ADVANCES IN OBSTETRICS AND GYNECOLOGY
Online ISSN : 1347-6742
Print ISSN : 0370-8446
ISSN-L : 0370-8446
Volume 48, Issue 3
Displaying 1-8 of 8 articles from this issue
  • Kyousuke TAKEUCHI, Noriyuki OHARA, Matsuto MOCHIZUKI, Yasuo UEDA
    1996 Volume 48 Issue 3 Pages 169-172
    Published: May 01, 1996
    Released on J-STAGE: September 27, 2010
    JOURNAL FREE ACCESS
    To assess the effect of maternal hyperglycemia on calcium metabolism in an animal model, we evaluated calcium homeostasis during pregnancy in diabetic rats. In streptozotocin-induced diabetic rats, maternal blood glucose level was controlled by daily injection of NPH insulin or saline from day 3 to 21of pregnancy. Serum concentrations of ionized calcium, calcium-regulating hormones and intestinal calcium absorption were measured on day 21 of pregnancy. No correlation was noted between serum ionized calcium concentration and maternal mean blood glucose (MBG). Serum concentrations of la, 25(OH)2 vitamin D3 and intestinal calcium absorption were negatively correlated with MBG. A marked proliferation of the duodenal villi were demonstrated as hyperglycemia progressed. Serum concentrations of PTH were positively correlated with MBG lower than 220mg/d1, whereas a negative correlation was observed with MBG higher than 220mg/d1. These results suggest that diabetic pregnant rats are characterized by reduction of serum 1a, 25 (OH)2vitamin D3 levels followed by decrease of intestinal calcium absorption. To maintain calcium homeostasis, PTH secretion was promoted under 220 240mg/dl of MBG, while it is suppressed over 220 240mg/dl of MBG, due in part to, by adverse effects of hyperglycemia on parathyroid gland. [Adv Obstet Gynecol 48]
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  • Kyousuke TAKEUCHI, Noriyuki OHARA, Matsuto MOCHIZUKI, Yasuo UEDA
    1996 Volume 48 Issue 3 Pages 173-176
    Published: May 01, 1996
    Released on J-STAGE: September 27, 2010
    JOURNAL FREE ACCESS
    The aim of this study was to clarify the effects of maternal hyperglycemia on fetal calcium metabolism. In streptozotocin-induced diabetic rats, maternal blood glucose levels during pregnancy were controlled by daily injection of NPH insulin or saline from day 3 to 21 of pregnancy. Serum concentrations of ionized calcium, PTH and calcitonin in fetuses from these rats were measured on day 21 of pregnancy. Fetal ionized calcium levels were negatively correlated with maternal mean blood glucose (MBG) in the groups of diabetic mothers whose MBG was higher than 220 240mg/dl of MBG. No correlation was noted between fetal PTH level and MBG. Fetal calcitonin level positively correlated with MBG in the groups whose MBG was lower than 220 240mg/dl, whereas a negative correlation was observed in the groups whose MBG was higher than 220 240mg/dl. These results suggest that hypersecretion of calcitonin in fetuses could be implicated in the pathogenesis of early neonatal hypocalcemia in infants of mild diabetic rats. [Adv Obstet Gynecol 48 (3): 173-176, 1996(H8.5)]
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  • Eiko WAKIMOTO, Hiroaki SHIBAHARA, Motohiro NISHIO, Tatsuo MORI, Toshit ...
    1996 Volume 48 Issue 3 Pages 177-182
    Published: May 01, 1996
    Released on J-STAGE: September 27, 2010
    JOURNAL FREE ACCESS
    Synopsis The incidence of primary tubal carcinoma is very rare in gynecological malignant tumors. We report here three cases of primary tubal carcinoma treated at Hyogo College of Medicine. From 1984 to 1993, the relative frequency of the tubal carcinoma was 0.70% (3/430). The mean patient age was 58.3 years. None of the patients were nulligravida. On their first visit to our hospital, their complaints were of lower abdominal pain and/or atypical genital bleeding. Their treatment consisted of an operation follwed by cisplatin-based chemotherapy. In two cases with postoperative stage III c, the CAl25 level in their sera was high, while in a patient with stage Ia, it was within normal limits. One of the patients, because of severe side effects, was not treated with a sufficient dose of cisplatin, and died of the disese 7years after the operation. Others showed no recurrent signs after the operation, for more than 10 years and 2.5 years respectively. These findings suggest that in a patients diagnosis, careful consideration should be given to primary tubal carcinoma, even though the incidence of the disease is very rare. Checking the patients CAl25 level might be helpful in the diagnosis of advanced primary tubal carcinoma. After maximal tumor reduction, cisplatin -based chemotherapy should be considered, to achieve higher survival rates in patients with advanced primary tubal carcinoma. [Adv Obstet Gynecol 48 (3); 177-182, 1996 (H8.5)]
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  • Morihisa YAHARA, Ikuo KONISHI, Kimitoshi IMAL, Nobuhiko KATAOKA, Miho ...
    1996 Volume 48 Issue 3 Pages 183-189
    Published: May 01, 1996
    Released on J-STAGE: September 27, 2010
    JOURNAL FREE ACCESS
    Immature teratoma is one of the malignant germ cell tumors of the ovary occurring in young women, and its pre-operative diagnosis is essential for consideration of conservative surgery. We encountered four patients with immature teratoma, and retrospectively reviewed the clinical features, especially the findings on ultrasonography, MRI, and serum tumor markers, to evaluate these potential for pre-operative diagnosis. Ultrasonography showed all 4 tumors to be a mixture of solid and cystic compo. nents, although the ratio of these areas varied in each case. MRI revealed the presence of a fat component of the tumor in all 3 cases examined by MRI, suggesting the teratomatous nature of the tumor. Among tumor markers, serum AFP level was elevated in 3 of the 4 patients, and was helpful to rule out the possibility of mature teratoma. Accordingly, combined analysis of MRI and tumor marker findings is useful for pre-operative diagnosis of ovarian immature teratoma. [Adv Obstet Gynecol 48 (3): 183---189, 199E (H8.5)]
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  • Tetsu MATSUOKAH, Hideaki MIWA, Shouji KAMIURA, Toru KANZAKI, Noboru MA ...
    1996 Volume 48 Issue 3 Pages 190-193
    Published: May 01, 1996
    Released on J-STAGE: September 27, 2010
    JOURNAL FREE ACCESS
    Placenta percreta is a rare complication during pregnancy, but can cause life-threatening hemorrhage and often leads to emergency hysterectomy. It has been reported that placenta percreta is associated with either previous cesarean section or dilation and curettege. Antenatal diagnosis is very difficult if there are no symptoms during the prenatal period. We report a case of a 34-year old woman, 2-gravida 2-para with placenta percreta and IDDM who was diagnosed at laparotomy under a diagnosis of hemoperitoneum after normal vaginal delivery. The case was managed conservatively and successfully. [Adv Obstet Gynecol 48 (3); 190-193, 1996 (H8.5)]
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  • Sinichiro SUZUKI, Naohico UMESAKI, Sachiko SHIBATA, Shoji TOMODA, Moto ...
    1996 Volume 48 Issue 3 Pages 194-198
    Published: May 01, 1996
    Released on J-STAGE: September 27, 2010
    JOURNAL FREE ACCESS
    We report a case with systemic lupus erythematosus who developed massive ascites on the 2nd day after delivery. The patient had prominent proteinuria, thrombocytopenia and hypertension during pregnancy and was diagnosed as having ITP and nephritis. She was treated with corticosterodis but without effect. Cord centesis showed a thrombocyte count in cord blood of over 150, 000/yl and a vaginal delivery was accomplished. At 1st day postpartum, oliguria appeared. On the next day massive ascites developed and 4900m1 of translucent ascitic fluid was removed. Retention of ascitic fluid was not detected thereafter. A renal biopsy performed on the 7th postpartum day confirmed the presence of lupus nephritis. In this case, the acute retention of ascites may be explained by the serositis due to SLE and the accelerated leakage caused by the decreased abdominal pressure after delivery. [Adv Obstet Gynecol 48(3); 194-198, 1996 (H8.5)]
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  • 1996 Volume 48 Issue 3 Pages 199-249
    Published: May 01, 1996
    Released on J-STAGE: September 27, 2010
    JOURNAL FREE ACCESS
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  • 1996 Volume 48 Issue 3 Pages 250-292
    Published: May 01, 1996
    Released on J-STAGE: September 27, 2010
    JOURNAL FREE ACCESS
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