巻号一覧
27 巻, 11 号
選択された号の論文の22件中1～22を表示しています
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臨床研究
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錦織 優, 空地 顕一, 土井 章一, 有田 裕, 亀崎 洋, 大野 仁嗣, 北 堅吉, 福原 資郎, 内野 治人, 山辺 博彦1986 年 27 巻 11 号 p. 2051-2058
発行日: 1986年
公開日: 2009/02/02
ジャーナル 認証ありTwelve of 110 patients (11%) with non-Hodgkin's lymphoma seen between 1975 and 1985 developed evidence of central nervous system (CNS) lymphoma. -Leptomeningeal involvement (9), focal cerebral involvement (2) and spinal cord compression (1)- The risk of CNS invasion was greatest for those with lymphoblastic and Burkitt type lymphoma, and CNS prophylaxis was clearly warranted in these subgroups. About 10% of patients with diffuse medium-sized, mixed and large cell type had CNS disease. Patints who developed CNS lymphoma largely had extranodal origin (9/12) and advanced disease at initial staging (9/12). The incidence of CNS involvement in peripheral T cell lymphoma remained to be clarified. CNS lymphoma was observed at all times during the clinical course (0∼21 months after the onset of lymphoma), but in some patients (4/12) CNS disease developed while they were in complete remission. Patients were treated with systemic chemotherapy or intrathecal methotrexate and/or whole brain irradiation. Median survival after recognition of CNS lymphoma was 7 months, and three patients are alive without symptomes for 18, 24 and 57 months respectiely. Treatment should be done by standard stherapeutic protocols according to the forms of CNS involvement.抄録全体を表示PDF形式でダウンロード (606K) -
石黒 精, 中畑 龍俊, 野呂瀬 昇, 岡野 周子, 稲垣 稔, 近藤 直実, 赤羽 太郎1986 年 27 巻 11 号 p. 2059-2064
発行日: 1986年
公開日: 2009/02/02
ジャーナル 認証ありA study was made in five cases of Wiskott-Aldrich syndrome (WAS), ranged in the age from seven months to twenty years. Various hemopoietic progenitors were analyzed by using in vitro clonal culture method in the bone marrow of one patient and in the peripheral blood of five patients. We have demonstrated the presence of normal to slightly elevated numbers of megakaryocytic progenitors in all of the patients' blood and bone marrow. Although one patient had decreased megakaryocytes in the bone marrow, simultaneous examination of megakaryocytic progenitors in the blood and bone marrow revealed normal or higher than normal value. Eosinophilic colonies from the peripheral blood significantly increased in three patients with eosinophilia, while those were within normal range in two patients without eosinophilia. The colonies of the other lineages were found to be grown well. No apparent morphological difference was observed in the constituent cells of the clonies between the patients and normal subjects. These resutlts indicate that the hemopoietic progenitors in the patients with WAS possess normal proliferative and maturational capacity. It is also suggested that eosinophilia in the patients with WAS may be caused by increment of eosinophilic progenitors.抄録全体を表示PDF形式でダウンロード (408K) -
三比 和美, 熊井 良司, 柵木 信男, 桜井 雅温, 金子 安比古, 服部 理男1986 年 27 巻 11 号 p. 2065-2069
発行日: 1986年
公開日: 2009/02/02
ジャーナル 認証ありBetween August 1979 and July 1985 one hundred and six episodes of fever in 72 patients with acute leukemia, most of which were accompanied by granulocytopenia, were treated empirically with a combination of piperacillin (4.0 g, every 6 hours) and amikacin (200 mg, every 6 hours) in Saitama Cancer Center. Profound granulocytopenia of less than 100/mm3 of granulocytes at the begining of the treatment was present in 54% of the episodes. Oral absorbable or nonabsorbable antibiotics were used in 68 febrile episodes. WBC transfusion was not given.
The response rate for all documented infections was 58%, including 4 of 7 (57%) episodes of bacteremia. A majority of infections with identified organisms were caused by aerobic gramnegative pathogens, such as P. aeruginosa (10 cases), Klebsiella spp. (3 cases), E. coli (3 cases), Proteus mirabillis (1 cases) and Serratia spp. (2 cases). The response rate of gram-negative bacillary infections was 47%. Pneumonia responded less satisfactorily than all other types of infections with the response rate of only 24%. The response rate for profound persistent granulocytopenia (less than 100/mm3 of granulocytes without a rise during therapy) was 50% and that with subsequent granulocyte rise was 86%.
The most common adverse effect was hepatotoxicity (10 patients). Nephrotoxicity occurred in 2 patients and skin rash in 8 patients.抄録全体を表示PDF形式でダウンロード (374K) -
高橋 徹, 広川 誠, 工藤 和治, 高津 洋, 吉田 広作, 三浦 亮1986 年 27 巻 11 号 p. 2070-2077
発行日: 1986年
公開日: 2009/02/02
ジャーナル 認証ありHematological malignancies with hypercalcemia in our clin during these fifteen years were evaluated.
Among 364 cases of the whole hematological malignancies, the cases which were beyond 11 mg/dl of serum Ca level were 17 ones just as follows.
Leukemia cases: Only 3 of 226 cases (1.3%) which included a case of chronic myelogenouse leukemia in blastic crisis and 2 cases of adult T cell leukemia (ATL). Malignant lymphoma cases: 6 of 108 cases (4.9%), which were all non Hodgkin lymphoma at the clinical stage IV. Myeloma and its related disorders cases: 8 of 30 cases (26.7%), which included 2 cases of IgG κ type, a case of IgG λ type, 2 cases of IgA κ type, a case of Bence Jones protein (BJP) κ &λ type and a case of non secretory κ type.
By the combined therapy with anticancer chemotherapy, prednisolone, saline infusion and diuretics, furethermore partly with addsion on thyrocalcitonin, serum calcium level was corrected transiently in 15 cases of 17 ones.
Throughout clinical coure, renal failure and hyperuricemia was observed except for 2 cases as a complication of hematological malignancies with hypercalcemia. Pulmonary edema was observed in 8 cases as the cause of death.
Median survival term after the onset of hypercalcemia was 3.4 months.
The causative mechanism of hypercalcemia in the hematological malignancies studied this time was not clarified clearly but it was considered that bone resorption by the direct infiltration of tumor cells into bone might play a principal role of hypercalcemia.抄録全体を表示PDF形式でダウンロード (599K) -
篠沢 隆1986 年 27 巻 11 号 p. 2078-2084
発行日: 1986年
公開日: 2009/02/02
ジャーナル 認証ありEnzyme-and immuno-histochemical methods were applied to 19 childhood non-Hodgkin's lymphomas. According to the LSG classification, all lymphomas were of the diffuse type and comprised of 4 cases of the medium-sized cell type, 1 the mixed cell type, 3 the large cell type, 3 the Burkitt type and 8 the lymphoblastic type.
Immunoperoxidase stains for the leukocyte common antigen on paraffin sections were positive in all 19 lymphomas while they were negative in all 6 childhood solid tumors. Surface and/or cytoplasmic immunoglobulin restricted to one light chain was demonstrated in 1 medium cell type and 3 Burkitt type lymphomas. Prolonged incubation of paraffin sections produced positive paranuclear ACP and ANAE reactions in 1 medium-sized cell type, 2 large cell and 4 lymphoblastic type lymphomas. Immunoperoxidase stains using monoclonal antibodies on fresh tissue imprints and frozen sections revealed appropriate surface markers for phenotyping individual lymphomas studied.
In conclusion, the application of enzyme-and immuno-histochemical techniques helped to establish the diagnosis with a biologically meaningful subclassification of non-Hodgkin's lymphomas in children.抄録全体を表示PDF形式でダウンロード (587K) -
—特に真菌とグラム陽性球菌の増加傾向について—森内 幸美, 上平 憲, 山口 恵三, 笹川 一平, 中村 秀男, 重橋 亨, 野中 博章, 樅田 三郎, 陣内 逸郎, 西野 健二, 雨森 ...1986 年 27 巻 11 号 p. 2085-2093
発行日: 1986年
公開日: 2009/02/02
ジャーナル 認証あり1. Postmortem bacteriological studies were performed on 100 cases of hematological malignancies during the period from 1980 to 1984.
Most common pathogens isolated from heart blood were pseudomonas, enterococcus and candida, while those from long tissue were pseudomonas, candida and staphylococcus.
Compared with the results obtained during the period from 1970 to 1979, E. coli and klebsiella were isolated less frequently. The isolations of fungus from heart blood and of staphylococcus from lung tissue were increased in incidence after 1980.
2. Histological examinations of 83 autopsy cases showed high incidence (37.3%) of systemic fungal infection, very high (55.9%) in neutropenic cases.
3. Prophylactic oral administration of anti-fungal agents (mostly amphotericin B) reduced the incidence of fungal infections of the alimentary tract. Aspergillosis was particularly less frequent among prophylactic group.
Prophylactic inhalation of amphotericin B reduced the incidence of systemic fungal infection, especially of candidiasis.抄録全体を表示PDF形式でダウンロード (634K) -
樅田 三郎, 池田 柊一, 上平 憲, 木下 研一郎, 市丸 道人1986 年 27 巻 11 号 p. 2094-2100
発行日: 1986年
公開日: 2009/02/02
ジャーナル 認証ありTo evaluate the particle aggulutination test (P.A.) for the detection of anti-ATLA (adult T-cell leukemia-cell-associated antigen) antibody, 1457 subjects including 1243 healthy adults and 105 patients with ATL related disorders, were examined for anti-ATLA antibody using both indirect immunofluorescence method (I.F.) and P.A.
By I.F. 432 (29.6%) of 1457 subjects were anti-ATLA positive (+) and 1025 (70.4%) were negative (-), definitely. By P.A. 422 (28.9%) of 1457 were anti-ATLA positive (+), 1017 (69.9%) were negative (-) and 18 (1.2%) were doubtfully aggulutinated (±).
In 1437 (98.6%) of 1457 subjects. the same results were obtained by both I.F. and P.A. Only one healthy adult was (+) by I.F. and (-) by P.A. i.e. false negative. There was also one false positive case. On the other hands, in cases of HTLV-I associated diseases such as ATL, T-ML and Pre-ATL, neither false positive case nor false negative case was found. It was concluded that P.A. was useful for screening of serum anti-ATLA antibody.
However, since 18 (±) cases with P.A. consisited of 10 positive cases and 8 negative cases with I.F, (±) cases with P.A. must be retested with I.F.抄録全体を表示PDF形式でダウンロード (527K) -
諸橋 文雄, 青沼 架佐賜, 加藤 正雄, 小林 敏美, 花岡 康彦, 辻 浩一郎, 野呂瀬 昇, 川合 博, 中畑 龍俊, 塚田 昌滋, ...1986 年 27 巻 11 号 p. 2101-2106
発行日: 1986年
公開日: 2009/02/02
ジャーナル 認証ありThirteen children with acute nonlymphocytic leukemia (ANLL) in first remission were treated with modified VAPA therapy including central nervous system (CNS) prophylaxis.
Twelve of 13 patients remain in continuous complete remission and 6 patients are in off therapy. A Kaplan-Meier analysis of patients predicts that 90.9% of patients will remain in remission at 2yr. Only one patient with FAB subtype M2 and high WBC count (182,500/cmm) had a bone marrow relapse.
Toxicities of this therapy consist of vomiting, marrow suppression and cardiotoxicity. However, with the intensive supportive care, patients were well tolerated.
We have concluded that modified VAPA therapy is very successful therapy for children with ANLL.抄録全体を表示PDF形式でダウンロード (424K)
症例
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古賀 震, 西村 要子, 河北 誠, 西村 弘道, 野村 裕常, 高月 清1986 年 27 巻 11 号 p. 2107-2111
発行日: 1986年
公開日: 2009/02/02
ジャーナル 認証ありA patient with aplastic anemia, typed as blood group B and CCDee, was treated with antilymphocyte globulin (ALG) intravenously, 40 mg/kg/day, for 4 days. She developed a positive direct antiglobulin test three days after the beginning of administration. Anti-C activity was detected in the administrated lot of ALG as well as the eluate from the patient's sensitized erythrocytes, when tested with C positive indicator red cells. In addition, laboratory findings provided the evidence for slight hemolysis. Careful investigation of ALG as a source of blood group specific antibody should be conducted.抄録全体を表示PDF形式でダウンロード (338K) -
中原 智子, 花田 尚, 滝田 齊1986 年 27 巻 11 号 p. 2112-2117
発行日: 1986年
公開日: 2009/02/02
ジャーナル 認証ありThe subcutaneous CSF reservoirs (Ommaya reservoir) were used for the prevention of CNS leukemia in two children with ALL during second remission. Cranial irradiation was already performed during first remission. Epidural hematoma beneath the reservoir and communicating hydrocephalus occurred during remission induction therapy for second bone marrow relapse. The CNS complications of Ommaya reservoir were summarized and the indications of the reservoir in childhood ALL were discussed.抄録全体を表示PDF形式でダウンロード (847K) -
—骨髄線維症の合併と血清中PDGF様活性の上昇を認めた1例—小田 健司, 加藤 修, 河野 道生, 岩戸 康治, 木村 昭郎, 今村 展隆, 藤村 欣吾, 蔵本 淳, 安井 弥, 梶原 博毅1986 年 27 巻 11 号 p. 2118-2123
発行日: 1986年
公開日: 2009/02/02
ジャーナル 認証ありA 67-year-old female with polycythemia vera who had been followed up for 6 years was admitted to our hospital because of anemia and thrombocytopenia with sudden onset. On CBC, WBC 5,400/μl, RBC 6.25×106/μl, Hb 6.6 g/dl, Hct 20.4%, platelet count 9.9×104/μl. Bone marrow aspiration resulted in dry tap and bone marrow biopsy showed hypoplastic marrow with marked fibrosis. Leukoerythroblastosis on peripheral blood film and extramedullary heamatopoiesis proved by ferrokinetics were also noted. A diagnosis of myelofibrosis was made. About two months later the patient became leukemic and she died of pulmonary infection and hemorrhage. Blast cells were 13∼20μm in diameter and nucleus-cytoplasmic ratio was relatively high. They had none or one nucleoli, basophilic cytoplasma and cytoplasmic bleb. On cytochemistry, myeloperoxidase, Sudan black B and PAS were negative. Acid phosphatase and α-naphtyl butylate esterase were positive. Most of the blast cells were surface GP IIb/IIIa positive and few cells were surface GP Ib positive. Platelet peroxidase reaction on electron microscopy was positive at perinuclear space and endoplasmic reticulum. Blast cells showed differentiation into multinucleated platelet-producing megakaryocytes in in vitro culture. Serum PDGF like activity was increased after leukemic transformation despite of thrombocytopenia and it was thought to be derived from megakaryoblast.抄録全体を表示PDF形式でダウンロード (785K) -
福島 幸隆, 三浦 偉久男, 新津 秀孝, 橋本 啓子, 高津 洋, 秋浜 哲雄, 三浦 亮1986 年 27 巻 11 号 p. 2124-2130
発行日: 1986年
公開日: 2009/02/02
ジャーナル 認証ありA 58-year-old man suffered from lumbago since August 1982. His symptom was exacerbated. In December the patient, who could not move at all, was admitted to the Akita University Hospital. He was diagnosed as nonsecreatry multiple myeloma (κ type), and a partial remission was achievd by MPPO combination chemotherapy. He was discharged from hospital in April 1983. He was treated with melphalan (2 mg/day) in our outpatient clinic. In December 1983, he complained of anorexia and lumbago, and readmitted to our hospital in January 1984 because of the difficulty in walking. At this time diagnosis of plasma cell leukemia was made. Various types of combination chemotherapy were repeatedly done, nevertheless, they were not effective at all. He died of cerebral bleeding at May 15, 1984.
Chromosome analysis revealed a normal karyotype when he suffered from multiple myeloma, but 14q+marker due to t(11; 14) and 1p- chromosomes were recognized when he was diagnosed as plasma cell leukemia. When he had a normal karyotype, he was responsive to chemotherapy. However, when 14q+ and 1p- chromosomes were revealed, he resisted to chemotherapy and died after 5 months. Cytogenetic studies are considered to be a significant marker which considerably affects the prognosis in multiple myeloma and plasma cell leukemia.抄録全体を表示PDF形式でダウンロード (595K) -
西村 元伸, 伊藤 国明, 津田 薫, 尾世川 正明, 王 伯銘1986 年 27 巻 11 号 p. 2131-2135
発行日: 1986年
公開日: 2009/02/02
ジャーナル 認証ありAn 83 year-old-woman was admitted to the hospital on Oct. 1984 because of anorexia, constipation and weight loss. Physical examinations revealed a mass on the right lateral abdomen. A computerized tomography of abdomen showed an irregular mass in the right kedney. The white blood cell count was 40,100/μl with 25% band forms, 52% segmented forms, 14% eosinophils and 5% lymphocytes. Cytologic study of a bone marrow (BM) aspirate showed myeloid hyperplasia. The CFU-GM was 45.3/2×105 BM cells. The white blood cell count rose to 84,500/μl and the patient died on Dec. 17, 1984. At autopsy, metastatic carcinoma was found in the liver, kidney, pancreas, lymph node, lung but not in BM. The histological diagnosis of the tumor was pleomorphic carcinoma of the kidney.
CSF was studied using non-adherent cells from normal human bone marrow as target. CSF activity were demonstrated in the ascites and the tumor extract from the autopsy materials. These findings indicated that the tumor cells produced CSF in vivo.抄録全体を表示PDF形式でダウンロード (411K) -
加藤 修, 滝本 泰生, 木村 昭郎, 今村 展隆, 小熊 信夫, 沖田 肇, 楠 洋一郎, 岡田 浩佑, 梶原 博毅, 蔵本 淳1986 年 27 巻 11 号 p. 2136-2142
発行日: 1986年
公開日: 2009/02/02
ジャーナル 認証ありTwo cases of adult T-cell leukemia (ATL) associated with gastric cancer and lung cancer were reported. The first case was a 73-year-old man, who was diagnosed as ATL, because of the presence of OKT3+, 4+, 11+, Tac+ atypical lymphocytes, lack of antigenic modulation of Tac antigen and expression of human T-cell leukemia virus associated antigens in short-term culture. He was induced in complete remission status by combination chemotherapy with CVP (cyclophosphamide (CY), Vincristine (VCR), and prednisolone (PSL)), then subtotal gastrectomy was carried out successfully. However, ATL recurred after the operation and he died of pseudomenbranous colitis under combination chemotherapy with CVP. Second case was a 53-year-old man, who was also diagnosed as ATL with similar features of the first cases. Incidentally he was found the lung cancer in right lobe. He was induced in partial remission status by the administration of PSL and alpha-interferon, then lobectomy of middle and lower lobes of right lung was carried out. His post-operative course was satisfactory by the administration of alphainterferon (provided by Sumitomo Pharmaceuticals), and he was discharged five months after the operation. In our clinic, double cancer had been found in five of sixteen patients with ATL. The incidence of double cancer (31.3%) is higher than that of other hematological disorders. Possible association of HTLV-I or the defect of the host immune surveillance mechanisms with double cancer were suggested.抄録全体を表示PDF形式でダウンロード (649K) -
遠藤 安行, 間宮 繁夫, 新津 秀孝, 岩本 恵子, 三浦 亮, 大久保 芳明, 吉岡 章, 金廣 昭美1986 年 27 巻 11 号 p. 2143-2147
発行日: 1986年
公開日: 2009/02/02
ジャーナル 認証ありA 33-year-old man, who had been diagnosed as congenital factor X deficiency having familial traits, was hemostatically and immunologically investigated in detail. Factor X activity (F.X: C) was below 1% by the determination using prothrombin time method, activated partial thromboplastin time method and Russell's viper venom time method. F.X: C was also below 1% by amidolytic method. Factor X antigen (F.X: Ag) was below 6.25%, below 1% and below 0.1%, by the assay using EIA, ELISA-P (polyclonal), and ELISA-M (monoclonal), respectively. Thus the patient was diagnosed as cross-reacting material negative (CRM—). This is the second case in Japan.
Because his mother's F.X: C is 40% and F.X: Ag is 32%, she may be heterozygous. Although his father's F.X can't be determined, the patient is probably homozygous.抄録全体を表示PDF形式でダウンロード (329K) -
石山 泰二郎, 平野 多加博, 阿部 総太郎, 堀江 誠一, 菅谷 直樹, 若林 芳久, 広瀬 俊一1986 年 27 巻 11 号 p. 2148-2154
発行日: 1986年
公開日: 2009/02/02
ジャーナル 認証あり64 year-old man was admitted to our hospital because of general fatigue and anorexia in January 1985. Physical examination on admission revealed mild hepatosplenomegaly and measleslike exanthema on his chest. The white cell count was 31,600/mm with 65.5% small lymphoid cells and 6.5% large lymphoid cells. The lymphoid cells in the peripheral blood was positive for Leu 3, Leu 4, Leu 10, HLA-DR and had E rosette-forming ability. The bone marrow aspirate showed 42.6% lymphoblast stained with PAS. From these findings, the patient was diagnosed as T cell type CLL in blastic crisis. He was treated with VEPA therapy and discharged on 26 Feb. 1985.
But on 2 May 1985, he was admitted by a emergency car with shock and lactic acidosis. The white-cell count was 161,600/mm3 with 82.4% small lymphoid cells and 1% large lymphoid cells. LDH WAS 11,775 IU/l.
Autopsy revealed leukemic infiltration in various organs.抄録全体を表示PDF形式でダウンロード (635K) -
滝本 泰生, 坂谷 敬子, 藏本 淳, 田中 公夫, 小熊 信夫, 鎌田 七男1986 年 27 巻 11 号 p. 2155-2161
発行日: 1986年
公開日: 2009/02/02
ジャーナル 認証ありIsochromosome 22q- was identified by in situ hybridization of abl gene in a case of CML in blastic crisis. A 19-year-old male had been treated with busulfan for Ph1 positive CML. Two years later, he developed blastic crisis with a type of tumor formation and died in the full developed leukemic conditions. At the stage of blastic crisis, almost all Ph1 chromosomes seemed to be disappeared and many small metacentiric chromosomes were found, instead of Ph1 chromosomes. In situ hybridization of the metaphase chromosomes by 3H-labelled v-abl (2.3 kb) resulted in highly significant labelling on these small metacentric chromosomes and band 9q34. Therefore, the small metacentric chromosomes were identified to be isochromosome of translocated #22 chromosome; i (22q-), originated from Ph1 chromosome.
By in situ hybridization of abl gene, the karyotype in blastic crisis was determined: 52, XY, +X, +Y, -4, +5, -9, +17, -18, -19, -22, +mar1, +mar2, del(7)(p11), +der(9) t(9;22)(q34;q11), +i(22q), +i(22q-), +der(19) t(1;19)(q11;q13), +der(19) t(1;19)(q11;q13). Thus, in situ hybridization of genes, those chromosomal localization have been mapped, seems one of the useful tool for the analysis of complicated chromosome abnormalities.抄録全体を表示PDF形式でダウンロード (621K) -
佐藤 純子, 湯浅 安人, 田中 弘, 二宮 恒夫, 広瀬 政雄, 宮尾 益英1986 年 27 巻 11 号 p. 2162-2167
発行日: 1986年
公開日: 2009/02/02
ジャーナル 認証ありA 10 year boy was admitted to our hospital because of lumbago and fever in July, 1985. Physical findings included no pallor and no petechia. The white cell count on admission was 7400/μl with 17% blast cells and bone marrow examination was interpreted as diagnosis of acute lymphocytic leukemia, L1 type in FAB classification.
Complete remission was induced by a combination chemotherapy of vincristine, cyclophosphamide and prednisolone. Intensification therapy was consisted of vincristine, given 12 hours later with high dose intravenous methotrexate (HD-MTX).
Five days after the 4th course of vincristine and HD-MTX therapy, he suddenly had generalized tonic convulsion and became loss of consciousness. These neurological signs were gradually resolved and within 5 days after the onset of symptoms he became neurologically normal. Laboratory values included platelet count of 9.4×104/μl and a lumbar puncture with an opening pressure 90 mmH2O, contents of protein and sugar of 19 mg/dl, of 82 mg/dl respectively and no cells. MTX level in cerebrospinal fluid was not detected by an enzyme immunoassay. Electroencephalography disclosed bilateral slowing with left parieto-temporo-occipital accentuation. Computed tomography of noncontrast enhancing of brain showed edema and a high density lesion in the left sylvian fissure, but 20 days after revealed no abnormal findings.抄録全体を表示PDF形式でダウンロード (514K) -
二宮 治彦, 依田 安弘, 渋谷 彰, 中沢 正樹, 長沢 俊郎, 阿部 帥, 森 尚義, 小宮山 淳1986 年 27 巻 11 号 p. 2168-2172
発行日: 1986年
公開日: 2009/02/02
ジャーナル 認証ありAbnormal expansion of azurophilic granular lymphocytes was observed in a case of 54-year-old man with non-Hodgkin lymphoma. The expanded cells had receptors for sheep erythrocytes but no Fcγ receptors. By phenotypical analysis using monoclonal antibodies, they were positive for Leu-1, -3, -4, -7, but negative for Leu-11. Cytochemical analysis revealed positivity for acid phosphatase and β-glucuronidase. The surface phenotype was obviously different from that of lymphoma cells (B1+). Furthermore, anti-HTLV-I antibody was negative. By functional analysis, these expanded cells had target binding capacity but no target lytic activity against K562 cells. They also had no proliferative response to IL-2.抄録全体を表示PDF形式でダウンロード (497K) -
大坂 顕通, 加納 康彦, 坂本 忍, 三浦 恭定, 斉藤 建, 森 茂郎1986 年 27 巻 11 号 p. 2173-2177
発行日: 1986年
公開日: 2009/02/02
ジャーナル 認証ありWe report a case of 55-year-old female with peripheral T-cell lymphoma (PTL) associated with Sjögren's syndrome. She was admitted to Jichi Medical School Hospital because of left axillary lymphadenopathy on August 9, 1984. Histological examination of the lymph nodes obtained by the first biopsy showed residual lymph follicles and an infiltration of immunoblasts, plasma cells, and epithelioid cells with capillary proliferation. A histological diagnosis of immunoblastic lymphadenopathy (IBL)-like lesion was suggested. The second and third lymph nodes biopsies were carried out. The histological findings did not fit any type of the Lymphoma Study Group (LSG) classification of Japan, and a diagnosis of PTL was considered. Immunohistochemical studies utilizing avidin-biotin-peroxidase complex (ABC) technique confirmed that proliferating cells predominated by peripheral T-cell with helper/inducer phenotype. Laboratory data disclosed normal level of serum LDH and no elevation of anti-virus titer of adult T-cell leukemia/lymphoma (ATLA). This case was considered to have clinical stage II B lymphoma.
The patient noticed xerostomia and foreign body sensation in the eyes several years before admission. Histological findings of minor salivary glands obtained by biopsy were compatible with the oral component of Sjögren's syndrome.
On October 11, 1984, chemotherapy was initiated with cyclophosphamide, adriamycin, vincristine, and prednisolone (CHOP) following irradiation to left axillary fields in a total dose of 40 Gy. She remained in complete remission for 12 months.
In the literature, malignant lymphoma associated with Sjögren's syndrome is mainly a monoclonal B-cell neoplasm. In this case, however, proliferating cells in the lymph nodes were polymorphous and immunohistochemical studies confirmed that they were of peripheral T-cell origin.抄録全体を表示PDF形式でダウンロード (531K) -
宮脇 修一, 根本 和雄, 若松 良二, 馬場 〓, 八代 邦彦, 内田 信一, 原沢 信雄, 藤屋敷 隆二, 戸部 伊助, 伊藤 秀明, ...1986 年 27 巻 11 号 p. 2178-2183
発行日: 1986年
公開日: 2009/02/02
ジャーナル 認証ありA 39-year-old male was admitted in March, 1984 with diagnosis of AML (M2). Two courses of BH-AC·DMP regimen induced complete remission of short duration. Second hematologic remission was obtained with BH-AC·AMP regimen, while marked pyrexia did not resolve. CT scans revealed multiple poorly-defined low-density lesions in the swollen tender liver. Since the liver biopsy failed to yield any positive cultures, administration of amphotericin B was tried through a cathetelinserted into the portal vein at laparotomy, along with oral 5-fuluorocytosine because of suspected mycotic etiology. His fever resolved to normal in 2 weeks after institution of this therapy, and the abnormal findings in CT scans disappeared as well. Amphotericin B was discontinued at the total dose of 1,076 mg without recurrence of the similar lesions.抄録全体を表示PDF形式でダウンロード (656K)
例会
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1986 年 27 巻 11 号 p. 2184-2206
発行日: 1986年
公開日: 2009/02/02
ジャーナル 認証ありPDF形式でダウンロード (2066K)
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