To elucidate causes and treatment for recurrent spontaneous abortion, factors involved in habitual abortion (uterine abnormalities, infectious diseases, endocrinological factors, chromosomal abnormalities and autoimmune factors) in 150 patients with a history of more than two consecutive spontaneous abortion were evaluated. Patients were diagnosed with the following disorders: 32 uterine abnormalities, 8 positive for chlamydia antibody, 26 endocrinological disorders, 6 chromosomal abnormalities, 98 autoimmune abnormalities, 74idiopathic (including many overlapping cases). The number of successfully having liveborn neonates after treatment were as follows: 13 uterine abnormalities, 6 endocrinological disorders, 4 chromosomal abnormalities, 14 autoimmune abnormalities. In the 74 idiopathic cases, immunotherapy was undertaken and 31 responded well. The present study suggests that aggressive therapies are available for cases of repeated abortion and habitual abortion, especially immunotherapy for idiopathic cases. [Adv Obstet Gynecol 48 (5): 529-534, 1996 (H8.9)]
View full abstract