Rinsho Ketsueki
Online ISSN : 1882-0824
Print ISSN : 0485-1439
ISSN-L : 0485-1439
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Volume 44, Issue 12
Displaying 1-6 of 6 articles from this issue
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  • Chronic myelogenous leukemia in cessation of therapy after sustained CCR with interferon
    Kensuke USUKI, Yoshinobu KANDA, Kimiko IIJIMA, Seiko IKI, Hisamaru HIR ...
    2003 Volume 44 Issue 12 Pages 1161-1165
    Published: 2003
    Released on J-STAGE: July 28, 2009
    DOIhttps://doi.org/10.11406/rinketsu.44.1161
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    In Ph (+) CML patients who achieved complete cytogenetic response (CCR) with interferon-α (IFN) treatment, how long the treatment should be continued has not well been investigated. We report here 2 CML cases who stopped the treatment after CCR had been sustained with IFN for 2∼3 years. A 49-year-old male (case 1) achieved CCR 6 months after the initiation of IFN treatment. CCR had been maintained for 3 years, and then the treatment was ceased. CCR has been sustained without any therapy for 4 years. In this case, RT-PCR became negative half a year after achievement of CCR, and since then negative RT-PCR has been maintained. In case 2, a 50-year-old male, CCR was achieved after 8 years of IFN treatment, and maintained for 2 years. One month after cessation of the treatment, CML relapsed cytogenetically. In case 2, negative RT-PCR results were not maintained during the period of CCR. In case 1, the levels of T-cells for PR1 were undetectable in the peripheral blood.
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  • 3q21q26 syndrome with minor-BCR/ABL type Ph chromosome
    Kazuko HIRABAYASHI, Hirotaka KAWAKAMI, Hiroshi KODAIRA
    2003 Volume 44 Issue 12 Pages 1166-1171
    Published: 2003
    Released on J-STAGE: July 28, 2009
    DOIhttps://doi.org/10.11406/rinketsu.44.1166
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    A 77-year-old man was referred to our hospital because of elevated LDH and leukoblastosis in the peripheral blood in June 2002. Physical examination revealed neither hepatosplenomegaly nor superficial lymphadenopathy. A bone marrow film showed dysmegakaryocytopoiesis with many micromega-karyocytes and MPO-positive blasts appearing in 20∼30% of NCC. A diagnosis of MDS (RAEB-t) was made. Blastic cells were positive for CD13, 33, 34 and HLA-DR. Karyotypic analysis at diagnosis revealed 46XY, inv(3)(q21q26), t(9;22)(q34;q11) and minor-BCR/ABL chimeric m-RNA was detected by RT-PCR. Mild chemotherapy (low dose Ara-C etc) was given but the disease progressed to the AML stage with thrombocytosis in August. In September imatinib was given because of Ph positivity, but the effect was transient. In October massive leukocytosis with myeloblastosis was uncontrollable. In December 2002 the patient died of pneumonia, after a total course of 7.5 months. This rare case with Ph chromosome and 3q21q26 syndrome showed a poor prognosis as previously reported.
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  • Hodgkin lymphoma of the nasopharynx associated with a pituitary adenoma
    Hidenori TAKASHIMA, Kazuyuki KAWASHIMA, Yukihiro ISAYAMA
    2003 Volume 44 Issue 12 Pages 1172-1174
    Published: 2003
    Released on J-STAGE: July 28, 2009
    DOIhttps://doi.org/10.11406/rinketsu.44.1172
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    A 46-year-old man had a headache and a slight superior bitemporal contraction of the visual field with no lymphadenopathy. Magnetic resonance imaging showed a sellar mass and a tumor of the nasopharynx. After the nasopharyngeal tumor was resected, the patient was diagnosed as having lymphocyterich classical Hodgkin lymphoma at clinical stage IEA. He achieved complete remission after 3 cycles of ABVD therapy followed by involved field irradiation. After the radiotherapy, transsphenoidal resection of the pituitary tumor was performed and a diagnosis of non-functioning adenoma was established. This is the first report describing Hodgkin lymphoma of the nasopharynx associated with a pituitary adenoma.
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