Rinsho Ketsueki
Online ISSN : 1882-0824
Print ISSN : 0485-1439
ISSN-L : 0485-1439
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Volume 37, Issue 6
Displaying 1-12 of 12 articles from this issue
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  • Homozygous β+-Thalassemia due to −31 A to G Mutation
    Takuya KOMENO, Takayoshi ITOH, Atsushi SHINAGAWA, Yuichi HASEGAWA, Tos ...
    1996 Volume 37 Issue 6 Pages 506-510
    Published: 1996
    Released on J-STAGE: April 28, 2009
    DOIhttps://doi.org/10.11406/rinketsu.37.506
    JOURNAL RESTRICTED ACCESS
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    A 20-year-old Japanese woman was admitted to our hospital with anemia and mild splenomegaly. Peripheral blood examination revealed Hb 9.4 g/dl, Ht 29.3%, RBC 4.74×106/μl, reticulocytes 2.4%, WBC 5,200/μl, platelets 24.9×104/μl, MCV 61.7 fl, and MCH 19.9 pg. Poikilocytosis with target cells was recognized on the peripheral blood smear. A bone marrow aspirate revealed erythroid hyperplasia. Serum iron and ferritin were in the normal range. β-thalassemia was suggested by the increase in HbA2 (6.5%) and HbF (7.5%). Analysis of β globin DNA by single strand conformation polymorphism (SSCP) and amplification refractory mutation system (ARMS) confirmed a diagnosis of homozygous β+-thalassemia due to −31 A to G mutation. A familial study revealed that her parents were heterozygous for this allele. This is the 8th case of homozygous β+-thalassemia due to −31 A to G mutation in Japan.
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  • Influenza-virus Associated Hemophagocytic Syndrome in a Patient with Pernicious Anemia
    Kenji SHIRONO, Hiroyuki TSUDA, Izumi AKAHOSHI
    1996 Volume 37 Issue 6 Pages 511-513
    Published: 1996
    Released on J-STAGE: April 28, 2009
    DOIhttps://doi.org/10.11406/rinketsu.37.511
    JOURNAL RESTRICTED ACCESS
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    A 59-year-old man with pernicious anemia (vitamin B12 deficiency) was admitted because of rapidly developing pancytopenia with the symptoms of influenza. Laboratory data indicated that the pancytopenia was manifested by influenza virus-associated hemophagocytic syndrome. In the patients with pernicious anemia, it is known that there are immunologic disturbances in either humoral and cellular immunity and increased hematopoiesis due to ineffective hematopoiesis. This patient was thought to have developed influenza virus-associated hemophagocytic syndrome due to the immunologic and hematopoietic abnormality in the pernicious anemia.
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