Various biochemical parameters, namely, urinary estriol as a parameter of function of the feto-placental unit; human placental lactogen (HPL), heat stable alkaline phosphatase (HSAP), leucine aminopeptidase (LAP), lactic dehydrogenase (LDH), β-glucuronidase (β-G) and copper as parameters of metabolic activity of the placenta;and α-fetoprotein (α-FP) as a parameter of function of the fetus were measured simultaneously, continuously with the progress of pregnancy and systematically in normal pregnant women and in patients with toxemia of pregnancy expecially at the later stage of pregnancy, and the dynamic state of each parameter was studied.
According to the classification by the Japan Society of Obstetrics and Gynecology, the diseases of these patients were divided into severe and mild ones. Further, mild toxemia was classified into 4 types, namely, hypertension type, edema-proteinuria type, edema type and proteinuria type.
The measured results of these parameters in edema or proteinuria type did not differ from those of normal pregnant women, but the measured values of estriol and hPL in hypertension type and in severe toxemia showed remarkable differences from those of normal pregnant women, and further the values of both parameters in hypertension type and in severe toxemia were evidently lower (P<0.05). Besides, the pattern of slow increase of the height of fundus of uterus measured at the same time, was extremely similar to the changing patterns of estriol and hPL in these disease types. In addition, the body weight of the fetus had a tendency to remain at a lower level and it was remarkable, especially in severe toxemia (P<0.05).
As the result, estriol, hPL and the height of uterine fundus were found extremely useful as parameters of function of the feto-placental unit in the clinical practice. Besides, a high-degree similarity among changing patterns of measured values of these 3 parameters and low values of the body weight of the fetus in hypertension type and in severe toxemia, suggested presence of a relationship between hypertension and toxemia of pregnancy, namely, a possibility of occurrence of angiospastic or angiosclerotic changes in utero-placental circulatory state in the above disease.
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