ADVANCES IN OBSTETRICS AND GYNECOLOGY
Online ISSN : 1347-6742
Print ISSN : 0370-8446
ISSN-L : 0370-8446
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Volume 35, Issue 3
Displaying 1-4 of 4 articles from this issue
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  • Statistical Study on the Prediction of Preterm Deliveries by the Scoring of Obstetrical Signs and Histories
    Norimasa SAGAWA, Tsuneo TAMAI, Takaaki NUNOTANI, Nobuya TATSUMI, Akira ...
    1983 Volume 35 Issue 3 Pages 229-235
    Published: May 01, 1983
    Released on J-STAGE: October 11, 2011
    DOIhttps://doi.org/10.11437/sanpunosinpo1949.35.229
    JOURNAL FREE ACCESS
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    The preterm delivery is the main cause of neonatal death. In the present investigation, the obstetrical signs such as uterine contraction, cervical dilatation, cervical effacement, station of the presenting part, genital bleeding, formation of forbag, and rapture of membranes were classified into four groups, viz. 0-3 points, and the total of these scores were corrected according to gestational ages, and other obstetrical histories and/or complications. Total score 7.2&plusmn;0.7(mean&plusmn;SEM, n=20) in patients who deliverd premature infants was significantlly higher than that (4.0&plusmn;0.5, n=61) in patients who had term deliveries.
    Approximately half of the patients who showed the corrected total score higher than 7 points resulted in deliveries of premature babies, while only 1 case out of 38 patients (3%) with scores less than 4 points resulted in a preterm delivery.
    From the results of the present investigation it was indicated that almost all of preterm labors which show total score lower than 4 points can be arrested by the treatment with rest and oral administrations of β-stimulant (isoxsuprine), and that patients who show scores higher than 7 points should be treated more intensively with β-stimulant more specific to β2-receptor than isoxsuprine, in combination with the administration of glucocorticoid to enhance the fetal lung maturation.
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  • Therapeutic Effect of Sulphide (Dogmatyl®) on Endometriosis
    Hiromu ONODA, Hisao SAKO, Yoshio OKAMOTO, Kazutaka HAMADA, Tadashi SUG ...
    1983 Volume 35 Issue 3 Pages 237-244
    Published: May 01, 1983
    Released on J-STAGE: December 02, 2011
    DOIhttps://doi.org/10.11437/sanpunosinpo1949.35.237
    JOURNAL FREE ACCESS
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    Sulpiride, a non-hormonal agent which induces hyperprolactinemia, is therapeutically effective in endometriosis since a secondary effect of the drug is anovulation or amenorrhea. We used sulpiride in the treatment on 15 female patients with endometriosis consisting of 7 who had conservative operation for endometriosis, 5 diagnosed as having endometriosis by physical examinations and laparoscopic findings or HSG, 2 with recurrent endometriosis after pseudopregnant therapy and 1 with hepatitis during pseudopregnant therapy.
    These patients were administered sulpiride in doses of 100 to 300mg/day for 90 to 200 days. Ten patients (66.7%) had amenorrhea and 12 (80%) had anovulatory cycle. In these patients, serum PRL concentration increased immediately after dosing and were maintained at about 200ng/ml, regardless of dose and duration. Serum gonadotropin levels were 10 to 20mIU/ml and LH surge was suppressed. Serum estradiol levels were as low as 45.2±16.9(±SD)pg/ml, i. e. similar to values in the early follicular phase and progesterone values were as low as 2.73±2.20pg/ml which confirms that they had anovulation. Of the 13 patients with dysmenorrhea, 10 (76, 9%) improved markedly and 1 of the 14 patients became pregnant after this treatment.
    These findings suggest that sulpiride is useful for the treatment of endomentriosis but theaction of the drug on endometriosis is due to hyperprolactinemia which causes anovulation or amenorrhea. The effect is assumed to be reversible.
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  • [title in Japanese]
    1983 Volume 35 Issue 3 Pages 261-285
    Published: May 01, 1983
    Released on J-STAGE: October 11, 2011
    DOIhttps://doi.org/10.11437/sanpunosinpo1949.35.261
    JOURNAL FREE ACCESS
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  • [title in Japanese]
    1983 Volume 35 Issue 3 Pages 287-318
    Published: May 01, 1983
    Released on J-STAGE: October 11, 2011
    DOIhttps://doi.org/10.11437/sanpunosinpo1949.35.287
    JOURNAL FREE ACCESS
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