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Volume 32 (1980)
- Issue 6 Pages 509-
- Issue 5 Pages 437-
- Issue 4 Pages 327-
- Issue 3 Pages 211-
- Issue 2 Pages 115-
- Issue 1 Pages 1-
Volume 32, Issue 6
Displaying 1-5 of 5 articles from this issue
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Masumi SAWADA1980 Volume 32 Issue 6 Pages 509-526
Published: November 01, 1980
Released on J-STAGE: October 11, 2011
JOURNAL FREE ACCESSHuman yolk sac tumor of the ovary was transplanted in nude mice. The transplanted tumor cells had an ability to grow in this heterologous host, and produced a solid tumor, which we have designated as YST-1 tumor. 1. Histology of the YST-1 tumor showed microcystic, reticular and solid area and was similar to that of the original tumor taken from the patient, even after serially transplanted in nude mice. 2. Electron microscopic observation suggested that the YST-1 tumor cells had a high proliferative activity, and were germ cell origin. 3. Autoradiogram of tumor cells labeled with 3H-thymidine revealed that tumor cells in solid area had higher proliferative activity than those in microcystic area. 4. The prescnce of α-fetoprotein (AFP) in the cytoplasma of the YST-1 cells was demonstrated by immunofluorescent antibody staining using a antiserum against human AFP. AFP was localized mainly in microcystic area. 5. Human serum proteins and enzymes including album in, transferrin, α1-antitrypsin, alkaline phosphatase, lactic dehydrogenase and AFP were detected in sera of nude mice bearing YST-1 tumors. 6. Karyotype of YST-1 tumor was proved to be human type.
Chemotherapy of yolk sac tumor heterotransplanted to nude mice was studied. Anticancer drugs clinically known to be effective for ovarian cancer, such as Adriamycin, Carbazilquinone, 5-Fluorouracil, Cyclophosphamide, Mitomycin C, Chromomycin A3, Vinblastine, Bleomycin and Cis-platinum diammine dichloride were administered intraperitoneally to tumor-bearing nude mice. 1. The rapeutic effects were evaluated by tumor size and relative tumor size before and after experiments. Cis-platinum, Vinblastine and Bleomycin showed the significant effect arresting the growth of YST-1 tumor. 2. Histological evaluation of effects of chemotherapy for YST-1 tumor was performed. 3. Serum AFP of mice bearing YST-1 tumor showed close correlation with tumor size (r=0.93, P<0.001).
The usefulness of this experimental system for clarifying the characteristics and searching an effective clinical treatment of the human yolk sac tumor is discussed.View full abstractDownload PDF (12386K) -
Minoru TANAKA, Sumio YAMASHITA, Shimpei TOJO1980 Volume 32 Issue 6 Pages 527-538
Published: November 01, 1980
Released on J-STAGE: October 11, 2011
JOURNAL FREE ACCESSThe diagnosticr adioisotopiac ngiography in the clinicalm anagement of trophoblasticn eoplasia was studied by analyzing the patterns of radioisotope (RI)-dinamic curve obtained by processing sequential image with a computer, and an attempt was made to express numerically the size of tumors present in vivo. It was demonstrated that the total activitieosf RI in the abnormal phase of RI-dynamic curves in trophoblasticn eoplasiaw ere closelyc orrelatedw ith the sizeso f the intrauterinet umors actually restricted.
Analyzing the data more priciselyt, h e followingf actsw ere found;the totala ctivityo f RI was very closely correlated with size of tumor in the cases of invasive mole (r=0.9273 p<0.01);correlation was not noted between them in the cases of choriocarcinoma. Student's T-test was employed to evaluate whether or not each case of choriocarcinoma belong to the same population with in vasivemole. As a consequence, some belonged, but some did not. It was demonstrated that the case of choriocarcinoma belonging to the same population with invasivem ole were rich in lacuna formation in its histologicaalr chitecture.View full abstractDownload PDF (11861K) -
Goro TOSHISHIGE, Yasuyoshi MIYAMOTO, Akira KUBOTA1980 Volume 32 Issue 6 Pages 539-541
Published: November 01, 1980
Released on J-STAGE: October 11, 2011
JOURNAL FREE ACCESSVaginal hysterectomy can sometimes cause injury to the urinary tract among the injuriest o adjacent tissues and organs caused by erroneous surgical techniques.
Injuries to the urinary tract consist of those to the bladder and those to ureter.
A. Preventive Measures against InJuries to the Bladder
1. D. I. P. as a pre-operative test (Drip Infusion Pyelography)
2. Thorough catheterizationb efore operation
3. Confirmation of the lower end of the bladder
4. Intravenous injection of Indigocarmine solution after pre-operative catheterization
5. Injectiono f a large amount of physiologicals alines olutionc ontaining 0.0003 to 0.0005% epinephrine around the cervix
B. Preventive Measures against Injuries to the Ureter
1. D. I. P. as a pre-operative test
2. Our treatment of the uterine vessels
3. Precautions related to ligation and cutting of ovarian vessels
4. Precautions related to closure of the dissected end of the vagina after the hystercctomyView full abstractDownload PDF (3948K) -
Yoshiaki NISHIMURA, Masami YOSHIDA, Nobuya ANDO1980 Volume 32 Issue 6 Pages 543-548
Published: November 01, 1980
Released on J-STAGE: October 11, 2011
JOURNAL FREE ACCESSA case of inforior celosomla, born from a 31 years old multlpara, is reported in this paper. This woman was doing well in her pregnant course, although she was on drugs for threatened premature delivery in her eighth month gestation. Otherwise, no significant facors causign malformation was observed. The baby weight was 1, 945g and the Apgar's score was 9. The lower part of umbilical cord was swelled, showing exomphalos. The defect of pubic bone and abdominal wall in the region of nable to pubic bone was observed. Instead of these tissues, a cystic tissue mass, 8×10×6cm, was found. The cystic mass was covered with mucous membrane of cecum in the middle part and of urinary bladder in the bilateral regions, presenting the vesico-intestinal fissure. Morphologically, both ureters and small intestine opened on this cystic tissue mass. The duodenum was located intraperitoneally and the cecum was found as trace. Sigmoid colon and rectum were absent with ankyloproctiae. No external genital organ, testis or ovary was noted. Complication of oligodactylia was also observed.View full abstractDownload PDF (9891K) -
1980 Volume 32 Issue 6 Pages 549-626
Published: November 01, 1980
Released on J-STAGE: October 11, 2011
JOURNAL FREE ACCESSDownload PDF (23774K)
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