臨床血液
Online ISSN : 1882-0824
Print ISSN : 0485-1439
ISSN-L : 0485-1439
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9 巻, 2 号
選択された号の論文の18件中1～18を表示しています
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第9回総会
特別講演
会長講演
シンポジウム：白血病細胞の組織化学
綜説
臨床研究
  • 後天性低線維素原血症の成因
    真木 正博, 佐藤 進
    1968 年 9 巻 2 号 p. 298-304
    発行日: 1968年
    公開日: 2008/10/20
    DOIhttps://doi.org/10.11406/rinketsu.9.298
    ジャーナル 認証あり
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    Basing on the fact that the digest products derived from fibrinogen were heat-labile, while those from fibrin were heat-stable, the techniques of differentiation between fibrinogenolytic state and intravascular coagulation with or without secondary fibrinolysis were presented by employing the thrombin clotting time and the immune assays. These techniques were indicated on 6 cases of obstetrical hemorrhage due to coagulation anomalies.
    A large amount of heat-labile digest products which might be derived from fibrin, the lowered levels in fibrinogen, Factor V and plasminogen were demonstrated in 3 of 6 cases, suggesting the patients as having hypofibrinogenemia due to intravascular coagulation with secondary fibrinolysis.
    Another case showed the almost same results with exception of fibrinogen level.
    Neither fibrinogen split products nor fibrin ones was detected in 1 of 6 cases, in spite of the lowered levels in platelets, fibrinogen, Factor V and plasminogen. This might indicate the hypofibrinogenemia was pure defibrination type.
    In the last case, a marked fibrinolytic activity was demonstrated on the thrombelastography, but her coagulation factors were entirely normal. The hemorrhage might be a results of thrombolysis which occurred in the injured vessels of the uterus.
    From the etiological view point, the indication and contraindication of antiplasmin therapy on the varieties of obstetrical hemorrhage were discussed.
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  • 本態性低色素性貧血の病態
    (I)鉄欠乏とビタミンE欠乏
    藤井 高明, 松本 幸三, 中田 功, 本津 浩一, 清水 宏
    1968 年 9 巻 2 号 p. 305-312
    発行日: 1968年
    公開日: 2008/10/20
    DOIhttps://doi.org/10.11406/rinketsu.9.305
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    The relationship between iron- and vitamin E deficiencies in the idiopathic hypochromic anemia was studied and the following results were obitained:
    1. Seventy-eight cases with idiopathic hypochromic anemia showed lower level of serum vitamin E, 0.88±0.16 mg/dl, determined by Rindi method, than that of 100 cases of normal adults, 1.25±0.12 mg/dl. Some cases with this anemia showed increase of the blood TBA (Thiobarbituric acid reaction) value and positive reaction of the dialuric acid hemolysis test.
    2. In those cases who showed good response to the treatment with iron preparation, apparent increase of serum vitamin E was observed, and in the relapsing cases the serum vitamin E level was depressed again at the recurrence. The cases with delayed response to this treatment, were proved to have transitory and labile increase of the serum vitamin E.
    3. The depression of serum vitamin E level in idiopathic hypochromic anemia appeared to have some causal relationship with iron-deficiency and endocrinological disturbance.
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  • 血液疾患における好中球アルカリホスファターゼ活性値およびその変動因子について
    篠田 敏男
    1968 年 9 巻 2 号 p. 313-317
    発行日: 1968年
    公開日: 2008/10/20
    DOIhttps://doi.org/10.11406/rinketsu.9.313
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    A) Neutrophil alkaline phosphatase activities (NAP) of 70 materials from 47 patients with various blood disorders were measured.
    Eleven cases with pancytopenia had normal or elevated NAP scores, and there was no demonstrable difference of NAP score between typical and atypical aplastic anemias.
    Of 4 cases with PNH, 2 cases with typical PNH showed low NAP scores, in the other 2 cases with aplastic PNH syndome NAP scores were elevated.
    In 7 cases with acute leukemia, NAP scores were varied from low to high.
    B) As there were two peaks in distribution of grade of NAP in CML and PNH, it is assumed that those diseases had two cell lines in neutrophils, while typical aplastic anemia one.
    C) Number of neutrophils and number of lobes of nuclei in neutrophils have no correlation with NAP score.
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  • 小児期悪性リンパ腫の白血化について
    伊勢 泰, 塙 嘉之
    1968 年 9 巻 2 号 p. 318-326
    発行日: 1968年
    公開日: 2008/10/20
    DOIhttps://doi.org/10.11406/rinketsu.9.318
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    Twenty-four children with malignant lymphoma have been presented.
    Leukemia developed in 12, or 93% of 13 children with lymphosarcoma, in 2, or 40% of 5 children with reticulum-cell sarcoma and one with Hodgkin's sarcoma of 6 cases with Hodgkin's disease.
    About a half of the cases with lymphosarcoma originated from the mediastinum, and in most of the cases leukemic transformation occurred in a relatively short course after the onset of the disease.
    Radiation therapy gave no leukemogenic effect to the patients with localized lesions.
    Leukemic lymphosarcomatosis could not be differentiated with acute lymphocytic leukemia on the clinical symptoms and even on cell morphology, nevertheless, the response to the chemotherapy was strikingly different between them: Response to the antileukemic agents was, in general, poor in the patients with leukemic lymphosarcomatosis.
    Relationship between cell morphology and sensitivity to the chemotherapy was discussed.
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症例
  • 6MPを使用した幼児特発性慢性栓球減少性紫斑病の1例
    富田 純正, 石川 昭, 寺田 秀夫
    1968 年 9 巻 2 号 p. 327-334
    発行日: 1968年
    公開日: 2008/10/20
    DOIhttps://doi.org/10.11406/rinketsu.9.327
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    One case of 5 years-old boy with ITP, in which a prolonged 6MP therapy revealed remarkable effects without any side effect, was reported. The steroid treatment would not bring out a complete remission and 6MP of 3.0∼1.5 mg dose daily was given for 102 days with total amount of 252.5 g in this case. After discontinuance of 6MP therapy, clinical hemorrhagic manifestations did not appeared more than 1 year.
    The etiology and therapy of ITP were reviewed in the literature.
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  • Macroglobulinemia Waldenströmの1例
    小川 哲平, 渡辺 清明, 篠田 敏男, 三藤 信, 外山 圭助, 中村 公一, 長谷川 彌人, 三方 淳男
    1968 年 9 巻 2 号 p. 335-342
    発行日: 1968年
    公開日: 2008/10/20
    DOIhttps://doi.org/10.11406/rinketsu.9.335
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    A 62-year-old male with macroglobulinemia Waldenström was reported.
    He had fatigue and easy bruising for four months and revealed generalized lymphadenopathy and hepathsplenomegaly.
    Laboratory examination showed accelerated ESR, positive Sia test and anemia. Lymphoid cells were 60 per cent of peripheral WBC and 47 per cent of bone marrow cells. Electron microscopic observation of these cells revealed a moderate development of roughsurfaced endoplasmic reticulum.
    Serum electrophoresis showed a sharp homogenous peak in the γ-region, 42.2 per cent of total protein. Immunoelectrophoresis demonstrated M-bow in the γM immunoglobulin. Ultracentrifugation revealed a 15.9S fraction constituting 16.4 per cent of the serum protein.
    At autopsy, marked hemorrhage was found in the skin, mucous membranes and serosa. It appears that the proliferative infiltration of reticulum cells which might have differentiated to the plasma cells and lymphocytes, was observed in lymph nodes, bone marrow, spleen, liver, kidneys, lungs, diaphragm, pericardium, epididymides and prostate gland.
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  • 長期生存した成人の急性白血病の1例
    天木 一太, 岩永 隆行, 早川 隆, 肥後 理, 岡本 雄二
    1968 年 9 巻 2 号 p. 343-347
    発行日: 1968年
    公開日: 2008/10/20
    DOIhttps://doi.org/10.11406/rinketsu.9.343
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    Although reports of acute leukemia cases with long-term survival were not rare, many of them were children. A case of acute lymphocytic leukemia in a 24-years old male controlled with anti-leukemic agents for two and a half years was reported. The diagnosis was confirmed by clinical manifestations, routine hematological examinations, phase contrast microscopy and electron microscopy.
    Two types of leukemic cells were differentiated electron-microscopically. One type, 5 to 7 μ in diameter, had the narrow cytoplasm with scanty organella in it and showed nuclear structure highly similar to that of mature lymphocytes. Another type, around 9 μ in diameter, had the fine nuclear structure with low electron density and large nucleoli. There were many transitional cells between these two types. Complete remission of five months' duration was obtained by treatment with steroid hormone at the first admission and he was followed up for two and a half years with combination therapy of steroid hormones and 6-mercaptopurine.
    Several factors relating to long-term survival of acute leukemia and the therapy of it were discussed.
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  • TrimethadioneおよびChloramphenicolに起因すると考えられる再生不良性貧血の各1例
    満谷 進, 岩野 莞爾, 平出 典, 井本 勉, 松本 秀敏
    1968 年 9 巻 2 号 p. 348-354
    発行日: 1968年
    公開日: 2008/10/20
    DOIhttps://doi.org/10.11406/rinketsu.9.348
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    Two cases of aplastic anemia induced by trimethadione and chloramphenicol administration were reported with special consideraton of pathogenesis.
    In one case, severe pancytopenia was developed after the administration of trimethadione and phenobarbital for about 9 months. The patient was cured through one year hospitalization. Clinical and laboratory findings including challenge tests suggested that the pathogenetic mechanism in this case was the direct toxic effect of trimethadione.
    In the second case, there was relatively acute bone marrow aplasia accompanied by high fever and severe hemorrhagic diathesis following chemotherapy for pneumonia. The patient was expired. Hypersensitivity reaction to chloramphenicol was suggested to be responsible for marrow aplasia in this case, on the basis of clinical and laboratory findings such as leukocyte agglutination test with the drug.
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