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Volume 38, Issue 12
Displaying 1-5 of 5 articles from this issue
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Yoshiko TAMAI, Hideki TAKAMI, Rieko NAKAHATA, Yuka NAKUI, Yuko SUZUKI, ...1997 Volume 38 Issue 12 Pages 1243-1248
Published: 1997
Released on J-STAGE: April 28, 2009
JOURNAL RESTRICTED ACCESSDuring 1990 to 1993, five patients who had been treated in our hospital for aplastic anemia (AA) with a normal karyotype, were found to have hypoplastic myelodysplastic syndromes (hMDS); three patients with RA, one RAEB, and one RAEB-T, and all of them have chromosomal abnormalities. The mean age of the hMDS patients (4 men, 1 woman) was 51.0 years (range 31-61). We retrospectively studied the hematological features of the 5 cases in the early stage without chromosomal abnormalities. They showed, 1) appearance of erythroblasts (3/5), 2) more reticulocyte counts than typical AA (mean 7.8×104/μl), 3) macrocytic anemia (mean MCV 106fl) in peripheral blood, 4) relative erythroid hyperplasia (M/E ratio 0.2-1.5), and 5) low lymphocyte counts (mean percentage of lymphocytes 32.8%) in bone marrow. Considering about the differences or transformation between AA and hMDS, it is interesting that all five patients have initially had a normal karyotype and subsequently developed chromosomal abnormalities.View full abstractDownload PDF (518K) -
Shu TANIKAWA, Hisashi SAKAMAKI, Shinichiro MORI, Hideki AKIYAMA, Hiros ...1997 Volume 38 Issue 12 Pages 1249-1253
Published: 1997
Released on J-STAGE: April 28, 2009
JOURNAL RESTRICTED ACCESSThe aim of this study was to evaluate the yield of nucleated cells in bone marrow harvested by means of Downs' Islam aspiration needles with or without side-holes. Twenty marrow donors for HLA identical sibling transplants were studied. Bone marrow nucleated cells were harvested 50 ml in the right iliac bone with a Downs' Islam aspiration needle with or without side-holes and 50 ml in the left with another kind of needle by means of 5 ml aspirations in each donor. There were no significant difference between the number of nucleated cells by means of Downs' Islam aspiration needles with and without side-holes by cross-over analysis. All nucleated cell counts were 33.06±12.93×103/μl (mean±standard deviation) by means of the needle with side-holes and 32.90±15.25×103/μl by means of the needle without side-holes. The Downs' Islam aspiration needle without side-holes seems to be better in bone marrow harvest from normal volunteers than that with side-holes, because the former may be stronger than the latter.View full abstractDownload PDF (427K) -
Kiyoshi OKADA, Naohito OGUCHI, Ken SHINOHARA, Nobuko TAMURA, Koji ISHI ...1997 Volume 38 Issue 12 Pages 1254-1262
Published: 1997
Released on J-STAGE: April 28, 2009
JOURNAL RESTRICTED ACCESSThe prognostic significance of of some clinical features in 41 patients with multiple myeloma (including 2 patients with plasma cell leukemia) from our institution was analyzed. Out of 14 variables isolated from the univariate analysis (P<0.05), only three (BUN, Bence Jones protein, and chromosomal aberrations) were significant in the multivariate model (P<0.05). Derived from these three variables, three subpopulations of patients were identified. The first group included 20 patients with a low risk of death and their median survival has not been reached. In particular, no one died during the first 60 months in this group. The second group also included 14 patients with an intermediate risk of death and a median survival of 49.2 months. The third group comprised seven patients with a high risk of death during 24 months after diagnosis and a median survival of 31.6 months (P<0.0001). Finally, Durie & Salmon's myeloma staging system was demonstrated in the present series, and it showed prognostic validity for each stage (P<0.0222). Compared with Durie & Salmon's staging system, our prognostic model for multiple myeloma was more useful to predict prognosis when applied to the present series.View full abstractDownload PDF (688K)
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Fumihiro FUJIWARA, Gen KANOH, Hiroshi OGAWA, Kazushi TAKAYA, Shigeyosh ...1997 Volume 38 Issue 12 Pages 1263-1268
Published: 1997
Released on J-STAGE: April 28, 2009
JOURNAL RESTRICTED ACCESSThis report describes the transient development of inhibitors in two cases of hemophilia A. Case 1 was an 8-month-old boy who suffered from subcutaneous hematoma with extremely low level (1.5%) of plasma factor VIII activity (F VIII:C). He showed an inhibitor titer of 2.5 Bethesda units (BU)/ml when he suffered from measles at age 24 months with poor clinical response to factor VIII. This inhibitor elevated to 11.6 BU/ml at 29 months, but completely disappeared at 32 months. Case 2 was a 5-monthold boy who suffered from subcutaneous hematoma with extremely low level (<1%) of plasma F VIII:C. At 8 months his inhibitor titer peaked at 19 BU/ml but subsequently declined to 11.5 BU/ml at 12 months and completely disappeared at 14 months. A review of the literature revealed that the median (range) titer of transient inhibitor initially developed at 2 (0.5-19) BU/ml on 225 (79-448) days, immediately peaked at 3.6 (0.5-60) BU/ml and disappeared by 665 (282-1140) days, suggesting that careful monitoring of F VIII inhibitors is required in the treatment of hemophilia A.View full abstractDownload PDF (439K)
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1997 Volume 38 Issue 12 Pages 1269-1283
Published: 1997
Released on J-STAGE: April 28, 2009
JOURNAL RESTRICTED ACCESSDownload PDF (1396K)
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