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Volume 27 (1975)
- Issue 6 Pages 449-
- Issue 5 Pages 405-
- Issue 4 Pages 315-
- Issue 3 Pages 169-
- Issue 2 Pages 83-
- Issue 1 Pages 1-
Volume 27, Issue 3
Displaying 1-6 of 6 articles from this issue
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Shigeki SHIBA, Haruhiko NISHIURA, Hiroshi FUJIMOTO, Haruki IKEDA, Hide ...1975 Volume 27 Issue 3 Pages 169-171
Published: May 01, 1975
Released on J-STAGE: October 11, 2011
JOURNAL FREE ACCESSChemotherapy is an ideal of the treatment of cancer, because in has possibilities of systemic treatment which causes neither organic nor functional injury, but now looking for the development of better drugs which are specifically effective against cancer cells, being less injurious to normal tissue.
In the treatment of uterine cervical carcinoma chemotherapy is also still far from practical use.
Bleomycin (BLM) is a hopeful drug which was discovered by Umezawa et al. in 1962 and introduced by Ichikawa et al. as a chemotherapeutic agent selectively effective for the treatment of uterine cervical carcinoma. Fujiwara et al., using 3H-labeled BLM (copper containing complex), studied the distribution of BLM by injecting to the mouse bearing experimentally induced uterine cervical carcinoma.
This paper discribes the fundamental studies both on incluing uterine cervical carcinoma in ICR mice by application of 20-methylcholanthrene and on observing incorporation of 14C-labeled BLM-A2, which is higher in stability of the specific radiactivity than 3H-BLM, into tumors and various organs after intravenous injection by measuring the radioactivity and the antimicrobial activity in them, and then examine the oncotropic characteristic of BLM. Evidence has been presented: A relatively large amount of BLM may be taked up selectively into squamous epithelium by intravenous injection and the percentage of active BLM may remain the highest in the skin, and next in the uterine cervical carcinoma besides the blood.View full abstractDownload PDF (2458K) -
Katsuma UEDA, Hisao SAKO, Hiroshi NAKAMORI, Motokazu HAYASHI, Shigefus ...1975 Volume 27 Issue 3 Pages 173-178
Published: May 01, 1975
Released on J-STAGE: October 11, 2011
JOURNAL FREE ACCESSFrom the point of view of transplantation immunity a successful intrauterine graft of genetically alien participants could never be explained without a peculiar mechanism in the usual mammals. This study was attempted to make the maternal cell-mediated immune status clear by the modified micro whole blood culture to phytohemagglutinin (PHA) technique and further by the microplate technique.
1) Change of maternal lymphocyte reactivity during the gestational period.
The lymphocyte reactivity to PHA in 150 pregnant subjects had a peculiar alteration in their response;significant elevation in the third trimester specially in the last gestational month in contrast with predominant reduction in the first trimester and gradual increase until lower limit of normal range in the second trimester.
2) Change of lymphocyte-subpopulation (T-cell, B-cell) during the gestational period.
The count of thymus derived lymphocyte (T-cell) per a unit blood volume which is responsible for cell-mediated immunity as a immunocompetent cell was similar to the pattern of PHAinduced lymphocyte reactivity as descrived above.
On the contrary, B-cell count showed to be inverse proportion with T-cell count.
It was concluded that pregnant individuals were maintained under the immunologically adaptive status and this characteristic alteration of maternal cell-mediated immunity referred to the change of lymphocyte-subpopulation such as T-cell and B-cell.
Such a rational change of maternal immune status seems to be prerequisite to the maintenance and immunological rejection (trigger factor of labor) of the fetus and its appendix.View full abstractDownload PDF (2631K) -
Takuma ETO, Tsutomu KITAGAWA1975 Volume 27 Issue 3 Pages 179-191
Published: May 01, 1975
Released on J-STAGE: October 11, 2011
JOURNAL FREE ACCESSThe activities of ATP-ase, cytochrome oxidase and succinic dehydrogenase were studied histochemically in the Wistar rat endometrium and the vicissitudes of their activities and localization were compared in proestrus, estrus and diestrus.
Clear microscopic findings were obtained which show marked cyclic changes of succinic dehydrogenase which have been reported to be difficult to be demonstrated by any histochemical procedures.
Further the influences of estradiol on the activities of the above-mentioned enzymes were studied histochemically by administering 0.05, 0.5, 5.0, 50, 500, and 5, 000 gamma, per body weight of estradiol, and some morphological findings which show marked changes of the localizations of the enzymes, especially those of succinic dehydrogenase, were also obtained.View full abstractDownload PDF (8640K) -
Shusei HIGASHIYAMA, Takeki IWASAKI, Yoshio NAKANO, Shuji KIZU1975 Volume 27 Issue 3 Pages 193-202
Published: May 01, 1975
Released on J-STAGE: October 11, 2011
JOURNAL FREE ACCESSThis report is concerned with the observation on the hormonal treatment of pelvic endometriosis. Hormonal treatment was indicated under the following conditions;(1) subsequent to conservative surgical operation (2) as pre-treatment to radical operation (3) as primary hormonal therapy in patients with subjective symptomes and with palpable findings. Patients with pelvic endometriosis were treated under the following protocol. Daily administration of a tablet which contained 5mg norethindrone and 0.05mg mestranol, was started from the 5th or 6th day of the cycle. When spotting occurred during the treatment, the dose of the tablet was increased up to maintenance dose of 20 or 30mg per day. The treatment lasted for 3 to 10 months. Effects of pseudopregnancy therapy to pelvic endometriosis were judged by the influence on the complaints and on the lesions.
Complete and incomplete regressions were obtained in 70% during or after this treatment. Differences in regression rate were recognized with the duration of treatment and with a total dosage of progestogen, and regression rate was high in patients whom the tablet was administered over a period of more than 150 days and over a total dose of more than 500mg of progestogen. Subsequent pregnancies occurred in 8 of 28 infertile patients (28.6%) in this series. One of the most important considerations in an evaluation of this therapy is the rate of recurrences after regression. It has been occurred in 8 of 28 patients to whom the treatment was effective. The major side effects were nausea, spotting, weight gain, elevation of GOT and GPT, and retation of BSP.View full abstractDownload PDF (1301K) -
Noboru NAKASHIMA, Kunitoshi KIDO, Noritune YAMADA, Susumu HAYASHI1975 Volume 27 Issue 3 Pages 203-207
Published: May 01, 1975
Released on J-STAGE: October 11, 2011
JOURNAL FREE ACCESSFor the treatment of anemia before the operation of uterine fibroma, fresh blood was transfused to a multiparous patient in whom blood transfusion has not ever been performed. As the result, shivering, fever, headache and sharp decrease of the leucocyte counts occured. Sharp and sudden leucocyte depletion which appears in the blood recipient is already known, and this is due to the reaction between leucocyte-antibodies of the blood donors and leucocytes of the blood recipient. Differing from this etiological cause, various laboratoty testings suggested the sharp depletion of leucocytes in this particular case on blood transfusion was brought about by the reaction between the leucocytes of donors and leucocyte iso-antibodies of the blood recipient which were produced in the serum during her past pregnancy. Thus, it must be noted that blood transfusion to a multipara, even without incompatibilities in the erythrocytic systems, could result in serious side effects because of the incompatibilities of the leucocytic system, which is attributable to the presence of leucocyte iso-antibodies produced during the past pregnancy.View full abstractDownload PDF (651K) -
Umio MIYAMOTO, Michio TAKAKI, Hideki AOCHI, Katuyuki HORIE1975 Volume 27 Issue 3 Pages 209-211
Published: May 01, 1975
Released on J-STAGE: October 11, 2011
JOURNAL FREE ACCESS410 cases of breech presentations were analysed statistically, compared with 1664 cases of cephalic presentations. It is concluded that breech presentations are more riskful for babies and mothers than cephalic presentations.View full abstractDownload PDF (381K)
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