SEISAN KENKYU
Online ISSN : 1881-2058
Print ISSN : 0037-105X
ISSN-L : 0037-105X
Volume 70 , Issue 3
Showing 1-17 articles out of 17 articles from the selected issue
Introduction to Special Section
Research Flash
  • Akane HARA, Shinji NAKAOKA, Kazuyuki AIHARA
    2018 Volume 70 Issue 3 Pages 141-144
    Published: May 01, 2018
    Released: May 30, 2018
    JOURNAL FREE ACCESS

    Close association between intestinal microbiota and the immune system suggests possibility of developing a novel treatment method for allergy by modulating intestinal microbiota. Although time-series data with sufficient length are required for microbiota modulation, no such datasets are found which match the requirement. In this study, we apply and examine a new method to reconstruct a pseudo-temporal path of allergy development from non-time-series samples reflecting various individual states in the process of allergy development. We aim to refine this method to provide a data-driven intervention strategy for prevention of allergy.

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Research Review
  • Yuji OKAMOTO
    2018 Volume 70 Issue 3 Pages 145-150
    Published: May 01, 2018
    Released: May 30, 2018
    JOURNAL FREE ACCESS

    The purpose of this paper is to introduce various nonnegative systems and preset the stability analysis method of each system. Biological phenomena are modeled using nonnegative conditions such as the number of animals, the concentration of chemicals in the body. Nonnegative systems represent not only biological and biological phenomena but also various phenomena. This paper introduces various nonnegative systems such as nonnegative linear system, Lotka-Volterra equation, positive secondary system, and so on. In addition, this paper clarifies the range of phenomena that each nonnegative system can express. Finally, this paper introduces the stability analysis method peculiar to the nonnegative system.

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  • Takahiro OMI
    2018 Volume 70 Issue 3 Pages 151-155
    Published: May 01, 2018
    Released: May 30, 2018
    JOURNAL FREE ACCESS

    In these decades, high-frequency financial data, which are big data containing detailed information on each transaction, have become available, and there has been growing needs for methods to analyze such data. Recently, point processes have been recognized as a useful tool to analyze high-frequency data. Point processes are probability models of timings of occurrences of events, and Hawkes processes, a type of point processes, can reproduce actually observed occurrence patterns of transactions or orders. In this article, we introduce a basic concept of point processes, and review our recent study on high-frequency financial data analysis using Hawkes processes.

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  • Tomoya TAKEUCHI
    2018 Volume 70 Issue 3 Pages 157-164
    Published: May 01, 2018
    Released: May 30, 2018
    JOURNAL FREE ACCESS

    We develop the theoretical foundation on the proximal method of multipliers for a class of nonsmooth convex optimization. The method generates a sequence of subproblems for the objective functions of the sum of the augmented Lagrangian due to Fortin and the proximal term. We show that the sequence of approximations to the subproblems converges to a saddle point of the standard Lagrangian even if the original optimization problem may possess multiple solutions. We employ a nonsmooth Newton method for computing an approximation to the subproblem. We exploit the theory of the nonsmooth analysis to provide a rigorous proof for the global convergence of the nonsmooth Newton algorithm.

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  • Kai MORINO
    2018 Volume 70 Issue 3 Pages 165-169
    Published: May 01, 2018
    Released: May 30, 2018
    JOURNAL FREE ACCESS

    This review article introduces timeseries analysis based on an aggregating algorithm Expert Advice. In the Expert Advice, an expert possesses its weight that is determined by its accumulated loss of errors. Then, the prediction of the Expert Advice is obtained by the weighted average over the predictions of these experts and their weights. This review article gives theoretical introduction and examples of application of the Expert Advice.

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Research Flash
Research Review
  • Hiroyuki YASUDA
    2018 Volume 70 Issue 3 Pages 175-181
    Published: May 01, 2018
    Released: May 30, 2018
    JOURNAL FREE ACCESS

    Noise-induced synchronization is a phenomenon that the nonlinear oscillators synchronize by adding common noise to each of them. A new synchronization scheme based on noise-induced synchronization phenomenon has been proposed, and uncoupled wireless devices are synchronized without any wireless communication by the scheme. In the proposed scheme, natural fluctuations are applied to the nonlinear oscillators as common noise of noise-induced synchronization phenomenon. This paper explains detail of this natural synchronization scheme. This paper gives a brief exposition about confirmation of synchronization phenomenon by theory and numerical simulations and verifying synchronization performance by an implementation to wireless sensor network and so on.

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Research Flash
  • Hiroto TAMURA, Takashi KOHNO, Kazuyuki AIHARA
    2018 Volume 70 Issue 3 Pages 183-185
    Published: May 01, 2018
    Released: May 30, 2018
    JOURNAL FREE ACCESS

    A deep neural network (DNN) has been in the center of attention in the field of machine learning, and the chaotic neuron and chaotic neural network (ChNN) models have been in the spotlight in computational neuroscience and nonlinear science. However, there are no studies on deep ChNN. In order to fill this gap, we propose a ReLU (rectifier linear unit) chaotic neuron model, which is necessary for the application of the chaotic neuron model to DNN with ReLU activation. We also show that even a single ReLU chaotic neuron can generate dynamically changing outputs in spite of the simplicity of ReLU.

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Introduction to Special Section
Other
  • Teru OKITSU, Eric LEBLANC, Dominique COLLARD, Hiroyuki FUJITA
    2018 Volume 70 Issue 3 Pages 189-191
    Published: May 01, 2018
    Released: May 30, 2018
    JOURNAL FREE ACCESS

    SMMiL-E is the first overseas laboratory of the Institute of Industrial Science, the University of Tokyo.

    In SMMiL-E, interdisciplinary and international collaborations are preformed to implement microsystems developed in LIMMS at the IIS into cancer therapies in Lille, France. To proceed with these collaborations smoothly and fruitfully, a new function called “Scientific Direction” has been implemented. Specifically, two medical doctors, one French and the other Japanese, have been selected and assigned as Scientific Directors to supervise and guide the research within SMMiL-E. Scientific Direction is now expected to expand to uphold the qualities of the collaborative projects in SMMiL-E, as the organization continues to grow in scale. Efficient Scientific Direction is a key to the success of the SMMiL-E endeavour.

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Research Review
Research Flash
  • Nobuhiro TANIYAMA, Yusuke SUNADA
    2018 Volume 70 Issue 3 Pages 197-199
    Published: May 01, 2018
    Released: May 30, 2018
    JOURNAL FREE ACCESS

    Transition metal compounds play an important role as the catalyst for the various organic transformation reactions in both laboratory experiments and industrial applications. It is well known that the ligand exchange is the primary step in many cases of these catalysis. In this paper, the ligand exchange reaction of the CNtBu ligands on the planar tetranuclear palladium cluster, Pd4[Si(iPr2)]3(CNtBu)4 (1), to the iPr2IMMe ligands have been elucidated. In the course of this reaction, formation of a new Pd4 cluster Pd4[Si(iPr2)]3(CNtBu)2 (iPr2IMMe)3 (3) as intermediary species was confirmed, suggesting that ligand exchange reaction proceeded through the associative mechanism.

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  • Rie KINOSHITA, Yuya HASHIZUME, Nobuyuki TAKAMA, Beomjoon KIM
    2018 Volume 70 Issue 3 Pages 201-204
    Published: May 01, 2018
    Released: May 30, 2018
    JOURNAL FREE ACCESS

    We observe the permeability of several commercially-available microneedle patches for cosmetic purposes to human skin (back of hand), and investigate methods of evaluating permeability to the stratum corneum, and its’ degree of pain. We predicted that the permeability of dissoluble microneedles differs according to the age and sex of humans, then we evaluated the permeability based on 18 person’s clinical tests by using imagediagnosis of“ optical coherence tomography (OCT)”. The basic data obtained in this research can be used for developing an experimental plan for new microneedle fabrication to be implemented in further medical applications.

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  • Shotaro KUROKAWA, Nobuyuki TAKAMA, Beomjoon KIM
    2018 Volume 70 Issue 3 Pages 205-208
    Published: May 01, 2018
    Released: May 30, 2018
    JOURNAL FREE ACCESS

    Blood extracting Microneedle has been studied for minimally invasive and rapid blood tests. However, in practical use of solid micro needles, the risk is concerned that microneedle can be easily broken due to the load of puncture and that of remaining broken needle in the subcutaneous. To solve the risk, this research has developed a blood extracting microneedle using biodegradable polymer. In this research, instead of the conventional hollow needle, we proposed the porous polymer needles to absorb blood. For the development of porous needles, experiments were conducted to determine suitable porosity. As a result, 60% or more of porosity is suitable for blood extracting and its minimum extracting speed is 1.75 μl/min.

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  • — Through comparison with ‘structure’. —
    Hiroko RYU, Yoshiro MORITA, Yukiko T. MATSUNAGA
    2018 Volume 70 Issue 3 Pages 209-213
    Published: May 01, 2018
    Released: May 30, 2018
    JOURNAL FREE ACCESS

    Continuing from our previous paper, in this section, we investigated the following three items in the Web of Science of academic literature search service: (i) the number of documents including ‘structure’ in their titles, (ii) in what research field does the literature includes ‘structure’ in the title, and (iii) what kind of research fields overlap for literature that include‘ structure’ in the title. We obtained the knowledge that the word of ‘structure’ was mainly used in the field of ‘Physical Sciences’. In recent years it was also used in the field of ‘Technology’.

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  • Kensaku HAYASHI, Momoko KUMEMURA, Shohei KANEDA, Teruo FUJII, Beomjoon ...
    2018 Volume 70 Issue 3 Pages 215-218
    Published: May 01, 2018
    Released: May 30, 2018
    JOURNAL FREE ACCESS

    Silicon nanotweezers (SNT) are a mechanical characterization tool for biological samples such as DNA bundles or single cells. With this device, it is possible to perform mechanical characterization followed by genetic analysis of a single cell. However, it is difficult to release cells from the SNT probes after mechanical characterization because cells tend to physically adhere to the silicon or glass surface of the device.

    To solve this problem, we explored surface modification techniques for the SNT probes using several types of chemical coatings as well as modifying the scallop size on the silicon sidewall during fabrication. We measured the hydrophobicity of modified silicon surfaces, then treated SNT probes and evaluated their performance in cell trapping and releasing.

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