In 15 cancer patients in the terminal stage, a continuous decrease of serum CEA value was observed by one-step method with Dainabot CEA RIA·kit.
In order to analyse this evidence, the CEA assay method itself was investigated in relation to the mechanism of the CEA decrease in the late stage of cancer patients.
We supposed that, in the one-step method, the extremely increased CEA or CEA-like substances might be combined with
125I-CEA-antibody with interruption of the CEA RIA-kit reaction resulting in a low value of CEA. It was considered on the other hand that, in the two-step method, the consumption of
125I-CEA-antibody was prevented without interruption of the CEA RIA·kit reaction resulting in no CEA decrease.
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