巻号一覧
31 巻, 3 号
選択された号の論文の20件中1～20を表示しています
- |<
- <
- 1
- >
- >|
総説
-
勇村 啓子, 原 純一, 多和 昭雄, 河 敬世1990 年 31 巻 3 号 p. 287-295
発行日: 1990年
公開日: 2009/03/12
ジャーナル 認証ありPDF形式でダウンロード (747K)
臨床研究
-
川上 睦美, 堤 久, 平井 真希子, 熊川 寿郎, 倉田 實一, 黒沢 晋一郎, 村井 善郎, 森 真由美1990 年 31 巻 3 号 p. 296-300
発行日: 1990年
公開日: 2009/03/12
ジャーナル 認証ありSeventy-five cases of myelodysplastic syndromes (MDS) in the aged (over 60 years) were analysed for hematological findings, immunological parameters and response to treatment in respect to prognostic significance. They were diagnosed according to the FAB classification, but patients with hypoplastic marrow were included if myelodysplasia was evident. Thirty-four percent of patients with primary acquired refractory anemia (PARA) or primary acquired sideroblastic anemia (PASA), and 36% of patients with RA with excess of blasts (RAEB) had hypoplastic bone marrow. The positive rates of antinuclear antibody in PARA or PASA, and of rheumatoid factor in PARA or PASA and in RAEB were higher than those in normal aged controls. Cellularity of bone marrow was inversely related to the length of survival. Among the patients with PARA or PASA, survival time was significantly longer in the group of hypoplastic bone marrow than in the group of hyper-or normoplastic bone marrow, and in the group of good responder to treatment than in the group of poor responder and nontreated patients.抄録全体を表示PDF形式でダウンロード (378K) -
—テタヌストキソイド初回免疫後のin vivoおよびin vitro抗原特異的抗体産生—大塚 実, 塩原 信太郎, 原田 実根, 上田 幹夫, 森 孝夫, 末永 孝生, 松田 保, 金沢大学骨髄移植チーム1990 年 31 巻 3 号 p. 301-307
発行日: 1990年
公開日: 2009/03/12
ジャーナル 認証ありThe ability of in vivo and in vitro tetanus toxoid (TT) antigen-specific antibody production after the primary immunization with TT vaccine was examined in 5 healthy adults and 3 long term survivors after HLA-identical allogeneic marrow grafting. Serum IgG anti-TT antibody titers became positive in 5 healthy adults but in only one of 3 patients. In vitro spontaneous IgG anti-TT antibody production was detected in 5 healthy adults but only one of 3 patients. In vitro TT antigen-dependent antibody production was detected in 5 healthy adults but only one of 3 patients and the pattern of the patient was different from one of healthy adults. These data indicate that long term survivors after marrow grafting are still disturbed in the ability of in vivo and in vitro TT antigen-specific antibody production after the primary immunization with TT vaccine. It is suggested that impaired spontaneous TT antigen-specific antibody producing B cells and TT antigen-specific memory B cells participate in the impediment.抄録全体を表示PDF形式でダウンロード (564K) -
鹿野 高明, 石川 順一, 小林 良二, 今野 武津子, 畑山 由起子, 中館 尚也, 畑江 芳郎, 武田 武夫1990 年 31 巻 3 号 p. 308-314
発行日: 1990年
公開日: 2009/03/12
ジャーナル 認証ありThirty-four children, including nine relapsed cases with acute lymphoblastic leukemia (ALL) having hyperdiploidy (>50 chromosomes) were studied on clinical and cytogenetic characteristics. The majority of children initially with hyperdiploidy (>50 chromosomes), who showed favorable prognostic features such as lower leukocyte counts, lower serum lactic dehydrogenase levels, ages between 2 and 10 years, or the presence of common ALL antigen, had the most favorable outcome among childhood ALL (5-year survival rate was 100%). Even nine children, who showed poor prognostic features such as ages over 10 years, leukocyte counts over 2×104/mm3 or lymphomatous signs, had also the same favorable outcome. There were no differences in clinical features between 6 patients with additional chromosomal structural abnormalities and 19 patients without them. Duplication of the long arm of chromosome 1 was frequently observed as additional chromosomal structural abnormalities.
Patients with hyperdiploidy (>50 chromosomes) observed at relapse, who had the same favorable clinical features as those at diagnosis, had a poorer prognosis.
These findings show that initial hyperdiploidy (>50 chromosomes) is an independent favorable prognostic sign in childhood ALL and additional chromosomal structural abnormalities may not indicate a poor prognosis among childhood ALL with hyperdiploidy (>50 chromosomes). On the other hand, relapsed children with hyperdiploidy (>50 chromosomes) have not a favorable outcome after the onset of relapse.抄録全体を表示PDF形式でダウンロード (1624K) -
田坂 英子, 生野 茅子, 岡村 純, 骨髄移植チーム1990 年 31 巻 3 号 p. 315-319
発行日: 1990年
公開日: 2009/03/12
ジャーナル 認証ありTwenty children with various hematological malignancies (nine with acute lymphoblastic leukemia, eight with acute non-lymphoblastic leukemia, two with chronic myelogenous leukemia, one with malignant lymphoma and one with 7-monosomy) and four with severe aplastic anemia were treated with allogeneic or syngeneic bone marrow transplantation (BMT) between September 1977 and September 1988. Eleven patients are surviving currently and ten are disease free 8 to 51 months after BMT. Conditioning regimen consisted of total body irradiation (TBI) and cyclophosphamide in twenty patients. Two patients did not receive TBI. Graft failure was observed in five patients and comrlete recovery of reciepent marrow was seen in two of them. Eleven patients developed acute graft-versus-host disease (GvHD) with grade I-II in enght patients. Three patients suffered from chronic GvHD. Seven patients with acute leukemia relapsed and all but one died of leukemia. Early death occurred in two undergone BMT in poor clonical conditions. Perfomance status in 100% in surviving patients except one.
Efforts to improv these results are that BMT should be considered early in the course of their disease for patients who are at risk for relapse with conventional chemotherapy and improved conditioning regimens to reduce leukemia relapse after BMT for patient with the second or susequent remission.抄録全体を表示PDF形式でダウンロード (386K)
症例
-
遠藤 ますみ, 金丸 峯雄, 久保 譲, 甲田 潔, 桜井 健, 飯塚 芳一, 竹内 仁, 堀越 昶, 大島 年照1990 年 31 巻 3 号 p. 320-324
発行日: 1990年
公開日: 2009/03/12
ジャーナル 認証ありA 16 year-old boy was admitted to our hospital in April 1985, because of bilateral submandibular swellings. Hematological examination revealed Hb was 7.3 g/dl, WBC was 89,000/μl (76% blast), and platelet was 154,000/μl. His bone marrow was hypercellular and consisted with 91% blasts. Myeloperoxidase staining was positive for 38% of blasts. Auer rods were seen in some of blasts. Thus, the diagnosis was M1 according to FAB classification. Cytogenetic studies of 20 marrow cells were performed and all cells had 46, XY, -1, -7, 3q-, 7q-, 17q+, +2mar. Eighty five percent of blasts expressed HLA-DR and 43% of blasts expressed CD2 and CD13 simultaneously. Thus, this leukemia was considered as the hybrid type of acute mixed leukemia by surface marker analysis.
DBMP-85 regimen, the chemotherapy for AML, was started after admission and complete remission (CR) was attained in June 1985. After 4 courses of post remission chemotherapy, he discharged in December 1985 and was followed at our outpatient clinic without chemotherapy. His disease was relapsed in June 1986, and the combination chemotherapy with mitoxantrone, etoposide and Ara-C was applied to him but failed to attain CR. Then, LVP protocol, the chemotherapy for ALL, was started and CR was achieved.
The blasts at relapse had morphologically myeloid features, and expressed HLA-DR, CD2 and CD13 as well as at diagnosis. Cytogenetic studies at relapse showed same karyotype except gaining 12p- anomaly. Therefore, same blasts were considered to emerge at relapse.
Our case suggests that LVP therapy may be effective for AML expressing myeloid and lymphoid surface markers.抄録全体を表示PDF形式でダウンロード (416K) -
三木 隆司, 王 伯銘, 平澤 晃, 森尾 聡子, 青墳 信之, 比留間 潔, 脇田 久, 遠藤 伸之, 五十嵐 忠彦, 浅井 隆善, 伊藤 ...1990 年 31 巻 3 号 p. 325-329
発行日: 1990年
公開日: 2009/03/12
ジャーナル 認証ありA Case of delivery in a 23-year-old woman after a prophylactic infusion of DDAVP is described. She had a life-long history of easy bruising and frequent epistaxis, with the diagnosis of vWD being made when she was 14 years old. A hemostatic examination showed a prolonged bleeding time, a moderate reduction in the factor VIII level (VIII: C) and von Willebrand Factor Antigen (vWF: Ag), decreased platelet aggregation by ristocetin, and depletion of platelet retention.
In April, 1988, in the 34th week of pregnancy, she was admitted to our clinic in order to avoid abnormal bleeding during labor. On admission, the level of factor VIII, ristocetin aggregation, and platelet retention were normal, but the bleeding time remained prolonged. The diagnosis of vWD type I was made on the normal multimeric structure. The DDAVP infusion test revleaed a shortening of the bleeding time and an increase in the vWF: Ag.
In the 41st week of pregnancy, labor was induced, accompanied by infusion of DDAVP, she gave a birth to an infant without any abnormal bleeding.
Since conventional treatments with human plasma derivatives may cause complicating viral infections, we propose the infusion of DDAVP is one of the treatments to prevent the abnormal bleeding of the patient with vWD during labor.抄録全体を表示PDF形式でダウンロード (567K) -
—Amphotericin Bの門脈内注入療法—石井 秀始, 比留間 潔, 森尾 聡子, 平沢 晃, 脇田 久, 遠藤 伸行, 王 伯銘, 吉田 尚, 青墳 信之, 浅井 隆善, 五十嵐 ...1990 年 31 巻 3 号 p. 330-334
発行日: 1990年
公開日: 2009/03/12
ジャーナル 認証ありA 36-year-old male with acute promyelocytic leukemia in second relapse was admitted to receive reinduction therapy in June, 1985, and entered into third complete remission, but he developed spiky fever after chemotherapy. Ultrasonic tomography revealed multiple liver abscesses and culture of the aspirates demonstrated Candida albicans in the abscesses. He was treated with intravenous administration of amphotericin B (AMPH-B) but the effect on the liver abscesses was unsatisfactory and consolidation therapy was difficult to start.
AMPH-B (30 mg/day) was administered by percutaneous transhepatic intraportal administration (PTIA). About two months later, multiple liver abscesses disappeared. No remarkable complications such as severe fever, chill and renal dysfunction were recognized during PTIA of AMPH-B. So PTIA of AMPH-B is considered to be useful and safe for the management of fungal liver abscesses.抄録全体を表示PDF形式でダウンロード (1084K) -
新倉 春男, 藤田 和博, 寺田 秀夫, 芳賀 章子, 山科 章1990 年 31 巻 3 号 p. 335-340
発行日: 1990年
公開日: 2009/03/12
ジャーナル 認証ありA case of Philadelphia (Ph1) chromosome positive acute myelogeneous leukemia (AML) following a refractory anemia with excess of blasts (RAEB) with 8 trisomy is reported.
The 80-year-old man developed pancytopenia during the course of follow-up after the surgical operation of the carcinoma of the sigmoid colon and the rectum for which no irradiation therapy nor chemotherapy had been applied. The diagnosis of RAEB was made accoring to the diagnostic criteria proposed by FAB co-operative group. Chromosomal analysis revealed 8 trisomy in 54% of the metaphases of bone marrow cells. The remainders showed normal karyotype without Ph1 chromosome. He was on androgenic steroid and activated Vitamin D3 without significant changes in the clinical and the hematological features until 3 months later when many atypical blasts appeared in the peripheral blood. The diagnosis of AML (M2) was made. Chromosomal analysis revealed Ph1 chromosome with the typical 9;22 translocation in 100% of the examined cells. 8 trisomy was not detected any more. Southern blot analysis using bcr probe showed bcr rearrangement. He was treated with a small dosis of Ara-C. There was some reduction in the number of blasts in the peripheral blood. However, he died of septicemia 2 months later.
The present case indicates that Ph1 positive acute leukemia with bcr rearrangement is not necessarily considered as a blastic transformation of chronic myelogeneous leukemia and such a cytogenic abnormality can appear in a leukemic transformation of myelodysplastic syndrome.抄録全体を表示PDF形式でダウンロード (462K) -
宇野 由佳, 重清 俊雄, 斎藤 史郎1990 年 31 巻 3 号 p. 341-345
発行日: 1990年
公開日: 2009/03/12
ジャーナル 認証ありA Japanese family with congenital plasminogen deficiency was described. The propositus was a 43-year-old woman, who complained of the attack of tonic convulsion. Her maternal grandfather was died of myocardial infarction and grandmother died of cerebral infarction. Her mother had thrombosis of the left femoral artery at the age of 56 years. She was made a diagnosis of late onset epilepsy due to cerebral infarction or cerebral tumor by electroencephalography, brain CT, and brain MRI. Her plasma plasminogen activity determined using chromogenic substrate was 54%, and the plasma level of plasminogen antigen measured by single radial immunodiffusion was 4.8 mg/dl. Family studies revealed parallel decreases in plasminogen activity and antigen levels in her mother and second daughter. These data suggest that congenital plasminogen deficiency is inherited as an autosomal dominant defect in this family.抄録全体を表示PDF形式でダウンロード (550K) -
青木 弥寿弘, 三宅 直樹, 山岨 道彦, 井上 文彦, 高松 輝行, 水本 孝, 岡田 隆道, 平井 通雄, 古川 裕夫1990 年 31 巻 3 号 p. 346-351
発行日: 1990年
公開日: 2009/03/12
ジャーナル 認証ありA case of autoimmune hemolyti anemia (AIHA) and bullous pemphigoid (BP)-like skin lesion combined with Idiopathic thrombocytopenic turpura (ITP) is reported. A 25-years-old male, who had been diagnosed as ITP and treated at another hospital, was admitted in this hospital recently complaining of disseminated bullous-vesicular eruptions on the whole body and autoimmune hemolytic anemia.
Examinations, disclosed that RBC was 364×104/μl, reticulocyte 40, platelet 3000/μl, direct and indirect Coombs test positive, and platelet Coombs consumption test was positive leading to the diagnosis of AIHA and ITP, known as “Evans syndrome”.
Vesicular biopsy-findings and immunofluorescence study showed suspicion of BP, but clinical course and blister was not improved though the administration of prednisolone was performed.
Reports of cases of BP complicated by Evans syndrome are very few. AIHA, ITP and BP are considered to have autoimmune disorders and their pathogenetic mechanism are discussed. This patient consulted another hospital one year later, when we heared that skin eruptions already had disappeared.抄録全体を表示PDF形式でダウンロード (1030K) -
岡本 隆弘, 赤木 利彰, 田村 周, 宮崎 栄二, 小馬場 理恵, 井上 信正, 篠原 慶希, 武元 良整, 神前 昌敏, 金丸 昭久, ...1990 年 31 巻 3 号 p. 352-358
発行日: 1990年
公開日: 2009/03/12
ジャーナル 認証ありA 46-year-old man was diagnosed as having chronic myelogenous leukemia (CML) in chronic phase in Dec. 1985. In Dec. 1987, anemia and leukocytopenia progressed, and the percentage of blast cells increased in the bone marrow. The blast cells were lymphoblastoid and positive for TdT. It was treated as a lymphoid crisis with vincristine and prednisolone, and complete remission was achieved. However, the blasts (11%) were observed in the bone marrow in Mar. 1988, and the chromosomal analysis revealed 46, XY, t(2q-;11q+), t(9q+;22q-) in 13 out of 20 cells. In June, the percentage of the blasts incresed again, but chromosomal analysis showed a different karyotype, 46, XY, t(2p-;11p+), t(9q+;22q-) which was observed in 9 out of 10 cells. Then, myeloblastoid cells increased rapidly in spite of the chemotherapy in Dec. 1988. The chromosomal analysis showed 46, XY, 2p-, 7q-, 9q+, 11p+, 22q- in all analyzed cells. The rearrangement of the bcr gene could be detected by the Southern blotting. The blasts were positive for CD7, CD11, CD13, CD33, CD36, CD41 and CD42, suggesting that the blasts had the surface phenotypes of both myeloid and megakaryocytoid-lineage. This is a case with the mixed blast crisis that changed from the lymphoid to the myelo-megakaryocytoid in nature, in which three clonal evolutions were observed during the clinical course.抄録全体を表示PDF形式でダウンロード (606K) -
彌重 博巳, 前川 平, 藤井 浩, 西田 一弘1990 年 31 巻 3 号 p. 359-364
発行日: 1990年
公開日: 2009/03/12
ジャーナル 認証ありA 73-year-old male was admitted to our hospital in October 1987 because of severe anemia, anorexia, and loss of weight. The hemoglobin level was 5.7 g/dl, the white blood cell count 2,500/μl with 5% myeloblasts positive for peroxidase, and the platelet count 8.6x104/μl. The LDH was 656 mU/ml, the total protein in the serum 7.4 g/dl, IgG 419 mg/dl, IgA 104 mg/dl, IgM 10 mg/dl, and urine Bence Jones (BJ) protein 8.8 g/day. The X-ray survey of the bones showed multiple osteolytic lesions. A bone marrow aspirate was hypercellular with 91.4% plasma cells, and was cultured a whole day for chromosome study. It revealed an abnormal karyotype of 46, XY, -15, t(6;14)(p21.1;q32.3), +der(15) t(1;15)(q23;q24). Immunoelectrophoresis demonstrated lamda type BJ protein. He was treated with melphalan and prednisolone. Proteinuria and marrow plasma cells decreased in amount. In December a white cell count was 6,030/μl with 80% myeloblasts. A bone marrow aspirate revealed an increase of 82.6% myeloblasts or promyelocytes. The patient was refractory to chemotherapy and died of sepsis in April 1988. An unrelated abnormal karyotype; 48, XY, +8, +13 appeared concomitant with an increase of the leukemic cells, but no cells showed the t(6;14). We cytogenetically discussed the simultaneous presence of multiple myeloma with acute myelogenous leukemia.抄録全体を表示PDF形式でダウンロード (750K) -
阿久津 保之, 森 和夫, 鈴木 宗三, 菅井 浩二, 石川 正明, 酒井 秀章, 遠藤 栄子, 安田 広康1990 年 31 巻 3 号 p. 365-370
発行日: 1990年
公開日: 2009/03/12
ジャーナル 認証ありA family with inherited combined deficiency of factor V and von Willebrand factor (vWF) is reported. Hematological examination of 41 year-old female proband and her younger brother revealed prolonged prothrombin time and Kaolin partial thromboplastin time. The level of both factor V activity and factor V antigen markedly decreased, below 15% of mormal. The decreased levels of factor VIII activity and vWF activity are also seen. Furthermore, abnormal mobilities were observed in crossed immunoelectrophoresis. The protein C, S antigens and activities, and protein C inhibitor activity were within normal. Four sons have received the 50% levels of factor V from their parents. One of them also showed the 50% of factor VIII and vWF activities. From above results, this family is thought to be a case of inherited deficiency of factor V and vWF, which are transmitted as an autosomal trait apparently.抄録全体を表示PDF形式でダウンロード (893K) -
杉本 正毅, 家崎 貴文, 若林 芳久, 足立 山夫, 廣瀬 俊一1990 年 31 巻 3 号 p. 371-374
発行日: 1990年
公開日: 2009/03/12
ジャーナル 認証ありA case of 78-year old man with megaloblastic anemia occurring 20 years after partial gastrectomy is reported. Since about 2 years earlier he had an episode of convulsion, and he had been on anti-convulsants (diphenylhydantion, phenobarbital) until adimission. Physical examination revealed a pale lean man with polyneuropathy and mental impairment. Laboratory findings revealed WBC 3100/μl, RBC 187×104/μl, HB 7.9 g/dl, MCV 124.4 μm3, MCH 42.7 μg, platelet counts 15.7×104/μl, serum vitmin B12 (VB12) 380 pg/ml, and serum folic acid 5.1 ng/ml. Serum autoantibodies to intrinsic factor (IF) and parietal cells were positive. Bone marrow examination revealed erythroid hyperplasia and megaloblastic changes. Schilling test revealed impaired absorption of VB12 with or without IF, but X-ray study of the small bowels was unremarkable. Treatment with intramuscular cyanocobalamin resulted in a rapid clinical improvement. A repeat Schilling test after 4 months of therapy showed a normal VB12 absorption in the presence of IF. These findings suggest that VB12 malabsorption of the 1st Schilling test was due to intestinal dysfunction caused by the VB12 deficiency state itself, and the improvement of VB12 absorption with IF after therapy suggests a pathogenesis similar to pernicious anemia in this patient.抄録全体を表示PDF形式でダウンロード (331K) -
衛藤 徹也, 岡村 秀樹, 岡村 孝, 権藤 久司, 工藤 二郎, 渋谷 恒文, 原田 実根, 仁保 喜之1990 年 31 巻 3 号 p. 375-380
発行日: 1990年
公開日: 2009/03/12
ジャーナル 認証ありA 56-year-old female was admitted because of generalized lymphadenopathy. Based upon histological findings of biopsied lymph node, malignant lymphoma, diffuse large cell type was diagnosed. The surface marker analysis showed that malignant cells were positive for CD4 and CD2 but negative for CD8. Although anti-ATLA (adult T-cell leukemia associated antigen) antibody was negative with the use of a gelatin particle agglutination method (P.A.), other methods such as an indirect immunofluorescence assay (I.F.), an enzyme-linked immunosorbent assay (E.I.A.) and a Western blotting assay revealed the positivity for anti-ATLA antibody. Adult T-cell leukemia/lymphoma (ATL/L) was confirmed by the presence of monoclonal integration of HTLV-I proviral DNA in biopsied specimen. This case, showing a pattern of P.A.(-) and I.F.(+), is extremely unusual, because I.F. and P.A. show highly close correlation. Thus, it is important to employ different methods for screening of anti-ATLA antibodies in the diagnosis of ATL/L.抄録全体を表示PDF形式でダウンロード (776K) -
田辺 昇, 堀田 知光, 村手 隆, 後藤 達彦, 稲垣 治郎, 木村 禧代二1990 年 31 巻 3 号 p. 381-385
発行日: 1990年
公開日: 2009/03/12
ジャーナル 認証あり59 year old female was admitted to Nagoya Memorial Hospital for anemia unknown etiology after the work up of the gastrointestinal tract. Peripheral blood count at admission was as follows: WBC 2,400/μl, RBC 321×104/μl, Hb 9.8 g/dl, Ht 30.1%, Plt 8.2×104/μl, which showed pancytopenia with normocytic, normochromic anemia. She had no hepatosplenomegaly, vitamin B12 nor folate deficiency. Bone marrow was hyperplastic and showed trilineage megalodysplastic changes. The diagnosis of myelodysplastic syndrome (Refactory anemia) was made. Progenitor assay showed no clony formation of BFU-E but showed normal growth of CFU-GM colony and cluster. She had chromosomal abnormality of 47, XX, +11. Administrated anabolic steroid, predonin and activated vitamin D3 were not effective and she died of brain hemorrhage in April 1987. Colony assay at this stage showed numerous leukemic clusters and no normal colonies. Re-performed chromosome assay showed 47, XX, +11. There are only a few reports of trisomy-11 in a patient with MDS. Especially we could follow this case till her leukemic transformation by colony assay.抄録全体を表示PDF形式でダウンロード (416K) -
中村 和彦, 井手口 裕, 岡嶋 泰一郎, 加藤 堅一1990 年 31 巻 3 号 p. 386-390
発行日: 1990年
公開日: 2009/03/12
ジャーナル 認証ありA 61-year-old woman was admitted with complaint of fever. The peripheral blood showed pancytopenia and bone marrow aspirate showed dysplasia in trilineage blood cells with increased blasts (18.2%). Bone marrow chromosome study revealed a karyotype of 46XX, -6, 3q-, +mar in 19 cells of 20 analyzed. She was diagnosed as refractory anemia with excess of blasts (RAEB). 95% of neutrophils in the bone marrow and 84% of that in the peripheral blood were stained with non-specific esterase using α-naphthyl acetate as substrate. On the other hand, the positivity of neutrophils for peroxidase, Sudan black B or chloroacetate esterase was markedly decreased. The phagocytotic activity of neutrophils was increased in comparison with normal control cells. Surface marker analysis of peripheral blood myeloid cells revealed increased expression of monocyte specific markers. These findings suggested that the patient's neutrophils, which were surely neutrophils in morphology, shared also monocyte-specific characters After treatment with low dose Ara-C, pancytopenia was recovered and blasts in the bone marrow were reduced. Also was decreased non-specific esterase positive neutrophils, indicating that the neutrophils were derived from abnormal myeloid clone.抄録全体を表示PDF形式でダウンロード (437K) -
山崎 竜弥, 松浦 周, 渡辺 完爾, 大里 守彦, 和久 茂仁, 斉藤 憲治, 榎原 英夫, 古沢 新平, 宍戸 英雄1990 年 31 巻 3 号 p. 391-395
発行日: 1990年
公開日: 2009/03/12
ジャーナル 認証ありA 65-year-old woman was admitted because of multiple cutaneous tumors in the left lumbar area in March 1983. In 1979, she had been diagnosed as solitary plasmacytoma (IgG, κ) of the left femur and amputation of the left leg had been performed. In 1981, the tumor relapsed in the left ilium in association with an increased level of serum IgG with M-component and normal activity of serum amylase. The serum M-protein had been disappeared after resection of the tumor. On admission laboratory examinations showed a slightly high level of serum IgG and elevated activities of serum and urine amylase. Amylase isoenzyme analysis revealed a predominance of the S-isozyme. Bone marrow aspiration revealed no atypical plasma cells. The supernate of cultured plasma cells obtained from the cutaneous tumor contained high amylase activity consisting exclusively of S-type. Thereafter serum amylase activies changed approximately in parallel with serum M-protein levels and total tumor volumes after chemotherapy or radiotherapy. At the terminal phase in 1986, however, serum amylase activities became extraordinarily high compared with serum M-protein levels, suggesting a clonal change of the plasmacytoma cells.抄録全体を表示PDF形式でダウンロード (432K)
短報
-
酒井 力, 高木 敏之, 小黒 昌夫, 菅 三知雄1990 年 31 巻 3 号 p. 396-397
発行日: 1990年
公開日: 2009/03/12
ジャーナル 認証ありAn acute myelomonocytic leukemia presenting transient skin rash during preleukemic phase was described. Following four years of unexplained leukopenia, a generalized exanthema developed and subsequently regressed spontaneously. The skin biopsy and immunohistochemistry revealed monocytic infiltration into the dermis. Twenty-eight months later, the patient became leukemic and died. The skin lesions, however, did not occur after leukemic transformation. Probably transient monocytic skin infiltrate was a symptom of preleukemia, a stem cell neoplasm manifested by functionally abnormal maturation.抄録全体を表示PDF形式でダウンロード (313K)
- |<
- <
- 1
- >
- >|