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Volume 31, Issue 2
Displaying 1-22 of 22 articles from this issue
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Tetsuji SOGA, Tsutomu FUKUROI, Mutsumasa YANABU, Naoaki SONE, Hirokazu ...1990 Volume 31 Issue 2 Pages 161-167
Published: 1990
Released on J-STAGE: March 12, 2009
JOURNAL RESTRICTED ACCESSFlow cytometry was used to detect fibrinogen (platelet associated fibrinogen: PAFbg) and fibronectin (PAFn) on the surface membrane of platelets in leukemia (9 cases), lung cancer (15 cases) and hepatoma (8 cases) patients (by one color analysis method), and simultaneously to investigate the binding of monoclonal anti-glycoprotein (GP) IIb/IIIa and anti-GP Ib antibodies (by two color analysis). All patient groups showed higher Fbg values than the normal control group, but no differences were found between patient groups. The values of Fbg and Fn showed a correlation, but the pattern of binding did not show a regular tendency in any patient group. There also was no significant correlation between Fbg values and the positive percentage of monoclonal anti-GPIIb/IIIa and anti-GPIb antibodies, and the binding of Fbg did not inhibit that of monoclonal antibody.
The results suggest the following.
1. There are no differences in platelet activation in leukemia, lung cancer and hepatoma patients, and the degree of platelet activation is decided by the degree and the kind of stimulation.
2. The increase of both PAFbg and PAFn prove to the existence of activated platelet.View full abstractDownload PDF (562K) -
Analysis of 105 CasesMorihisa YAMAGISHI, Shigeru OGUMA, Yataro YOSHIDA, Haruto UCHINO1990 Volume 31 Issue 2 Pages 168-171
Published: 1990
Released on J-STAGE: March 12, 2009
JOURNAL RESTRICTED ACCESSWe analyzed 105 cases of aplastic anemia diagnosed between 1958 and 1985 to clarify the variables that are related to prognosis. The most significant variable at diagnosis was reticulocyte count, followed in order by percent bone marrow lymphocyte, red cell turnover rate, T-score severity grade, iron utilization and aplastic anemia study group (AASG) severity grade. Reticulocyte count was the single significant variable in multivariate analysis. Three months after diagnosis, the most significant variable was still the reticulocyte count, followed by AASG severity grade. Changes of variables during the 3 months were not correlated to prognosis. Our result reconfirmed that reticulocyte count was the most important variable related to prognosis.View full abstractDownload PDF (306K)
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Naoya SAKAMOTO, Yoshitaka AOYAGI, Yukio OZAKI, Masaaki KANAYAMA, Yuji ...1990 Volume 31 Issue 2 Pages 172-176
Published: 1990
Released on J-STAGE: March 12, 2009
JOURNAL RESTRICTED ACCESSA thirty-eight-year-old man developed gradually progressing right retroorbital pain, diplopia on the left lateral gaze, and left ptosis. On examination paresthesia was present on the first division of right trigeminal nerve. Orbital venography revealed obstruction of right superior orbital vein on the entering portion to the cavernous sinus. A daily administration of 30 mg of prednisolone resulted in a rapid improvement of the symptoms. Diagnosis of Tolosa-Hunt syndrome was made on the basis of neurological symptoms, roentogenographic findings and responsiveness to prednisolone. One year later, weakness of right leg accompanied with left cervical and axillary lymphadenopathy was developed. A biopsy specimen of cervical lymph node was identical with the Hodgkin's disease, lymphocyte predominance type. He was treated with COPP regimen; lymphadenopathy decreased in size. We reported a rare case of Hodgkin's disease preceded by Tolosa-hunt syndrome which might be caused by the extranodal lesions.View full abstractDownload PDF (847K) -
Takasi MURATA, Sigeki MOTOMURA, Hirosi HARANO, Heiwa KANAMORI, Hiroko ...1990 Volume 31 Issue 2 Pages 177-182
Published: 1990
Released on J-STAGE: March 12, 2009
JOURNAL RESTRICTED ACCESSWe describe a patient with CML who developed hypercalcemia in his course of blast crisis.
A 25-years-old man was diagnosed as CML with priapism in April 1985, and controlled with BHAC-DVP, VMP, busufan therapy. In Decenber 1987, he readmited to our hospital with abdominal pain. Investgations at that time showed: white blood cell count 11600/μl (blast cells 9%); hemoglobin 8.4 g/μl; platlets 19.0×104/μl; serum calcium 13.2 mg/dl; BUN 44 mg/dl; creatinine 2.7 mg/dl.
Treatment with predonine, 6-MP and vincristine was begun. But serum calcium level rose gradually up to 16.5 mg/dl. So we tried middle dose Ara-c therapy, serum calcium decreased to 6.8 mg/dl.
At once he was in a chronic phase, but he relapsed and died of heart failure.
Necropsy showed extensive leukemic blast-cell infiltration of the bone marrow, liver, spleen, lung, and kidney.
The cause of hypercalcemia in our case was suspected of local osteolitic hypercalcemia, because multiple bone destruction was found.View full abstractDownload PDF (527K) -
—A Case Report and Its Gene Analysis—Yukio HATTORI, Yasuhiro YAMASHIRO, Kiyomi YAMAMOTO, Machiko MORISHITA, ...1990 Volume 31 Issue 2 Pages 183-188
Published: 1990
Released on J-STAGE: March 12, 2009
JOURNAL RESTRICTED ACCESSHereditary HbH disease was found in a Japanese family. The propositus showed hypochromic microcytic anemia and chronic hemolysis. HbH inclusion bodies were detected in red cells, and an abnormal band corresponding HbH was found in an isoelectric focusing of the hemolysate.
Gene analysis of the propositus revealed double heterozygosity for α+ and α0 thalassemias. Four of six his siblings shared the α0 thalassemia and one the α+ thalassemia. Another one was normal. The α+ thalassemia was of 3.7kb-deletion type and α0 was close to Southeast Asian type.
This is the fourth Japanese family with hereditary HbH disease.View full abstractDownload PDF (440K) -
Hiroshi KOJIMA, Yuichi HASEGAWA, Kazuko SHIBUYA, Masaki NAKAZAWA, Yasu ...1990 Volume 31 Issue 2 Pages 189-193
Published: 1990
Released on J-STAGE: March 12, 2009
JOURNAL RESTRICTED ACCESSA 55-year-old man was admitted to our hospital for the evaluation of neutropenia. On physical examination, he had apthae and splenomegaly. CBC showed 1,000/μl WBC with 5% neutrophils, and microcytic anemia consistent with iron deficiency. Bone marrow examination revealed a marked decrease of mature neutrophils, but normal percentage of immature myeloid cells. There was no morphological abnormality in the hemopoietic cells. He had no drug or family history responsible for the neutropenia. Anti-neutrophil auto-antibody was negative. Hence, a diagnosis of chronic idiopathic neutropenia (CIN) was made. He developed frequent episodes of infection such as penitis, peri-anal infection, gingivitis, and pharingitis. He was treated with steroid pulse therapy, anabolic hormone, and high dose γ-globulin infusion, but no significant improvement occured. Then, recombinant granulocyte-colony stimulating factor (rG-CSF) was started. The neutrophil count was normalized by the 7th day of 5 μg/kg/day rG-CSF administration. The administration of G-CSF was discontinued after a 14-day course. Thereafter, the neutrophil count remained at near normal level (approximately 1,500/μl) and there have been no episodes of infection in the last 5 months. However this cannot be explained simply by the direct effect of rG-CSF on the myeloid precursors; rather, it suggests some unknown effect of G-CSF on the bone marrow microenvironment regulating myeloid hemopoiesis. We consider this to be a rare case of CIN with frequent episodes of infection, which was successfully treated with G-CSF.View full abstractDownload PDF (382K) -
Hiroyuki NOZAKI, Keiko TANAKA, Toshihiko KUBOTA, Mitsumoto KOMATSUDA, ...1990 Volume 31 Issue 2 Pages 194-197
Published: 1990
Released on J-STAGE: March 12, 2009
JOURNAL RESTRICTED ACCESSA 41-year-old female, who had been diagnosed as having paroxysmal nocturnal hemoglobinuria (PNH) in 1985, was admitted to our hospital with cough, fever, diarrhea, vomiting and palpitation in April 1988. The chest X-ray showed pneumonia in her right lung. In the peripheral blood, red blood cell count was 1.64×106/μl, hemoglobin 4.7 g/dl and reticulocytes 19%. The levels of serum LDH, indirect bilirubin and creatinine were high. Pneumonia improved by the administration of antibiotics, however, anemia and renal failure deteriorated. After washed red blood cell transfusions totalling 2,000 ml and six times of hemodialysis, renal function returned to normal. This patient with PNH appeared to have developed acute renal failure by dehydration and hemolytic crisis due to pneumonia.View full abstractDownload PDF (410K) -
Mari AKIBA, Yasuyuki KUNIEDA, Shiro MAEDA, Makoto OITA, Mihiro OKABE, ...1990 Volume 31 Issue 2 Pages 198-203
Published: 1990
Released on J-STAGE: March 12, 2009
JOURNAL RESTRICTED ACCESSThe anti-tumor therapy followed by tumor lysis syndrome may cause the metabolic disorders including hyperkalemia, hyperphosphatemia and hyperuricemia. It should be known that it occurs frequently in lymphoproliferative diseases, especially in Burkitt's lymphoma.
Two cases of T-ALL accompanied by this syndrome, from which the patients were recovered, at the induction therapy of the first complete remission are reported here.
Case 1. A 28-year-old man received VP therapy under the diagnosis of T-ALL with massive hepatosplenomegaly and bilateral enlarged kidneys. During the therapy, metabolic disorders with both renal failure and ventricular tachycardia happened. They were resolved by certain series of treatments. The patient was brought to a complete remission with normal size of liver, spleen and kidneys.
Case 2. A boy aged 15 having received the intrasubarachnoidal infusion of MTX and 1-Ad-VP therapy under the diagnosis of T-ALL accompanied by this syndrome which was improved by an appropriate treatment, and the patient was lead to the remission.
The risk factors of this syndrome. such as 1-high drug sensitivity of the tumor; 2-renal dysfunction; 3-rapid cytokinetics of the tumor cell; 4-bigger size of the tumor, as well as the preventive treatment of this syndrome are reviewed.View full abstractDownload PDF (510K) -
Yuji SATO, Akira SHIBUYA, Hideki KUDO, Yamao ADACHI, Keishi KINUGASA, ...1990 Volume 31 Issue 2 Pages 204-208
Published: 1990
Released on J-STAGE: March 12, 2009
JOURNAL RESTRICTED ACCESSA 70-year-old man, who had been diagnosed as primary myelofibrosis in 1987 at Tokyo Womans Medical School, was admitted to our hospital because of left hip-joint pain in May 1988.
Physical examinations revealed marked hepatosplenomegaly and multiple ruddy papules on the skin. The peripheral blood showed marked leukoerythroblastosis and severe anemia with poikilocytosis.
Bone marrow aspirations were dry tap. Needle biopsy of iliac crest showed a diffuse fibrosis. Biopsy of the papules showed an extramedullary haematopoiesis.
He was treated with low dose Ara-C for seven days. Although hepatosplenomegaly and skin papules were reduced, he died of pneumonia a month later.
At autopsy, leukemic cells massively infiltrated into the multiple organs, including bone marrow. The cells were identified with megakaryoblast, as those were positive for factor VIII related antigen.
As far as we know, this is the third case of primary myelofibrosis transformed into acute megakaryoblastic leukemia.View full abstractDownload PDF (811K) -
Hiroko SHIGEMI, Satoshi MURAKAMI, Nariaki OKU, Kunihiko ITOH, Naohisa ...1990 Volume 31 Issue 2 Pages 209-213
Published: 1990
Released on J-STAGE: March 12, 2009
JOURNAL RESTRICTED ACCESSA 43-year-old man was admitted to our hospital because of legs edema and periorbital edema in Dec. 1983. Laboratory findings showed massive proteinuria (3.7 g/day), Bence Jones protein (BJP) in urine, and hypoproteinemia. Peripheral blood examinations were normal and a bone marrow aspiration showed hypocellularity with slight increase of monocytes and plasma cells. Serum immunoelectrophoresis showed two M-components (IgGκ, IgAλ). Serum IgG was 1,690 mg/dl, IgA 379 mg/dl and IgM 160 mg/dl. No remarkable findings were obtained in bone survey, Ga-scintigraphy and rectal biopsy, and a diagnosis of diclonal gammopathy with nephrotic syndrome was made.
In Aug. 1986, serum IgA started to increase rapidly with conocomitant decrease of IgG. He died of pneumonia due to pancytopenia in Dec. 1986, when serum IgG was 450 mg/dl, IgA 1,014 mg/dl, and IgM <39 mg/dl. Immunoelectrophoresis showed two M-components (IgGκ, IgAλ) in serum and BEP (κ, λ), IgG (κ) and IgA (λ) in urine. An autopsy showed massive infiltration of myeloma cells which were positive for λ light chain in bone marrow, suggesting a development of myeloma from a diclonal gammopathy in about 3 years.View full abstractDownload PDF (810K) -
Chizuko OHTA, Koushi OHISHI, Hiroshi ANAZAWA, Akinori ISHIHARA, Takao ...1990 Volume 31 Issue 2 Pages 214-218
Published: 1990
Released on J-STAGE: March 12, 2009
JOURNAL RESTRICTED ACCESSAn 18 years old female was admitted to hospital due to pancytopenia on May 25, 1987 and found to have petechiae, mild hepatomegaly and severe splenomegaly. The bone marrow was found to contain 12% of blast cells. Splenectomy was performed followed by CHOP therapy. In September, 1987 the peripheral blood was found to contain tumor cells, which turned out to be resistant to various combination chemotherapies. The patient died on August 21, 1988.
The phenotype of tumor cells in this case was CD2+ CD7+ CD3+ CD4- CD8- WT31-. Genetic analysis detected rearrangement of the β and γ chain of TcR but not transcription or translation of the β chain of TcR, while the antibodies of δ TCS 1 and TcRδ 1 to the δ chain of TcR were positive. From this fact, the present case was considered to be the malignant counterpart of normal CD3+ WT31- double negative T cells. The reactivity of this tumor cells to IL-2 and IL-1β suggested the assosiation of the IL-2Rβ chain.View full abstractDownload PDF (599K) -
Shinji IJICHI, Yuji SANO, Fumiho UNE, Ikuro MARUYAMA, Mitsuhiro OSAME1990 Volume 31 Issue 2 Pages 219-223
Published: 1990
Released on J-STAGE: March 12, 2009
JOURNAL RESTRICTED ACCESSProtease inhibiting agents, which have inhibiory effects on complement system, were used to treat a patient with autoimmune hemolytic anemia (AIHA) associated with B cell chronic lymphocytic leukemia (B-CLL). Although this patient had failed to respond thoroughly to prednisolone, the additional use of protease inhibitors induced a disease remission of hemolytic anemia. The result suggests that complement components are of importance in the pathogenesis of hemolysis in AIHA, and supports the accessory use of protease inhibiting agents in autoimmune hematologic diseases associated with the complement activation and hypersplenism.View full abstractDownload PDF (378K) -
Masayuki KAWASAKI, Yujiro YAMANO, Yutaka KIKUCHI, Tatsuo SATA, Mine HA ...1990 Volume 31 Issue 2 Pages 224-228
Published: 1990
Released on J-STAGE: March 12, 2009
JOURNAL RESTRICTED ACCESSA 28-year-old man was admitted to our hospital because of cardiac tamponade and pleural effusion. Although his peripheral blood picture was normal, his pericardial fluid contained a lot of myeloblasts with Auer bodies and a diagnosis of acute myeloblastic leukemia (M2) was made from the finding of bone marrow smears. The pericarditis was successfully treated with instillation of mitoxantrone into the pericardial space after drainage. He responded well to the systemic chemotherapy and achieved a complete remission. Although 27 cases of leukemia complicated with cardiac tamponade have so far reported, only three cases gave normal findings of the peripheral blood on admission. Leukemic pericardial effusion with cardiac tamponade in very rare as an initial manifestation of AML. The efficacy and safety of pericardial infusion of mitoxantrone were demonstrated in this patient.View full abstractDownload PDF (595K) -
Mieko MATSUI, Miwako MATSUZAKI, Yoshinori SHIMAMOTO, Mutsumi SHIGYO, M ...1990 Volume 31 Issue 2 Pages 229-233
Published: 1990
Released on J-STAGE: March 12, 2009
JOURNAL RESTRICTED ACCESSA case of non-Hodgkin's lymphoma with nephrotic syndrome and acute renal failure is described.
A 60-year-old Japanese male was admitted to our hospital in November, 1988, because of lymphadenopathy, fever, night sweat, weight loss. On physical examination, lymphadenopathy was present in both cervical, submandibular, supraclavicular, axillar and inguinal regions. The leukocyte count was 9,700/μl with 85% neutrophils and 2% atypical lymphocytes. Renal function was normal. Lymph node biopsy showed non-Hodgkin's lymphoma of diffuse, large cell type. Immunohistologic examination showed T cell type.
A few days later, he fell into acute renal failure. After systemic chemotherapy, he showed prompt improvement in renal function. Echo and computerized tomography (CT) of abdomen revealed no compression of the ureters and bladder. Renal biopsy findings suggested mesangium proliferlative glomerulonephritis without invasion of tumor cells.
Our case seemed to be rare and was compared with previous reports.View full abstractDownload PDF (523K) -
Kazuya SHIMODA, Yuji YUFU, Hiroyuki TAKAHIRA, Masahiro YAMAMOTO, Hiros ...1990 Volume 31 Issue 2 Pages 234-238
Published: 1990
Released on J-STAGE: March 12, 2009
JOURNAL RESTRICTED ACCESSIt is quite rare that aplastic anemia except Fanconi's type occurs in members of a single family. Here we reported two patients with aplastic anemia, a 14-year-old female and a 49-year-old her mother. In both cases, hematological findings were compatible to that of a typical aplastic anemia. In the case of daughter, CFU-E formation of control bone marrow cells was significantly inhibited by the addition of the patient's bone marrow cells, suggesting the presence of cellular immune mechanism. In the case of mother, no inhibitory activity on CFU-C formation of control bone marrow cells was detected in the patient's serum, though the ratio of helper/suppressor T lymphocytes in the peripheral blood was increased. We could not sufficiently clarify the common immune mechanism causing aplastic anemia in both cases. It was noticeable, however, that both cases share HLA DR2, which is frequently found in patients with various autoimmune diseases and is belived to relate closely to the pathogenesis of autoimmune diseases. This evidence suggests the possibility that genetically inherited susceptibility may also be the important factor for causing aplastic anemia.View full abstractDownload PDF (349K) -
Hideyo NATORI, Eiji NAKAMURA, Ken TANAKA, Katsunobu NAITO, Koichiro EG ...1990 Volume 31 Issue 2 Pages 239-244
Published: 1990
Released on J-STAGE: March 12, 2009
JOURNAL RESTRICTED ACCESSA 22-year-old female was admitted to our hospital because of general fatigue. The lymph nodes, liver and spleen were not palpable. She was without cutaneous lesions.
Haematological examinations revealed leukocytes 3,200/μl with 44% blasts of myelomonocytic origin, and platelets 15,000/μl. Bone marrow smears were hypercellular marrow with 51% blasts of myelomonocytic origin and focal involvement of mast cells. Serum histamine and vitamine B12 level was high.
Mast cells were round with rounded or segmented nuclei. The nucleoli were inconspicious and the cytoplasm contained a number of metachromatic granules. Cytochemically, mast cells stained possitive for α-naphthol-AS·D-chloroacetate esterase and acide phosphatase, and negative for peroxidase, Sudan black B and α-naphtyl butylate esterase. In toluidine blue staining, mast cells had stained similarly with pH values from 2.5 to 6.5.
She was diagnosed as acute myelomonocytic leukemia with benign mastocytosis, and treated with BH·AC-DNP. A complete remission was obtained, but mast cells in the marrow did not decrease.
Relationship between leukemia and mastocytosis was not known, but it was suggested that mast cells responded to the proliferation of the leukemic cells.View full abstractDownload PDF (872K) -
Masuhira SAI, Yoshikazu KAWANISHI, Yoshikazu ITOH, Shin AIZAWA, Takesh ...1990 Volume 31 Issue 2 Pages 245-248
Published: 1990
Released on J-STAGE: March 12, 2009
JOURNAL RESTRICTED ACCESSWe present a patient with refractory anemia (RA) who developed Sweet's syndrome during the treatment of recombinant human granulocyte colony-stimulating factor (rhG-CSF). A 30-year-old man was admitted to the hospital for evaluation of anemia. He was diagnosed as MDS (RA). As a phase II study in MDS, rhG-CSF therapy was begun. Fever associated with cutaneous lesion developed over the left shoulder. Antibiotics showed no effects. skin biopsy revealed Sweet's syndrome. This skin lesion disappeared thoroughly with discontinuance of G-CSF and administration of prednisolone. To examine whether Sweet's syndrome was related to the G-CSF therapy, we analyzed the effect of G-CSF on the function of patient's neutrophils. However, the function of patient's neutrophils was not activated by G-CSF administration.View full abstractDownload PDF (457K) -
Takashi SHIMAMOTO, Junko OHYASHIKI, Kenta UTSUMI, Kazuma OHYASHIKI, Ke ...1990 Volume 31 Issue 2 Pages 249-253
Published: 1990
Released on J-STAGE: March 12, 2009
JOURNAL RESTRICTED ACCESSWe report here a patient who was diagnosed as having acute lymphoblastic leukemia (ALL-L2) and colon carcinoma simultaneously and a successful operation for the colon carcinoma was performed preceded to the treatment of ALL. The patient was a 43-year-old male who presented with acute abdomial symptoms and was diagnosed as ALL by the hematological examination and as colon carcinoma (well differentiated adenocarcinoma, Borrmann II) by colon fiberscope. The patient was underwent sigmoidcolectomy for colon carcinoma and was received antibiotics as well as recombinant human granulocyte colony-stimulating factor (rhG-CSF), Approximatelly two weeks later, the patient received AdVP (Adriamycin, vincristine, and prednisolone) for ALL and achieved a complete remission. It might be possible for some leukemia patients manifesting acute abdomial symptoms to perform surgical approaches, since the prognosis of leukemia patients improved and supportive therapies, including an application of rh-CSF, have developed.View full abstractDownload PDF (694K)
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—A Qualitative Platelet Defect in Pernicious Anemia—Hideo TERADE, Haruo NIIKURA, Hiraku MORI, Shoji HAGIWARA, Yoshio TAKIZ ...1990 Volume 31 Issue 2 Pages 254-255
Published: 1990
Released on J-STAGE: March 12, 2009
JOURNAL RESTRICTED ACCESSIn order to know the entities of platelet defect in pernicious anemia, we investigated platelet functions in ten cases with pernicious anemia. Three of the cases had total gastrectomy. Five cases showed thrombocytopenia and four cases revealed prolongation of Ivy bleeding time. Decreased adhesiveness was oberved in three cases. Various abnormalities in platelet aggregation were observed.
However, almost all of the cases showed remarkable improvement of decreased platelet functions after the therapy of Vitamin B12 injection. The results of adenine nucleotides in platelets and the release of them following collagen or epinephrine aggregation were analysed in comparison with normal platelets. The ADP was definitely decreased and the ATP/ADP ratio was increased. In addition, the release of ATP and ADP at collagen or epinephrine induced aggregation was markedly decreased, and after the therapy of Vitamin B12, the decrease of adenine nucleotide release remarkably increased. In summary, the acquired defects of platelet function in pernicious anemia are regarded as a secondary storage pool disease, and its defects improve after Vitamin B12 therapy.View full abstractDownload PDF (212K) -
Kenji SHINOHARA, Kouichro OKAFUJI, Hideo AYAME, Naoki UEDA1990 Volume 31 Issue 2 Pages 256-257
Published: 1990
Released on J-STAGE: March 12, 2009
JOURNAL RESTRICTED ACCESSA 50 years old female suffered from idiopathic autoimmune hemolytic anemia. She was initially treated with prednisolone, and anemia was improved moderately. However, maintenance of Hb value was difficult with the decreased dosage of prednisolone. She was subsequently administered denazol, and anemia was completely improved. It is worth to use danazol for the treatment of the patient of autoimmune hemolytic anemia who is refractory to prednisolone therapy.View full abstractDownload PDF (141K) -
Tsutomu NAKASE, Kouichi MORITA, Makoto TOMEOKU, Masami KATOU1990 Volume 31 Issue 2 Pages 258-259
Published: 1990
Released on J-STAGE: March 12, 2009
JOURNAL RESTRICTED ACCESSCase 1: A 68-year-old male, who was admitted to our hospital because of massive intestinal bleeding, died 1 day after admission. Case 2: An 80-year-old male, who was admitted to our hospital because of a loss of consciousness, died 4 days after admission. In both cases prodromic infection was not detected. At autopsy, phagocytosis of RBC and WBC by histiocytes was shown markedly in the spleen in case 1 and in the bone marrow in case 2. So diagnosis of virus-associated hemophagocytic syndrome was made. It might be related to some underlying immunologic derangement, because both cases were in advanced age.View full abstractDownload PDF (281K)
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1990 Volume 31 Issue 2 Pages 260-272
Published: 1990
Released on J-STAGE: March 12, 2009
JOURNAL RESTRICTED ACCESSDownload PDF (1265K)
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