Gene expression profile of yeast in response to extremely low frequency electromagnetic fields (ELF-MF) wasinvestigated by means of DNA microarray.Sixty-seven ORFs were up-regulated and 122 ORFs were down-regulated.The
UBC4 gene was up-regulated.Ubc4p participates in the degradation of denatured proteins.This suggests thatdenaturation or premature of proteins may occur as a result of ELF-MF exposure.Interestingly,
RAD50, which isinvolved in DNA damage repair, is also induced by ELF-MF exposure.Moreover,
DPB11,
SLD3 and
PES4, which areinvolved in DNA replication by DNA polymerase ε, were down-regulated by ELF-MF exposure.
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