巻号一覧
42 巻 (1990)
- 6 号 p. 683-
- 5 号 p. 575-
- 4 号 p. 467-
- 3 号 p. 289-
- 2 号 p. 171-
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42 巻, 6 号
選択された号の論文の4件中1～4を表示しています
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植田 政嗣, 岡本 吉明, 山田 隆司, 清木 康雄, 御前 治, 鶴長 建充, 岩井 恵美, 福田 吉彦, 前田 洋一, 植木 実, 杉本 ...1990 年 42 巻 6 号 p. 683-691
発行日: 1990年
公開日: 2011/07/05
ジャーナル フリーA new human cell line designated OMC-6 was established from a tumor of an endometrial stromal sarcoma. OMC-6 was successively subcultured 25 times in about 2 years.
The monolayer cultured cells appeared to be non-epithelial with prominent nucleoli and tendency to pile up without contact inhibition. Electronmicroscopically, cultured cells contained small mitochondria, dilated rough ER and abundant lysosomes. The population doubling time was 160 hours, the saturation density was 6.1×104 cells/cm2, the plating efficiency was 8.5 % and the mitotic index was 3.0 %. Chromosome studies showed aneuploidy with a modal number of 40 and abnormal karyotype pattern. Transplanted tumor into the back of nude mice resembled the original tumor histologically. The OMC-6 cells produced TPA in culture media and the accumulated TPA titer in 25 days was 611 U/L. TPA was also demonstrated immunocytochemically in cultured cells.
This original TPA producing cell line (OMC-6) may be quite useful for studying biological characteristics of endometrial stromal sarcoma and for obtaining basic information for its management.抄録全体を表示PDF形式でダウンロード (8919K) -
沢田 重成, 山本 宝, 藤田 宏行, 伊藤 良治, 保田 仁介, 岡田 弘二1990 年 42 巻 6 号 p. 693-698
発行日: 1990年
公開日: 2011/07/05
ジャーナル フリーChemotherapy is rather more effective for choriocarcinoma than for most other cancers. Etoposide (EP), a podophyllotoxin derivative, is an increasingly used drug in cancer medicine. It has been used mostly intravenously, although the consequences of oral administration are not as serious as those of injection, and oral administration is rather effective for an asymptomatic patient. We treated a case of choriocarcinoma with vaginal and lung metastasis with daily oral EP and examined clinical effect. The patient was a 46-year-old woman, who delivered her last baby at full term in 1978. Abnormal vaginal bleeding was noted in November, 1988. Intrauterine curettage was performed, and suspected incomplete abortion. However, since bleeding continued, a vaginal biopsy was performed and metastatic choriocarcinoma was diagnosed. She received 2 courses of a 21-day schedule of oral EP (50 mg/m2/day). HCG levels decreased markedly and no side effect was obserbed.抄録全体を表示PDF形式でダウンロード (2840K) -
1990 年 42 巻 6 号 p. 713-774
発行日: 1990年
公開日: 2011/07/05
ジャーナル フリーPDF形式でダウンロード (22764K) -
1990 年 42 巻 6 号 p. 777-799
発行日: 1990年
公開日: 2011/07/05
ジャーナル フリーPDF形式でダウンロード (7360K)
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