The present study was designed to verify that patency of the emissary pathways is necessary for selective brain cooling during body warming in human subjects. In a climatic chamber (25°C-20% R.H.), tympanic (Tty) and esophageal (Tes) temperatures, and blood flow patterns in the angularis oculi vein (AOV) were recorded in male subjects during body warming with equipment (box shaped body warming unit) which provided a controlled climate. Each subject's head protruded outside the body warming unit and the direction and velocity of blood flow through the AOV were determined using an ultrasonic-Doppler recorder. The subject's face was fanned from the beginning with room air at a wind speed of about 2.5 m⋅sec
-1 at the nose. After Tes reached the temperature 0.8-1.0°C higher than the prewarming level and while Tes and Tty were rising linearly by body warming, blood flow through the AOV was obstructed for 8 min by compression on the AOV. While obstructed, the rate of rise in Tty became greater than before while that in Tes did not change. After the obstruction was released, the rate of rise in Tty gradually returned to the pre-obstruction value. In a second series of experiments, blood flow through the facial veins was obstructed for 8 min by occlusion of the facial veins at an alinasal level after Tes reached the temperature 0.6-0.7°C higher than the prewarming level. While obstructed, inward flow through the AOV (from the face to the brain) was increased and the rate of rise in Tty became less than before but that in Tes did not change. From these results we conclude that patency of the emissary pathways is important for selective brain cooling during body warming in normal subjects.
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