Carcinosarcomas (CSs) of the corpus uteri are rare and occur predominantly in elderly women. They have been subdivided into two categories with new terminologies since 1996 in the new General Rules for Clinical and Pathological Management of Uterine Corpus Cancer, homologous and heterologous, according to its sarcomatous elements. Since their prognosis has been reported to be quite poor, early diagnosis and treatment are of crucial important. We present the clinical and pathologic features of the two patients with CS; heterologous of the corpus uteri. A 29-year-old and 70-year-old women visited our hospital with a complaint of abnormal genital bleeding. In both cases endometrial cytology before operation showed atypical epithelial cells with large round pleomorphic nuclei and prominent nucleoli, which were regarded as a adenocarcinoma cells. Preoperative biopsy specimens from the uterine cavity also showed endometrial adenocarcinomas. After radical surgery, in both cases, chondrosarcoma was identified histologically in the primary lesion as well as malignant epithelial elements. Other histologic components of fibrosacoma, rhabdomyosarcoma, malignant myxoma, and spindle cell sarcoma were detected. Imprint smears of the resected tumors showed many atypical cells of both epithelial and non-epithelial origin. The adenocarcinoma cell were in papillary clusters or in acinar form with varying degrees of cytoplasmic vacuolization, enlarged nuclei, abnormal chromatin patterns and prominent nucleoli. On the other hand, non-epithelial components were seen as isolated cells or loose aggregates. They were elongated or caudate with scant and cyanophilic cytoplasm, which suggested connective tissue or muscle origin. Rhabdomyosarcoma cells appeared independently and sporadicaIly, were relatively large with a polyhedral band form. The cell margins were rather unclear and the cytoplasm was generally stained light green. Chondrosarcoma cells are round to oval in shape with large round nuclei and one or two prominent nucleoli. Their cytoplasm was rather thick and the cell border was sharp. These cytologic findings were comparable to the histologic features of the original tumors. Despite the postoperative chemotherapy, two patiens died from the original disease 9 months after surgery. The detection of non-epithelial atypical cells in endometrial cytology is considered to be of prognostic value. [Adv Obstet Gynecol 49 (4); 392-400, 1997 (H9.7)]
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