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Volume 45, Issue 12
Displaying 1-7 of 7 articles from this issue
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[in Japanese]2004 Volume 45 Issue 12 Pages 1223-1232
Published: 2004
Released on J-STAGE: July 28, 2009
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[in Japanese]2004 Volume 45 Issue 12 Pages 1233-1240
Published: 2004
Released on J-STAGE: July 28, 2009
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Mutsumi TAKAHATA, Satoshi HASHINO, Fumie FUJISAWA, Takeshi KONDO, Syui ...2004 Volume 45 Issue 12 Pages 1241-1246
Published: 2004
Released on J-STAGE: July 28, 2009
JOURNAL RESTRICTED ACCESSEvaluation of minimal residual disease (MRD) provides prognostic information on various hematological malignancies. We describe here the prognostic efficacy of real-time quantitative polymerase chain reaction (RQ-PCR)-based analysis of major bcr/abl mRNA in cases of Philadelphia chromosome-positive leukemia (Ph-leukemia). Twenty-one patients with Ph-leukemia were enrolled as subjects to determine the usefulness of RQ-PCR-based measurement of bcr-abl/abl ratios. Imatinib mesylate (imatinib) was administered to seven of the 21 patients before allogeneic stem cell transplantation (SCT). Hematological relapse or failure of treatment with SCT was observed in 2 of those patients who showed bcr-abl/abl ratios of more than 0.002%, and 5 of the 7 patients showed both RQ-PCR and RT-PCR negativity immediately after SCT. All of the 5 patients who did not receive imatinib before allogeneic SCT showed RQ-PCR negativity immediately after SCT, but the results of RT-PCR were positive in 3 patients at the same time points, and those became negative after donor lymphocyte infusion or the appearance of graft-versus-host disease. Administration of imatinib before SCT was thought to induce an early remission. On the other hand, 8 patients who received imatinib without SCT showed a remarkable decrease in bcr-abl/abl ratios. The ratio gradually rose in one patient with Ph+ALL, enabling prediction of the hematological relapse preceding detection by fluorescence in situ hybridization (FISH) analysis. Standardization of RQ-PCR analysis of bcr-abl mRNA will help to predict early hematological relapse in patients with MRD. In conclusion, it is thought that measurement of RQ-PCR-based major bcr/abl mRNA in patients who were given imatinib and were treated with SCT is useful for the evaluation of MRD and in deciding additional treatment.View full abstractDownload PDF (313K)
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Kazuya TAKAHASHI, Kumiko GOI, Hiroki SATOU, Atsushi NEMOTO, Kanako UNO ...2004 Volume 45 Issue 12 Pages 1247-1251
Published: 2004
Released on J-STAGE: July 28, 2009
JOURNAL RESTRICTED ACCESSWe report a 6-year-old boy who was diagnosed as having neuron-specific enolase (NSE)-positive pro-T cell type lymphoblastic lymphoma preceded with a variety of symptoms such as skin rash, giant splenomegaly, and hyper-γ globulinemia. He first showed cervical lymphadenopathy in June 1999, followed by a fever of unknown origin with atypical erythema, hepatosplenomegaly, and a few lymphoblastoid cells present in the bone marrow in September. However, no specific treatments were started at this point because a cervical lymph node biopsy failed to show malignancy and the patient's signs and symptoms resolved spontaneously. Two months later, oral prednisolone therapy was started due to recurrence of the fever and erythema, but resulted in exacerbation of the skin lesions and generalized lymphadenopathy. A biopsy of the right inguinal lymph node performed in January 2000 revealed proliferation of lymphoblastic cells positive for CD3, CD5 and NSE with a rearrangement of T cell receptor gene Jδ, leading to the diagnosis of lymphoblastic lymphoma. After intensified chemotherapy, he received an autologous peripheral blood stem cell transplantation and has been in complete remission for 4 years.View full abstractDownload PDF (445K)
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—The associateion between the activity of Helicobacter pylori and platelet recovery—Kazuya SATO, Tadashi NAGAI, Kazuo MUROI, Norio KOMATSU, Keiya OZAWA2004 Volume 45 Issue 12 Pages 1252-1254
Published: 2004
Released on J-STAGE: July 28, 2009
JOURNAL RESTRICTED ACCESSWe investigated the prevalence of Helicobacter pylori infection and the effect of eradication therapy in patients with idiopathic thrombocytopenic purpura (ITP). H. pylori infection was found in 9 of 11 patients (81.8%). H. pylori eradication was obtained in all patients and significant platelet recovery was found in 5 of 9 patients (55.6%). One patient required reeradication therapy because the urea breath test remained positive after the first therapy. After complete eradication, long time remission was obtained. The results suggested that the platelet count might be correlated closely with the amount of H. pylori in some patients with H. pylori positive ITP.View full abstractDownload PDF (226K) -
Ako KIKUCHI, Hiroshi KAWADA, Yasunobu IWAKI, Shinichirou MACHIDA, Taka ...2004 Volume 45 Issue 12 Pages 1255-1257
Published: 2004
Released on J-STAGE: July 28, 2009
JOURNAL RESTRICTED ACCESSWe measured rituximab concentrations in the cerebrospinal fluid (CSF) in 2 patients with diffuse large B-cell lymphoma in whom central nervous system (CNS) invasion had developed. They received rituximab intravenously following irradiation therapy (patient no. 1) or along with chemotherapy (patient no. 2). The rituximab concentrations in the CSF were considered to be very low (0.2-0.6μg/ml), and could not be increased significantly by serial intravenous administrations of rituximab. The lymphoma relapsed in patient no. 1, and the combined therapy was not effective in patient no. 2. An alternative approach such as intrathecal administration of rituximab could be anticipated as a new therapeutic strategy for CNS lymphoma.View full abstractDownload PDF (218K)
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2004 Volume 45 Issue 12 Pages 1258-1268
Published: 2004
Released on J-STAGE: July 28, 2009
JOURNAL RESTRICTED ACCESSDownload PDF (627K)
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