Allergic reaction to BH-AC has been considered to be due to HCO60 (polyoxyethylene hydrogenated Casteo oil) which was contained in BH-AC as a solvent. Confirming the evidence of allergic reaction to HCO60, challenge test on Ara-C was performed. As expected, administration of Ara-C elicited no symptom of allergic reaction. And so, we confirmed the diagnosis of allergic reaction to HCO60 contained in BH-AC. To our knowledge, allergic reaction to BH-AC accompanied by leukoytosis is a first case in the literature.
Such allergic reaction to BH-AC should be known and proper treatment should be required, because BH-AC is one of the potential and useful drugs in the treatment of acute leukemias.View full abstractDownload PDF (371K) -
Akira MIURA, Eiichi TAMATE, Etsuro SATOH, Kumiko NAITOH, Takefumi KATO ...1985 Volume 26 Issue 4 Pages 560-565
Published: 1985
Released on J-STAGE: February 02, 2009
JOURNAL RESTRICTED ACCESSA 40-year-old man born in Onagawa, a town in Miyagi prefecture, visited Ishinomaki Red Cross Hospital with erythema on his face and legs in 1977. At that time, there was no lymphnode enlargement nor hepatosplenomegaly. His WBC was 13,200/μl with 38% abnormal lymphocytes having lobulated or convoluted nuclei. The 97.7% of these abnormal cells were T cell and 70% of these cells were positive for PAS stain. The bone marrow showed very mild infiltration (0.2%). The ATLA antibody titer was ×20 positive. He was treated with cyclophosphamide 50mg p.o. for 15 months and his erythema completely disappeared. Thereafter he discontinued the therapy for more than 4 years until 1982.
At the time of his second admission, he had no erythema but systemic lymphnode swelling. His WBC was 5,800/μl in which abnormal lymphocytes were only 4%. The biopsy specimen of the lymphnode was diagnosed diffuse pleomorphic type non-Hodgkin lymphoma in LSG classification. He was treated with CHOP but with little response and finally died of intracranial bleeding.
His autopsy findings revealed the spreading of malignant cells to lmphnodes, bone marrow, and pancreas.View full abstractDownload PDF (791K) -
Motoi NISHI, Hisaya NAKADATE, Takuya HATTORI, Yoshio HATAE, Takeo TAKE ...1985 Volume 26 Issue 4 Pages 566-570
Published: 1985
Released on J-STAGE: February 02, 2009
JOURNAL RESTRICTED ACCESSExaminations of anterior pituitary hormones were made for a case of 5-year-old boy with relapsed acute lymphoblastic leukemia forming a tumor in the forehead. In the skull X-ray film, processus clinoideus anterior, the bottom of sella turcica, and dorsum sellae were seen to be thinned or destroyed. In the CT film, a tumor shadow was seen to exist within and over sella turcica, and partly, in sinus cavernosus. The patient had neither neurological or ophthalmological disturbance nor symptom of hypopituitarism, but no response in GH and TSH secretion was realized and high basal level of prolactin (PRL) as well as exaggerated response of PRL were observed before coming to remission (before disappearance of the tumors). After obtaining remission, recovery of the responses of GH and TSH, and normalization of basal level and response of PRL were observed together with disappearance of the tumors. In the CT film, the tumor in the forehead was found not to be connected with the intracranial tumor. From these findings that these disturbances disappeared through the leukemia therapy, the masses were considered to be caused by leukemic cells. This case would be regarded to be a type of central nervous system leukemia forming leukemic tumor, which transient and subclinical hypothalamic-pituitary disorders could be seized.View full abstractDownload PDF (440K) -
Takashi YAMADA, Susumu YAMAKADO, Seiji GOMI, Shigeru SUZUKI, Yasuhito ...1985 Volume 26 Issue 4 Pages 571-576
Published: 1985
Released on J-STAGE: February 02, 2009
JOURNAL RESTRICTED ACCESSTwo cases of thrombotic thrombocytopenic purpura (TTP) treated with success are reported. Case 1, a 26-year-old housewife, presented with the pentad of TTP. She had taken oral contraceptives until her admission. Complete remission was attained one month later by daily administration of 1.0 g of aspirin, 300 mg of dipyridamole and 100 mg of prednisolone. No relapse occurred so far over a follow-up period of 16 months. Case 2, an 18-year-old male, presented with a variety of remittent neurologic manifestations. He had the pentad of TTP except for renal dysfunction. Having failed to respond to the same medication as in case 1, he received 22 courses of plasma exchanges over a period of four months using 2,000 ml of fresh frozen plasma in each course, which were proved partially effective. Since a relapse of the disease occurred four months later, the patient underwent splenectomy and three additional plasma exchanges, leading to a complete remission in two weeks, He has been well for one year henceforth.
Although a variety of therapeutic measures have indisputably contributed to improvement in the prognosis of TTP, the superiority one to the other still remains contraversial. Further experience in many patients is required to establish the therapeutic guide for TTP.View full abstractDownload PDF (460K) -
Morio AIHARA, Ikuo KUDOH, Yohko TSUSHIMA, Shigeo MORIMOTO, Yoichi CHIB ...1985 Volume 26 Issue 4 Pages 577-581
Published: 1985
Released on J-STAGE: February 02, 2009
JOURNAL RESTRICTED ACCESSA mediastinal castleman lymphoma was found in a 29-year-old female associated with microangiopathic hemolytic anemia (MHA). Systemic manifestation and laboratory findings of trancient neurological sign, fever, proteinuria, thrombocytopenia and MHA suggested thrombotic thrombocytopenic purpura (TTP). Histologically, the proliferation of capillaries and mature lymphocytes were seen within the tumor and the formation of numerous thrombus was disclosed in the capsular vessels.
The hematological abnormalities were normalized by the administration of prednisolone. No reccurence of hemolysis has been observed after the removal of the tumor. This is the first case report of castleman lymphoma of hyaline vascular type associated with MHA or TTP.View full abstractDownload PDF (678K) -
Ryouji HANADA, Yasuhide HAYASHI, Yuji HABU, Yuji FUJII, Keiko YAMAMOTO ...1985 Volume 26 Issue 4 Pages 582-587
Published: 1985
Released on J-STAGE: February 02, 2009
JOURNAL RESTRICTED ACCESS15 years old boy complained of recurrent cough. X-p and CT scan revealed massive pleural effusion on the right and anterior mediastinal mass extending to the bifurcation. Superior vena cava syndrome was noted. Bone marrow aspiration revealed 18% of lymphoid blasts. Cell surface marker analysis of pleural effusion cells showed T-cell character. Chromosomal analysis with G-banding showed the abnormality of 46, XY, ins (1; ?) (q21; ?). Histological diagnosis was lymphoblastic lymphoma. Soon after the beginning of the chemotherapy, hyperuricemia, hyperkalemia, hyperphosphatemia. azotemia, hypercreatinemia, and hypocalcemia caused by “Tumor Lysis” developed. But the abnormal blood chemistry recovered within a few days following peritoneal dialysis and hemodialysis. Therefore the chemotherapy was done without delay. We considered that the renal damage was minimal by the effect of hemodialysis in this patient, who could achieve complete remission by the multi-agent chemotherapy.View full abstractDownload PDF (451K) -
Masayuki MITA, Makoto HIRAKURI, Rokuo ABE, Tadashi SATO, Hideo KIMURA, ...1985 Volume 26 Issue 4 Pages 588-593
Published: 1985
Released on J-STAGE: February 02, 2009
JOURNAL RESTRICTED ACCESSA 47-year-old female was admitted to our hospital with hypogastralgia caused by the adnexal tumor on May 10, 1984. On physical examination, a goose-egg sized hypogastric tumor was palpable. No hepatosplenomegaly or lymphadenopathy was noted. The white blood cell count was 5,800/μl with 85% blasts. Bone marrow aspiration revealed hypercellular marrow with 95.2% peroxydase-negative blasts. The immunological phenotype was Ia+, B4+, CALLA-, B1- and Cμ-. T cell, granulocyte, monocyte and megakaryocyte markers were negative. TdT was positive. A diagnosis of non-T ALL type L1, according to FAB classification, was made. Aspiration biopsy specimens of the hypogastric tumor showed many leukemic cells infiltration. She was treated with adriamycin, vincristine and prednisolone. But she died of respiratory failure caused by hemoptysis on June 22, 1984.
Classification of non-T ALL based on immunological phenotypes and tumor-forming leukemia were discussed.View full abstractDownload PDF (601K)
-
1985 Volume 26 Issue 4 Pages 602-622
Published: 1985
Released on J-STAGE: February 02, 2009
JOURNAL RESTRICTED ACCESSDownload PDF (1967K)
-
1985 Volume 26 Issue 4 Pages 623-626
Published: 1985
Released on J-STAGE: February 02, 2009
JOURNAL RESTRICTED ACCESSDownload PDF (367K)
- |<
- <
- 1
- >
- >|