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Volume 42, Issue 12
Displaying 1-7 of 7 articles from this issue
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[in Japanese]2001 Volume 42 Issue 12 Pages 1155-1161
Published: 2001
Released on J-STAGE: July 28, 2009
JOURNAL RESTRICTED ACCESSDownload PDF (505K)
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Clinical significance of WHO classification and MDS 2000 classification in myelodysplastic syndromesMiki AKIBA, Akira MATSUDA, Motohiro MISUMI, Fumiharu YAGASAKI, Masami ...2001 Volume 42 Issue 12 Pages 1162-1169
Published: 2001
Released on J-STAGE: July 28, 2009
JOURNAL RESTRICTED ACCESSExcluding chronic myelomonocytic leukemia, a total of 92 consecutive patients with myelodysplastic syndrome showing less than 20% blasts in the bone marrow were analyzed. We evaluated the clinical significance of the WHO and MDS 2000 classifications by reviewing each MDS patient according to the classification. The WHO criteria classified the MDS patients into 36 with RA, 22 with RCMD and 33 with RAEB, whereas according to the MDS 2000 criteria there were 19 RAEB-I patients and 15 RAEB-II patients. Based on the WHO classification, the RCMD patients had higher platelet counts and percentages of blasts among BM cells than the RA patients (P=0.0018, P=0.0001). Twenty percent of the RA patients, 44.8% of the RCMD patients, and 70.8% of the RAEB patients had cytogenetic abnormalities. Among them, the poor karyotype was present in 6.7% of the RA patients, 21.0% of the RCMD patients and 41.6% of the RAEB patients. The rate of acute leukemia death was 14.3% in the RA patients, 67.7% in the RAEB patients and 50.0% in the RCMD patients. Analysis of survival times revealed significant differences between RA and RCMD patients (P=0.0482). The clinical features of RCMD patients were intermediate between those of RAEB and RA patients. There was no difference between the clinical features of the RAEB-I and RAEB-II patients in the MDS 2000 classification.View full abstractDownload PDF (585K)
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Kazuo TANAKA, Atsuko MIGITANI, Hirofumi TESHIMA, Youichi TATSUMI, Take ...2001 Volume 42 Issue 12 Pages 1170-1175
Published: 2001
Released on J-STAGE: July 28, 2009
JOURNAL RESTRICTED ACCESSWe report 2 cases of bronchus-associated lymphoid tissue lymphoma (BALT lymphoma), which is a rare disease. Patient 1 was a 76-year-old woman with a chief complaint of cough. Since plain chest radiography revealed an abnormal shadow in the hilum of the lung, she visited our hospital. Patient 2 was a 56-year-old man, who had been diagnosed as having pseudolymphoma at a medical check-up in a local hospital. During follow-up, however, he was referred to our hospital because of enlarged tumors and chest pain. In both patients, bronchofiberscopy demonstrated submucosal tumors and biopsy samples showed formation of lymphoepithelial lesions by centrocyte-like cells with a B-cell staining pattern. The patients were therefore diagnosed as having BALT lymphoma. Both received CEOP-E treatment, which improved the clinical symptoms but did not result in complete remission. The patients have been followed up after discontinuation of the medication. The progress of the disease has been slow, and both patients are alive as of September 2001.View full abstractDownload PDF (819K) -
Yoshimi HARADA, Yoko EGI, Yoshihide HONDA, Tsunemichi SHIROTA, Tohru H ...2001 Volume 42 Issue 12 Pages 1176-1180
Published: 2001
Released on J-STAGE: July 28, 2009
JOURNAL RESTRICTED ACCESSA 57-year-old woman was diagnosed as having monoclonal IgGκ gammopathy of undetermined significance with Sjögren syndrome. Five years later, she was admitted with an increased level of serum IgG and diagnosed as having multiple myeloma. After admission, fever and painful erythema developed. Combined chemotherapy with adrenal cortical steroid diminished the skin lesions. Erythema recurred during treatment with granulocyte colony-stimulating factor for neutropenia due to chemotherapy. A biopsy specimen from the skin revealed dense neutrophilic infiltration in the dermis, and a diagnosis of Sweet disease was made.View full abstractDownload PDF (515K) -
Teruyuki TAKAMATSU2001 Volume 42 Issue 12 Pages 1181-1186
Published: 2001
Released on J-STAGE: July 28, 2009
JOURNAL RESTRICTED ACCESSWe report a case of acute lymphoblastic leukemia (ALL) presenting as severe jaundice. The patient, a 59-year-old man, was found to have abnormal liver function, including an elevated total bilirubin level (13.5 mg/dl) with hepatosplenomegaly, but no detectable lymphadenopathy. A liver biopsy and bone marrow examination revealed a lymphoid neoplasm. Pathologic features included invasion of an abnormal clone into the sinusoidal region of the liver, diffuse bone marrow involvement (41.6% of all nucleated cells) and splenomegaly. Small numbers of malignant cells were also detected in the peripheral blood. B-cell markers, such as terminal deoxynucleotidyl transferase (TdT), CD10, CD19, CD20 and HLA-DR were positive, and CD2, CD3, CD4, CD5, CD7, CD8, κ, λ, cytoplasmic μ and myeloperoxidase were negative. Cytogenetic analysis detected hyperdiploidy. In this case, a dose-attenuated CHOP regimen attained complete remission. To date, preferential infiltration to liver sinusoids has been noted in hepatosplenic γ/δ T-cell lymphoma, other NK/T-cell malignancies, and some cases of hairy cell leukemia. Severe jaundice due to preferential infiltration of leukemic cells into liver sinusoids is rather uncommon as a presenting feature of ALL.View full abstractDownload PDF (597K) -
Takanori TOYAMA, Yoko KUBUKI, Hidenori SASAKI, Tomonori HIDAKA, Masash ...2001 Volume 42 Issue 12 Pages 1187-1191
Published: 2001
Released on J-STAGE: July 28, 2009
JOURNAL RESTRICTED ACCESSA 71-year-old woman was admitted for further examination of an increased serum LDH level. Abdominal ultrasonography and CT scan showed a large tumor in her spleen. Because malignant lymphoma was suspected, the spleen was removed for diagnosis and treatment planning. The histopathological and immunohistochemical features of the tumor indicated diffuse large B-cell lymphoma (DLBL). The flow-cytometric immunophenotype of the lymphoma cells was CD2-, CD3-, CD4-, CD5-, CD8+, CD10+, CD19+, CD20+, CD23-, κ+, λ-, CD25+, and CD56-. From these findings, the patient was diagnosed as having CD8+ DLBL. To our knowledge, this is the first reported case of primary splenic CD8-positive DLBL.View full abstractDownload PDF (624K)
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Hideo GOTO, Takehisa KIKUTA, Akira OTA, Hideharu TSUJI, Ryoshun HINO2001 Volume 42 Issue 12 Pages 1192-1194
Published: 2001
Released on J-STAGE: July 28, 2009
JOURNAL RESTRICTED ACCESSA 53-year-old woman was diagnosed as having idiopathic thrombocytopenic purpura (ITP) in 1990, and treated with prednisolone and splenectomy, which did not result in remission. In November 2000, gastrointestinal endoscopy showed superficial gastritis, and Helicobacter pylori infection was revealed by the rapid urease test and histologic examination. After eradication of Helicobacter pylori by amoxicillin, clarithromycin and lansoprazole, the patient's platelet count was increased from 24×109/l to 134×109/l and platelet-associated IgG (PAIgG) was decreased from 695 ng/107 cells to 33 ng/107 cells. This case suggests that eradication of Helicobacter pylori may be useful for treating some patients with refractory ITP.View full abstractDownload PDF (167K)
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