Rinsho Ketsueki
Online ISSN : 1882-0824
Print ISSN : 0485-1439
ISSN-L : 0485-1439
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Volume 46, Issue 6
Displaying 1-10 of 10 articles from this issue
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  • Clinical course of 8 patients with intravascular large B-cell lymphoma diagnosed while alive
    Rika OHSHIMA, Naoto TOMITA, Kenji MOTOHASHI, Atsuko IEDA, Rie HYOU, Sh ...
    2005 Volume 46 Issue 6 Pages 453-457
    Published: 2005
    Released on J-STAGE: July 28, 2009
    DOIhttps://doi.org/10.11406/rinketsu.46.453
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    We retrospectively evaluated the diagnosis and clinical courses of 8 patients with intravascular large B-cell lymphoma (IVL) diagnosed while they were alive. The median age was 67 years old (range 54 to 82). Most complaints at diagnosis were fever or dyspnea. All patients were in clinical stage IV with B symptoms and 4 patients showed performance status 4. The diagnosis of IVL was confirmed by biopsy specimens from the bone marrow in 4, lung in 2, muscle, adrenal gland, and lymph node in 1 case, respectively. Initial bone marrow involvement was found in 6 patients. Chemotherapy was performed in 7 patients. Rituximab was added to chemotherapy in 5 patients. Though 5 patients are alive at the median follow up of 12.3 months, only 1 patient is in remission. Four of 5 patients treated with Rituximab relapsed. In suspicious cases, it is important to bear IVL in mind and examine bone marrow biopsies for an early diagnosis. In addition, it is suggested that Rituximab may play only a temporary role in the treatment of IVL.
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  • Diffuse large B-cell lymphoma with strongly positive MIB-1 stain and clinical features resembling Burkitt lymphoma
    Naoki WAKIMOTO, Motohiro MISUMI, Tomoya MAEDA, Tsuneyuki SHIMADA, Dais ...
    2005 Volume 46 Issue 6 Pages 458-462
    Published: 2005
    Released on J-STAGE: July 28, 2009
    DOIhttps://doi.org/10.11406/rinketsu.46.458
    JOURNAL RESTRICTED ACCESS
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    A 62-year-old woman was admitted to our hospital because of gastric mucosal bleeding. Gastroendoscopy revealed a gastric tumor which was diagnosed from the biopsied specimen as diffuse large B-cell lymphoma (DLBCL). Lymphoma cells had infiltrated the bone marrow showed morphological features resembling Burkitt lymphoma (BL). Nearly 100% of the cells in the bone marrow were positive for MIB-1 immunostaining. The chromosomal study was normal. Surface marker analysis disclosed that the cells were positive for CD10, CD19, CD20 and CD25. As lymphoma cells had infiltrated the central nervous system, combined chemotherapy was performed accompanied with intrathecal administration of anticancer drugs. Although transient improvement was observed, the patient died of the advanced disease three months after admission. As we have shown here, there are some cases of DLBCL with immunohistochemical features resembling BL. Further consideration about the appropriate chemotherapy program for this type of disease might be necessary.
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