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Volume 28, Issue 12
Displaying 1-21 of 21 articles from this issue
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—The Criteria for Screening of Iron Deficiency Anemia—Yasuhiko IKEDA, Masaru YOKOYAMA1987 Volume 28 Issue 12 Pages 2085-2090
Published: 1987
Released on J-STAGE: February 02, 2009
JOURNAL RESTRICTED ACCESSHematologic variables were mesured in 702 junior high school students. Hematologic parameters were measured on each venous sample by Toa CC-170. The lower limit of the 90% range was estimated to be 12g/dl for hemoglobin (Hb) in all the subjects except 15 year-old boys in whom it was 12.5g/dl for Hb. In this study Hb≤12g/dl was employed as the criteria of anemia. Serum iron (S-Fe) and serum ferritin (S-Fer) were assayed in 359 males and 343 females. S-Fe was measured by WAKO FeB Test, and S-Fer by n-EIA Ferritin enzyme immunoassay. Lower limits of 90% range were 50μg/dl for serum iron and 10ng/ml for serum ferritin, which were employed as the criteria of iron deficiency.View full abstractDownload PDF (413K) -
—The Study on the Frequency and Pathogenesis of Anemia—Yasuhiko IKEDA, Masaru YOKOYAMA1987 Volume 28 Issue 12 Pages 2091-2095
Published: 1987
Released on J-STAGE: February 02, 2009
JOURNAL RESTRICTED ACCESSHematological variables were measured in 702 junior high school students. The hemoglobin level lower than 12g/dl was found in 12 of 365 males (3.3%) and 49 of 339 females (14.5%). The cases of anemia were divided into four groups: group 1, low serum iron and low serum ferritin; group 2, low serum iron and normal serum ferritin; group 3, normal serum iron and low serum ferritin; and group 4, normal serum iron and normal serum ferritin. Of the anemic cases, 34% belonged to group 1, 8.5% to group 2, 19.1% to group 3, and 38.3% to group 4. Most of cases in group 1 showed a typical iron dificiency anemia with lowerd serum iron, serum ferritin and transferin saturation as well as hypochromic, microcytic features. However, we could not find any evidence of iron dificiency in students with mild anemia in groups 3 and 4. Further evaluation is necessary to understand what is the pathogenesis of mild anemia in adolescence.View full abstractDownload PDF (348K) -
Kenji SHINOHARA, Masahisa TANAKA, Hiroyuki TANAKA, Chikako OOE, Kazuhi ...1987 Volume 28 Issue 12 Pages 2096-2099
Published: 1987
Released on J-STAGE: February 02, 2009
JOURNAL RESTRICTED ACCESSTwo cases of allogeneic bone marrow transplant recipients developed late onset hemorrhagic cystitis among the 8 cases of allogeneic bone marrow transplantation who were preconditioned with cyclophosphamide and total body irradiation. Adenovirus type 11 was isolated in the urine of these patients. The hydration and administration of mesna were performed in all of the cases, and late onset hemorrhagic cystitis occurred in only the cases in which bladder irrigation was omitted. The effectiveness of bladder irrigation was suggested for the prevention of late onset hemorrhagic cystitis.View full abstractDownload PDF (317K) -
—Studies by Electrophoresis and Electron Microscopy—Takeshi KAGEOKA, Masaki NAKAZAWA1987 Volume 28 Issue 12 Pages 2100-2105
Published: 1987
Released on J-STAGE: February 02, 2009
JOURNAL RESTRICTED ACCESSThe platelet injury during storage under various conditions was examined using electron microscopy, SDS-polyacrylamide gel electrophoresis (SDS-PAGE) and high resolution two-dimensional gel electrophoresis. The platelet damages were not remarkable in agitation at room temperature and no agitation at 4C on the analysis of these methods. On the other hand, the platelets stored in no agitation at room temperature and agitation in Tris-saline buffer showed marked morphological changes and appearance of four new bands (Mr=200Kd, 140Kd, 100Kd, 91Kd) on SDS-PAGE and a 140Kd peptide by the side of Gp I b/II a on two dimensional electrophoresis.
These results indicate that a suitable agitation and presence of plasma are important for the platelet preservation. Furthermore, this study also showed that storage of platelets at 4C was no notable change in the morphological and electrophoretic studies.View full abstractDownload PDF (1758K) -
Noboru MATSUMOTO, Ken YAGA, Shinya FUJII, Masashi OHKUBO, Yukio HIROSH ...1987 Volume 28 Issue 12 Pages 2106-2109
Published: 1987
Released on J-STAGE: February 02, 2009
JOURNAL RESTRICTED ACCESSSeven patients with refractory anemia (RA) were treated with high doses of intravenous bolus methylprednisolone (pulse therapy). Criteria for significant responses included an increment in hemoglobin (Hb)≥1.5g/dl, neutrophils ≥1,000/μl, and platelets ≥2×104/μl above the initial level. A Hb response was noted in 5 patients, but its duration was relatively short, the mean being 2.4 months. A neutrophil response occurred in 4 patients with the mean duration of 35 days. A platelet response was noted in 4 patients with the mean duration of 2.8 months. Three patients showed a response in three hematologic parameters, and two in two of the parameters (one with Hb and platelet responses, and another with Hb and neutrophil responses). The remaining two patients were refractory in spite of two courses of the therapy. There were no severe adverse effects during the observation period, and all patients are alive at the time of this writing. Because the natural course of RA is relatively long, a transient response obtained by this therapy seems to have little benefit in the treatment of RA. However, the fact that some patients with RA response to pulse therapy may give a clue to elucidate the pathogenesis and to establish the effective therapy in this hematologic disorder.View full abstractDownload PDF (339K) -
Takakazu TSUKASATO, Yoshikazu MARUYAMA, Ikurou MARUYAMA1987 Volume 28 Issue 12 Pages 2110-2116
Published: 1987
Released on J-STAGE: February 02, 2009
JOURNAL RESTRICTED ACCESSTo evaluate the antithrombogenic activity of endothelium, we intravenously injected heparin (60u/kg) in patients with DIC and healthy cotrols, and measured both plasma platelet factor 4 (PF4) and β-thromboglobulin (βTG).
Plasma PF4 increased transiently 5 minutes after heparin injection, while βTG did not. During this course urinary PF4 remarkably increased, however βTG decreased. This may suggest that PF4 was released from the heparin-like molecules on the surface of endothelium. As the heparin exerts its anticoagulant activities by potentiating the antithrombin III (ATIII) against the coagulation factor proteinases, more increasing amounts of PF4 released from endothelium neutralize larger heparin-like molecules on the endothelium and decrease the antithrombogenic activities of endothelium.
In healthy controls, there was direct correlation between βTG and PF4. Increased βTG was observed in healthy controls over 60 years old, but not in younger controls, while PF4 did not show significant changes with advancing age.
Four cases with DIC showed abnormal profile, whose levels of pre-βTG and PF4 were markedly higher than those of controls. DIC in large part, is regarded as a consequence of intravascular thrombin formation, which is immediately neutralized by the ATIII bound to the heparin-like molecules on endothelium. However, PF4 released from the activated platelets also immediately binds to the heparin-like molecules on endothelium. This way, with more increasing amounts of PF4 released from platelets, larger heparin-like molecules on the endothelium will be neutralized. This process may decrease the endothelial antithrombogenic activities in DIC.
The decreased antithrombogenic activity revealed by this heparin injection test, may play a role for the pathogenesis of DIC.View full abstractDownload PDF (494K) -
Hoyu TAKAHASHI, Wataru TATEWAKI, Reizo NAGAYAMA, Masaharu HANANO, Shin ...1987 Volume 28 Issue 12 Pages 2117-2124
Published: 1987
Released on J-STAGE: February 02, 2009
JOURNAL RESTRICTED ACCESSCryoprecipitate has proved to correct the hemostatic defects in von Willebrand's disease (vWD). However, recent studies have revealed that transmission of the AIDS retrovirus (HIV) occurs through exposure to blood products including cryoprecipitate. Treatment with heat-treated factor VIII concentrates may have certain advantages over treatment with non-heated products, if these preparations are efficacious in vWD and related disorders. We investigated the multimeric composition of von Willebrand factor (vWf), contents of vWf antigen (vWf: Ag) and ristocetin cofactor (RCof) in the heat-treated concentrates and cryoprecipitate, and their capacity to directly induce aggregation of platelet-type vWD platelets in vitro. The vWf multimers were visualized by a newly developed, immuno-enzymatic staining of the gel, following a discontinuous SDS-agarose gel electrophoresis. The RCof/vWf: Ag ratio was around 1.0 in cryoprecipitate, and ranged from 0.19 to 0.96 in factor VIII concentrates. Among four commercially available concentrates studied, Haemate P contained the most high-molecular-weight multimers of vWf and the highest RCof relative to vWf: Ag, and induced the aggregation at the lowest concentration. When infused into a patient with platelet-type vWD, Haemate P (14.4 U vWf: Ag/kg) shortened the prolonged bleeding time and caused spontaneous platelet aggregation in vitro with a mild diminution of platelet count. These results indicate that some of the heat-treated factor VIII concentrates may provide a safer, yet still effective, treatment for platelet-type vWD, and possibly for various types of vWD.View full abstractDownload PDF (664K) -
Fumio BESSHO, Akira KIKUCHI, Yuji HABU, Hiroshi KINUMAKI, Shunichiro Y ...1987 Volume 28 Issue 12 Pages 2125-2132
Published: 1987
Released on J-STAGE: February 02, 2009
JOURNAL RESTRICTED ACCESSThe long-term prognosis of 29 children with aplastic anemia was studied. Out of 29 cases, 24 were idopathic aplastic anemia and 5 were Fanconi's anemia. The prognosis of idiopathic type was fairly well predicted by the criteria proposed by Hotta, et al. The percentage of hematopoietic cells in bone marrow significantly well predicted the prognosis; patients with less than 20% hematopoietic cells in bone marrow had significantly worse prognosis.
The long-term prognosis of 14 patients who had survived more than 1 year was not satisfactory. Hepatic tumors developed in 3 cases. Hepatomegaly of unknown etiology associated with jaundice, diabetes mellitus, and cataract were also seen. One patient with Fanconi's anemia developed leukemia as well as hepatoma.
There were only 2 (8%) survivors without any complications. This suggests that the development of complications should be kept in mind when considering the indications of bone marrow transplantation.View full abstractDownload PDF (534K)
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Masahiro SUGAWARA, Naoki SUGAYA, Yoshihisa WAKABAYASHI, Shun-ichi HIRO ...1987 Volume 28 Issue 12 Pages 2133-2139
Published: 1987
Released on J-STAGE: February 02, 2009
JOURNAL RESTRICTED ACCESSWe reported a case of IgA multiple myeloma characterized with pleural fluid and multiple extramedullary tumor formation at terminal stage.
The patient was a 61-year-old female who had been suffering from lumbal pain since early December in 1982, but had received no treatment. When she fell out in the middle of March in 1983, she was injured in the right knee joint (intra-articular hemorrhage) and came to our clinic. The result of blood and biochemical analyses strongly suggested the presence of IgA myeloma and chemotherapy was started. Because the presence of fluid in the right pleural cavity was suggested on the chest roentgenograms, pleurocentesis was performed. The aspirated pleural fluid contained many multinuclear, highly metamorphic plasmacytes. While the serum IgA level decreased under VENP therapy, a palpable tumor came out in the right abdomen in early December, which rapidly grew larger. Finally the patient died from blood loss due to marked hemorrhagic diathesis, which did not respond to any treatment.
Autopsy revealed direct tumor extention into femurs, vertebrae, ribs and sternum. Metastatic lesions were present in various organs, including stomach, duodenum, pancreas, urinary bladder, endometrium and abdominal wall. Especially in abdominal wall, the tumor took the shape of a Borrmann IV type tumor with 8-cm diameter. Fluorescent antibody study demonstrated marked staining of the tumor cells with anti-IgA serum.View full abstractDownload PDF (717K) -
Junji TANAKA, Teiichi HIRANO, Takuto MIYAGISHIMA, Yoshitomo KUROKAWA, ...1987 Volume 28 Issue 12 Pages 2140-2145
Published: 1987
Released on J-STAGE: February 02, 2009
JOURNAL RESTRICTED ACCESSA 47-year-old woman was admitted because of general fatigue and the brownish skin rashes which were slowly increased since 7 years ago. Systemic lymphadenopathy with polyclonal hypergammaglobulinemia was observed. But M-protein and BJ-protein were not observed. Bone marrow aspiration revealed 6.9% plasma cells without atypsim. There were no evidence of specific infections and collagen diseases. Histological examination of lymph node showed the proliferation of mature plasma cells without atypism between follicles but did not show any destruction of the structure. And histological examination of the skin rashes showed the infiltration of mature plasma cells without atypism in perivascular area of the dermis. From these findings, this case was diagnosed systemic plasmacytosis, since the systemic proliferation of mature plasma cells without atypism was observed.
In the course of this case, brain tumor was revealed and the operation was done. Histological examination of the tumor showed astrocytoma.
The improvement of the systemic lymphadenopathy, skin rashes and polyclonal hypergammaglobulinemia were not observed after resection of the tumor.View full abstractDownload PDF (995K) -
Hiroshi SAO, Ryo SOBUE, Koichi MIYAMURA, Yoshihisa KODERA, Yasuo MORIS ...1987 Volume 28 Issue 12 Pages 2146-2152
Published: 1987
Released on J-STAGE: February 02, 2009
JOURNAL RESTRICTED ACCESSA 22 year old man with severe aplastic anemia (AA) who already became refractory to platelet transfusions has been successfully treated by allogeneic bone marrow transplantation (BMT).
He was diagnosed as mild AA at 6 years before BMT. Treatment with prednisolone, mepitiostane, methyl-prednisolone and anti-lymphocyte globulin failed to be effective, and AA became to be severe gradually. He transfused more than 300 unit of blood, and bacame to be refractory to platelet transfusions. Therefore, platelet and lymphocyte crossmatch was performed borore BMT, and 6 matched platelet donors among 400 persons were selected for platelet pheresis.
At May 9 1985, he was transplanted bone marrow from HLA identical brother after the premedication of high dose cyclophosphamide and total lymphoid irradiation. Cyclosporin was given for the prevention of graft versus host disease. Prompt engraftment of bone marrow and recovery of peripheral blood leukocyte and platelet were observed. Crossmatch negative platelet transfusions were effective and no hemorrhagic tendency had occurred during BMT. Patient is surviving with almost normal hematopoiesis and with good clinical conditions more than two years after BMT.View full abstractDownload PDF (482K) -
Naokuni UIKE, Mitsuo KOZURU, Naohisa TAKEICHI, Keisuke SHIBATA, Itsuro ...1987 Volume 28 Issue 12 Pages 2153-2160
Published: 1987
Released on J-STAGE: February 02, 2009
JOURNAL RESTRICTED ACCESSA 74-year-old febrile male with myelodysplastic syndrome (MDS) associated with Ig (λ) monoclonal gammopathy was initially treated with melphalan and prednisone for 27 days without apparent benefit. The patient was then admitted to our hospital on June 26, 1984. Hematological study revealed severe pancytopenia with hypogranular and Pelger-Huët-like abnormalities of neutrophils. Bone marrow aspirate was normocellular and showed marked dysplasia of trilineage blood cells. Plasma cells accounted for 12% of the myelogram but neither bone destruction nor abnormal renal function could be found. Bone marrow chromosome study revealed that the karyotype was 43, X, -Y, -2, -5, -7, -12, -16, -17, -20, -22, 15q+, +6 mar in all 20 banded cells analyzed.
He was then treated with metenolon enantate and prednisone. After 29 days, peripheral blood film showed a sudden increase in number of mature neutrophils with Pelger-Hüet-like abnormality and hypogranular appearance. He died of respiratory failure on July 28, 1984 with evidence of extensive diffuse shadows on his chest X-ray examination.
At autopsy the bone marrow was hypercellular with a number of neutrophils and sparse plasma cells. A surprising evidence was that diffuse infiltrates of plasma cells were seen in multiple organs such as lungs, liver, spleen, kidneys, pancreas and gastrointestinal canals. Furthermore, proliferation of these plasma cells seemed polyclonal rather than monoclonal because, using the PAP method for cytoplasmic (c-) Ig staining, c-κ positive cells and c-λ positive ones were almost equal in number on the liver specimen.
It is of interest that such polyclonal prolyferation of plasma cells as observed in this case may be ascribed to the idea of genetically unstable myeloid-lymphoid stem cells in MDS.View full abstractDownload PDF (1467K) -
Fumiaki SANO, Masanao TERAMURA, Toshiko MOTOJI, Kazuo OSHIMI, Hideaki ...1987 Volume 28 Issue 12 Pages 2161-2164
Published: 1987
Released on J-STAGE: February 02, 2009
JOURNAL RESTRICTED ACCESSA case of primary myelofibrosis with various immunological abnormalities is reported. A 77-year-old female was admitted to our hospital on April 11, 1985, because of progressive anemia. On admission, she was diagnosed as having primary myelofibrosis because of splenomegaly, bone marrow fibrosis, and peripheral blood leukoerythroblastosis and poikilocytosis. She was also considered to have cold agglutinin-induced hemolysis because of positive direct Coombs' test (complement type), positive cold agglutinin, increase in indirect bilirubin, low haptoglobin, short red cell life span and Raynaud's phenomenon. Moreover, she had other various immunological abnormalities such as positive thyroid test, positive microsome test, low complement activity and false positve reaction of STS. It has been reported that primary myelofibrosis is accompanied by various autoimmune diseases such as systemic lupus erythematosus, polyarteritis nodosa or warm type autoimmune hemolytic anemia. The various immunological abnormalities noted in this case may suggest the involvement of B lymphocytes in this disease.View full abstractDownload PDF (403K) -
Masami NAGAI, Yasuhiro SHIMADA, Michiaki TOKUDA, Shozo IRINO1987 Volume 28 Issue 12 Pages 2165-2169
Published: 1987
Released on J-STAGE: February 02, 2009
JOURNAL RESTRICTED ACCESSA rare case of aggressive plasma cell myeloma of a 54-year-old female is reported. The patient was admitted to our hospital because of high fever and left exophthalamos. Hematological and serological studies revealed multiple myeloma, IgA-k type. Morphologically, the myeloma cells were characterized by their multilobated nuclei with distinct nucleoli, which have been believed to be a morphologic marker for T-cell origin. Clinically, she once responded to intensive chemotherapy, but soon relapsed with intraperitoneal tumor. She died of gastrointestinal bleeding and pneumonia 5 months after the diagnosis. Autopsy findings revealed giant tumor in the retroperitoneum and it invaded to soft tissues.
This case seemed to be corresponded to “Aggressive plasma cell myeloma”.View full abstractDownload PDF (1236K) -
Akira FUJINAMI, Mako MURAKAMI, Mariko GOTO, Masahiro SAKO, Yoshiyuki T ...1987 Volume 28 Issue 12 Pages 2170-2175
Published: 1987
Released on J-STAGE: February 02, 2009
JOURNAL RESTRICTED ACCESSRecently, many cases of lineage switch in acute leukemia have been reported. We reported a case of lineage switch from non-Hodgkin's lymphoma to acute monocytic leukemia. A two-year-old male was admitted because of tumors on the head. The bone marrow was hypercellular with 64.6% of blasts. Leukemic cells were negative for peroxidase and sudan black B, and positive for PAS and L1 type. Cell surface markers were Ia+, B4+, OKT10+, CALLA-, OKT4-, and OKT8-. Southern blot analysis of DNA revealed immunoglobulin heavy chain gene rearrangement. A diagnosis of non-Hodgkin's lymphoma with B cell marker was made. At the time of relapse monoblasts and monocytes increased in peripheral blood. These cells were positive for peroxidase and α-naphtyl butyrate esterase, negative for PAS, and M5 in type. Analysis of cell surface marker showed Ia+, My7+, Mo2+, CALLA-, and B4-. Southern blot analysis did not exhibit immunoglobulin gene rearrangement. Lysozyme increased in blood and urine. Thus, a lineage switch from non-Hodgkin's lymphoma to acute monocytic leukemia was confirmed in this case. After some months, myeloblastoid cells increased in the peripheral blood. These cells were positive for OKT10, My9, and negative for Mo2, My7 by immunological examination.
To our knowledge, this case was the first case in Japan of lineage switch confirmed by DNA analysis in acute leukemia.View full abstractDownload PDF (904K) -
Yoshimi SAITO, Yasunobu NONAKA, Yumiko TAKEUCHI, Tsuneaki SUGIMOTO1987 Volume 28 Issue 12 Pages 2176-2181
Published: 1987
Released on J-STAGE: February 02, 2009
JOURNAL RESTRICTED ACCESSA 18-year old male with Hodgkin's disease, who developed the complication of amyloidosis manifesting nephrotic syndrome is reported.
He was admitted because of cervical lymphadenopathy, general edema and diarrhea in September, 1984. He had a severe nephrotic syndrome; protinurea 4 (+); serum albumin 0.9mg/dl. Nodular sclerosis type of Hodgkin's disease was revealed by the lymphnode biopsy, and colonic involvement of amyloidosis was disclosed by the colon biopsy.
Treatment with combination chemotherapy (VENP, BCOP) gave rapid improvement of Hodgkin's disease such as decreasing size of lymphadenopathy, but gave little relief with serious diarrhea and proteinurea. He died of generalized infection with herpes simplex, 3 months after admission. Permission for a posmortem was not obtained except renal necrobiopsy, which showed extensive amyloid deposits.
It is extremly rare in this case that early complication of amyloidosis of kidney and colon is associated with Hodgkin's disease. It suggests that amyloidosis occured almost simultaneously with Hodgkin's disease due to the same immunological abnormality.
The incidence of this rare complication is reviewed from reports in the literature.View full abstractDownload PDF (1220K) -
Yoshitaka KOISO, Koichiro IKUTA, Tetsunori FUNABIKI, Shusuke MATSUYAMA1987 Volume 28 Issue 12 Pages 2182-2186
Published: 1987
Released on J-STAGE: February 02, 2009
JOURNAL RESTRICTED ACCESS3 patients with hereditary spherocytosis in a family developed aplastic crisis. All showed acute onsets of severe anemia and reticulocytopenia and prodromal symptoms including fever, abdominal pain and headache. Aplastic crisis had been associated with the epidemic of erythema infectiosum and the third patient was demonstrated seroconversion of anti-human parvovirus B19 antibody by countercurrent immunoelectrophoresis. The acute-phase sera of three patients inhibited the formation of colony forming units-erythroid (CFU-E) and burst forming units-erythroid (BFU-E)-derived colonies from other normal subjects. Our results indicate that human parvovirus B19 was an etiologic agent in an outbreak of aplastic crisis in patients with hereditary spherocytosis.View full abstractDownload PDF (316K) -
Junji TOMIYAMA, Hideki KUDOU, Yamao ADACHI, Keiji KINUGASA, Takashi HA ...1987 Volume 28 Issue 12 Pages 2187-2192
Published: 1987
Released on J-STAGE: February 02, 2009
JOURNAL RESTRICTED ACCESSA 39 year-old man was admitted to our hospital because of acute hepatitis on the 4th of May 1986. The liver function test showed a marked elevation of serum transaminases and total bilirubin (GOT 706 IU/l, GPT 1068 IU/l, T. Bil 33.7 mg/dl). Antigen and antibody to hepatitis B were negative, but antibody to hepatitis A was positive and IgM index was 8.1. The liver function test improved gradually, but anemia and reticulocytopenia with thrombocytopenia (Hb. 7.9 g/dl, Retic. 0‰, Plt. 5.2×104/mm3) was noted on the 17th hospital day. Bone marrow showed marked depretion of erythroid series (Erythroid series 0.4%, M/E ratio 211.5). A diagnosis of pure red cell aplasia (PRCA) was done, but reticulocyte recovered spontaneously follwed by a temporary elevation of leukocyte and thrombocyte (Hb. 4.7 g/dl, Retic. 16‰, WBC 56,500/mm3, Plt. 201.9×104/mm3) on the 23th hospital day. Bone marrow showed erythroid hypreplasia (Erythroid series 40.2%, M/E ratio 1.3). Prednisolone (30 mg/day) was administered because of shortening of red cell life span, and then anemia improved with decrease of reticulocyte. The serum and IgG taken during acute phase of PRCA did not inhibit both CFU-E and CFU-GM of autologous bone marrow after remission. This case is the first report that developed acute PRCA after hepatitis A.View full abstractDownload PDF (618K) -
Fumiaki NAKAJIMA, Midori TAKAGI, Kuniko TSUCHIYA, Kazuhide IWAMOTO, Yu ...1987 Volume 28 Issue 12 Pages 2193-2197
Published: 1987
Released on J-STAGE: February 02, 2009
JOURNAL RESTRICTED ACCESSA 10-year-old male patient with adult type chronic myelogenous leukemia is reported. The patient had a rare complex Ph1 translocation, t (4; 18; 13; 9; 22) (q12; q11.2; q14; q34; q11.2) and had no splenomegaly at diagnosis. He developed several episodes of peptic ulcer during his six and a half year-long chronic phase, and eventually died 3 months later of acute blast crisis, unresponsive to chemotherapy (VCR/L-asp/Pred and BHAC/ACMA). Despite their low TdT activity, the blasts at crisis expressed CALLA and Ia-like antigen, were positive for PAS but not for peroxidase staining, and were classified as L1 by FAB conventions, suggesting of lymphoid lineage.View full abstractDownload PDF (585K) -
Fumiaki URASE, Hideaki SHIMOTSUMA, Hiroyuki HAMAZAKI, Takashi ASHIDA, ...1987 Volume 28 Issue 12 Pages 2198-2203
Published: 1987
Released on J-STAGE: February 02, 2009
JOURNAL RESTRICTED ACCESSWe experienced two cases of psychoneurological symptoms, who were given ciclosporin A (CYA) to minimize graft-versus-host disease (GVHD) after allogeneic bone marrow transplantation; one was a generalized convulsion, and the other tremor and depression. Both symptoms occured when serum magnesium level became low, and released by elevated magnesium level.
We considered these symptoms were due to hypomagnesemia caused by CYA, as same as two papers had been published.
Although the cause of hypomagnesemia caused by CYA is not yet known, there are some occasions of hypomagnesemia in cases of allogeneic bone marrow transplantation given CYA for the treatment of acute leukemia, we suggest that adequate magnesium replacement is important for prevention of such psychoneurological symptoms.View full abstractDownload PDF (434K) -
Hirotaka IWABUCHI, Kuang-Yung LIN, Junko H. OHYASHIKI, Kazuma OHYASHIK ...1987 Volume 28 Issue 12 Pages 2204-2208
Published: 1987
Released on J-STAGE: February 02, 2009
JOURNAL RESTRICTED ACCESSA case of acute myelomonocytic leukemia with inv (16) (p13q22) developed in an XY/XYY mosaic male was reported. Chromosome analysis of bone marrow cells on admission revealed 47, XY, +Y, inv (16) (p13q22)/48, XY, +Y, +22, inv (16) (p13q22). The bone marrow cells and PHA-stimulated blood cells in remission revealed that the patient was an XY/XYY mosaic male. Fragile site at 16q22 was not confirmed by distamycin A or berenil treatments in the peripheral blood cells. This indicated that this heritable fragile site at 16q22 is not always present in leukemia cases with inv (16) (p13q22).View full abstractDownload PDF (453K)
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