THE SHINSHU MEDICAL JOURNAL

THE SHINSHU MEDICAL JOURNAL

Online ISSN : 1884-6580
Print ISSN : 0037-3826
ISSN-L : 0037-3826

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Volume 63, Issue 5

Displaying 1-10 of 10 articles from this issue

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Foreword

Mission of Shinshu University Hospital

Kazuhiro HONGO

2015 Volume 63 Issue 5 Pages 271-272
Published: October 10, 2015
Released on J-STAGE: October 30, 2015

DOIhttps://doi.org/10.11441/shinshumedj.63.271

JOURNAL FREE ACCESS

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Review

Pathology of Antibody-mediated Rejection in Kidney Transplantation

Kazuho HONDA

2015 Volume 63 Issue 5 Pages 273-280
Published: October 10, 2015
Released on J-STAGE: October 30, 2015

DOIhttps://doi.org/10.11441/shinshumedj.63.273

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Original

Nox4-generated ROS Regulate TGF-β1-induced Motility of Colon Cancer Cells through the Low Molecular Weight Protein Tyrosine Phosphatase-Rho Signaling Pathway

Ye ZHANG, Jun NAKAYAMA, Tohru KAMATA

2015 Volume 63 Issue 5 Pages 281-293
Published: October 10, 2015
Released on J-STAGE: October 30, 2015

DOIhttps://doi.org/10.11441/shinshumedj.63.281

JOURNAL FREE ACCESS

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We investigated the role of NADPH oxidase (Nox) 4 in colon cancer development. The expression of Nox4, unlike Nox1, was specifically induced in colon carcinoma and was quite similar to that of transforming growth factor-β (TGF-β)1. TGF-β1 treatment of colon cancer cells upregulated the Nox4 expression and ROS production through SMAD3. Knockdown of Nox4 suppressed TGF-β1-induced cell motility. Nox4 modulated the Rho activity through redox regulation of the low molecular weight protein tyrosine phosphatase (LMW-PTP)-p190RhoGAP pathway upon TGF-β1 stimulation. These finding suggests that Nox4 contributes to TGF-β1-dependent motility of colon carcinoma through the LMW-PTP-p190RhoGAP-Rho signaling pathway.

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[title in Japanese]

2015 Volume 63 Issue 5 Pages 295-349
Published: October 10, 2015
Released on J-STAGE: October 30, 2015

DOIhttps://doi.org/10.11441/shinshumedj.63.295

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Current Topics

[title in Japanese]

Fumie AOSAI

2015 Volume 63 Issue 5 Pages 351-353
Published: October 10, 2015
Released on J-STAGE: October 30, 2015

DOIhttps://doi.org/10.11441/shinshumedj.63.351

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My Choice of Speciality

[title in Japanese]

Michitaro ICHIKAWA, Go MATSUMOTO

2015 Volume 63 Issue 5 Pages 354
Published: October 10, 2015
Released on J-STAGE: October 30, 2015

DOIhttps://doi.org/10.11441/shinshumedj.63.354

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Book Review by Author

[title in Japanese]

Tomonori MINAGAWA

2015 Volume 63 Issue 5 Pages 355
Published: October 10, 2015
Released on J-STAGE: October 30, 2015

DOIhttps://doi.org/10.11441/shinshumedj.63.355

JOURNAL FREE ACCESS

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What’s New? -The Latest from the Labs

[title in Japanese]

Shun'ichiro TANIGUCHI

2015 Volume 63 Issue 5 Pages 356
Published: October 10, 2015
Released on J-STAGE: October 30, 2015

DOIhttps://doi.org/10.11441/shinshumedj.63.356

JOURNAL FREE ACCESS

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[title in Japanese]

Kenji OKADA

2015 Volume 63 Issue 5 Pages 357
Published: October 10, 2015
Released on J-STAGE: October 30, 2015

DOIhttps://doi.org/10.11441/shinshumedj.63.357

JOURNAL FREE ACCESS

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Abstract of Meetings

[title in Japanese]

2015 Volume 63 Issue 5 Pages 359-361
Published: October 10, 2015
Released on J-STAGE: October 30, 2015

DOIhttps://doi.org/10.11441/shinshumedj.63.359

JOURNAL FREE ACCESS

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