Purpose: To compare the retinal ganglion cell (RGC) density in the control and coenzyme Q10-treated rat models of methanol toxic optic neuropathy (MTON). Methods: This experimental animal study was conducted in 14 MTON model rats divided into two groups, the control group (I) and the coenzyme Q10 group (II). Both groups were exposed to N2O:O2 and orally administered methanol (3 g/kg body weight). After 4 h, the rats in the group II were orally administered coenzyme Q10. After 8 h, the eyes were enucleated and histopathological specimens were prepared. The specimens were imaged under a microscope at 200× magnification and the RGC densities were counted. Results: The average RGC densities for the group I and group II were 36.57 (SD 5.84) and 57.67 (SD 7.63), respectively. A significant difference was identified between the two groups (p<0.001). Conclusion: RGC density was higher in the MTON model rats that were treated with coenzyme Q10 compared to the control group.