巻号一覧
42 巻 (1990)
- 6 号 p. 683-
- 5 号 p. 575-
- 4 号 p. 467-
- 3 号 p. 289-
- 2 号 p. 171-
- 1 号 p. 1-
42 巻, 5 号
選択された号の論文の8件中1～8を表示しています
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川村 直樹1990 年 42 巻 5 号 p. 575-583
発行日: 1990年
公開日: 2011/07/05
ジャーナル フリーWe investigated the viability of cryopreserved ovarian tissue in rats. Ovaries were resected from immature female rats treated subcutaneously with 30 I.U. of PMS 2 days prior to resection. These were minced, washed, and divided into the following 4 groups : group A, cryopreserved with culture medium only ; group B, cryopreserved with culture medium containing 10% dimethylsulfoxide (DMSO) as a cryoprotectant ; group C, preincubated with LH (100mg/ml) for 120 min and cryopreserved with 10% DMSO ; and a fresh tissue group. Ovarian tissues of groups A, B, and C were cooled slowly, cryopreserved at-196°C for 14 days, and thawed rapidly in a 37°C water bath. Minced ovarian tissue (10mg) was then transplanted into the renal subcapsular site in female rats castrated 14 days before. In the first 8 days after transplantation, the positive rate of an estrogen effect on vaginal cytology was as follows : fresh, 80% ; A, 0% ; B, 21% ; C, 60% and non transplantation, 0%. After injection of 30 I.U. of PMS the rates became 100%, 0%, 88%, 80%, and 0%, respectively. Plasma estradiol levels on the 5th day after transplantation were 54±25, 22±8, 26±7, 43±18, and 15±9pg/ ml, respectively. After PMS stimulation, estradiol levels increased significantly in the fresh group and group B (84±29 and 47±11 pg/ml). Most of the transplanted ovarian tissue was necrotic in group A, but in the other groups follicular formation and luteinization were observed. These findings indicated that cryopreserved ovarian tissue in good condition can maintain its response to gonadotropins.抄録全体を表示PDF形式でダウンロード (6886K) -
clonogenic assay法を用いて藤田 宏行, 藤本 次良, 山本 宝, 岡田 弘二1990 年 42 巻 5 号 p. 585-592
発行日: 1990年
公開日: 2011/07/05
ジャーナル フリーTo investigate whether the growth inhibitory effect of progestogen is mediated via progestogen receptors (PgR), a clonogenic assay was performed with Ishikawa cells, which originate from well differentiated endometrial cancer and produce PgR. The colony-formation of dispersed Ishikawa cells was inhibited by 10-6M medroxyprogesterone acetate (MPA), but not by 10-6M norethindrone (ENT) or RU-486, an antiprogestogen agent. There was no significant difference in the colony-formation between cells treated with MPA alone and those treated with MPA combined with either ENT or RU-486, both of which have high affinity to PgR as does MPA. These findings indicate that the effect of MPA is independent of PgR. The inhibition rate of colony-formation of dispersed Ishikawa cells was more than 30% with MPA, progesterone, 5 β-pregnane-3, 20-dione, 17 α-hydroxy -progesterone caproate and megestrol acetate, whereas it was less than 30% with 5 α -pregnane-3, 20-dione, norethindrone and norgestrel. These results indicate that cancer growth inhibition by progestogen does not parallel progestational activity, and that the 5 β-pregnane nucleus with 3, 20 oxygen function may be involved in the growth inhibitory effect抄録全体を表示PDF形式でダウンロード (1093K) -
切迫早産妊婦の管理より阪井 胖, 冨沢 明子, 小林 八郎, 浜西 正三, 岩井 敏子1990 年 42 巻 5 号 p. 593-602
発行日: 1990年
公開日: 2011/07/05
ジャーナル フリー1. i) In threatened premature labor, viewed from a uterine contraction wave and a subjective complaint obtained by means of a cardiotocogram, B waves and L waves were observed in many cases when the patient complained of a lower abdominal pain and/or lumbago.
With these pains, or with a complaint of abdominal distension, the threatened premature labor is possible, and an objective evaluation of uterine contractions by means of the cardiotocogram is necessary.
The uterine contraction was recorded with a cardiotocogram.
The recorded waves were evaluated by Nakae's classification (1978), and given points for each wave : 1 point for A wave, (31-60 sec), 1.5 point for B wave (61-180 sec).
ii) From this study, as a prime therapeutic factor, the wave of uterine contractions with less than two contractions (A and/or B waves) in 30 minites, i.e. below 3 points of contraction is provided.
2. Correlativity between these points and lower abdominal pain and lumbago is heightened and subjective complaints are increased as the point of uterine contraction becomes larger.
3. In the case of 4 points of contraction or more, subjective complaints with lower abdominal distension, lower abdominal pain and lumbago were considerably increased.
4. In the case of uterine contractions with more than 7 points having such pains as lower abdominal pain and lumbago, the patient was prematurely delivered at a relatively earlier time.
5. The uterine contraction, one of the four factors in Tocolytic Index (T.I.) (Baumgarten, 1974) which is frequently used in foreseeing pre-term delivery mentions just irregular or regular. To assure more concrete determination, we studied the uterine contraction points in order to apply them to T.I.抄録全体を表示PDF形式でダウンロード (3876K) -
伊熊 健一郎, 山崎 ひろみ, 山田 聖, 小松 敏也, 太子 やえ, 竹村 正1990 年 42 巻 5 号 p. 603-611
発行日: 1990年
公開日: 2011/07/05
ジャーナル フリーPlacental site trophoblastic tumor (PSTT) was found in a 44-year-old woman, gravida 4 para 2, 9 years after an induced abortion. To date, a total of 76 cases of PSTT have been reported in the literature, and in at least 13 cases the tumor showed aggressive behavior.
Pathological examination after total abdominal hysterectomy revealed a tumor occupying the cervical canal of the uterus. Immunohistochemical staining techniques with hPL and hCG demonstrated the intermediate trophoblasts.
The postoperative course was uneventful, and the patient has remained well without evidence of the disease and negative titers of tumor markers for the past 18 months.抄録全体を表示PDF形式でダウンロード (10667K) -
辻 雅路, 木村 順治, 佐々木 純一, 細田 修司1990 年 42 巻 5 号 p. 613-618
発行日: 1990年
公開日: 2011/07/05
ジャーナル フリーWe report 4 cases of idiopathic thrombocytopenic purpura in pregnancy. Two were refractory to treatment with corticosteroid and responded poorly to high doses of gamma-globulin therapy. Therefore, fresh blood and/or platelet transfusion was needed to elevate the platelet count in order to lower the risk of maternal intracranial hemorrhage before and at the time of delivery. Of these two patients, one delivered artificially an extremely premature female infant at 29 weeks of gestation, and the other delivered a normal female infant by cesarean section at 37 weeks of gestation. The third patient had a spontaneous remission at 30 weeks of gestation and delivered a normal female at 38 weeks of gestation. The fourth patient conceived during a clinical remission after splenectomy and delivered a normal male infant at 39 weeks of gestation. None of the neonates were affected by neonatal thrombocytopenia.抄録全体を表示PDF形式でダウンロード (763K) -
中川 昌子, 平 省三, 小林 真一郎, 別所 健史, 竹村 正, 礒島 晋三, 大歳 健一, 垣下 栄三1990 年 42 巻 5 号 p. 619-625
発行日: 1990年
公開日: 2011/07/05
ジャーナル フリーAcute fatty liver of pregnancy (AFLP) is one of the diseases which occur mainly in the third trimester of pregnancy and has a grave prognosis. It is difficult to distinguish AFLP from virus hepatitis by clinical symptoms alone. The diagnosis of AFLP requires histologic examination, but typical histologic findings are rarely clear in the early stage when pregnancy can be terminated and the clinical outcome is relatively good. We report here two cases of AFLP suspected from the clinical findings. In both cases the mothers survived without fetal death thanks to prompt caesarean section. Liver biopsies were done during the recovery period in both cases, so typical histologic findings of active disease were not observed. This shows that hepatic cells probably recover relatively early. We emphasize the importance of early diagnosis of AFLP and prompt termination of pregnancy for the health of both mother and fetus.抄録全体を表示PDF形式でダウンロード (4638K) -
有澤 正義, 益弘 和雄, 今井 史郎, 末原 則幸, 中山 雅弘1990 年 42 巻 5 号 p. 627-633
発行日: 1990年
公開日: 2011/07/05
ジャーナル フリーThe phenotype characteristics and prenatal diagnosis of trisomy 18 have been well described. The purpose of this paper is to describe the clinical and ultrasound findings of 4 cases with typical abnomalities in trisomy 18.
The following abnormalities were observed during ultrasound examinations :
Case 1. Intrauterine growth retardation, overlapping fingers, and rockerbottom feet (typical clinical findings in trisomy 18 and omphalocele).
Case 2. Typical clinical findings in trisomy 18 and radial aplasia.
Case 3. Typical clinical findings in trisomy 18, double-outlet right ventricle and cerebellar hypo-plasia.
Case 4. IUGR, rockerbottom feet, broad thumb, and holoprosencephaly. Prenatal diagnosis by ultrasound examinations of cases 1, 2, and 3, were trisomy 18, and that of case 4 was a bad prognosis anomaly.
These results suggest that ultrasound examination is useful for prenatal diagnosis of trisomy 18 and we should further study trisomy 18 and its abnomalities.抄録全体を表示PDF形式でダウンロード (12612K) -
1990 年 42 巻 5 号 p. 663-676
発行日: 1990年
公開日: 2011/07/05
ジャーナル フリーPDF形式でダウンロード (5835K)
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