Synopsis The incidence of primary tubal carcinoma is very rare in gynecological malignant tumors. We report here three cases of primary tubal carcinoma treated at Hyogo College of Medicine. From 1984 to 1993, the relative frequency of the tubal carcinoma was 0.70% (3/430). The mean patient age was 58.3 years. None of the patients were nulligravida. On their first visit to our hospital, their complaints were of lower abdominal pain and/or atypical genital bleeding. Their treatment consisted of an operation follwed by cisplatin-based chemotherapy. In two cases with postoperative stage III c, the CAl25 level in their sera was high, while in a patient with stage Ia, it was within normal limits. One of the patients, because of severe side effects, was not treated with a sufficient dose of cisplatin, and died of the disese 7years after the operation. Others showed no recurrent signs after the operation, for more than 10 years and 2.5 years respectively. These findings suggest that in a patients diagnosis, careful consideration should be given to primary tubal carcinoma, even though the incidence of the disease is very rare. Checking the patients CAl25 level might be helpful in the diagnosis of advanced primary tubal carcinoma. After maximal tumor reduction, cisplatin -based chemotherapy should be considered, to achieve higher survival rates in patients with advanced primary tubal carcinoma. [Adv Obstet Gynecol 48 (3); 177-182, 1996 (H8.5)]
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