Objective: The efficacy of ovulation induction was investigated in women with infertility despite normal ovulation. Patients: One hundred thirty-one normally ovulatory women received treatment for infertility at the Department of obstetrics and Gynecology of Shiga University of Medical Science from January to December 1998. Women with bilateral tubal occlusion and those whose husbands had azoospermia were excluded. Methods: Patients who did not become pregnant during an observation period of 3months after the first visit received ovulation induction using clomiphene citrate(CC), cyclofenil, or human menopausal gonadotropins(hMG) alone or in combination. The pregnancy rate per cycle of ovulation induction was compared to the spontaneous rate retrospectively. Results: Pregnancy was confirmed in 33 cycles during the pcriod of investigation, including 23 cycles with ovulation induction and 10 spontaneous cycles. Among the 10 spontaneous cycles, 7 occurred with in 3 months after the first visit. After the observation period(3months), the pregnancy rate was significantly higher with ovulation induction than with spontaneous cycles (16 / 374 (4.3%) and 3 /284 (1.1%) respectively). The pregnancy rates for cycles with hMG (4 / 60, 6.7%) and cycles with cyclofenil (5 / 114, 4.4%) were significantly higher than for spontaneous cycles. However, the pregnancy rate for cycles with CC (7 / 209, 3.3%) was not significantly different from that for spontaneous cycles. Conclusion: Ovulation induction with hMG or cyclofenil is effective in increasing the pregnancy rate, while CC is not beneficial for normally ovulatory women. [Adv Obstet Gynecol 52 (1); 1
-- 5, 2000 (H.12.1)]
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