臨床血液
Online ISSN : 1882-0824
Print ISSN : 0485-1439
ISSN-L : 0485-1439
7 巻, 5 号
選択された号の論文の12件中1~12を表示しています
綜説
臨床研究
  • 寺田 秀夫, 佐野 欣一, 河野 順子
    1966 年 7 巻 5 号 p. 434-439
    発行日: 1966年
    公開日: 2008/10/20
    ジャーナル 認証あり
    The changes of platelet and leucocyte counts in 15 healthy adults and one boy after the inoculation with influenza vaccine were studied. Platelet counts were calculated by Brecher-Cronkite's direct method.
    The major cases showed definite tendency of decrease in platelet counts from the time of 4 hours to 24 hours after each inoculation and in 6 of 16 cases the count did not recover to the initial value even after one week. On the contrary, leucocyte increased temporarily at 4 hours after inoculation.
    From the results mentioned above and the previously reported ones of rabbits which were injected living influenza virus intravenously and its vaccine intramusculary, influenza virus and its vaccine could be considered to damage platelets and induce thrombocytopenia.
  • (第2報:胃癌200例の臨床病理検査成績についで)
    原島 三郎
    1966 年 7 巻 5 号 p. 440-445
    発行日: 1966年
    公開日: 2008/10/20
    ジャーナル 認証あり
    To investigate the mechanism involved in the development of the anemia in gastric cancer cases, various clinical examinations were done in 200 cases of gastric cancer. Serum protein averaged 6.9 g per 100 ml and 13.8% of these cases showed lower serum protein level than 6.0 g per 100 ml. The red cell sedimentation rate showed slight acceleration in the early and marked acceleration in the end stage. The average value of icterus index in 146 cases, nonprotein nitrogen level in 52 and zinc-sulfate turbidity test in 146 were 10.0, 21.5 mg per 100 ml and 10.4 units respectively. Abnormality of the BSP retention was found in 39.5% of 147 cases and serum Takata reaction was positive in 20.0% of 165 cases. Urine urobilinogen was positively proved in 11.7% of 179 cases and protein present in 13.4% of 171 cases. Fecal occult blood reaction was positive in 80.1% of 158 cases and ovum of parasites were found in feces of 4.1% of 147 cases. Anacidity occured in 59.3%, hypoacidity in 27.1%, normoacidity in 10.2% and hypoacidity in 3.4% of 117 cases.
    Statistical analysis revealed significant correlation between the hemoglobin content and serum protein value. No definite correlation was found between the level of the hemoglobin content and icterus index or value of zinc sulfate test. The occult blood reaction in feces showed no significant correlation with hemoglobin content.
  • 西沢 一郎
    1966 年 7 巻 5 号 p. 446-452
    発行日: 1966年
    公開日: 2008/10/20
    ジャーナル 認証あり
    In the first report, it was revealed that the anemia of rheumatoid arthritis had a significant correlation to ESR and Stage of the disease in the group of above-50-years-old women.
    Accordingly, hemoglobin (Hb), Serum iron (SFe), serum total iron binding capacity (TIBC), serum copper (SCu) and serum total protein (TP) were measured in 44 cases of above-50-years-old female patients.
    The materials in this study were biassed to the patients having more intense inflammatory sign than the patients in the first report, because they were selected from the patients having intra-articular injections of corticosteroid hormone.
    Blood specimens were obtained between 10:00 a.m. and 12.00 a.m. and the results were compared with normal values under the same condition in consideration of the diurnal change.
    The average values of these specimens are shown in Table 3. Table 4 shows a significant decrease in Hb, SFe and TIBC, and a significant increase in SCu, as compared with the values of normal young women.
    The relation of these values to the state of the disease was analysed statistically (as shown in Table 5. 6. 7. 8. 9. 10.).
    It was revealed that the higher the ESR rose, the more marked appeared the feature of the infectious anemia as suggested by Wintrobe previously.
    On the contrary, as the S+age of the disease progressed, the blood changes had a tendency to show a feature of iron deficiency anemia, though there was no statistically significant proof except a negative partial correlation between Hb and Stage.
    Stage of the disease, which is classified mainly by the roentogenological findings of the affected joints, related closely to the duration of the disease and proved independent to ESR. (Table 8).
    There are some reports, which suggest that iron deficiency play a part in the anemia of rheumatoid arthritis. Thus the anemia of rheumatoid arthritis is considered to belong basically to an iron deficiency anemia which progresses as the Stage of the disease advances and which is modified by the inflammatory process adding the feature of infectious anemia.
  • 上田 文男, 柴田 常仁, 丹羽 滋郎, 加藤 義忠, 村瀬 俊策, 猪飼 通夫, 田島 明, 森島 巖
    1966 年 7 巻 5 号 p. 453-461
    発行日: 1966年
    公開日: 2008/10/20
    ジャーナル 認証あり
    A new potent antifibrinolytic agent, Transamin (4-aminomethylcyclo-hexane-1-carboxylic acid) was administered to cases with rheumatoid arthritis who received prolonged oral administration of steroid hormones and evaluated its anti-inflammatory action and its possible substitutional ability partial or complete with drawal of steroids as will as its reaction mechanism.
    1) The effect of Transamin on the prituitary-adrenocortical system was investigated by eosinophil counts after its intravenous injection, and with rheumatoid arthritis marked decrease of eosinophils was proved 1 to 2 hrsafter injection, which was restored to the initial level after 6 hrs.
    2) The efficacy was 72% in patients of rheumatoid arthritis as the steroid therapy could be successfully withdrawn in 8 of 11 cases. This drug was found more effective in cases with short-standing and relatively acute symptomes than in so-called termined cases.
    In successful cases its medication was accompanied with decrease of plasminogen or its proactivator and relative increase of antiplasmin.
    3) The urinary level of 17-OHCS and 17-KS was not lowered so evidently, after withdrawal of steroid hormones, but slightly elevated in some of the successful cases.
  • 浅川 英男
    1966 年 7 巻 5 号 p. 462-466
    発行日: 1966年
    公開日: 2008/10/20
    ジャーナル 認証あり
    Study on paraprotein using paper-, immuno-, and starch gel electrophoresis has been performed in 12 patients with myeloma and one with macroglobulinemia Waldensröm.
    Of these 12 cases of myeloma, 7 had IgG type serum abnormalities and 3 had IgA type. In 2 cases, the electrophoretic patterns showed one abnormal peak but Bence Jones protein was demonstrable in urine. Immunoelectrophoresis of the serum in one of these two cases revealed the presence of Bence Jones protein.
    Light chains were K-and L types in 6 cases respectively. The case of macroglobulinemia Waldenström had K type macroglobulin.
    The polymorphysm of paraprotein was demonstrated by starch gel electrophoresis.
症例
  • 滝野 辰郎, 谷口 正美, 馬場 道夫, 田所 久賢, 木村 政美, 猪谷 孟雄, 佐々木 輝雄, 高梨 忠寛, 近藤 元治, 阿部 達生, ...
    1966 年 7 巻 5 号 p. 467-471
    発行日: 1966年
    公開日: 2008/10/20
    ジャーナル 認証あり
    Eosinophilia is seen in various disorders, such as allergic diseases, parasitic infestation, Loeffler's syndrome, certain diseases of the hemopoietic system and some other diseases.
    We experienced a patient with extreme eosinophilia. Although family survey showed slight eosinophilia, it was insufficient to decide it as a familial anomaly. Under the diagnosis of idiopathic eosinophilia, a patient was treated with corticosteroid and revealed transient improvement, but eosinophilia again aggravated after the suspension of corticosteroid. With a reoperation of ileocoecal region for ileus symptom, eosinophilia was gradually improved and eosinophilic count maintained lower level. The histology of resected intestine showed marked eosinophile and macrophage infiltration.
    This case was considered to be intestinal allergic infiltration and the etiology of the eosinophilia was discussed.
  • 山口 潜, 野村 武夫, 千葉 一夫, 深須 新一郎, 井上 清
    1966 年 7 巻 5 号 p. 472-476
    発行日: 1966年
    公開日: 2008/10/20
    ジャーナル 認証あり
    A fifty-nine year old male, farmer, was admitted with the complaint of anemia in March 1965. Physical examinations revealed no jaundice, hepatomegaly or lymphadenopathy. Peripheral blood: normochromic anemia with leukoerythroblastosis. Bone marrow aspirations: dry tap. Urine: albuminuria without Bence Jones protein. Blood chemistry: total protein 10.9 gm/100 ml with 49.2 per cent of gamma globulin. Ferrokinetics: PIT 27.0 mg/day and RCIU 63.2 per cent; radioactivity was high over the liver and low over the spleen and bone marrow. Needle biopsy of the bone marrow: myelofibrosis. Surgical biopsy of the bone marrow: myeloma with myelofibrosis. Immunoelectrophoresis of the serum: γA myeloma. Roentgenogram of the bones: destructive changes. No effect of blood transfusions nor prednisolone. The patient died of serum hepatitis on September 22, 1965.
  • 阿部 敏尚, 斎藤 美恵子, 高橋 正年, 早川 隆, 堀内 篤, 肥後 理
    1966 年 7 巻 5 号 p. 477-481
    発行日: 1966年
    公開日: 2008/10/20
    ジャーナル 認証あり
    The patient was a 15-year-old, junior high school boy. His family and past history were non-contributory. He had an onset of lymphadenopathies at cervical region around September, 1964, and was admitted to hospital on October 29th because of enlargement of lymphnodes at axillar and inguinal regions.
    Physical examination on admission showed no sign of anemia, tonsil hypertrophy, hepatosplenomegaly, and several to more than ten, pea-to child fist sized lymphnodes were noticed at each region mentioned above. White blood cell count was 12500. Peripheral blood pictures showed 73.5% of lymphoid cell with nuclei and lymphatic leukemia was suspected from bone marrow smear pathological findings of lymphnodes. However, phase contrast microscopy showed cytoplasmic protrusions to each direction, but did not reveal the movement of “hand-miller-type”. Electron microscopy proved cells different from lymphocytes, but fibrous structure was not so marked in the silver impregnation stain of lymphnodes. From these findings the diagnosis of leukemic reticulum cell sarcoma was given. Temporary regressions of lymphnodes and hepatosplenomegaly were noted by endoxan and radiotherapy, although prednisolone was not responded.
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