ADVANCES IN OBSTETRICS AND GYNECOLOGY
Online ISSN : 1347-6742
Print ISSN : 0370-8446
ISSN-L : 0370-8446
Volume 43, Issue 1
Displaying 1-6 of 6 articles from this issue
  • Yoshio ITANI
    1991 Volume 43 Issue 1 Pages 1-10
    Published: January 01, 1991
    Released on J-STAGE: July 05, 2011
    JOURNAL FREE ACCESS
    Phosphoinositide-specific phospholipase C (PLC) was partially purified as three fractions (PLC 1, 2 and 3) from gestational human myometrium homogenate by a series of centrifugation, dialysis and high performance liquid chromatography. These fractions varied in their apparent molecular weigh, affinity to anion exchanger but showed similar Ca2+ dependence and pH profile. At a concetration of 10-6M progesterone, estrone or estriol suppressed phosphatidyl inositol 4, 5-bisphosphate (PIP2) hydrolyzing activity of PLC1 and PLC3 to 52-92% of control. The same concentration of dehydroepiandrosterone sulphate stimulated the activity of PLC3 slightly. These findings indicate the presence of direct effects of these gestation related steroids on excitation-contraction (E-C) coupling in myometrium through the inhibition of PLC s in PI response pathway, suggesting dissociation of the E-C coupling by this inhibition as a possible mechanism for hormone-suppressed myometrial contraction during pregnancy.
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  • Yuichiro NAKAI, Tadahiro TAKEBAYASHI, Shigeki MATSUO, Motoharu IMANAKA ...
    1991 Volume 43 Issue 1 Pages 11-17
    Published: January 01, 1991
    Released on J-STAGE: July 05, 2011
    JOURNAL FREE ACCESS
    The umbilical artery, the fetal descending aorta and the fetal middle cerebral artery were examined by Doppler flow velocimetry for a total of 125 times in 109 normal pregnant women who ranged from the 24th to 41 st gestational week. Then a pulsatility index (PI) and a resistance index (RI) were calculated from blood flow velocity waveforms in each vessel. Moreover, we calculated the ratio of the descending aorta to the middle cerebral artery (DA/MCAratio) and the ratio of the umbilical artery to the middle cerebral artery (UA/MCAratio) for each index for further evaluation of fetal circulation. In the statistical evaluations, an unpaired t-test was used for comparisons.
    As far as the umbilical artery was concerned, PI declined from 1.23±0.13 (mean±SD) to 0.88 ±0.13 (p< 0.001) from the 24th to the 33rd week, and after the 34th gestational week, kept almost the same value. RI of the umbilical artery also showed the same pattern as PI ; that is, it decreased from 0.699±0.039 to 0.585±0.062 (p <0.001) from the 24th to the 33rd week and no remarkable changes were observed after the 34th week of gestation.
    No remarkable changes were observed in PI and RI of the fetal descending aorta through the pregnancy course after the 24th week, while indices in the fetal middle cerebral artery showed more complex changes. From the 24th to 29th gestational week, both PI and RI values increased from 2.29 ± 0.30 to 2.34±0.40, and 0.863 ±0.058 to 0.904±0.072, while they continuously decreased thereafter to 1.26 ±0.25, 0.655 ± 0.070 (p<0.001) at the 40th-41st weeks of gestation respectively.
    DA/MCA ratios of PI increased from 0.765±0.050 to 1.076±0.236 (p < 0.001) from the 24th to 41 st gestational week. DA/MCA ratios of RI declined slightly from 0.943±0.054 to 0.911±0.077 from the 24th to 29th week, while thereafter they increased linealy up to 1.261 ±0.139 (p<0.001) at the 41 st week of gestation. UA/MCA ratios of PI and RI decreased until the 33rd week of gestation, and they turned to increase after the 34th week.
    These findings suggest that changes in the fetal circulation and blood flow distribution reflect closely fetal physiological growth. Hence, such factors as fetal acidosis or insufficient feto-placental circulation and/or fetal growth retardation may be detected by means of Doppler flow velocimetry.
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  • Changes in sex steroid hormone secretion and receptor levels in the endometrium of patients with “luteal insufficiency”
    Masayoshi NAKANO
    1991 Volume 43 Issue 1 Pages 18-27
    Published: January 01, 1991
    Released on J-STAGE: July 05, 2011
    JOURNAL FREE ACCESS
    Successful implantation requires a well-developed and well-functioning endometrium. Improper growth of the endometrium may be one of the causes of infertility. In this study, we measured serum estradiol (E2) and progesterone (P) levels in eighty-one infertile women and obtained endometrial tissue for histological dating. In addition, estrogen receptor (ER) and progesterone receptor (PR) were stained with an immunohistochemical method using monoclonal antibodies in twenty endometrial tissue specimens.
    Seventeen patients had low P levels in the mid-luteal phase (<10 ng/ml). Sixty-four patients had normal P levels (≥10ng/ml).
    Twenty-four of the latter patients (24/64) had out-of-phase endometrium. Furthermore, nuclei were positively stained for ER and PR. ER staining disappeared in 69% (9/13) of the patients with in-phase endometrium. On the other hand, all patients (7/7) with out-of-phase endometrium still had positive ER cells in the mid-luteal phase. These findings indicated that there is an abnormality of ER turnover in patients with “endometrial insufficiency”.
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  • Yoshiaki YAMAMOTO, Yoshiki TAKAHASHI, Akiko YAMAMOTO, Tatsuya ISHIGURO ...
    1991 Volume 43 Issue 1 Pages 28-32
    Published: January 01, 1991
    Released on J-STAGE: July 05, 2011
    JOURNAL FREE ACCESS
    Diagnostic second-look operations were performed on 45 patients with primary epithelial ovarian cancer, and the diagnostic value of the operation was evaluated by multivariate analysis (JUSE-QCAS/ MA1 program). Sufficient chemotherapy was administered prior to the second-look operation to 26 of 45 patients. The finding “recurrent tumor” was the criterion variable. The following findings appeared to be predictor variables : “age”, “clinical stage”, “histological type”, “chemotherapy”, “residual tumor after primary operation”, “findings of the second-look operation”, “lymph node metastasis”, “amount of ascitic fluid”, and “peritoneal dissemination”. The data showed that the findings at the time of the second-look operation after chemotherapy could not provide more useful informations than the clinical stage, in evaluating the prognosis. Second-look operations were of diagnostic value only in stage III ovarian cancer. It is advised that the operation must be performed only in cases without apparent relapse.
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  • Hirosumi IMOTO, Shinsuke OKAMURA, Takashi YAMADA, Yoshiaki OKAMOTO, Mi ...
    1991 Volume 43 Issue 1 Pages 33-37
    Published: January 01, 1991
    Released on J-STAGE: July 05, 2011
    JOURNAL FREE ACCESS
    Skull metastases from the uterine cervical cancer have been rarely reported. We present a case in this report.
    A 44-year-old patient with stage II b uterine cervical cancer received radical hysterectomy with regional lymphadenectomy in The Hospital of Osaka Medical College on Mamch 5, 1986. The operation, however, was incompletely performed due to advanced matastasis to the left side pelvic lymph node. Subsequently, she was treated with radiation therapy and also BMF chemotherapy. 2years later she was admitted to our hospital due to head tumor in the left parietal portion on May 1988. Several examinations revealed that it was metastasis from uterine cervical cancer. The tumor was removed and the histology showed squamous cell carcinoma strongly suggesting of a skull metastasis from the uterine cervical cancer.
    In this case, we reviewed the pertinent literature and discussed the mechanisms of Metastasis.
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  • Yoshiya ANDO, Ikuko SHIMAMOTO, Motohiko ICHIJYO, Naoyuki SHIMOZATO, Hi ...
    1991 Volume 43 Issue 1 Pages 38-44
    Published: January 01, 1991
    Released on J-STAGE: July 05, 2011
    JOURNAL FREE ACCESS
    Twenty-five female patients with genital herpes were treated with oral acyclovir 200mg five times daily for five days to evaluate the efficacy and safery of this treatment.
    Sixteen patients had a primary episode and the remaining nine had recurrent episodes. Viral identification was carried out in fourteen patients. In four patients the cause was herpes simplex virus type 1 (primary : recurrent, 3 : 1). In the remaining ten herpes simplex type 2 was isolated (5 : 5). The overall efficacy of treatment was 87.5% (14/16) in patients with primary episodes and 100% in recurrent cases. Only one adverse effect (mild stomachache) was recorded by one patient. At the end of treatment. herpes simplex virus antigen was not detected in any patients. Oral acyclovir at a dose of 200mg five times daily is an effective treatment for primary and recurrent genital herpes.
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