Recently there has been increasing concern about the properties and efficacy of cosmetics because the government regulation of the effects of cosmetic has been eased and the publicizing of the skin care effects of foundations or lipsticks has been officially permitted since April 2001. On the other hand, bioengineering techniques closely related to the substantiation of cosmetics have been well-developed and nowadays the internal structure of human skin and cutaneous cells can be studied non-invasively using these methods. In this paper I describe a few such techniques, which are
in vivo measurement of the microtopography of human skin surface (texture and wrinkles),
in vivo confocal lazer microscopy to study depigmentation, optical coherence tomography (OCT) for stratum corneum thickness and epidermal-dermal undulation measurement, and
in vivo confocal Raman microspectroscopy for measurement of water distribution in stratum corneum. The possibility of application to efficacy testing of cosmetics is also mentioned.
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