SEISAN KENKYU
Online ISSN : 1881-2058
Print ISSN : 0037-105X
ISSN-L : 0037-105X
Volume 72 , Issue 3
Showing 1-9 articles out of 9 articles from the selected issue
Introduction to Special Section
Research Review
  • Kazuyuki ISHII
    Type: Research Review
    2020 Volume 72 Issue 3 Pages 227-231
    Published: May 01, 2020
    Released: June 13, 2020
    JOURNAL FREE ACCESS

    The homochirality of life, which is related to the origin of life, is still unsolved. For explaining the origin, three candidates, such as the Earth’s rotational motion (the Coriolis force), circularly polarized light-induced asymmetric photochemical reactions, and asymmetric photochemical reactions under a magnetic field, have been proposed. In this paper, recent studies on both the magneto-chiral dichroism and the relationship between molecular chirality and vortex motions are introduced in terms of chemical approaches to the origin of homochirality of life.

    Download PDF (1406K)
  • Kazuyuki ISHII
    Type: Research Review
    2020 Volume 72 Issue 3 Pages 233-237
    Published: May 01, 2020
    Released: June 13, 2020
    JOURNAL FREE ACCESS

    Red or near-infrared light(> 650 nm) can show high permeability to living tissue. Phthalocyanines are useful for biological applications, because they have intense Q absorption bands and fluorescence in the red or near-infrared light region, and can efficiently generate singlet oxygen. The photobiological applications of phthalocyanines are introduced from the viewpoint of new photodynamic therapy photosensitizers and fluorescence probes for detecting ascorbic acid.

    Download PDF (1971K)
  • Hikaru SASAKI, Toshiyuki HIRANO, Fumitoshi SATO
    Type: Research Review
    2020 Volume 72 Issue 3 Pages 239-246
    Published: May 01, 2020
    Released: June 13, 2020
    JOURNAL FREE ACCESS

    Insulin-like growth factor (IGF-1), whose structure is similar to insulin, promotes growth and differentiation of cells. On the other hand, insulin lowers the level of sugar in the blood. These proteins are similar in structure, but they bind to different receptors. To infer what differences are used to discriminate between them, we compared those electronic structures. As a result, the significant differences were found in the distribution on electrostatic potential and electron density.

    Download PDF (1164K)
Research Flash
  • Misaki KATO, Yusuke SUNADA
    Type: Research Flash
    2020 Volume 72 Issue 3 Pages 247-249
    Published: May 01, 2020
    Released: June 13, 2020
    JOURNAL FREE ACCESS

    Transition metal compounds bearing group 14 element as the auxiliary ligands are known to show unique chemical and/or physical properties including catalytic performance. In this paper, we wish to report the synthesis transition metal complexes having organogermanium ligand by the reaction of hexaphenyldigermane with low valent nickel precursor. In the course of this reaction, insertion of the nickel species into both GeGe and Ge-Ph bonds took place to afford the corresponding mononuclear nickel complexes. Insertion of nickel species into Ge-Ge bond preferentially occurred when the reaction was conducted under higher reaction temperature.

    Download PDF (635K)
Research Review
  • Tatsuya OSAKI, Yuna KINJO, Yoshiho IKEUCHI
    Type: Research Review
    2020 Volume 72 Issue 3 Pages 251-255
    Published: May 01, 2020
    Released: June 13, 2020
    JOURNAL FREE ACCESS

    Brain is the most complex organ in the body which controls all human activities including movement, sensing, consciousness, and memory. To understand mechanisms underlying human brain functions, various techniques such as EEG and fMR have been developed and advanced. In addition, recently, brain-like tissue called “brain organoid” is employed for the studies. The organoid technology open, a new avenue to elucidate the mechanism of complex human brain functions and to develop cure for brain diseases. Herein, we discuss where we stand and where we are going in the organoid research.

    Download PDF (922K)
Research Flash
Research Review
  • Yukinori IKEDA, Yukiko T. MATSUNAGA
    Type: Research Review
    2020 Volume 72 Issue 3 Pages 261-267
    Published: May 01, 2020
    Released: June 13, 2020
    JOURNAL FREE ACCESS

    Understanding the interaction between blood vessel and cancer is important for developing new strategy of cancer treatment because it is estimated that metastasis is responsible for the majority of cancer-related deaths. However, there is a technical limitation in realizing cellular dynamics during metastasis using conventional 2D culture model or animals. Recently, sophisticated in vitro systems so called organ-on-a-chip mimicking microphysiological living systems have started to attract attention in this area. They allow mimicking 3D cancer microenvironment with control of physical and chemical parameters, and also visualizing cellular dynamics at a cellular level under the microscope, which are difficult in conventional animal experiments. In this article, we introduce recent microvessel models which can be used in cancer metastasis research.

    Download PDF (1150K)
Research Flash
  • Hiroyuki ONEYAMA, Satoshi NIIKURA, Masami YANAGIHARA, Takashi OGUCHI
    Type: Research Flash
    2020 Volume 72 Issue 3 Pages 269-274
    Published: May 01, 2020
    Released: June 13, 2020
    JOURNAL FREE ACCESS

    The article reports the empirical analysis on the effects of traffic signal head location difference with real vehicles at test track of the Institute of Industrial Science located at Kashiwa-campus of the University of Tokyo. In the case of 'near' signal, drivers tend to pass the intersection rather far upstream location and later time point compared with the case of 'far' signal. The start-up behavior at the onset of green signal can be interpreted by the difference of crossing direction signal head visibility between 'far' and 'near' signal. The right-turners at the signal change interval from green signal after confirming the stopping behavior of counterdirectional through traffic tend to start to move about 1 second later in the case of 'near' signal.

    Download PDF (1070K)
feedback
Top