For the purpose of investigating the seasonal change in immune function, seasonal changes in the levels of serum immunoglobulins, complements and some serum proteins were examined.
Blood samples from the median cubital vein were collected every month (between May 1983 and February 1984) from a group of healthy adults (13 males) with a mean age of 21.5 years.
1. Blood was collected always at the rising time A.M. 6: 30 or A.M. 6: 00 in summer time) in basal metabolic condition.
2. Serum total protein and albumin were measured by Technicon Autoanalyzer SMAC, and serum immunoglobulins, complements and some serum proteins were measured by Nephelotek system. The obtained values were individually standardized for each individual subject and then were used for the examination of seasonal changes.
3. Immunoglobulins, IgG, IgA and IgM changed significantly with a circannual rhythm; drop in levels were found from May to July and rose from October to December. Statistical significances (P<0.1%; T-test) were observed in all immunoglobulins between the highest monthly mean values and the lowest.
4. Complements, C3 and C4 also changed significantly. The seasonal change of C3 was similar to that of the immunoglobulins but the change of C4 was unique; drops in levels were found from January to May and rose from September to October.
5. Albumin and prealbumin did not change according to the season. But, some other types of serum protein; α-1-antitrypsin, α-2-macroglobulin, haptoglobin and transferrin also changed significantly with a circannual rhythm similar to that of the immunoglobulins.
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