Rinsho Ketsueki
Online ISSN : 1882-0824
Print ISSN : 0485-1439
ISSN-L : 0485-1439
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Volume 51, Issue 7
Displaying 1-19 of 19 articles from this issue
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Picture in Clinical Hematology No.46
The 70th Annual Meeting of the Japanese Society of Hematology
Special Award Received Lecture
The 71st Annual Meeting of the Japanese Society of Hematology
Symposium 1
Symposium 3
Symposium 6
Symposium 12
Case Reports
  • Secondary chronic myelogenous leukemia following postoperative TS-1 therapy for advanced gastric cancer
    Yoshiki UEMURA, Toshi IMAI, Takuya MACHIDA, Yasuo SHIMA
    2010 Volume 51 Issue 7 Pages 559-563
    Published: 2010
    Released on J-STAGE: August 05, 2010
    DOIhttps://doi.org/10.11406/rinketsu.51.559
    JOURNAL RESTRICTED ACCESS
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    A 78-year-old man received total gastrectomy for advanced gastric cancer in September 2006, and was subsequently treated with oral anti-metabolite TS-1 for 38 months. He had no evidence of recurrence of gastric cancer, although he had a continuous poor appetite due to TS-1. Leukocytosis was found in November 2008. On the basis of bone marrow findings, Philadelphia chromosome and BCR-ABL fusion gene, he was diagnosed as having chronic phase of secondary chronic myeloid leukemia (CML). Two weeks after starting imatinib therapy, skin eruption, palpebral edema and appetite loss were observed; moreover, thrombocytopenia gradually worsened. He stopped taking imatinib and hydroxyurea was subsequently started. The above symptoms disappeared and the platelet count normalized. CML is rare in secondary leukemia. Our case is the second reported case of secondary CML following TS-1 treatment and suggests that therapy for secondary CML should be selected on the basis of QOL in patients with advanced cancer.
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  • Primary neurolymphomatosis of the cervical nerve root
    Miyuki MIKI, Yasufumi MASAKI, Takuji NAKAMURA, Haruka IWAO, Akio NAKAJ ...
    2010 Volume 51 Issue 7 Pages 564-567
    Published: 2010
    Released on J-STAGE: August 05, 2010
    DOIhttps://doi.org/10.11406/rinketsu.51.564
    JOURNAL RESTRICTED ACCESS
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    A 74-year-old woman was admitted with muscle weakness and sharp pain in her upper limbs. On 18FDG-PET, abnormal accumulation was noted on both sides of the brachial plexus at the cervical spinal cord. A diagnosis of primary peripheral nerve neurolymphomatosis was made based on biopsy of the third cervical nerve. Following R-CHOP therapy, the abnormal accumulation of 18FDG-PET scan disappeared. However, disturbance of consciousness occurred 6 months later and recurrence as multiple brain tumors was detected. Although salvage chemotherapy was performed, the patient died of overwhelming sepsis. Primary peripheral nerve neurolymphomatosis is extremely rare. Early distinct diagnosis using 18FDG-PET and combination chemotherapy of rituximab and high dose methotrexate may improve the outcome for such patients.
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