Rinsho Ketsueki
Online ISSN : 1882-0824
Print ISSN : 0485-1439
ISSN-L : 0485-1439
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Volume 46, Issue 1
Displaying 1-4 of 4 articles from this issue
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  • Childhood acute lymphoblastic leukemia with t(1;19) lacking E2A-PBX1 chimeric transcripts
    Kousaku MATSUBARA, Takuya HIRATA
    2005 Volume 46 Issue 1 Pages 7-12
    Published: 2005
    Released on J-STAGE: July 28, 2009
    DOIhttps://doi.org/10.11406/rinketsu.46.7
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    We present a pediatric case of acute lymphoblastic leukemia (ALL) with chromosomal translocation 1;19 lacking E2A-PBX1 chimeric transcripts. On admission, the patient showed remarkable splenomegaly. Laboratory findings demonstrated that WBC was 12900/μl with blasts 61.5%. Bone marrow examination revealed 1282×103/μl of the nucleated cell count with 95.5% lymphoblasts. Surface marker analysis showed an early pre-B lineage immunophenotype (CD10+, CD19+, CD34+, surface Ig−). Although G-banding chromosomal analysis showed 46, XY, der(19) t(1;19)(q23;p13), E2A-PBX1 chimeric transcripts and E2A gene rearrangement were not detected with the polymerase chain reaction method and Southern blot analysis, respectively. The patient was assigned to high-risk ALL according to the criteria of the Japan Association of Childhood Leukemia Study. His clinical response to prednisolone monotherapy for the initial 7 days and subsequent multidrug chemotherapy was excellent, and he achieved complete remission on day 15, which has lasted for more than 30 months. We reviewed the bibliography of the clinical and biological features of 17 children with t(1;19)+E2A-PBX1− ALL including this case. The two prominent characteristics included an early pre-B immunophenotype (11/13) and hyperdiploid (>50 chromosomes) chromosome abnormality (8/14). However, there was substantial heterogeneity in the demographic features and prognosis. Further accumulation of such patients will facilitate the determination of the appropriate treatment for childhood t(1;19)+E2A-PBX1− ALL.
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  • Mantle cell lymphoma mimicking chronic lymphocytic leukemia
    Akitoshi HANAMURA, Masaya HAYAKAWA, Kazuyuki NAITO
    2005 Volume 46 Issue 1 Pages 13-18
    Published: 2005
    Released on J-STAGE: July 28, 2009
    DOIhttps://doi.org/10.11406/rinketsu.46.13
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    A 62-year-old male was admitted to our hospital complaining of dyspnea in March, 2002. He had remarkable bone marrow invasion with a significant number of leukemic cells, anemia and thrombocytopenia. In addition he had generalized lymphadenopathy including a bulky mass in the left cervix. Surface marker analysis of abnormal cells showed CD5+, 10-, 19+, 20+, 23+, and κ+, and immunohistochemistry revealed cyclin D1-positive cells. Chromosome analysis showed del(11q). The patient was diagnosed as having mantle cell lymphoma, stage IVB, and received combination chemotherapy. He could not obtain complete remission and died after 29 months. We found it very difficult in this case to make a differential diagnosis between mantle cell lymphoma and chronic lymphocytic leukemia. We report on this case and summarize the problem of the differential diagnosis.
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  • Clinical significance of anti-phosphatidylserine-prothrombin complex antibodies in antiphospholipid syndrome
    Junichi KABURAKI, Masataka KUWANA, Hideto KAMEDA, Tsutomu TAKEUCHI, Ju ...
    2005 Volume 46 Issue 1 Pages 19-21
    Published: 2005
    Released on J-STAGE: July 28, 2009
    DOIhttps://doi.org/10.11406/rinketsu.46.19
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    We clarified the clinical significance of IgG anti-phosphatidylserine-prothrombin complex (PS-PT) antibodies in the antiphospholipid syndrome (APS). The study population consisted of 122 patients with SLE and lupus-like disease. IgG anti-PS-PT antibodies were detected in 44% of 59 patients according to the diagnostic criteria by Harris and Hughes. This frequency was significantly (p<0.005) higher than the 14% seen in patients without APS. IgG anti-PS-PT antibodies were strongly (p<0.005) associated with thrombosis. In addition, IgG anti-PS-PT antibodies were positive in 64% of IgG β2-GPI dependent anti-cardiolipin antibody negative APS patients under the Sapporo criteria. The above findings indicate that IgG anti-PS-PT antibodies as well as β2-GPI dependent anti-cardiolipin antibodies should be examined in the diagnosis of APS.
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