All issues
Volume 27 (1975)
- Issue 6 Pages 449-
- Issue 5 Pages 405-
- Issue 4 Pages 315-
- Issue 3 Pages 169-
- Issue 2 Pages 83-
- Issue 1 Pages 1-
Volume 27, Issue 4
Displaying 1-5 of 5 articles from this issue
- |<
- <
- 1
- >
- >|
-
Etsuji OHSAWA1975 Volume 27 Issue 4 Pages 315-322
Published: July 01, 1975
Released on J-STAGE: October 11, 2011
JOURNAL FREE ACCESSThe newly developed non-steroidal drugs, cyclofenil was administered to anovulatory women, and clinical effects were evaluated endocrinologically in comparison with the other ovulationinducing drugs.
The following characteristic results were obtained.
1) Ovulation was induced successfully among 129 (47.8%) of the 270 anovulatory womenand among 180 cycles (47.7%) of the 377 therapeutic cycles.
2) Among the 187 ovulated women, 42 (22.5%) of them became pregnant and all the babies born were single, mature and full-term.
3) The drugs didn't influence on the BBT records of the regularly menstruating women.
4) As to the administration schedule, dose of 400mg in 10 days and 600mg in 5 days followed by 200mg in 10 days showed the best ovulation-inducing effect.
5) Measurement of urinary gonadotropin revealed that cyclofenil might act principally on the central nervous system. The drug possibly act on the hypothalamus at first and the pituitary in turn, and the release of LH-dominant gonadotropin was stimulated.
6) No serious side effects were observed during the period of administration.
7) The result of the present study suggests the possible role of cyclofenil in the treatment of anovulation, if the choice of anovulatory case is reasonable.
Thus, it might be concluded that the non-steroidal drug, cyclofenil could be the drug of the first choice in the treatment of anovulation.View full abstractDownload PDF (1043K) -
Etsuji OHSAWA1975 Volume 27 Issue 4 Pages 323-330
Published: July 01, 1975
Released on J-STAGE: October 11, 2011
JOURNAL FREE ACCESSThe mode of action of cyclofenil, one of the chemical inducers of ovulation was investigated by several animal experiments, and the following conclusions were obtained.
1) Both cyclofenil and clomiphene have an action of increasing the number of ova discharged.
2) In ovulating rats with PMS administration, cyclofenil increased the pituitary content of FSH and the release of LH into blood. In contrast, clomiphene also acted as a LH releaser although its effect was weaker and manifested earlier than that of cyclofenil.
3) Both cyclofenil and clomiphene have a dose dependent effect which enhances gonadotropic effect on the ovary. It appears that the optimum dose for such an effect varies according to the nature of the exogenously administered gonadotropin.
4) The activity of 3β-HSD, G-6-PDH, NAD- and NADP-diaphorase in the ovary was higher in hypophysectomized rats given cyclofenil than that in the control rats.
5) The distribution pattern of 14C-cyclofenil in various organs showed that the drug is taken up to a marked extent not only in central but also in peripheral organ, particularly in the ovary and the uterus.
Thus, cyclofenil showed not only a biological action on the hypothalamopituitary axis to promote gonadotropin release, but also a suspected direct action on the ovary to enhance the response of the gonad to gonadotropin.View full abstractDownload PDF (1143K) -
Toshiyuki SHIMURA1975 Volume 27 Issue 4 Pages 331-341
Published: July 01, 1975
Released on J-STAGE: October 11, 2011
JOURNAL FREE ACCESSUtero-tubo-ovarian units obtained from the cases of myomatous uteri or uterine tumor with pregnancy, or uteri with cancer were perfused in vitro. The detailed method of perfusion was already reported (Tojo et al. 1970, 1972, 1974). The perfusion medium was prepared with 100ml of blood, 25ml of Dextran and 350ml of Hanks solution. The pH of this medium was adjusted at 7.4 by sodium bicarbonate and oxygenated by 95% O2 and 5% CO2. Progesterone was extracted by the method of Jahansson and assayed by the competitive protein binding method with pregnant guinea pig's serum. The limit of sensitivity was 0.5ng. Progesterone was measured in various conditions.
1) Basic experiment for the perfusion of these units.
a) When progesterone was added to the perfusate and circulated without the unit, the progesterone concentration in the perfusate was almost constant for 3 hours.
b) When progesterone was exogenously injected into the unit, then the progesterone appeared very quickly in the perfusate and rapidly became undetectable.
2) Base line level of progesterone in various units. Progesterone was detectable only in the perfusate of the luteal phase or of pregnancy. In both cases, progesterone concentration was already high at 15 min of perfusion and then gradually decreased but still could be detectable at the end of 3 hours of perfusion. The concentration was higher in the units of pregnancy than in that of luteal phase. Progesterone was not detectable in the units of menstrual period, follicular phase and postmenopausal cases.
3) Perfusion of the units with hCG. 3, 000 to 30, 000IU of hCG were administerd to the various units. Then progesterone was markedly increased only in the unit of luteal phase and the lag time was within 3 min.
4) Perfusion of the unit with pregnenolone. When 40μg of pregnenolone was injected in the perfusate in the luteal phase, progesterone was increased promptly.
5) Perfusion of the unit with pregnenolone, and hCG. When 40μg of pregnenolone was injected at 90min and then 3, 000IU of hCG was administered to the units of luteal phase at 120min, it appeared that progesterone was increased.View full abstractDownload PDF (1224K) -
Minoru UEKI, Sonosuke DOI1975 Volume 27 Issue 4 Pages 349-354
Published: July 01, 1975
Released on J-STAGE: October 11, 2011
JOURNAL FREE ACCESSWe encountered 9 cases which revealed positive cytology and negative colposcopy and histology, and corresponded to 1.6% of all the cases of cervical cancer. Those cases were examined retrospectively by histology and cytology. While, on the other cases without carcinoma, the cervical region retained even by conebiopsy was measured.
Thus, an attempt was made to evaluate that cervical curettage might not be satisfactory in diagnosis of invisible early cancer and also cane biopsy was not without some problems, whether or not there had been some residual lesion, and whether conization had been perfectly done or not.
As a result, cytology is a most important diagnostic method in these cases and indication for surgery is preferably determined following cytology.View full abstractDownload PDF (2319K) -
Hiroshi URABE1975 Volume 27 Issue 4 Pages 355-358
Published: July 01, 1975
Released on J-STAGE: October 11, 2011
JOURNAL FREE ACCESSA few kinds of gynecological operations such as total hysterectomy, Caesarian Section, Manchester's operation for prolapse of uterus and etc. were devised as to the little changes of their operative arrangements.
The retrograde total hysterectomy is forwarded to the exposing part of the arteria uterina pouring a fluid of Bosmin into the fornix of the vagina without any ligation. The total hysterectomy with dividing procedure is easily performed with the little section. In the Caesarian Section the child's head is delivered by the use of forceps. And, for the prolapse of uterus (Manchester's operation) Tefron Tapes are used to protect the vaginal canal from its postoperative widening.View full abstractDownload PDF (5052K)
- |<
- <
- 1
- >
- >|